Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors
Ding, Xiao, Dai, Xuedong, Long, Kai, Peng, Cheng, Andreotti, Daniele, Bamborough, Paul, Eatherton, Andrew J., Edge, Colin, Jandu, Karamjit S., Nichols, Paula L., Philps, Oliver J., Stasi, Luigi Piero, Wan, Zehong, Xiang, Jia-Ning, Dong, Kelly, Dossang, Pamela, Ho, Ming-Hsun, Li, Yi, Mensah, Lucy, Guan, Xiaoming, Reith, Alastair D., Ren, Feng
Published in Bioorganic & medicinal chemistry letters (01.09.2017)
Published in Bioorganic & medicinal chemistry letters (01.09.2017)
Get full text
Journal Article
Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists
HALL, Adrian, ATKINSON, Stephen, MICHEL, Anton D, NAYLOR, Alan, SWEETING, Jennifer A, BROWN, Susan H, CHESSELL, Iain P, CHOWDHURY, Anita, GIBLIN, Gerard M. P, GOLDSMITH, Paul, HEALY, Mark P, JANDU, Karamjit S, JOHNSON, Matthew R
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Get full text
Journal Article
5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction enables efficacy
Ding, Xiao, Stasi, Luigi Piero, Dai, Xuedong, Long, Kai, Peng, Cheng, Zhao, Baowei, Wang, Hailong, Sun, Changhui, Hu, Huan, Wan, Zehong, Jandu, Karamjit S., Philps, Oliver J., Chen, Yan, Wang, Lizhen, Liu, Qian, Edge, Colin, Li, Yi, Dong, Kelly, Guan, Xiaoming, Tattersall, F. David, Reith, Alastair D., Ren, Feng
Published in Bioorganic & medicinal chemistry letters (15.01.2019)
Published in Bioorganic & medicinal chemistry letters (15.01.2019)
Get full text
Journal Article
Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain
Myatt, James W., Healy, Mark P., Bravi, Gianpaolo S., Billinton, Andrew, Johnson, Christopher N., Matthews, Kim L., Jandu, Karamjit S., Meng, Wenjing, Hersey, Anne, Livermore, David G., Douault, Clement B., Witherington, Jason, Bit, Rino A., Rowedder, James E., Brown, Jason D., Clayton, Nick M.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Get full text
Journal Article
Pyridine-3-carboxamides as novel CB(2) agonists for analgesia
Mitchell, William L, Giblin, Gerard M P, Naylor, Alan, Eatherton, Andrew J, Slingsby, Brian P, Rawlings, Anthony D, Jandu, Karamjit S, Haslam, Carl P, Brown, Andrew J, Goldsmith, Paul, Clayton, Nick M, Wilson, Alex W, Chessell, Iain P, Green, Richard H, Whittington, Andrew R, Wall, Ian D
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
Get full text
Journal Article
Pyridine-3-carboxamides as novel CB2 agonists for analgesia
MITCHELL, William L, GIBLIN, Gerard M. P, CLAYTON, Nick M, WILSON, Alex W, CHESSELL, Iain P, GREEN, Richard H, WHITTINGTON, Andrew R, WALL, Ian D, NAYLOR, Alan, EATHERTON, Andrew J, SLINGSBY, Brian P, RAWLINGS, Anthony D, JANDU, Karamjit S, HASLAM, Carl P, BROWN, Andrew J, GOLDSMITH, Paul
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
Get full text
Journal Article
Structure-activity relationships of antifilarial antimycin analogs: a multivariate pattern recognition study
Selwood, David L, Livingstone, David J, Comley, John C. W, O'Dowd, Alan B, Hudson, Alan T, Jackson, Peter, Jandu, Karamjit S, Rose, Valerie S, Stables, Jeremy N
Published in Journal of medicinal chemistry (01.01.1990)
Published in Journal of medicinal chemistry (01.01.1990)
Get full text
Journal Article
Pyridine-3-carboxamides as novel CB 2 agonists for analgesia
