Allosteric Modulation of GPCRs of Class A by Cholesterol
Jakubík, Jan, El-Fakahany, Esam E
Published in International journal of molecular sciences (16.02.2021)
Published in International journal of molecular sciences (16.02.2021)
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Journal Article
Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids
Szczurowska, Ewa, Szánti-Pintér, Eszter, Chetverikov, Nikolai, Randáková, Alena, Kudová, Eva, Jakubík, Jan
Published in International journal of molecular sciences (28.12.2022)
Published in International journal of molecular sciences (28.12.2022)
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Journal Article
Agonist-selective activation of individual G-proteins by muscarinic receptors
Nelic, Dominik, Chetverikov, Nikolai, Hochmalová, Martina, Diaz, Christina, Doležal, Vladimír, Boulos, John, Jakubík, Jan, Martemyanov, Kirill, Janoušková-Randáková, Alena
Published in Scientific reports (26.04.2024)
Published in Scientific reports (26.04.2024)
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Journal Article
The operational model of allosteric modulation of pharmacological agonism
Jakubík, Jan, Randáková, Alena, Chetverikov, Nikolai, El-Fakahany, Esam E, Doležal, Vladimír
Published in Scientific reports (02.09.2020)
Published in Scientific reports (02.09.2020)
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Journal Article
Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators
Dolezal, Vladimír, Jakubík, Jan, El-Fakahany, Esam E, Randáková, Alena
Published in PloS one (27.03.2019)
Published in PloS one (27.03.2019)
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Journal Article
Agonist-Specific Conformations of the M2 Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics
Randáková, Alena, Nelic, Dominik, Doležal, Vladimír, El-Fakahany, Esam E, Boulos, John, Jakubík, Jan
Published in Journal of chemical information and modeling (27.04.2020)
Published in Journal of chemical information and modeling (27.04.2020)
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Journal Article
Agonist-Specific Conformations of the M 2 Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics
Randáková, Alena, Nelic, Dominik, Doležal, Vladimír, El-Fakahany, Esam E, Boulos, John, Jakubík, Jan
Published in Journal of chemical information and modeling (27.04.2020)
Published in Journal of chemical information and modeling (27.04.2020)
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Journal Article
Novel long‐acting antagonists of muscarinic ACh receptors
Randáková, Alena, Rudajev, Vladimír, Doležal, Vladimír, Boulos, John, Jakubík, Jan
Published in British journal of pharmacology (01.05.2018)
Published in British journal of pharmacology (01.05.2018)
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Journal Article
Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors
Dolejší, Eva, Chetverikov, Nikolai, Szánti-Pintér, Eszter, Nelic, Dominik, Randáková, Alena, Doležal, Vladimír, El-Fakahany, Esam E., Kudová, Eva, Jakubík, Jan
Published in Biochemical pharmacology (01.10.2021)
Published in Biochemical pharmacology (01.10.2021)
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Journal Article
Novel M2‐selective, Gi‐biased agonists of muscarinic acetylcholine receptors
Randáková, Alena, Nelic, Dominik, Ungerová, Dana, Nwokoye, Peter, Su, Qiwen, Doležal, Vladimír, El‐Fakahany, Esam E., Boulos, John, Jakubík, Jan
Published in British journal of pharmacology (01.05.2020)
Published in British journal of pharmacology (01.05.2020)
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Journal Article
Fusion with Promiscuous Gα16 Subunit Reveals Signaling Bias at Muscarinic Receptors
Randáková, Alena, Nelic, Dominik, Hochmalová, Martina, Zimčík, Pavel, Mulenga, Mutale Jane, Boulos, John, Jakubík, Jan
Published in International journal of molecular sciences (18.09.2021)
Published in International journal of molecular sciences (18.09.2021)
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Journal Article
Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline
Randáková, Alena, Dolejší, Eva, Rudajev, Vladimír, Zimčík, Pavel, Doležal, Vladimír, El-Fakahany, Esam E., Jakubík, Jan
Published in Neuropharmacology (01.05.2018)
Published in Neuropharmacology (01.05.2018)
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Journal Article
Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors
Jakubík, Jan, Randáková, Alena, Zimčík, Pavel, El-Fakahany, Esam E, Doležal, Vladimír
Published in Scientific reports (16.01.2017)
Published in Scientific reports (16.01.2017)
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Journal Article
Towards predictive docking at aminergic G-protein coupled receptors
Jakubík, Jan, El-Fakahany, Esam E., Doležal, Vladimír
Published in Journal of molecular modeling (01.11.2015)
Published in Journal of molecular modeling (01.11.2015)
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