CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease
Dairaghi, Daniel J., Oyajobi, Babatunde O., Gupta, Anjana, McCluskey, Brandon, Miao, Shichang, Powers, Jay P., Seitz, Lisa C., Wang, Yu, Zeng, Yibin, Zhang, Penglie, Schall, Thomas J., Jaen, Juan C.
Published in Blood (16.08.2012)
Published in Blood (16.08.2012)
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SAR and mode of action of novel non-nucleoside inhibitors of hepatitis CNS5b RNA polymerase
Powers, JP, Piper, DE, Li, Y, Mayorga, Anzola, J, Chen, JM, Jaen, JC, Lee, G, Liu, JQ, Peterson, MG, Tonn, GR, Ye, QP, Walker, NPC, Wang, ZL
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Pharmacokinetic and pharmacodynamic evaluation of the novel CCR1 antagonist CCX354 in healthy human subjects: implications for selection of clinical dose
Dairaghi, D J, Zhang, P, Wang, Y, Seitz, L C, Johnson, D A, Miao, S, Ertl, L S, Zeng, Y, Powers, J P, Pennell, A M, Bekker, P, Schall, T J, Jaen, J C
Published in Clinical pharmacology and therapeutics (01.05.2011)
Published in Clinical pharmacology and therapeutics (01.05.2011)
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OP0204 Characterization of the novel C5AR antagonist CCX168, a potential therapeutic for ANCA-vasculitis, rheumatoid arthritis, and other autoimmune disorders
Powers, J.P., Bekker, P.J., Dairaghi, D.J., Jennette, J.C., Johnson, D.A., Leleti, M., Miao, S., Seitz, L.C., Wang, Y., Xiao, H., Schall, T.J., Jaen, J.C.
Published in Annals of the rheumatic diseases (01.06.2013)
Published in Annals of the rheumatic diseases (01.06.2013)
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Selective, Covalent Modification of β -Tubulin Residue Cys-239 by T138067, an Antitumor Agent with in vivo Efficacy against Multidrug-Resistant Tumors
Shan, Bei, Medina, Julio C., Santha, Edit, Frankmoelle, Walter P., Ting-C. Chou, Learned, Robert M., Narbut, Mathew R., Stott, Dean, Wu, Pengguang, Jaen, Juan C., Rosen, Terry, Pieter B. M. W. M. Timmermans, Beckmann, Holger
Published in Proceedings of the National Academy of Sciences - PNAS (11.05.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (11.05.1999)
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2-Amino-4H-3,1-benzoxazin-4-ones as Inhibitors of C1r Serine Protease
Hays, Sheryl J, Caprathe, Bradley W, Gilmore, John L, Amin, Nilam, Emmerling, Mark R, Michael, Walter, Nadimpalli, Ravi, Nath, Rathna, Raser, Kadee J, Stafford, Daniel, Watson, Desiree, Wang, Kevin, Jaen, Juan C
Published in Journal of medicinal chemistry (26.03.1998)
Published in Journal of medicinal chemistry (26.03.1998)
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Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells
Medina, Julio C., Roche, Daniel, Shan, Bei, Learned, R.Marc, Frankmoelle, Walter P., Clark, David L., Rosen, Terry, Jaen, Juan C.
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
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Hydrophilic, Pro-Drug Analogues of T138067 Are Efficacious in Controlling Tumor Growth In Vivo and Show a Decreased Ability To Cross the Blood Brain Barrier
Rubenstein, Steven M, Baichwal, Vijay, Beckmann, Holger, Clark, David L, Frankmoelle, Walter, Roche, Daniel, Santha, Edit, Schwender, Susan, Thoolen, Martin, Ye, Qiuping, Jaen, Juan C
Published in Journal of medicinal chemistry (25.10.2001)
Published in Journal of medicinal chemistry (25.10.2001)
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Novel antineoplastic agents with efficacy against multidrug resistant tumor cells
Medina, Julio C., Shan, Bei, Beckmann, Holger, Farrell, Robert P., Clark, David L., Marc Learned, R., Roche, Daniel, Li, Angela, Baichwal, Vijay, Case, Casey, Baeuerle, Patrick A., Rosen, Terry, Jaen, Juan C.
