Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
Janas, Maja M, Schlegel, Mark K, Harbison, Carole E, Yilmaz, Vedat O, Jiang, Yongfeng, Parmar, Rubina, Zlatev, Ivan, Castoreno, Adam, Xu, Huilei, Shulga-Morskaya, Svetlana, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Keirstead, Natalie D, Maier, Martin A, Jadhav, Vasant
Published in Nature communications (19.02.2018)
Published in Nature communications (19.02.2018)
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Journal Article
Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets
Horman, Shane R., Janas, Maja M., Litterst, Claudia, Wang, Bingbing, MacRae, Ian J., Sever, Mary J., Morrissey, David V., Graves, Paul, Luo, Biao, Umesalma, Shaikamjad, Qi, Hank H., Miraglia, Loren J., Novina, Carl D., Orth, Anthony P.
Published in Molecular cell (09.05.2013)
Published in Molecular cell (09.05.2013)
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Journal Article
siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs
Akabane-Nakata, Masaaki, Erande, Namrata D, Kumar, Pawan, Degaonkar, Rohan, Gilbert, Jason A, Qin, June, Mendez, Martha, Woods, Lauren Blair, Jiang, Yongfeng, Janas, Maja M, O’Flaherty, Derek K, Zlatev, Ivan, Schlegel, Mark K, Matsuda, Shigeo, Egli, Martin, Manoharan, Muthiah
Published in Nucleic acids research (18.03.2021)
Published in Nucleic acids research (18.03.2021)
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Journal Article
Transcription Factor/microRNA Axis Blocks Melanoma Invasion Program by miR-211 Targeting NUAK1
Bell, Rachel E., Khaled, Mehdi, Netanely, Dvir, Schubert, Steffen, Golan, Tamar, Buxbaum, Amir, Janas, Maja M., Postolsky, Benny, Goldberg, Michael S., Shamir, Ron, Levy, Carmit
Published in Journal of investigative dermatology (01.02.2014)
Published in Journal of investigative dermatology (01.02.2014)
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Journal Article
Intronic miR-211 Assumes the Tumor Suppressive Function of Its Host Gene in Melanoma
Levy, Carmit, Khaled, Mehdi, Iliopoulos, Dimitrios, Janas, Maja M., Schubert, Steffen, Pinner, Sophie, Chen, Po-Hao, Li, Shuqiang, Fletcher, Anne L., Yokoyama, Satoru, Scott, Kenneth L., Garraway, Levi A., Song, Jun S., Granter, Scott R., Turley, Shannon J., Fisher, David E., Novina, Carl D.
Published in Molecular cell (10.12.2010)
Published in Molecular cell (10.12.2010)
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Journal Article
Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins
Janas, Maja M, Wang, Bingbing, Harris, Abigail S, Aguiar, Mike, Shaffer, Jonathan M, Subrahmanyam, Yerramilli V B K, Behlke, Mark A, Wucherpfennig, Kai W, Gygi, Steven P, Gagnon, Etienne, Novina, Carl D
Published in RNA (Cambridge) (01.11.2012)
Published in RNA (Cambridge) (01.11.2012)
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Journal Article
Feed-forward microprocessing and splicing activities at a microRNA-containing intron
Janas, Maja M, Khaled, Mehdi, Schubert, Steffen, Bernstein, Jacob G, Golan, David, Veguilla, Rosa A, Fisher, David E, Shomron, Noam, Levy, Carmit, Novina, Carl D
Published in PLoS genetics (01.10.2011)
Published in PLoS genetics (01.10.2011)
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Journal Article
Mechanisms of RNA loading into exosomes
Janas, Teresa, Janas, Maja M., Sapoń, Karolina, Janas, Tadeusz
Published in FEBS letters (04.06.2015)
Published in FEBS letters (04.06.2015)
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Journal Article
Reduced Expression of Ribosomal Proteins Relieves MicroRNA-Mediated Repression
Janas, Maja M., Wang, Eric, Love, Tara, Harris, Abigail S., Stevenson, Kristen, Semmelmann, Karlheinz, Shaffer, Jonathan M., Chen, Po-Hao, Doench, John G., Yerramilli, Subrahmanyam V.B.K., Neuberg, Donna S., Iliopoulos, Dimitrios, Housman, David E., Burge, Christopher B., Novina, Carl D.
