Alzheimer's Disease: From Pathology to Therapeutic Approaches
Jakob-Roetne, Roland, Jacobsen, Helmut
Published in Angewandte Chemie (International ed.) (14.04.2009)
Published in Angewandte Chemie (International ed.) (14.04.2009)
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Molecular Recognition at the Active Site of Catechol-O-Methyltransferase: Energetically Favorable Replacement of a Water Molecule Imported by a Bisubstrate Inhibitor
Ellermann, Manuel, Jakob-Roetne, Roland, Lerner, Christian, Borroni, Edilio, Schlatter, Daniel, Roth, Doris, Ehler, Andreas, Rudolph, Markus Georg, Diederich, François
Published in Angewandte Chemie (International ed.) (01.01.2009)
Published in Angewandte Chemie (International ed.) (01.01.2009)
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Molecular Recognition at the Active Site of Catechol-O-methyltransferase (COMT): Adenine Replacements in Bisubstrate Inhibitors
Ellermann, Manuel, Paulini, Ralph, Jakob-Roetne, Roland, Lerner, Christian, Borroni, Edilio, Roth, Doris, Ehler, Andreas, Schweizer, W. Bernd, Schlatter, Daniel, Rudolph, Markus G., Diederich, François
Published in Chemistry : a European journal (27.05.2011)
Published in Chemistry : a European journal (27.05.2011)
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Journal Article
Catechol-O-methyltransferase in complex with substituted 3′-deoxyribose bisubstrate inhibitors
Ellermann, Manuel, Lerner, Christian, Burgy, Guillaume, Ehler, Andreas, Bissantz, Caterina, Jakob-Roetne, Roland, Paulini, Ralph, Allemann, Oliver, Tissot, Heloïse, Grünstein, Dan, Stihle, Martine, Diederich, Francois, Rudolph, Markus G.
Published in Acta crystallographica. Section D, Biological crystallography. (01.03.2012)
Published in Acta crystallographica. Section D, Biological crystallography. (01.03.2012)
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Journal Article
X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity
Lerner, Christian, Ruf, Armin, Gramlich, Volker, Masjost, Birgit, Zürcher, Gerhard, Jakob-Roetne, Roland, Borroni, Edilio, Diederich, François
Published in Angewandte Chemie (International ed.) (05.11.2001)
Published in Angewandte Chemie (International ed.) (05.11.2001)
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Journal Article
Synthesis and Biological Evaluation of Potent Bisubstrate Inhibitors of the Enzyme Catechol O-Methyltransferase (COMT) Lacking a Nitro Group
Paulini, Ralph, Lerner, Christian, Diederich, François, Jakob-Roetne, Roland, Zürcher, Gerhard, Borroni, Edilio
Published in Helvetica chimica acta (01.09.2006)
Published in Helvetica chimica acta (01.09.2006)
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Journal Article
Bisubstrate Inhibitors of the Enzyme Catechol O-Methyltransferase (COMT): Efficient Inhibition Despite the Lack of a Nitro Group
Paulini, Ralph, Lerner, Christian, Jakob-Roetne, Roland, Zürcher, Gerhard, Borroni, Edilio, Diederich, François
Published in Chembiochem : a European journal of chemical biology (06.09.2004)
Published in Chembiochem : a European journal of chemical biology (06.09.2004)
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Journal Article
Structure-Based Design, Synthesis, and in vitro Evaluation of Bisubstrate Inhibitors for Catechol O-Methyltransferase (COMT)
Masjost, Birgit, Ballmer, Patrick, Borroni, Edilio, Zürcher, Gerhard, Winkler, Fritz K., Jakob-Roetne, Roland, Diederich, François
Published in Chemistry : a European journal (17.03.2000)
Published in Chemistry : a European journal (17.03.2000)
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Journal Article
Bisubstrate Inhibitors of Catechol O-Methyltransferase (COMT): the Crucial Role of the Ribose Structural Unit for Inhibitor Binding Affinity
Paulini, Ralph, Trindler, Christian, Lerner, Christian, Brändli, Lukas, Schweizer, W. Bernd, Jakob-Roetne, Roland, Zürcher, Gerhard, Borroni, Edilio, Diederich, François
Published in ChemMedChem (13.03.2006)
Published in ChemMedChem (13.03.2006)
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Bisubstrate Inhibitors for the Enzyme Catechol O-Methyltransferase (COMT): Dramatic Effects of Ribose Modifications on Binding Affinity and Binding Mode
Lerner, Christian, Siegrist, Romain, Schweizer, Eliane, Diederich, François, Gramlich, Volker, Jakob-Roetne, Roland, Zürcher, Gerhard, Borroni, Edilio
