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Spaulding, Caitlin N., Klein, Roger D., Ruer, Ségolène, Kau, Andrew L., Schreiber, Henry L., Cusumano, Zachary T., Dodson, Karen W., Pinkner, Jerome S., Fremont, Daved H., Janetka, James W., Remaut, Han, Gordon, Jeffrey I., Hultgren, Scott J.
Published in Nature (London) (22.06.2017)
Published in Nature (London) (22.06.2017)
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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
Ma, Cynthia X, Janetka, James W, Piwnica-Worms, Helen
Published in Trends in molecular medicine (01.02.2011)
Published in Trends in molecular medicine (01.02.2011)
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MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A
Rocha, Agostinho G, Franco, Antonietta, Krezel, Andrzej M, Rumsey, Jeanne M, Alberti, Justin M, Knight, William C, Biris, Nikolaos, Zacharioudakis, Emmanouil, Janetka, James W, Baloh, Robert H, Kitsis, Richard N, Mochly-Rosen, Daria, Townsend, R Reid, Gavathiotis, Evripidis, Dorn, 2nd, Gerald W
Published in Science (American Association for the Advancement of Science) (20.04.2018)
Published in Science (American Association for the Advancement of Science) (20.04.2018)
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A FimH Inhibitor Prevents Acute Bladder Infection and Treats Chronic Cystitis Caused by Multidrug-Resistant Uropathogenic Escherichia coli ST131
Totsika, Makrina, Kostakioti, Maria, Hannan, Thomas J., Upton, Mathew, Beatson, Scott A., Janetka, James W., Hultgren, Scott J., Schembri, Mark A.
Published in The Journal of infectious diseases (15.09.2013)
Published in The Journal of infectious diseases (15.09.2013)
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Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides
Han, Zhenfu, Pinkner, Jerome S, Ford, Bradley, Chorell, Erik, Crowley, Jan M, Cusumano, Corinne K, Campbell, Scott, Henderson, Jeffrey P, Hultgren, Scott J, Janetka, James W
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
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A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis
McLellan, Lisa K, McAllaster, Michael R, Kim, Arthur S, Tóthová, Ľubomíra, Olson, Patrick D, Pinkner, Jerome S, Daugherty, Allyssa L, Hreha, Teri N, Janetka, James W, Fremont, Daved H, Hultgren, Scott J, Virgin, Herbert W, Hunstad, David A
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Published in PLoS pathogens (29.01.2021)
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AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
Zabludoff, Sonya D, Deng, Chun, Grondine, Michael R, Sheehy, Adam M, Ashwell, Susan, Caleb, Benjamin L, Green, Stephen, Haye, Heather R, Horn, Candice L, Janetka, James W, Liu, Dongfang, Mouchet, Elizabeth, Ready, Shannon, Rosenthal, Judith L, Queva, Christophe, Schwartz, Gary K, Taylor, Karen J, Tse, Archie N, Walker, Graeme E, White, Anne M
Published in Molecular cancer therapeutics (01.09.2008)
Published in Molecular cancer therapeutics (01.09.2008)
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Combinatorial Small-Molecule Therapy Prevents Uropathogenic Escherichia coli Catheter-Associated Urinary Tract Infections in Mice
GUITON, Pascale S, CUSUMANO, Corinne K, KLINE, Kimberly A, DODSON, Karen W, ZHENFU HAN, JANETKA, James W, HENDERSON, Jeffrey P, CAPARON, Michael G, HULTGREN, Scott J
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
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Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets
Franco, Francisco M., Jones, Darin E., Harris, Peter K.W., Han, Zhenfu, Wildman, Scott A., Jarvis, Cassie M., Janetka, James W.
