Novel 3-Pyridyl Ethers with Subnanomolar Affinity for Central Neuronal Nicotinic Acetylcholine Receptors
Abreo, Melwyn A, Lin, Nan-Horng, Garvey, David S, Gunn, David E, Hettinger, Ann-Marie, Wasicak, James T, Pavlik, Patricia A, Martin, Yvonne C, Donnelly-Roberts, Diana L, Anderson, David J, Sullivan, James P, Williams, Michael, Arneric, Stephen P, Holladay, Mark W
Published in Journal of medicinal chemistry (16.02.1996)
Published in Journal of medicinal chemistry (16.02.1996)
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Identification and Initial Structure−Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors
Holladay, Mark W, Wasicak, James T, Lin, Nan-Horng, He, Yun, Ryther, Keith B, Bannon, Anthony W, Buckley, Michael J, Kim, David J. B, Decker, Michael W, Anderson, David J, Campbell, Jeffrey E, Kuntzweiler, Theresa A, Donnelly-Roberts, Diana L, Piattoni-Kaplan, Marietta, Briggs, Clark A, Williams, Michael, Arneric, Stephen P
Published in Journal of medicinal chemistry (12.02.1998)
Published in Journal of medicinal chemistry (12.02.1998)
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Journal Article
A-85380 [3-(2( S)-azetidinylmethoxy) pyridine]: In Vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand
Sullivan, James P., Donnelly-Roberts, Diana, Briggs, Clark A., Anderson, David J., Gopalakrishnan, Murali, Piattoni-Kaplan, Marietta, Campbell, Jeffrey E., McKenna, David G., Molinari, Edwardo, Hettinger, Ann-Marie, Garvey, David S., Wasicak, James T., Holladay, Mark W., Williams, Michael, Arneric, Stephen P.
Published in Neuropharmacology (01.06.1996)
Published in Neuropharmacology (01.06.1996)
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Conference Proceeding
Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice
Decker, Michael W, Bannon, Anthony W, Buckley, Michael J, Kim, David J.B, Holladay, Mark W, Ryther, Keith B, Lin, Nan-Horng, Wasicak, James T, Williams, Michael, Arneric, Stephen P
Published in European journal of pharmacology (03.04.1998)
Published in European journal of pharmacology (03.04.1998)
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Novel Isoxazoles which Interact with Brain Cholinergic Channel Receptors Have Intrinsic Cognitive Enhancing and Anxiolytic Activities
Garvey, David S, Wasicak, James T, Decker, Michael W, Brioni, Jorge D, Buckley, Michael J, Sullivan, James P, Carrera, George M, Holladay, Mark W, Arneric, Stephen P, Williams, Michael
Published in Journal of medicinal chemistry (01.04.1994)
Published in Journal of medicinal chemistry (01.04.1994)
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Ligands for Brain Cholinergic Channel Receptors: Synthesis and in Vitro Characterization of Novel Isoxazoles and Isothiazoles as Bioisosteric Replacements for the Pyridine Ring in Nicotine
Garvey, David S, Wasicak, James T, Elliott, Richard L, Lebold, Suzanne, Hettinger, Ann-Marie, Carrera, George M, Lin, Nan-Horng, He, Yun, Holladay, Mark W
Published in Journal of medicinal chemistry (01.12.1994)
Published in Journal of medicinal chemistry (01.12.1994)
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Synthesis and in vitro characterization of novel amino terminally modified oxotremorine derivatives for brain muscarinic receptors
Garvey, David S, Wasicak, James T, Chung, John Y. L, Shue, Youe Kong, Carrera, George M, May, Paul D, McKinney, Michael M, Anderson, David, Cadman, Evelyn
Published in Journal of medicinal chemistry (01.05.1992)
Published in Journal of medicinal chemistry (01.05.1992)
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ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization
Donnelly-Roberts, D L, Puttfarcken, P S, Kuntzweiler, T A, Briggs, C A, Anderson, D J, Campbell, J E, Piattoni-Kaplan, M, McKenna, D G, Wasicak, J T, Holladay, M W, Williams, M, Arneric, S P
Published in The Journal of pharmacology and experimental therapeutics (01.05.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.05.1998)
Journal Article
ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization
Bannon, A W, Decker, M W, Curzon, P, Buckley, M J, Kim, D J, Radek, R J, Lynch, J K, Wasicak, J T, Lin, N H, Arnold, W H, Holladay, M W, Williams, M, Arneric, S P
Published in The Journal of pharmacology and experimental therapeutics (01.05.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.05.1998)
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Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice
Holladay, Mark W., Bai, Hao, Li, Yihong, Lin, Nan-Horng, Daanen, Jerome F., Ryther, Keith B., Wasicak, James T., Kincaid, John F., He, Yun, Hettinger, Anne-Marie, Huang, Peggy, Anderson, David J., Bannon, Anthony W., Buckley, Michael J., Campbell, Jeffrey E., Donnelly-Roberts, Diana L., Gunther, Karen L., Kim, David J.B., Kuntzweiler, Theresa A., Sullivan, James P., Decker, Michael W., Arneric, Stephen P.
