Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG
Brandsma, Arianne M, Bondza, Sina, Evers, Mitchell, Koutstaal, Rosanne, Nederend, Maaike, Jansen, J H Marco, Rösner, Thies, Valerius, Thomas, Leusen, Jeanette H W, Ten Broeke, Toine
Published in Frontiers in immunology (11.04.2019)
Published in Frontiers in immunology (11.04.2019)
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Journal Article
Effective, Long-Term, Neutrophil Depletion Using a Murinized Anti-Ly-6G 1A8 Antibody
Olofsen, Patricia A, Stip, Marjolein C, Jansen, J H Marco, Chan, Chilam, Nederend, Maaike, Tieland, Ralph G, Tsioumpekou, Maria, Leusen, Jeanette H W
Published in Cells (Basel, Switzerland) (27.10.2022)
Published in Cells (Basel, Switzerland) (27.10.2022)
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Journal Article
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy
Logtenberg, Meike E. W., Jansen, J. H. Marco, Raaben, Matthijs, Toebes, Mireille, Franke, Katka, Brandsma, Arianne M., Matlung, Hanke L., Fauster, Astrid, Gomez-Eerland, Raquel, Bakker, Noor A. M., van der Schot, Simone, Marijt, Koen A., Verdoes, Martijn, Haanen, John B. A. G., van den Berg, Joost H., Neefjes, Jacques, van den Berg, Timo K., Brummelkamp, Thijn R., Leusen, Jeanette H. W., Scheeren, Ferenc A., Schumacher, Ton N.
Published in Nature medicine (01.04.2019)
Published in Nature medicine (01.04.2019)
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Journal Article
Immune Effector Functions of Human IgG2 Antibodies against EGFR
Rösner, Thies, Kahle, Steffen, Montenegro, Francesca, Matlung, Hanke L, Jansen, J H Marco, Evers, Mitchell, Beurskens, Frank, Leusen, Jeanette H W, van den Berg, Timo K, Valerius, Thomas
Published in Molecular cancer therapeutics (01.01.2019)
Published in Molecular cancer therapeutics (01.01.2019)
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Journal Article
Enhancement of epidermal growth factor receptor antibody tumor immunotherapy by glutaminyl cyclase inhibition to interfere with CD47/signal regulatory protein alpha interactions
Baumann, Niklas, Rösner, Thies, Jansen, J. H. Marco, Chan, Chilam, Marie Eichholz, Klara, Klausz, Katja, Winterberg, Dorothee, Müller, Kristina, Humpe, Andreas, Burger, Renate, Peipp, Matthias, Schewe, Denis M., Kellner, Christian, Leusen, Jeanette H. W., Valerius, Thomas
Published in Cancer science (01.08.2021)
Published in Cancer science (01.08.2021)
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Journal Article
Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody‐dependent cell‐mediated cytotoxicity and complement‐dependent cytotoxicity
Lohse, Stefan, Loew, Sebastian, Kretschmer, Anna, Jansen, J. H. Marco, Meyer, Saskia, ten Broeke, Toine, Rösner, Thies, Dechant, Michael, Derer, Stefanie, Klausz, Katja, Kellner, Christian, Schwanbeck, Ralf, French, Ruth R., Tipton, Thomas R. W., Cragg, Mark S., Schewe, Denis M., Peipp, Matthias, Leusen, Jeanette H. W., Valerius, Thomas
Published in British journal of haematology (01.05.2018)
Published in British journal of haematology (01.05.2018)
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Journal Article
Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells
Lustig, Marta, Chan, Chilam, Jansen, J H Marco, Bräutigam, Maria, Kölling, Max A, Gehlert, Carina Lynn, Baumann, Niklas, Mester, Simone, Foss, Stian, Andersen, Jan Terje, Bastian, Lorenz, Sondermann, Peter, Peipp, Matthias, Burger, Renate, Leusen, Jeanette H W, Valerius, Thomas
Published in Frontiers in immunology (2023)
Published in Frontiers in immunology (2023)
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Journal Article
Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9
Chan, Chilam, Lustig, Marta, Jansen, J H Marco, Garcia Villagrasa, Laura, Raymakers, Leon, Daamen, Lois A, Valerius, Thomas, van Tetering, Geert, Leusen, Jeanette H W
Published in Cancers (29.06.2023)
Published in Cancers (29.06.2023)
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Journal Article
Bovine IgG Prevents Experimental Infection With RSV and Facilitates Human T Cell Responses to RSV
Nederend, Maaike, van Stigt, Arthur H, Jansen, J H Marco, Jacobino, Shamir R, Brugman, Sylvia, de Haan, Cornelis A M, Bont, Louis J, van Neerven, R J Joost, Leusen, Jeanette H W
Published in Frontiers in immunology (06.08.2020)
Published in Frontiers in immunology (06.08.2020)
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Journal Article
Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting
Meyer, Saskia, Nederend, Maaike, Jansen, J H Marco, Reiding, Karli R, Jacobino, Shamir R, Meeldijk, Jan, Bovenschen, Niels, Wuhrer, Manfred, Valerius, Thomas, Ubink, Ruud, Boross, Peter, Rouwendal, Gerard, Leusen, Jeanette H W
Published in mAbs (01.01.2016)
Published in mAbs (01.01.2016)
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Journal Article
FcRγ-chain ITAM signaling is critically required for cross-presentation of soluble antibody-antigen complexes by dendritic cells
Boross, Peter, van Montfoort, Nadine, Stapels, Daphne A C, van der Poel, Cees E, Bertens, Christian, Meeldijk, Jan, Jansen, J H Marco, Verbeek, J Sjef, Ossendorp, Ferry, Wubbolts, Richard, Leusen, Jeanette H W
Published in The Journal of immunology (1950) (01.12.2014)
Published in The Journal of immunology (1950) (01.12.2014)
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Journal Article
Mac-1 (CD11b/CD18) is crucial for effective Fc receptor–mediated immunity to melanoma
van Spriel, Annemiek B., van Ojik, Heidi H., Bakker, Annie, Jansen, MarcoJ.H., van de Winkel, JanG.J.
