Structural basis for specific inhibition of the deubiquitinase UCHL1
Grethe, Christian, Schmidt, Mirko, Kipka, Gian-Marvin, O’Dea, Rachel, Gallant, Kai, Janning, Petra, Gersch, Malte
Published in Nature communications (10.10.2022)
Published in Nature communications (10.10.2022)
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Journal Article
Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation
Rousová, Dorota, Nivsarkar, Vaishnavi, Altmannova, Veronika, Raina, Vivek B, Funk, Saskia K, Liedtke, David, Janning, Petra, Müller, Franziska, Reichle, Heidi, Vader, Gerben, Weir, John R
Published in eLife (24.12.2021)
Published in eLife (24.12.2021)
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Journal Article
Image‐Based Morphological Profiling Identifies a Lysosomotropic, Iron‐Sequestering Autophagy Inhibitor
Laraia, Luca, Garivet, Guillaume, Foley, Daniel J., Kaiser, Nadine, Müller, Sebastian, Zinken, Sarah, Pinkert, Thomas, Wilke, Julian, Corkery, Dale, Pahl, Axel, Sievers, Sonja, Janning, Petra, Arenz, Christoph, Wu, Yaowen, Rodriguez, Raphaël, Waldmann, Herbert
Published in Angewandte Chemie International Edition (27.03.2020)
Published in Angewandte Chemie International Edition (27.03.2020)
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Journal Article
Covalent-Allosteric Kinase Inhibitors
Weisner, Jörn, Gontla, Rajesh, van der Westhuizen, Leandi, Oeck, Sebastian, Ketzer, Julia, Janning, Petra, Richters, André, Mühlenberg, Thomas, Fang, Zhizhou, Taher, Abu, Jendrossek, Verena, Pelly, Stephen C., Bauer, Sebastian, van Otterlo, Willem A. L., Rauh, Daniel
Published in Angewandte Chemie International Edition (24.08.2015)
Published in Angewandte Chemie International Edition (24.08.2015)
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Journal Article
Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics
Kawamura, Tatsuro, Futamura, Yushi, Shang, Erchang, Muroi, Makoto, Janning, Petra, Ueno, Masayoshi, Wilke, Julian, Takeda, Shigeki, Kondoh, Yasumitsu, Ziegler, Slava, Watanabe, Nobumoto, Waldmann, Herbert, Osada, Hiroyuki
Published in Bioscience, biotechnology, and biochemistry (01.12.2020)
Published in Bioscience, biotechnology, and biochemistry (01.12.2020)
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Journal Article
Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease
Ulbrich, Sarah, Janning, Petra, Seidel, Ralf, Matschke, Jakob, Gonsberg, Anika, Jung, Sebastian, Glatzel, Markus, Engelhard, Martin, Winklhofer, Konstanze F, Tatzelt, Jörg
Published in PloS one (23.05.2018)
Published in PloS one (23.05.2018)
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Journal Article
Natural product–inspired cascade synthesis yields modulators of centrosome integrity
Dückert, Heiko, Pries, Verena, Khedkar, Vivek, Menninger, Sascha, Bruss, Hanna, Bird, Alexander W, Maliga, Zoltan, Brockmeyer, Andreas, Janning, Petra, Hyman, Anthony, Grimme, Stefan, Schürmann, Markus, Preut, Hans, Hübel, Katja, Ziegler, Slava, Kumar, Kamal, Waldmann, Herbert
Published in Nature chemical biology (25.12.2011)
Published in Nature chemical biology (25.12.2011)
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Journal Article
Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors
Goebel, Lisa, Kirschner, Tonia, Koska, Sandra, Rai, Amrita, Janning, Petra, Maffini, Stefano, Vatheuer, Helge, Czodrowski, Paul, Goody, Roger S, Müller, Matthias P, Rauh, Daniel
Published in eLife (27.03.2023)
Published in eLife (27.03.2023)
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Journal Article
Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M
Rusch, Marion, Zimmermann, Tobias J., Bürger, Marco, Dekker, Frank J., Görmer, Kristina, Triola, Gemma, Brockmeyer, Andreas, Janning, Petra, Böttcher, Thomas, Sieber, Stephan A., Vetter, Ingrid R., Hedberg, Christian, Waldmann, Herbert
Published in Angewandte Chemie International Edition (10.10.2011)
Published in Angewandte Chemie International Edition (10.10.2011)