Published in Bioorganic & medicinal chemistry letters (06.10.1998)
Published in Bioorganic & medicinal chemistry letters (06.10.1998)
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Journal Article
Structural aspects of high affinity ligands for the α4β2 neuronal nicotinic receptor
Dart, Michael J., Wasicak, James T., Ryther, Keith B., Schrimpf, Michael R., Kim, Ki H., Anderson, David J., Sullivan, James P., Meyer, Michael D.
Published in Pharmaceutica acta Helvetiae (01.03.2000)
Published in Pharmaceutica acta Helvetiae (01.03.2000)
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Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework
Lin, Nan-Horng, Abreo, Melwyn A., Gunn, David E., Lebold, Suzanne A., Lee, Edmund L., Wasicak, James T., Hettinger, Ann-Marie, Daanen, Jerome F., Garvey, David S., Campbell, Jeffrey E., Sullivan, James P., Williams, Michael, Arneric, Stephen P.
Published in Bioorganic & medicinal chemistry letters (20.09.1999)
Published in Bioorganic & medicinal chemistry letters (20.09.1999)
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Journal Article
ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A Novel, Orally Effective Antinociceptive Agent Acting viaNeuronal Nicotinic Acetylcholine Receptors: II. In VivoCharacterization
Anthony W. Bannon, Michael W. Decker, Peter Curzon, Michael J. Buckley, David J. B. Kim, Richard J. Radek, John K. Lynch, James T. Wasicak, Nan-Horng Lin, William H. Arnold, Mark W. Holladay, Michael Williams, Stephen P. Arneric
Published in The Journal of pharmacology and experimental therapeutics (01.05.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.05.1998)
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ABT-594 [(R)-5-(2-Azetidinylmethoxy)-2-Chloropyridine]: A Novel, Orally Effective Analgesic Acting via Neuronal Nicotinic Acetylcholine Receptors: I. In VitroCharacterization
Diana L. Donnelly-Roberts, Pamela S. Puttfarcken, Theresa A. Kuntzweiler, Clark A. Briggs, David J. Anderson, Jeffrey E. Campbell, Marietta Piattoni-Kaplan, David G. Mckenna, James T. Wasicak, Mark W. Holladay, Michael Williams, Stephen P. Arneric
Published in The Journal of pharmacology and experimental therapeutics (01.05.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.05.1998)
Journal Article
Synthesis and structure-activity relationships of pyrrolidine-modified analogs of the potent cholinergic channel activator, ABT 418
Lin, Nan-Horng, He, Yun, David J., Anderson, Wasicak, James T., Kasson, Richard, Sweeny, David, James P., Sullivan
Published in Bioorganic & medicinal chemistry letters (1994)
Published in Bioorganic & medicinal chemistry letters (1994)
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Journal Article
3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS
LYNCH, JOHN K, SULLIVAN, JAMES P, HOLLADAY, MARK W, ARNERIC, STEPHEN P, BAI, HAO, LIN, NAN-HORNG, EHRLICH, PAUL P, OR, YAT SUN, DART, MICHAEL J, RYTHER, KEITH B, WASICAK, JAMES T
Year of Publication 01.05.2012
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Year of Publication 01.05.2012
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