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Maralixibat for the treatment of PFIC: Long‐term, IBAT inhibition in an open‐label, Phase 2 study
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Lung-derived soluble mediators are pathogenic in ventilator-induced lung injury
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Multitracer Stable Isotope Quantification of Arginase and Nitric Oxide Synthase Activity in a Mouse Model of Pseudomonas Lung Infection
Ratjen, Felix, Rafii, Mahroukh, Huang, Hailu, Mehl, Anne, Jaecklin, Thomas, Grasemann, Hartmut, Pencharz, Paul
Published in Mediators of Inflammation (01.01.2014)
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Efficacy and safety of maralixibat treatment in patients with Alagille syndrome and cholestatic pruritus (ICONIC): a randomised phase 2 study
Gonzales, Emmanuel, Hardikar, Winita, Stormon, Michael, Baker, Alastair, Hierro, Loreto, Gliwicz, Dorota, Lacaille, Florence, Lachaux, Alain, Sturm, Ekkehard, Setchell, Kenneth D R, Kennedy, Ciara, Dorenbaum, Alejandro, Steinmetz, Jana, Desai, Nirav K, Wardle, Andrew J, Garner, Will, Vig, Pamela, Jaecklin, Thomas, Sokal, Etienne M, Jacquemin, Emmanuel
Published in The Lancet (British edition) (30.10.2021)
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Systematic Literature Review on the Incidence and Prevalence of Heart Failure in Children and Adolescents
Shaddy, Robert E., George, Aneesh Thomas, Jaecklin, Thomas, Lochlainn, Eimear Nic, Thakur, Lalit, Agrawal, Rumjhum, Solar-Yohay, Susan, Chen, Fabian, Rossano, Joseph W., Severin, Thomas, Burch, Michael
Published in Pediatric cardiology (01.03.2018)
Published in Pediatric cardiology (01.03.2018)
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Serum bile acid control in long-term maralixibat-treated patients is associated with native liver survival in children with progressive familial intrahepatic cholestasis due to bile salt export pump deficiency
Thompson, Richard, Kelly, Deirdre, Miethke, Alexander, Rajwal, Sanjay, Soufi, Nisreen, Jankowska, Irena, Mack, Cara, Lachaux, Alain, Jaecklin, Thomas, Vig, Pamela, Wardle, Andrew, Squires, Robert, Loomes, Kathleen
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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LBO08 - Serum bile acid control in long-term maralixibat-treated patients is associated with native liver survival in children with progressive familial intrahepatic cholestasis due to bile salt export pump deficiency
Thompson, Richard, Kelly, Deirdre, Miethke, Alexander, Rajwal, Sanjay, Soufi, Nisreen, Jankowska, Irena, Mack, Cara, Lachaux, Alain, Jaecklin, Thomas, Vig, Pamela, Wardle, Andrew, Squires, Robert, Loomes, Kathleen
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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LBO-08-Growth analysis in children with progressive familial intrahepatic cholestasis treated with the apical sodium-dependent bile acid transporter inhibitor maralixibat
Thompson, Richard, Kelly, Deirdre, Rajwal, Sanjay, Miethke, Alexander, Soufi, Nisreen, Rivet, Christine, Jankowska, Irena, mack, Cara, Jaecklin, Thomas, Squires, Robert, Loomes, Kathleen
Published in Journal of hepatology (01.04.2019)
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Do soluble mediators cause ventilator-induced lung injury and multi-organ failure?
Jaecklin, Thomas, Otulakowski, Gail, Kavanagh, Brian P.
Published in Intensive care medicine (01.05.2010)
Published in Intensive care medicine (01.05.2010)
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Patient-ventilator asynchrony during noninvasive pressure support ventilation and neurally adjusted ventilatory assist in infants and children
Vignaux, Laurence, Grazioli, Serge, Piquilloud, Lise, Bochaton, Nathalie, Karam, Oliver, Levy-Jamet, Yann, Jaecklin, Thomas, Tourneux, Pierre, Jolliet, Philippe, Rimensberger, Peter C
Published in Pediatric critical care medicine (01.10.2013)
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PS-193-Phase 2 open-label study with a placebo-controlled drug withdrawal period of the apical sodium-dependent bile acid transporter inhibitor maralixibat in children with Alagille Syndrome: 48-week interim efficacy analysis
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Optimizing patient-ventilator synchrony during invasive ventilator assist in children and infants remains a difficult task
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Published in Pediatric critical care medicine (01.09.2013)
Published in Pediatric critical care medicine (01.09.2013)
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Safety, tolerability, and efficacy of maralixibat in adults with primary sclerosing cholangitis: Open-label pilot study
Bowlus, Christopher L, Eksteen, Bertus, Cheung, Angela C, Thorburn, Douglas, Moylan, Cynthia A, Pockros, Paul J, Forman, Lisa M, Dorenbaum, Alejandro, Hirschfield, Gideon M, Kennedy, Ciara, Jaecklin, Thomas, McKibben, Andrew, Chien, Elaine, Baek, Marshall, Vig, Pamela, Levy, Cynthia
Published in Hepatology communications (01.06.2023)
Published in Hepatology communications (01.06.2023)
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Lung arginase expression and activity is increased in cystic fibrosis mouse models
Jaecklin, Thomas, Duerr, Julia, Huang, Hailu, Rafii, Mahroukh, Bear, Christine E, Ratjen, Felix, Pencharz, Paul, Kavanagh, Brian P, Mall, Marcus A, Grasemann, Hartmut
Published in Journal of applied physiology (1985) (01.08.2014)
Published in Journal of applied physiology (1985) (01.08.2014)
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Maralixibat in progressive familial intrahepatic cholestasis (MARCH-PFIC): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
Miethke, Alexander G, Moukarzel, Adib, Porta, Gilda, Covarrubias Esquer, Joshue, Czubkowski, Piotr, Ordonez, Felipe, Mosca, Antonella, Aqul, Amal A, Squires, Robert H, Sokal, Etienne, D'Agostino, Daniel, Baumann, Ulrich, D'Antiga, Lorenzo, Kasi, Nagraj, Laborde, Nolwenn, Arikan, Cigdem, Lin, Chuan-Hao, Gilmour, Susan, Mittal, Naveen, Chiou, Fang Kuan, Horslen, Simon P, Huber, Wolf-Dietrich, Jaecklin, Thomas, Nunes, Tiago, Lascau, Anamaria, Longpre, Lara, Mogul, Douglas B, Garner, Will, Vig, Pamela, Hupertz, Vera F, Gonzalez-Peralta, Regino P, Ekong, Udeme, Hartley, Jane, Laverdure, Noemie, Ovchinsky, Nadia, Thompson, Richard J
Published in The lancet. Gastroenterology & hepatology (01.07.2024)
Published in The lancet. Gastroenterology & hepatology (01.07.2024)
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