Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats
Harriman, Geraldine, Greenwood, Jeremy, Bhat, Sathesh, Huang, Xinyi, Wang, Ruiying, Paul, Debamita, Tong, Liang, Saha, Asish K., Westlin, William F., Kapeller, Rosana, Harwood, H. James
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2016)
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Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models
Svensson, Robert U, Parker, Seth J, Eichner, Lillian J, Kolar, Matthew J, Wallace, Martina, Brun, Sonja N, Lombardo, Portia S, Van Nostrand, Jeanine L, Hutchins, Amanda, Vera, Lilliana, Gerken, Laurie, Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Westlin, William F, Harwood, H James, Saghatelian, Alan, Kapeller, Rosana, Metallo, Christian M, Shaw, Reuben J
Published in Nature medicine (01.10.2016)
Published in Nature medicine (01.10.2016)
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An allosteric mechanism for potent inhibition of human ATP-citrate lyase
Wei, Jia, Leit, Silvana, Kuai, Jun, Therrien, Eric, Rafi, Salma, Harwood, H. James, DeLaBarre, Byron, Tong, Liang
Published in Nature (London) (01.04.2019)
Published in Nature (London) (01.04.2019)
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Acetyl‐coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double‐blind, crossover study
Stiede, Kathryn, Miao, Wenyan, Blanchette, Heather S., Beysen, Carine, Harriman, Geraldine, Harwood, H. James, Kelley, Heather, Kapeller, Rosana, Schmalbach, Tess, Westlin, William F.
Published in Hepatology (Baltimore, Md.) (01.08.2017)
Published in Hepatology (Baltimore, Md.) (01.08.2017)
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Nonhuman primates and other animal models in diabetes research
Harwood, Jr, H James, Listrani, Paul, Wagner, Janice D
Published in Journal of diabetes science and technology (01.05.2012)
Published in Journal of diabetes science and technology (01.05.2012)
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Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals
Hawkins, Julie L, Robbins, Michael D, Warren, Laurie C, Xia, Donghui, Petras, Stephen F, Valentine, James J, Varghese, Alison H, Wang, Ing-Kae, Subashi, Timothy A, Shelly, Lorraine D, Hay, Bruce A, Landschulz, Katherine T, Geoghegan, Kieran F, Harwood, Jr, H James
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
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class of selective antibacterials derived from a protein kinase inhibitor pharmacophore
Miller, J. Richard, Dunham, Steve, Mochalkin, Igor, Banotai, Craig, Bowman, Matthew, Buist, Susan, Dunkle, Bill, Hanna, Debra, Harwood, H. James, Huband, Michael D, Karnovsky, Alla, Kuhn, Michael, Limberakis, Chris, Liu, Jia Y, Mehrens, Shawn, Mueller, W. Thomas, Narasimhan, Lakshmi, Ogden, Adam, Ohren, Jeff, Prasad, J.V.N. Vara, Shelly, John A, Skerlos, Laura, Sulavik, Mark, Thomas, V. Hayden, VanderRoest, Steve, Wang, LiAnn, Wang, Zhigang, Whitton, Amy, Zhu, Tong, Stover, C. Kendall
Published in Proceedings of the National Academy of Sciences - PNAS (10.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (10.02.2009)
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CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans
Chandler, Charles E, Wilder, Donald E, Pettini, Judith L, Savoy, Yvette E, Petras, Stephen F, Chang, George, Vincent, John, Harwood, Jr, H James
Published in Journal of lipid research (01.10.2003)
Published in Journal of lipid research (01.10.2003)
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Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2
Corbett, Jeffrey W., Freeman-Cook, Kevin D., Elliott, Richard, Vajdos, Felix, Rajamohan, Francis, Kohls, Darcy, Marr, Eric, Zhang, Hailong, Tong, Liang, Tu, Meihua, Murdande, Sharad, Doran, Shawn D., Houser, Janet A., Song, Wei, Jones, Christopher J., Coffey, Steven B., Buzon, Leanne, Minich, Martha L., Dirico, Kenneth J., Tapley, Susan, Kirk McPherson, R., Sugarman, Eliot, James Harwood, H., Esler, William
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals
Harwood, H.James, Petras, Stephen F., Shelly, Lorraine D., Zaccaro, Lawrence M., Perry, David A., Makowski, Michael R., Hargrove, Diane M., Martin, Kelly A., Tracey, W.Ross, Chapman, Justin G., Magee, William P., Dalvie, Deepak K., Soliman, Victor F., Martin, William H., Mularski, Christian J., Eisenbeis, Shane A.
Published in The Journal of biological chemistry (26.09.2003)
Published in The Journal of biological chemistry (26.09.2003)
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Old World nonhuman primate models of type 2 diabetes mellitus
Wagner, J.D, Kavanagh, K, Ward, G.M, Auerbach, B.J, Harwood, H.J. Jr, Kaplan, J.R
Published in ILAR journal (2006)
Published in ILAR journal (2006)
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A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys
Wagner, Janice D, Shadoan, Melanie K, Zhang, Li, Ward, Gina M, Royer, Lori J, Kavanagh, Kylie, Francone, Omar L, Auerbach, Bruce J, Harwood, Jr, H James
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
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A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys
Wagner, Janice D, Zhang, Li, Kavanagh, Kylie, Ward, Gina M, Chin, Janice E, Hadcock, John R, Auerbach, Bruce J, Harwood, Jr, H James
Published in The Journal of pharmacology and experimental therapeutics (01.10.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2010)
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Aminopyrrolidineamide inhibitors of site-1 protease
Hay, Bruce A., Abrams, Barbara, Zumbrunn, Allice Y., Valentine, James J., Warren, Laurie C., Petras, Stephen F., Shelly, Lorraine D., Xia, Angela, Varghese, Alison H., Hawkins, Julie L., Van Camp, Jennifer A., Robbins, Michael D., Landschulz, Katherine, Harwood, H. James
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma
Lally, James S.V., Ghoshal, Sarani, DePeralta, Danielle K., Moaven, Omeed, Wei, Lan, Masia, Ricard, Erstad, Derek J., Fujiwara, Naoto, Leong, Vivian, Houde, Vanessa P., Anagnostopoulos, Alexander E., Wang, Alice, Broadfield, Lindsay A., Ford, Rebecca J., Foster, Robert A., Bates, Jamie, Sun, Hailing, Wang, Ting, Liu, Henry, Ray, Adrian S., Saha, Asish K., Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Miao, Wenyan, Rocnik, Jennifer L., Westlin, William F., Muti, Paola, Tsakiridis, Theodoros, Harwood, H. James, Kapeller, Rosana, Hoshida, Yujin, Tanabe, Kenneth K., Steinberg, Gregory R., Fuchs, Bryan C.
Published in Cell metabolism (08.01.2019)
Published in Cell metabolism (08.01.2019)
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