Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ
Hurtado, Cecilia, Safarova, Alena, Smith, Michael, Chung, Raeeun, Bruyneel, Arne A. N., Gomez-Galeno, Jorge, Oswald, Franz, Larson, Christopher J., Cashman, John R., Ruiz-Lozano, Pilar, Janiak, Philip, Suzuki, Teri, Mercola, Mark
Published in Scientific reports (25.07.2019)
Published in Scientific reports (25.07.2019)
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Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy
Beauverger, Philippe, Ozoux, Marie-Laure, Bégis, Guillaume, Glénat, Valérie, Briand, Véronique, Philippo, Marie-Claire, Daveu, Cyril, Tavares, Georges, Roy, Sébastien, Corbier, Alain, Briand, Pascale, Dorchies, Olivier, Bauchet, Anne-Laure, Nicolai, Eric, Duclos, Olivier, Tamarelle, Dorothée, Pruniaux, Marie-Pierre, Muslin, Anthony J, Janiak, Philip
Published in Cardiovascular research (01.02.2020)
Published in Cardiovascular research (01.02.2020)
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Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models
Illiano, Stephane, Poirier, Bruno, Minoletti, Claire, Pasquier, Olivier, Riva, Laurence, Chenede, Xavier, Menguy, Isabelle, Guillotel, Michel, Prigent, Philippe, Le Claire, Stéphane, Gillot, Florence, Thill, Gilbert, Lo Presti, François, Corbier, Alain, Le Bail, Jean-Christophe, Grailhe, Patrick, Monteagudo, Edith, Ingenito, Raffaele, Bianchi, Elisabetta, Philippo, Christophe, Duclos, Olivier, Mallart, Sergio, Bathgate, Ross, Janiak, Philip
Published in Scientific reports (28.11.2022)
Published in Scientific reports (28.11.2022)
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Lysophosphatidic Acid Receptor Agonism: Discovery of Potent Nonlipid Benzofuran Ethanolamine Structures
Guillot, Etienne, Le Bail, Jean-Christophe, Paul, Pascal, Fourgous, Valérie, Briand, Pascale, Partiseti, Michel, Cornet, Bruno, Janiak, Philip, Philippo, Christophe
Published in The Journal of pharmacology and experimental therapeutics (01.08.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2020)
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A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome
Evaristi, Maria Francesca, Poirier, Bruno, Chénedé, Xavier, Lefebvre, Anne-Marie, Roccon, Alain, Gillot, Florence, Beeské, Sandra, Corbier, Alain, Pruniaux-Harnist, Marie-Pierre, Janiak, Philip, Parkar, Ashfaq A
Published in PloS one (01.01.2022)
Published in PloS one (01.01.2022)
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High Glucose Activates YAP Signaling to Promote Vascular Inflammation
Ortillon, Jeremy, Le Bail, Jean-Christophe, Villard, Elise, Léger, Bertrand, Poirier, Bruno, Girardot, Christine, Beeske, Sandra, Ledein, Laetitia, Blanchard, Véronique, Brieu, Patrice, Naimi, Souâd, Janiak, Philip, Guillot, Etienne, Meloni, Marco
Published in Frontiers in physiology (04.06.2021)
Published in Frontiers in physiology (04.06.2021)
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Rimonabant reduces obesity‐associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats
Gary‐Bobo, Magali, Elachouri, Ghizlane, Gallas, Jean François, Janiak, Philip, Marini, Pietro, Ravinet‐Trillou, Christine, Chabbert, Michèle, Cruccioli, Noël, Pfersdorff, Christian, Roque, Claude, Arnone, Michèle, Croci, Tiziano, Soubrié, Philippe, Oury‐Donat, Florence, Maffrand, Jean Pierre, Scatton, Bernard, Lacheretz, Frederic, Le Fur, Gérard, Herbert, Jean Marc, Bensaid, Mohammed
Published in Hepatology (Baltimore, Md.) (01.07.2007)
Published in Hepatology (Baltimore, Md.) (01.07.2007)
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CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis
Bracken, Christina, Beauverger, Philippe, Duclos, Olivier, Russo, Ryan J, Rogers, Kelly A, Husson, Hervé, Natoli, Thomas A, Ledbetter, Steven R, Janiak, Philip, Ibraghimov-Beskrovnaya, Oxana, Bukanov, Nikolay O
Published in American journal of physiology. Renal physiology (01.06.2016)
Published in American journal of physiology. Renal physiology (01.06.2016)
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Generation of iPSC line from MYH7 R403L mutation carrier with severe hypertrophic cardiomyopathy and isogenic CRISPR/Cas9 corrected control
Fontaine, Vincent, Duboscq-Bidot, Laetitia, Jouve, Charlène, Hamlin, Matthieu, Curjol, Angélique, Briand, Véronique, Janiak, Philip, Hulot, Jean-Sébastien, Pruniaux-Harnist, Marie-Pierre, Charron, Philippe, Villard, Eric
Published in Stem cell research (01.04.2021)
Published in Stem cell research (01.04.2021)
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A label‐free impedance assay in endothelial cells differentiates the activation and desensitization properties of clinical S1P1 agonists
Grailhe, Patrick, Boutarfa‐Madec, Asma, Beauverger, Philippe, Janiak, Philip, Parkar, Ashfaq A.