Published in Helvetica chimica acta (01.04.2003)
Published in Helvetica chimica acta (01.04.2003)
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Journal Article
Discovery of Balovaptan, a Vasopressin la Receptor Antagonist for the Treatment of Autism Spectrum Disorder
Schnider, Patrick, Bissantz, Caterina, Bruns, Andreas, Dolente, Cosimo, Goetschi, Erwin, Jakob-Roetne, Roland, Kuennecke, Basil, Mueggler, Thomas, Muster, Wolfgang, Parrott, Neil, Pinard, Emmanuel, Ratni, Hasane, Risterucci, Celine, Rogers-Evans, Mark, von Kienlin, Markus, Grundschober, Christophe
Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
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Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells
Patsch, Christoph, Challet-Meylan, Ludivine, Thoma, Eva C, Urich, Eduard, Heckel, Tobias, O'Sullivan, John F, Grainger, Stephanie J, Kapp, Friedrich G, Sun, Lin, Christensen, Klaus, Xia, Yulei, Florido, Mary H C, He, Wei, Pan, Wei, Prummer, Michael, Warren, Curtis R, Jakob-Roetne, Roland, Certa, Ulrich, Jagasia, Ravi, Freskgård, Per-Ola, Adatto, Isaac, Kling, Dorothee, Huang, Paul, Zon, Leonard I, Chaikof, Elliot L, Gerszten, Robert E, Graf, Martin, Iacone, Roberto, Cowan, Chad A
Published in Nature cell biology (01.08.2015)
Published in Nature cell biology (01.08.2015)
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Stepwise Design of γ‑Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere
Rodríguez Sarmiento, Rosa María, Bissantz, Caterina, Bylund, Johan, Limberg, Anja, Neidhart, Werner, Jakob-Roetne, Roland, Wang, Lisha, Baumann, Karlheinz
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Journal Article
Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O‑Methyltransferase Derived from a Fragment Screening Approach Targeting the S‑Adenosyl‑l‑methionine Pocket
Lerner, Christian, Jakob-Roetne, Roland, Buettelmann, Bernd, Ehler, Andreas, Rudolph, Markus, Rodríguez Sarmiento, Rosa María
Published in Journal of medicinal chemistry (23.11.2016)
Published in Journal of medicinal chemistry (23.11.2016)
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Journal Article
Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder
Schnider, Patrick, Bissantz, Caterina, Bruns, Andreas, Dolente, Cosimo, Goetschi, Erwin, Jakob-Roetne, Roland, Künnecke, Basil, Mueggler, Thomas, Muster, Wolfgang, Parrott, Neil, Pinard, Emmanuel, Ratni, Hasane, Risterucci, Céline, Rogers-Evans, Mark, von Kienlin, Markus, Grundschober, Christophe
Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
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Journal Article
Controlling Polymerization of β-Amyloid and Prion-derived Peptides with Synthetic Small Molecule Ligands
Kuner, Pascal, Bohrmann, Bernd, Tjernberg, Lars O., Näslund, Jan, Huber, Gerda, Celenk, Suna, Grüninger-Leitch, Fiona, Richards, J.Grayson, Jakob-Rœtne, Roland, Kemp, John A., Nordstedt, Christer
Published in The Journal of biological chemistry (21.01.2000)
Published in The Journal of biological chemistry (21.01.2000)
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Journal Article
Discovery of RO7185876, a Highly Potent gamma-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer's Disease
Ratni, Hasane, Alker, Andre, Bartels, Bjoern, Bissantz, Caterina, Chen, Weichun, Gerlach, Irene, Limberg, Anja, Lu, Mingqiu, Neidhart, Werner, Pichereau, Solen, Reutlinger, Michael, Rodriguez-Sarmiento, Rosa-Maria, Jakob-Roetne, Roland, Schmitt, Georg, Zhang, Eric, Baumann, Karlheinz
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Journal Article
Correction to Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O‑Methyltransferase Derived from a Fragment Screening Approach Targeting the S‑Adenosyl‑l‑methionine Pocket
Lerner, Christian, Jakob-Roetne, Roland, Buettelmann, Bernd, Ehler, Andreas, Rudolph, Markus G, Rodríguez Sarmiento, Rosa María
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Journal Article
X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity
Lerner, Christian, Ruf, Armin, Gramlich, Volker, Masjost, Birgit, Zürcher, Gerhard, Jakob-Roetne, Roland, Borroni, Edilio, Diederich, François
Published in Angewandte Chemie (05.11.2001)
Published in Angewandte Chemie (05.11.2001)
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