Published in Bioorganic & medicinal chemistry letters (06.10.1998)
Published in Bioorganic & medicinal chemistry letters (06.10.1998)
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Journal Article
Acetylcholinesterase inhibition by fused dihydroquinazoline compounds
Jaén, Juan C., Gregor, Vlad E., Lee, Chet, Davis, Robert, Emmerling, Mark
Published in Bioorganic & medicinal chemistry letters (19.03.1996)
Published in Bioorganic & medicinal chemistry letters (19.03.1996)
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4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties
Jaen, Juan C, Wise, Lawrence D, Caprathe, Bradley W, Tecle, Haile, Bergmeier, Stephen, Humblet, Christine C, Heffner, Thomas G, Meltzer, Leonard T, Pugsley, Thomas A
Published in Journal of medicinal chemistry (01.01.1990)
Published in Journal of medicinal chemistry (01.01.1990)
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Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors
Gilmore, John L., Hays, Sheryl J., Caprathe, Bradley W., Lee, Chitase, Emmerling, Mark R., Michael, Walter, Jaen, Juan C.
Published in Bioorganic & medicinal chemistry letters (19.03.1996)
Published in Bioorganic & medicinal chemistry letters (19.03.1996)
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Design and Synthesis of m1-Selective Muscarinic Agonists: (R)-(−)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3‘-Methoxyphenyl)-2-propynyl)- oxime Maleate (CI-1017), a Functionally m1-Selective Muscarinic Agonist
Tecle, Haile, Barrett, Stephen D, Lauffer, David J, Augelli-Szafran, Corinne, Brann, Mark R, Callahan, Michael J, Caprathe, Bradley. W, Davis, Robert E, Doyle, Patricia D, Eubanks, David, Lipiniski, William, Mirzadegan, Tara, Moos, Walter H, Moreland, D. W, Nelson, Carrie B, Pavia, Michael R, Raby, Charlotte, Schwarz, Roy D, Spencer, Carolyn J, Thomas, Anthony J, Jaen, Juan C
Published in Journal of medicinal chemistry (02.07.1998)
Published in Journal of medicinal chemistry (02.07.1998)
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Aryl 1-But-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as Potential Antipsychotic Agents: Synthesis and Structure−Activity Relationships
Glase, Shelly A, Akunne, Hyacinth C, Heffner, Thomas G, Jaen, Juan C, MacKenzie, Robert G, Meltzer, Leonard T, Pugsley, Thomas A, Smith, Sarah J, Wise, Lawrence D
Published in Journal of medicinal chemistry (02.08.1996)
Published in Journal of medicinal chemistry (02.08.1996)
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Journal Article
Kynurenic Acid Derivatives Inhibit the Binding of Nerve Growth Factor (NGF) to the Low-Affinity p75 NGF Receptor
Jaen, Juan C, Laborde, Edgardo, Bucsh, Ruth A, Caprathe, Bradley W, Sorenson, Roderick J, Fergus, James, Spiegel, Katharyn, Marks, James, Dickerson, Melvin R, Davis, Robert E
Published in Journal of medicinal chemistry (01.10.1995)
Published in Journal of medicinal chemistry (01.10.1995)
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Journal Article
Identification and Characterization of m1 Selective Muscarinic Receptor Antagonists
Augelli-Szafran, Corinne E, Blankley, C. John, Jaen, Juan C, Moreland, David W, Nelson, Carrie B, Penvose-Yi, Jan R, Schwarz, Roy D, Thomas, Anthony J
Published in Journal of medicinal chemistry (11.02.1999)
Published in Journal of medicinal chemistry (11.02.1999)
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Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and .sigma. receptors
Jaen, Juan C, Caprathe, Bradley W, Pugsley, Thomas A, Wise, Lawrence D, Akunne, Hyacinth
Published in Journal of medicinal chemistry (26.11.1993)
Published in Journal of medicinal chemistry (26.11.1993)
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