Development and validation of an automated static headspace gas chromatography–mass spectrometry (SHS-GC–MS) method for monitoring the formation of ethyl methane sulfonate from ethanol and methane sulfonic acid
Jacq, Karine, Delaney, Ed, Teasdale, Andrew, Eyley, Steve, Taylor-Worth, Karen, Lipczynski, Andrew, Reif, Van D., Elder, David P., Facchine, Kevin L., Golec, Simon, Oestrich, Rolf Schulte, Sandra, Pat, David, Frank
Published in Journal of pharmaceutical and biomedical analysis (15.12.2008)
Published in Journal of pharmaceutical and biomedical analysis (15.12.2008)
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Journal Article
The Utility of Sulfonate Salts in Drug Development
Elder, David P., Delaney, Ed, Teasdale, Andrew, Eyley, Steve, Reif, Van D., Jacq, Karine, Facchine, Kevin L., Oestrich, Rolf Schulte, Sandra, Patrick, David, Frank
Published in Journal of pharmaceutical sciences (01.07.2010)
Published in Journal of pharmaceutical sciences (01.07.2010)
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Journal Article
Analysis of potential genotoxic impurities in pharmaceuticals by two-dimensional gas chromatography with Deans switching and independent column temperature control using a low-thermal-mass oven module
David, Frank, Jacq, Karine, Sandra, Pat, Baker, Andrew, Klee, Matthew S
Published in Analytical and bioanalytical chemistry (01.02.2010)
Published in Analytical and bioanalytical chemistry (01.02.2010)
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Journal Article
A Detailed Study of Sulfonate Ester Formation and Solvolysis Reaction Rates and Application toward Establishing Sulfonate Ester Control in Pharmaceutical Manufacturing Processes
Teasdale, Andrew, Delaney, Edward J, Eyley, Stephen C, Jacq, Karine, Taylor-Worth, Karen, Lipczynski, Andrew, Hoffmann, Wilfried, Reif, Van, Elder, David P, Facchine, Kevin L, Golec, Simon, Schulte Oestrich, Rolf, Sandra, Pat, David, Frank
Published in Organic process research & development (16.07.2010)
Published in Organic process research & development (16.07.2010)
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Journal Article
Mechanism and Processing Parameters Affecting the Formation of Methyl Methanesulfonate from Methanol and Methanesulfonic Acid: An Illustrative Example for Sulfonate Ester Impurity Formation
Teasdale, Andrew, Eyley, Stephen C, Delaney, Ed, Jacq, Karine, Taylor-Worth, Karen, Lipczynski, Andrew, Reif, Van, Elder, David P, Facchine, Kevin L, Golec, Simon, Schulte Oestrich, Rolf, Sandra, Pat, David, Frank
Published in Organic process research & development (15.05.2009)
Published in Organic process research & development (15.05.2009)
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Journal Article
Strategic Approaches to the Chromatographic Analysis of Genotoxic Impurities
David, Frank, Jacq, Karine, Vanhoenacker, Gerd, Sandra, Pat
Published in Genotoxic Impurities (14.02.2011)
Published in Genotoxic Impurities (14.02.2011)
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Book Chapter
Method selection for trace analysis of genotoxic impurities in pharmaceuticals
Vanhoenacker, Gerd, Sandra, Pat, David, Frank, Baker, Andrew, Jacq, Karine
Published in LC GC Europe (01.12.2009)
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Published in LC GC Europe (01.12.2009)
Magazine Article