Published in Molecular cell (27.04.2012)
Published in Molecular cell (27.04.2012)
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Journal Article
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
Brown, Kirk M, Nair, Jayaprakash K, Janas, Maja M, Anglero-Rodriguez, Yesseinia I, Dang, Lan T H, Peng, Haiyan, Theile, Christopher S, Castellanos-Rizaldos, Elena, Brown, Christopher, Foster, Donald, Kurz, Jeffrey, Allen, Jeffrey, Maganti, Rajanikanth, Li, Jing, Matsuda, Shigeo, Stricos, Matthew, Chickering, Tyler, Jung, Michelle, Wassarman, Kelly, Rollins, Jeff, Woods, Lauren, Kelin, Alex, Guenther, Dale C, Mobley, Melissa W, Petrulis, John, McDougall, Robin, Racie, Timothy, Bombardier, Jessica, Cha, Diana, Agarwal, Saket, Johnson, Lei, Jiang, Yongfeng, Lentini, Scott, Gilbert, Jason, Nguyen, Tuyen, Chigas, Samantha, LeBlanc, Sarah, Poreci, Urjana, Kasper, Anne, Rogers, Arlin B, Chong, Saeho, Davis, Wendell, Sutherland, Jessica E, Castoreno, Adam, Milstein, Stuart, Schlegel, Mark K, Zlatev, Ivan, Charisse, Klaus, Keating, Mark, Manoharan, Muthiah, Fitzgerald, Kevin, Wu, Jing-Tao, Maier, Martin A, Jadhav, Vasant
Published in Nature biotechnology (01.10.2022)
Published in Nature biotechnology (01.10.2022)
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Journal Article
From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization
Schlegel, Mark K, Janas, Maja M, Jiang, Yongfeng, Barry, Joseph D, Davis, Wendell, Agarwal, Saket, Berman, Daniel, Brown, Christopher R, Castoreno, Adam, LeBlanc, Sarah, Liebow, Abigail, Mayo, Tara, Milstein, Stuart, Nguyen, Tuyen, Shulga-Morskaya, Svetlana, Hyde, Sarah, Schofield, Sally, Szeto, John, Woods, Lauren Blair, Yilmaz, Vedat O, Manoharan, Muthiah, Egli, Martin, Charissé, Klaus, Sepp-Lorenzino, Laura, Haslett, Patrick, Fitzgerald, Kevin, Jadhav, Vasant, Maier, Martin A
Published in Nucleic acids research (08.07.2022)
Published in Nucleic acids research (08.07.2022)
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Journal Article
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex
Datta, Dhrubajyoti, Theile, Christopher S, Wassarman, Kelly, Qin, June, Racie, Tim, Schmidt, Karyn, Jiang, Yongfeng, Sigel, Rachel, Janas, Maja M, Egli, Martin, Manoharan, Muthiah
Published in Chemical communications (Cambridge, England) (23.05.2023)
Published in Chemical communications (Cambridge, England) (23.05.2023)
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Journal Article
The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies
Janas, Maja M., Harbison, Carole E., Perry, Victoria K., Carito, Brenda, Sutherland, Jessica E., Vaishnaw, Akshay K., Keirstead, Natalie D., Warner, Garvin
Published in Toxicologic Pathology (01.10.2018)
Published in Toxicologic Pathology (01.10.2018)
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Book Review
Journal Article
Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials
Gane, Ed, Lim, Young-Suk, Kim, Jae B., Jadhav, Vasant, Shen, Ling, Bakardjiev, Anna I., Huang, Stephen A., Cathcart, Andrea L., Lempp, Florian A., Janas, Maja M., Cloutier, Daniel J., Kaittanis, Charalambos, Sepp-Lorenzino, Laura, Hinkle, Gregory, Taubel, Jorg, Haslett, Patrick, Milstein, Stuart, Anglero-Rodriguez, Yesseinia I., Hebner, Christy M., Pang, Phillip S., Yuen, Man-Fung
