A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists
Reynaud, Steve, Ciolek, Justyna, Degueldre, Michel, Saez, Natalie J, Sequeira, Ana Filipa, Duhoo, Yoan, Brás, Joana L. A, Meudal, Hervé, Cabo Díez, Miguel, Fernández Pedrosa, Victoria, Verdenaud, Marion, Boeri, Julia, Pereira Ramos, Oscar, Ducancel, Frédéric, Vanden Driessche, Margot, Fourmy, Rudy, Violette, Aude, Upert, Grégory, Mourier, Gilles, Beck-Sickinger, Annette G, Mörl, Karin, Landon, Céline, Fontes, Carlos M. G. A, Miñambres Herráiz, Rebeca, Rodríguez de la Vega, Ricardo C, Peigneur, Steve, Tytgat, Jan, Quinton, Loïc, De Pauw, Edwin, Vincentelli, Renaud, Servent, Denis, Gilles, Nicolas
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries
Ciolek, Justyna, Zoukimian, Claude, Dhot, Justine, Burban, Mélanie, Triquigneaux, Mathilde, Lauzier, Benjamin, Guimbert, Christelle, Boturyn, Didier, Ferron, Marine, Ciccone, Lidia, Tepshi, Livia, Stura, Enrico, Legrand, Pierre, Robin, Philippe, Mourier, Gilles, Schaack, Béatrice, Fellah, Imen, Blanchet, Guillaume, Gauthier-Erfanian, Chantal, Beroud, Rémy, Servent, Denis, De Waard, Michel, Gilles, Nicolas
Published in Biomedicine & pharmacotherapy (01.06.2022)
Published in Biomedicine & pharmacotherapy (01.06.2022)
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Evaluation of the Spider ( Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates
Gonçalves, Tânia C, Lesport, Pierre, Kuylle, Sarah, Stura, Enrico, Ciolek, Justyna, Mourier, Gilles, Servent, Denis, Bourinet, Emmanuel, Benoit, Evelyne, Gilles, Nicolas
Published in Toxins (22.08.2019)
Published in Toxins (22.08.2019)
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First animal toxins active on melanocortin receptors, an innovation from the european venomics project
Reynaud, Steve, Ciolek, Justyna, Mourier, Gilles, Servent, Denis, Gilles, Nicolas
Published in Toxicon (Oxford) (01.02.2019)
Published in Toxicon (Oxford) (01.02.2019)
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Animal toxins as innovative ligands of melanocortin 4 receptor
Reynaud, Steve, Ciolek, Justyna, Servent, Denis, Mourier, Gilles, Gilles, Nicolas
Published in Toxicon (Oxford) (01.07.2018)
Published in Toxicon (Oxford) (01.07.2018)
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Journal Article
Muscarinic toxin 9: A novel peptide from Dendroaspis polylepis venom that selectively targets muscarinic type 2 receptor
Ciolek, Justyna, de Susa Carvalho, Christelle, Quinton, Loïc, Mou rier, Gilles, Servent, Denis, Gilles, Nicolas
Published in Toxicon (Oxford) (01.07.2018)
Published in Toxicon (Oxford) (01.07.2018)
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Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease
Ciolek, Justyna, Reinfrank, Helen, Quinton, Loïc, Viengchareun, Say, Stura, Enrico A., Vera, Laura, Sigismeau, Sabrina, Mouillac, Bernard, Orcel, Hélène, Peigneur, Steve, Tytgat, Jan, Droctové, Laura, Beau, Fabrice, Nevoux, Jerome, Lombès, Marc, Mourier, Gilles, De Pauw, Edwin, Servent, Denis, Mendre, Christiane, Witzgall, Ralph, Gilles, Nicolas
Published in Proceedings of the National Academy of Sciences - PNAS (03.07.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (03.07.2017)
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From a Cone Snail Toxin to a Competitive MC4R Antagonist
Reynaud, Steve, Laurin, Suli-Anne, Ciolek, Justyna, Barbe, Peggy, Van Baelen, Anne-Cécile, Susset, Michaël, Blondel, Florian, Ghazarian, Marine, Boeri, Julia, Vanden Driessche, Margot, Upert, Grégory, Mourier, Gilles, Kessler, Pascal, Konnert, Laure, Beroud, Rémy, Keck, Mathilde, Servent, Denis, Bouvier, Michel, Gilles, Nicolas