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Journal Article
2‐Sulfonylpyrimidines Target the Kinesin HSET via Cysteine Alkylation
Förster, Tim, Shang, Erchang, Shimizu, Kenshiro, Sanada, Emiko, Schölermann, Beate, Huebecker, Mylene, Hahne, Gernot, López‐Alberca, Maria Pascual, Janning, Petra, Watanabe, Nobumoto, Sievers, Sonja, Giordanetto, Fabrizio, Shimizu, Takeshi, Ziegler, Slava, Osada, Hiroyuki, Waldmann, Herbert
Published in European journal of organic chemistry (01.09.2019)
Published in European journal of organic chemistry (01.09.2019)
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Journal Article
Hypertonicity‐induced cation channels in HepG2 cells: architecture and role in proliferation vs. apoptosis
Koos, Björn, Christmann, Jens, Plettenberg, Sandra, Käding, Domenic, Becker, Julia, Keteku, Melody, Klein, Christian, Imtiaz, Sarah, Janning, Petra, Bastiaens, Philippe I. H., Wehner, Frank
Published in The Journal of physiology (01.04.2018)
Published in The Journal of physiology (01.04.2018)
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Journal Article
PhzA/B Catalyzes the Formation of the Tricycle in Phenazine Biosynthesis
Ahuja, Ekta G, Janning, Petra, Mentel, Matthias, Graebsch, Almut, Breinbauer, Rolf, Hiller, Wolf, Costisella, Burkhard, Thomashow, Linda S, Mavrodi, Dmitri V, Blankenfeldt, Wulf
Published in Journal of the American Chemical Society (17.12.2008)
Published in Journal of the American Chemical Society (17.12.2008)
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Journal Article
Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1
Zhang, Si-Cai, Gremer, Lothar, Heise, Henrike, Janning, Petra, Shymanets, Aliaksei, Cirstea, Ion C, Krause, Eberhard, Nürnberg, Bernd, Ahmadian, Mohammad Reza
Published in PloS one (11.07.2014)
Published in PloS one (11.07.2014)
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Journal Article
A pull-down procedure for the identification of unknown GEFs for small GTPases
Koch, Daniel, Rai, Amrita, Ali, Imtiaz, Bleimling, Nathalie, Friese, Timon, Brockmeyer, Andreas, Janning, Petra, Goud, Bruno, Itzen, Aymelt, Müller, Matthias P., Goody, Roger S.
Published in Small GTPases (02.04.2016)
Published in Small GTPases (02.04.2016)
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Journal Article
Structure and Function of the Phenazine Biosynthetic Protein PhzF from Pseudomonas fluorescens
Blankenfeldt, Wulf, Kuzin, Alexandre P., Skarina, Tatiana, Korniyenko, Yuriy, Tong, Liang, Bayer, Peter, Janning, Petra, Thomashow, Linda S., Mavrodi, Dmitri V., Cook, R. James
Published in Proceedings of the National Academy of Sciences - PNAS (23.11.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (23.11.2004)
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Journal Article
Ras Pathway Modulator Melophlin A Targets Dynamins
Knoth, Tanja, Warburg, Karin, Katzka, Catherine, Rai, Amrita, Wolf, Alexander, Brockmeyer, Andreas, Janning, Petra, Reubold, Thomas F, Eschenburg, Susanne, Manstein, Dietmar J, Hübel, Katja, Kaiser, Markus, Waldmann, Herbert
Published in Angewandte Chemie (International ed.) (01.01.2009)
Published in Angewandte Chemie (International ed.) (01.01.2009)
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Journal Article
Identification of Ustilago maydis Aurora Kinase As a Novel Antifungal Target
Tückmantel, Sandra, Greul, Jörg N, Janning, Petra, Brockmeyer, Andreas, Grütter, Christian, Simard, Jeffrey R, Gutbrod, Oliver, Beck, Michael E, Tietjen, Klaus, Rauh, Daniel, Schreier, Peter H
Published in ACS chemical biology (16.09.2011)
Published in ACS chemical biology (16.09.2011)
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Journal Article
Small-Molecule Target Engagement in Cells
Schürmann, Marc, Janning, Petra, Ziegler, Slava, Waldmann, Herbert
Published in Cell chemical biology (21.04.2016)
Published in Cell chemical biology (21.04.2016)
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Journal Article