Published in Bioorganic & medicinal chemistry (15.05.2015)
Published in Bioorganic & medicinal chemistry (15.05.2015)
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Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins
Budelier, Melissa M, Cheng, Wayland W. L, Bergdoll, Lucie, Chen, Zi-Wei, Abramson, Jeff, Krishnan, Kathiresan, Qian, Mingxing, Covey, Douglas F, Janetka, James W, Evers, Alex S
Published in Analytical chemistry (Washington) (21.02.2017)
Published in Analytical chemistry (Washington) (21.02.2017)
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Distinguishing the Contribution of Type 1 Pili from That of Other QseB-Misregulated Factors when QseC Is Absent during Urinary Tract Infection
KOSTAKIOTI, Maria, HADJIFRANGISKOU, Maria, CUSUMANO, Corinne K, HANNAN, Thomas J, JANETKA, James W, HULTGREN, Scott J
Published in Infection and Immunity (01.08.2012)
Published in Infection and Immunity (01.08.2012)
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Aspartyl Protease Inhibitors as Anti-Filarial Drugs
Beld, Liana, Jung, Hyeim, Bulman, Christina A., Rosa, Bruce A., Fischer, Peter U., Janetka, James W., Lustigman, Sara, Sakanari, Judy A., Mitreva, Makedonka
Published in Pathogens (Basel) (18.06.2022)
Published in Pathogens (Basel) (18.06.2022)
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Keeping checkpoint kinases in line: new selective inhibitors in clinical trials
Ashwell, Susan, Janetka, James W, Zabludoff, Sonya
Published in Expert opinion on investigational drugs (01.09.2008)
Published in Expert opinion on investigational drugs (01.09.2008)
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Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer
Han, Zhenfu, Harris, Peter K. W, Jones, Darin E, Chugani, Ryan, Kim, Tommy, Agarwal, Manjula, Shen, Wei, Wildman, Scott A, Janetka, James W
Published in ACS medicinal chemistry letters (13.11.2014)
Published in ACS medicinal chemistry letters (13.11.2014)
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Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine
Kawaguchi, Makiko, Yamamoto, Koji, Takeda, Naoki, Fukushima, Tsuyoshi, Yamashita, Fumiki, Sato, Katsuaki, Kitamura, Kenichiro, Hippo, Yoshitaka, Janetka, James W., Kataoka, Hiroaki
Published in Communications biology (04.01.2019)
Published in Communications biology (04.01.2019)
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An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease
Tyagi, Rahul, Bulman, Christina A, Cho-Ngwa, Fidelis, Fischer, Chelsea, Marcellino, Chris, Arkin, Michelle R, McKerrow, James H, McNamara, Case W, Mahoney, Matthew, Tricoche, Nancy, Jawahar, Shabnam, Janetka, James W, Lustigman, Sara, Sakanari, Judy, Mitreva, Makedonka
Published in Pathogens (Basel) (14.01.2021)
Published in Pathogens (Basel) (14.01.2021)
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Mechanism-Based Macrocyclic Inhibitors of Serine Proteases
Damalanka, Vishnu C., Banas, Victoria, De Bona, Paolo, Kashipathy, Maithri M., Battaile, Kevin, Lovell, Scott, Janetka, James W.
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
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Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections
Maddirala, Amarendar Reddy, Tamadonfar, Kevin, Pinkner, Jerome S., Sanick, Denise, Hultgren, Scott J., Janetka, James W.
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
Mahoney, Matthew, Damalanka, Vishnu C., Tartell, Michael A., Chung, Dong hee, Lourenço, André Luiz, Pwee, Dustin, Bridwell, Anne E. Mayer, Hoffmann, Markus, Voss, Jorine, Karmakar, Partha, Azouz, Nurit P., Klingler, Andrea M., Rothlauf, Paul W., Thompson, Cassandra E., Lee, Melody, Klampfer, Lidija, Stallings, Christina L., Rothenberg, Marc E., Pöhlmann, Stefan, Whelan, Sean P. J., O’Donoghue, Anthony J., Craik, Charles S., Janetka, James W.
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.2021)
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