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Published in ACS chemical biology (21.06.2013)
Published in ACS chemical biology (21.06.2013)
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Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
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Published in Nature communications (29.04.2019)
Published in Nature communications (29.04.2019)
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A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
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Published in Nature chemical biology (01.03.2016)
Published in Nature chemical biology (01.03.2016)
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An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering
Cui, Gaofeng, Botuyan, Maria Victoria, Drané, Pascal, Hu, Qi, Bragantini, Benoît, Thompson, James R., Schuller, David J., Detappe, Alexandre, Perfetti, Michael T., James, Lindsey I., Frye, Stephen V., Chowdhury, Dipanjan, Mer, Georges
Published in Nature communications (29.09.2023)
Published in Nature communications (29.09.2023)
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Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7
Lamb, Kelsey N, Bsteh, Daniel, Dishman, Sarah N, Moussa, Hagar F, Fan, Huitao, Stuckey, Jacob I, Norris, Jacqueline L, Cholensky, Stephanie H, Li, Dongxu, Wang, Jingkui, Sagum, Cari, Stanton, Benjamin Z, Bedford, Mark T, Pearce, Kenneth H, Kenakin, Terry P, Kireev, Dmitri B, Wang, Gang Greg, James, Lindsey I, Bell, Oliver, Frye, Stephen V
Published in Cell chemical biology (17.10.2019)
Published in Cell chemical biology (17.10.2019)
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Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors
Jefferys, Stuart R, Burgos, Samuel D, Peterson, Jackson J, Selitsky, Sara R, Turner, Anne-Marie W, James, Lindsey I, Tsai, Yi-Hsuan, Coffey, Alisha R, Margolis, David M, Parker, Joel, Browne, Edward P
Published in PLoS pathogens (01.02.2021)
Published in PLoS pathogens (01.02.2021)
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Structure–Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains
Stuckey, Jacob I, Simpson, Catherine, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Lee, Junghyun, Pasca, Ryan, Cheng, Nancy, Dickson, Bradley M, Pearce, Kenneth H, Frye, Stephen V, James, Lindsey I
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing
Barnash, Kimberly D, Lamb, Kelsey N, Stuckey, Jacob I, Norris, Jacqueline L, Cholensky, Stephanie H, Kireev, Dmitri B, Frye, Stephen V, James, Lindsey I
Published in ACS chemical biology (16.09.2016)
Published in ACS chemical biology (16.09.2016)
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Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2
Barnash, Kimberly D, The, Juliana, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Worley, Beau M, Li, Fengling, Stuckey, Jacob I, Brown, Peter J, Vedadi, Masoud, Arrowsmith, Cheryl H, Frye, Stephen V, James, Lindsey I
Published in ACS combinatorial science (13.03.2017)
Published in ACS combinatorial science (13.03.2017)
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Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception
Pellock, Samuel J, Creekmore, Benjamin C, Walton, William G, Mehta, Naimee, Biernat, Kristen A, Cesmat, Andrew P, Ariyarathna, Yamuna, Dunn, Zachary D, Li, Bo, Jin, Jian, James, Lindsey I, Redinbo, Matthew R
Published in ACS central science (25.07.2018)
Published in ACS central science (25.07.2018)
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MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing
Vital, Tamara, Wali, Aminah, Butler, Kyle V, Xiong, Yan, Foster, 2nd, Joseph P, Marcel, Shelsa S, McFadden, Andrew W, Nguyen, Valerie U, Bailey, Benton M, Lamb, Kelsey N, James, Lindsey I, Frye, Stephen V, Mosely, Amber L, Jin, Jian, Pattenden, Samantha G, Davis, Ian J
Published in Frontiers in oncology (30.01.2023)
Published in Frontiers in oncology (30.01.2023)
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Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons
Sun, Zhao‐Wei, Waybright, Jarod M., Beldar, Serap, Chen, Lu, Foley, Caroline A., Norris‐Drouin, Jacqueline L., Lyu, Tian‐Jie, Dong, Aiping, Min, Jinrong, Wang, Yu‐Pu, James, Lindsey I., Wang, Yun
Published in Advanced science (01.04.2022)
Published in Advanced science (01.04.2022)
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Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons
Sun, Zhao‐Wei, Waybright, Jarod M., Beldar, Serap, Chen, Lu, Foley, Caroline A., Norris‐Drouin, Jacqueline L., Lyu, Tian‐Jie, Dong, Aiping, Min, Jinrong, Wang, Yu‐Pu, James, Lindsey I., Wang, Yun
Published in Advanced science (01.09.2023)
Published in Advanced science (01.09.2023)
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Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library
Shell, Devan J., Rectenwald, Justin M., Buttery, Peter H., Johnson, Rebecca L., Foley, Caroline A., Guduru, Shiva K.R., Uguen, Mélanie, Rubiano, Juanita Sanchez, Zhang, Xindi, Li, Fengling, Norris-Drouin, Jacqueline L., Axtman, Matthew, Brian Hardy, P., Vedadi, Masoud, Frye, Stephen V., James, Lindsey I., Pearce, Kenneth H.
Published in SLAS discovery (01.12.2022)
Published in SLAS discovery (01.12.2022)
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Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins
Lamb, Kelsey N, Dishman, Sarah N, Waybright, Jarod M, Engelberg, Isabelle A, Rectenwald, Justin M, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Pearce, Kenneth H, James, Lindsey I, Frye, Stephen V
Published in ACS omega (11.01.2022)
Published in ACS omega (11.01.2022)
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Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader
Potjewyd, Frances, Turner, Anne-Marie W., Beri, Joshua, Rectenwald, Justin M., Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Margolis, David M., Pearce, Kenneth H., Herring, Laura E., James, Lindsey I.
Published in Cell chemical biology (16.01.2020)
Published in Cell chemical biology (16.01.2020)
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Development of VHL-recruiting STING PROTACs that suppress innate immunity
Zhu, Zhichuan, Johnson, Rebecca L., Zhang, Zhigang, Herring, Laura E., Jiang, Guochun, Damania, Blossom, James, Lindsey I., Liu, Pengda
Published in Cellular and molecular life sciences : CMLS (01.06.2023)
Published in Cellular and molecular life sciences : CMLS (01.06.2023)
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