Mitchell, William L., Giblin, Gerard M.P., Naylor, Alan, Eatherton, Andrew J., Slingsby, Brian P., Rawlings, Anthony D., Jandu, Karamjit S., Haslam, Carl P., Brown, Andrew J., Goldsmith, Paul, Clayton, Nick M., Wilson, Alex W., Chessell, Iain P., Green, Richard H., Whittington, Andrew R., Wall, Ian D.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
Get full text
Journal Article
Pyridine-3-carboxamides as novel CB sub(2) agonists for analgesia
Mitchell, William L, Giblin, Gerard MP, Naylor, Alan, Eatherton, Andrew J, Slingsby, Brian P, Rawlings, Anthony D, Jandu, Karamjit S, Haslam, Carl P, Brown, Andrew J, Goldsmith, Paul, Clayton, Nick M, Wilson, Alex W, Chessell, Iain P, Green, Richard H, Whittington, Andrew R, Wall, Ian D
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
Get full text
Journal Article
Discovery of novel, non-acidic 1,5-biaryl pyrrole EP 1 receptor antagonists
Hall, Adrian, Atkinson, Stephen, Brown, Susan H., Chessell, Iain P., Chowdhury, Anita, Giblin, Gerard M.P., Goldsmith, Paul, Healy, Mark P., Jandu, Karamjit S., Johnson, Matthew R., Michel, Anton D., Naylor, Alan, Sweeting, Jennifer A.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
Get full text
Journal Article
Pyridine derivatives as cb2 receptor modulators
NAYLOR ALAN, EATHERTON ANDREW J, GREEN RICHARD H, PALOMBI GIOVANNI, DOUGHTY JENNIFER M, WHITTINGTON ANDREW R, GIBLIN GERARD M.P, JANDU KARAMJIT S, MITCHELL WILLIAM L, RAWLINGS DEREK A, SLINGSBY BRIAN P
Year of Publication 07.06.2007
Get full text
Year of Publication 07.06.2007
Patent
Pyridine derivatives as cb2 receptor modulators
NAYLOR ALAN, EATHERTON ANDREW J, GREEN RICHARD H, PALOMBI GIOVANNI, DOUGHTY JENNIFER M, WHITTINGTON ANDREW R, JANDU KARAMJIT S, MITCHELL WILLIAM L, GIBLIN GERARD MARTIN P, RAWLINGS DEREK A, SLINGSBY BRIAN P
Year of Publication 26.10.2006
Get full text
Year of Publication 26.10.2006
Patent
COMBINATION OF CB2 MODULATORS AND PDE4 INHIBITORS FOR USE IN MEDICINE
WILLIAMSON, RICHARD, ALEXANDER, EATHERTON, ANDREW, J, JANDU, KARAMJIT, S, O'SHAUGHNESSY, CELESTINE, T, GREEN, RICHARD, HOWARD, SLINGSBY, BRIAN, P, BROWN, ANDREW, J, TRALAU-STEWART, CATHERINE, JANE, NAYLOR, ALAN, GIBLIN, GERARD, M. P, PALOMBI, GIOVANNI, RAWLINGS, DEREK, A, CONNOR, HELEN, ELIZABETH, KNOWLES, RICHARD, G, MITCHELL, WILLIAM, L, WHITTINGTON, ANDREW, RICHARD
Year of Publication 20.12.2006
Get full text
Year of Publication 20.12.2006
Patent
PCSK9 INHIBITORS AND METHODS OF USE THEREOF
SERRANO-WU MICHAEL H, HINCHLIFFE PAUL, JANDU KARAMJIT, CLARKE DAVID, CHAMBERS MARK, GOLDSMITH ERICA, TIERNEY JASON
Year of Publication 29.10.2021
Get full text
Year of Publication 29.10.2021
Patent
PCSK9 inhibitors and methods of use thereof
CLARK, DAVID, CHAMBERS, MARK, GOLDSMITH, ERICA, TIERNEY, JASON, JANDU, KARAMJIT, HINCHLIFFE, PAUL, SERRANO-WU, MICHAEL H
Year of Publication 01.12.2020
Get full text
Year of Publication 01.12.2020
Patent
Novel compounds
JANDU, KARAMJIT SINGH, EATHERTON, ANDREW JOHN, LIU, QIAN, ANDREOTTI, DANIELE, PHILPS, OLIVER JAMES, DAI, XUEDONG
Year of Publication 01.02.2013
Get full text
Year of Publication 01.02.2013
Patent
Novel compounds
PHILPS OLIVER JAMES, BAMBOROUGH PAUL, EATHERTON ANDREW JOHN, ANDREOTTI DANIELE, JANDU KARAMJIT SINGH, NICHOLS PAULA LOUISE
Year of Publication 18.07.2012
Get full text
Year of Publication 18.07.2012
Patent