Published in Journal of hepatology (01.10.2023)
Published in Journal of hepatology (01.10.2023)
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Journal Article
Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates
Janas, Maja M, Zlatev, Ivan, Liu, Ju, Jiang, Yongfeng, Barros, Scott A, Sutherland, Jessica E, Davis, Wendell P, Liu, Jingxuan, Brown, Christopher R, Liu, Xiumin, Schlegel, Mark K, Blair, Lauren, Zhang, Xuemei, Das, Biplab, Tran, Chris, Aluri, Krishna, Li, Jing, Agarwal, Saket, Indrakanti, Ramesh, Charisse, Klaus, Nair, Jayaprakash, Matsuda, Shigeo, Rajeev, Kallanthottathil G, Zimmermann, Tracy, Sepp-Lorenzino, Laura, Xu, Yuanxin, Akinc, Akin, Fitzgerald, Kevin, Vaishnaw, Akshay K, Smith, Peter F, Manoharan, Muthiah, Jadhav, Vasant, Wu, Jing-Tao, Maier, Martin A
Published in Nucleic acids research (23.04.2019)
Published in Nucleic acids research (23.04.2019)
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Journal Article
Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease
Kumar, Pawan, Degaonkar, Rohan, Guenther, Dale C, Abramov, Mikhail, Schepers, Guy, Capobianco, Marie, Jiang, Yongfeng, Harp, Joel, Kaittanis, Charalambos, Janas, Maja M, Castoreno, Adam, Zlatev, Ivan, Schlegel, Mark K, Herdewijn, Piet, Egli, Martin, Manoharan, Muthiah
Published in Nucleic acids research (07.05.2020)
Published in Nucleic acids research (07.05.2020)
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Journal Article
Shorter Is Better: The α‑(l)‑Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs
Matsuda, Shigeo, Bala, Saikat, Liao, Jen-Yu, Datta, Dhrubajyoti, Mikami, Atsushi, Woods, Lauren, Harp, Joel M., Gilbert, Jason A., Bisbe, Anna, Manoharan, Rajar M., Kim, MaryBeth, Theile, Christopher S., Guenther, Dale C., Jiang, Yongfeng, Agarwal, Saket, Maganti, Rajanikanth, Schlegel, Mark K., Zlatev, Ivan, Charisse, Klaus, Rajeev, Kallanthottathil G., Castoreno, Adam, Maier, Martin, Janas, Maja M., Egli, Martin, Chaput, John C., Manoharan, Muthiah
Published in Journal of the American Chemical Society (13.09.2023)
Published in Journal of the American Chemical Society (13.09.2023)
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Journal Article
Impact of Serum Proteins on the Uptake and RNAi Activity of GalNAc-Conjugated siRNAs
Agarwal, Saket, Allard, Ruth, Darcy, Justin, Chigas, Samantha, Gu, Yongli, Nguyen, Tuyen, Bond, Sarah, Chong, Saeho, Wu, Jing-Tao, Janas, Maja M
Published in Nucleic acid therapeutics (01.08.2021)
Published in Nucleic acid therapeutics (01.08.2021)
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Journal Article
Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β‑C‑methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Target Effects
Guenther, Dale C., Mori, Shohei, Matsuda, Shigeo, Gilbert, Jason A., Willoughby, Jennifer L. S., Hyde, Sarah, Bisbe, Anna, Jiang, Yongfeng, Agarwal, Saket, Madaoui, Mimouna, Janas, Maja M., Charisse, Klaus, Maier, Martin A., Egli, Martin, Manoharan, Muthiah
Published in Journal of the American Chemical Society (17.08.2022)
Published in Journal of the American Chemical Society (17.08.2022)
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Journal Article