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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A new Kunitz‐type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor
Droctové, Laura, Ciolek, Justyna, Mendre, Christiane, Chorfa, Amélia, Huerta, Paola, Carvalho, Chrystelle, Gouin, Charlotte, Lancien, Manon, Stanajic‐Petrovic, Goran, Braco, Lorine, Blanchet, Guillaume, Upert, Gregory, De Pauw, Gregory, Barbe, Peggy, Keck, Mathilde, Mourier, Gilles, Mouillac, Bernard, Denis, Servent, Rodríguez de la Vega, Ricardo C., Quinton, Loïc, Gilles, Nicolas
Published in British journal of pharmacology (01.07.2022)
Published in British journal of pharmacology (01.07.2022)
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Crystal structure and functional domains of the Mambaquaretin-1, a vasopressin type 2 receptor peptide inhibitor for kidney cysts treatment
Droctové, Laura, Ciolek, Justyna, Lancien, Manon, Stura, Enrico A., Vera, Laura, Floquet, Nicolas, Witzgall, Ralph, Mouillac, Bernard, Mendre, Christiane, Mourier, Gilles, Servent, Denis, Gilles, Nicolas
Published in Toxicon (Oxford) (01.07.2018)
Published in Toxicon (Oxford) (01.07.2018)
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Journal Article
Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease
Ciolek, Justyna, Reinfrank, Helen, Quinton, Loïc, Viengchareun, Say, Stura, Enrico, Vera, Laura, Sigismeau, Sabrina, Mouillac, Bernard, Orcel, Hélène, Peigneur, Steve, Tytgat, Jan, Droctové, Laura, Beau, Fabrice, Nevoux, Jerome, Lombès, Marc, Mourier, Gilles, de Pauw, Edwin, Servent, Denis, Mendre, Christiane, Witzgall, Ralph, Gilles, Nicolas
Published in Proceedings of the National Academy of Sciences - PNAS (19.06.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (19.06.2017)
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Vasopressin-2 receptor antagonist peptides and uses thereof
DROCTOVÉ, Laura, CIOLEK, Justyna, GILLES, Nicolas, MAILLERE, Bernard, NOZACH, Hervé
Year of Publication 31.10.2024
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Year of Publication 31.10.2024
Patent
Vasopressin-2 receptor antagonist peptides and uses thereof
DROCTOVÉ, Laura, CIOLEK, Justyna, GILLES, Nicolas, MAILLERE, Bernard, NOZACH, Hervé
Year of Publication 16.05.2024
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Year of Publication 16.05.2024
Patent
VASOPRESSIN-2 RECEPTOR ANTAGONIST PEPTIDES AND USES THEREOF
DROCTOVE, Laura, NOZACH, Herve, CIOLEK, Justyna, GILLES, Nicolas, MAILLERE, Bernard
Year of Publication 27.07.2023
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Year of Publication 27.07.2023
Patent
VASOPRESSIN-2 RECEPTOR ANTAGONIST PEPTIDES AND USES THEREOF
DROCTOVÉ, Laura, CIOLEK, Justyna, GILLES, Nicolas, MAILLERE, Bernard, NOZACH, Hervé
Year of Publication 03.05.2023
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Year of Publication 03.05.2023
Patent
Vasopressin-2 receptor antagonist peptides and uses thereof
DROCTOVÉ, Laura, CIOLEK, Justyna, GILLES, Nicolas, MAILLERE, Bernard, NOZACH, Hervé
Year of Publication 02.02.2023
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Year of Publication 02.02.2023
Patent
VASOPRESSIN-2 RECEPTOR ANTAGONIST PEPTIDES AND USES THEREOF
CIOLEK, JUSTYNA, MAILLERE, BERNARD, DROCTOVE, LAURA, GILLES, NICOLAS, NOZACH, HERVE
Year of Publication 30.12.2021
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Year of Publication 30.12.2021
Patent