Published in FEBS open bio (01.10.2020)
Published in FEBS open bio (01.10.2020)
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Pharmacological Characterization of SAR407899, a Novel Rho-Kinase Inhibitor
Löhn, Matthias, Plettenburg, Oliver, Ivashchenko, Yuri, Kannt, Aimo, Hofmeister, Armin, Kadereit, Dieter, Schaefer, Matthias, Linz, Wolfgang, Kohlmann, Markus, Herbert, Jean-Marc, Janiak, Philip, O’Connor, Stephen E, Ruetten, Hartmut
Published in Hypertension (Dallas, Tex. 1979) (01.09.2009)
Published in Hypertension (Dallas, Tex. 1979) (01.09.2009)
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The oral Ca/calmodulin‐dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure
Mustroph, Julian, Drzymalski, Marzena, Baier, Maria, Pabel, Steffen, Biedermann, Alexander, Memmel, Bernadette, Durczok, Melanie, Neef, Stefan, Sag, Can Martin, Floerchinger, Bernhard, Rupprecht, Leopold, Schmid, Christof, Zausig, York, Bégis, Guillaume, Briand, Veronique, Ozoux, Marie‐Laure, Tamarelle, Dorothee, Ballet, Veronique, Janiak, Philip, Beauverger, Philippe, Maier, Lars S., Wagner, Stefan
Published in ESC Heart Failure (01.10.2020)
Published in ESC Heart Failure (01.10.2020)
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Role of Peripheral Benzodiazepine Receptors in Mitochondrial, Cellular, and Cardiac Damage Induced by Oxidative Stress and Ischemia-Reperfusion
Leducq, Nathalie, Bono, Françoise, Sulpice, Thierry, Vin, Val érie, Janiak, Philip, Fur, Gérard Le, O'Connor, Steve E., Herbert, Jean-Marc
Published in The Journal of pharmacology and experimental therapeutics (01.09.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2003)
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PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo
Villard, Elise F., PhD, Thedrez, Aurélie, PhD, Blankenstein, Jorg, PhD, Croyal, Mikaël, BSc, Tran, Thi-Thu-Trang, PhD, Poirier, Bruno, PhD, Le Bail, Jean-Christophe, PhD, Illiano, Stéphane, PhD, Nobécourt, Estelle, MD, PhD, Krempf, Michel, MD, PhD, Blom, Dirk J., MD, PhD, Marais, A. David, MD, Janiak, Philip, PhD, Muslin, Anthony J., MD, PhD, Guillot, Etienne, PhD, Lambert, Gilles, PhD
Published in JACC. Basic to translational science (01.10.2016)
Published in JACC. Basic to translational science (01.10.2016)
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Long-term blockade of angiotensin AT1 receptors increases survival of obese Zucker rats
JANIAK, Philip, BIDOUARD, Jean-Pierre, CADROUVELE, Catherine, POIRIER, Bruno, GOURAUD, Laurent, GRATALOUP, Yoann, PIERRE, Francoise, BMNEVAL, Patrick, O'CONNOR, Stephen Eric, HERBERT, Jean-Marc
Published in European journal of pharmacology (18.03.2006)
Published in European journal of pharmacology (18.03.2006)
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Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice
Dol, F, Martin, G, Staels, B, Mares, A M, Cazaubon, C, Nisato, D, Bidouard, J P, Janiak, P, Schaeffer, P, Herbert, J M
Published in Journal of cardiovascular pharmacology (01.09.2001)
Published in Journal of cardiovascular pharmacology (01.09.2001)
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Abstract 4138674: Long-acting CRF2 receptor agonist, COR-1389, improves cardiopulmonary function in the rat model of Sugen plus hypoxia-induced pulmonary hypertension and right heart failure
Kowala, Mark, Guignabert, Christophe, Ozoux, Marie-Laure, Lawson, Francesca, Janiak, Philip
Published in Circulation (New York, N.Y.) (12.11.2024)
Published in Circulation (New York, N.Y.) (12.11.2024)
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Abstract 4138716: A novel Urocortin-2 analog COR-1167 corrects cardiac and renal dysfunction on top of Empagliflozin in a rat model of acute decompensated heart failure
Stephan, Yohan, Corruble, Clement, Charrier, Lucie, NICOL, Lionel, Kowala, Mark, Ozoux, Marie-Laure, Lawson, Francesca, Janiak, Philip, Mulder, Paul
Published in Circulation (New York, N.Y.) (12.11.2024)
Published in Circulation (New York, N.Y.) (12.11.2024)
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Abstract 16840: A Novel Long-Acting CRF2 Receptor Agonist COR-1167 Improves Cardiac and Renal Function on Top of Furosemide in a Sheep Model of Pacing Induced Heart Failure
Kowala, Mark C, Rademaker, Miriam T, Scott, Nicola J, Charles, Chris J, Lawson, Francesca C, Ozoux, Marie-Laure, Janiak, Philip
Published in Circulation (New York, N.Y.) (07.11.2023)
Published in Circulation (New York, N.Y.) (07.11.2023)
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