Published in Blood (01.01.2003)
Published in Blood (01.01.2003)
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Journal Article
MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL
Vikström, Ingela B, Slomp, Anne, Carrington, Emma M, Moesbergen, Laura M, Chang, Catherine, Kelly, Gemma L, Glaser, Stefan P, Jansen, J H Marco, Leusen, Jeanette H W, Strasser, Andreas, Huang, David C S, Lew, Andrew M, Peperzak, Victor, Tarlinton, David M
Published in Cell death & disease (25.08.2016)
Published in Cell death & disease (25.08.2016)
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Journal Article
The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden
BOROSS, Peter, MARCO JANSEN, J. H, LEUSEN, Jeanette H. W, DE HAIJ, Simone, BEURSKENS, Frank J, VAN DER POEL, Cees E, BEVAART, Lisette, NEDEREND, Maaike, GOLAY, Josée, VAN DE WINKEL, Jan G. J, PARREN, Paul W. H. I
Published in Haematologica (Roma) (01.12.2011)
Published in Haematologica (Roma) (01.12.2011)
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Journal Article
The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking
Overdijk, Marije B, Jansen, J H Marco, Nederend, Maaike, Lammerts van Bueren, Jeroen J, Groen, Richard W J, Parren, Paul W H I, Leusen, Jeanette H W, Boross, Peter
Published in The Journal of immunology (1950) (01.08.2016)
Published in The Journal of immunology (1950) (01.08.2016)
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Journal Article
ITPK1 Sensitizes Tumor Cells to IgA-dependent Neutrophil Killing In Vivo
Richterich, Connor A, Logtenberg, Meike E W, Jansen, Marco J H, Toebes, Mireille, Bresser, Kaspar, Borst, Anne, Jurgens, Anouk P, Leusen, Jeanette H W, Schumacher, Ton N
Published in The Journal of immunology (1950) (15.10.2024)
Published in The Journal of immunology (1950) (15.10.2024)
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Journal Article
The relevance of tumor target expression levels on IgA-mediated cytotoxicity in cancer immunotherapy
Chan, Chilam, Cabanes, Núria Casalé, Jansen, J. H. Marco, Guillaume, Joël, Nederend, Maaike, Passchier, Elsemieke M., Gómez-Mellado, Valentina E., Peipp, Matthias, Boes, Marianne, van Tetering, Geert, Leusen, Jeanette H. W.
Published in Cancer Immunology, Immunotherapy : CII (03.10.2024)
Published in Cancer Immunology, Immunotherapy : CII (03.10.2024)
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Journal Article
Enhancing Neutrophil Cytotoxicity of a Panel of Clinical EGFR Antibodies by Fc Engineering to IgA3.0
Chan, Chilam, Jansen, J H Marco, Hendriks, Ilona S T, van der Peet, Ida C, Verdonschot, Meggy E L, Passchier, Elsemieke M, Tsioumpekou, Maria, Nederend, Maaike, Klomp, Sharon A, Valerius, Thomas, Peipp, Matthias, Leusen, Jeanette H W, Olofsen, Patricia A
Published in Molecular cancer therapeutics (04.09.2024)
Published in Molecular cancer therapeutics (04.09.2024)
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Journal Article
Characterization of human Fc alpha receptor transgenic mice: comparison of CD89 expression and antibody-dependent tumor killing between mouse strains
Stip, Marjolein C., Jansen, J. H. Marco, Nederend, Maaike, Tsioumpekou, Maria, Evers, Mitchell, Olofsen, Patricia A., Meyer-Wentrup, Friederike, Leusen, Jeanette H. W.
Published in Cancer Immunology, Immunotherapy (01.09.2023)
Published in Cancer Immunology, Immunotherapy (01.09.2023)
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Journal Article
An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo
Lohse, Stefan, Meyer, Saskia, Meulenbroek, Laura A P M, Jansen, J H Marco, Nederend, Maaike, Kretschmer, Anna, Klausz, Katja, Möginger, Uwe, Derer, Stefanie, Rösner, Thies, Kellner, Christian, Schewe, Denis, Sondermann, Peter, Tiwari, Sanjay, Kolarich, Daniel, Peipp, Matthias, Leusen, Jeanette H W, Valerius, Thomas
Published in Cancer research (Chicago, Ill.) (15.01.2016)
Published in Cancer research (Chicago, Ill.) (15.01.2016)
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Journal Article