Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases
Caldwell, Richard D, Qiu, Hui, Askew, Ben C, Bender, Andrew T, Brugger, Nadia, Camps, Montserrat, Dhanabal, Mohanraj, Dutt, Vikram, Eichhorn, Thomas, Gardberg, Anna S, Goutopoulos, Andreas, Grenningloh, Roland, Head, Jared, Healey, Brian, Hodous, Brian L, Huck, Bayard R, Johnson, Theresa L, Jones, Christopher, Jones, Reinaldo C, Mochalkin, Igor, Morandi, Federica, Nguyen, Ngan, Meyring, Michael, Potnick, Justin R, Santos, Dusica Cvetinovic, Schmidt, Ralf, Sherer, Brian, Shutes, Adam, Urbahns, Klaus, Follis, Ariele Viacava, Wegener, Ansgar A, Zimmerli, Simone C, Liu-Bujalski, Lesley
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Metallophosphites as Umpolung Catalysts: The Enantioselective Cross Silyl Benzoin Reaction
Linghu, Xin, Potnick, Justin R, Johnson, Jeffrey S
Published in Journal of the American Chemical Society (17.03.2004)
Published in Journal of the American Chemical Society (17.03.2004)
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Metallophosphite-Catalyzed Asymmetric Acylation of α,β-Unsaturated Amides
Nahm, Mary R, Potnick, Justin R, White, Peter S, Johnson, Jeffrey S
Published in Journal of the American Chemical Society (01.03.2006)
Published in Journal of the American Chemical Society (01.03.2006)
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Metallophosphite-Induced Nucleophilic Acylation of α,β-Unsaturated Amides: Facilitated Catalysis by a Diastereoselective Retro [1,4] Brook Rearrangement
Nahm, Mary R., Linghu, Xin, Potnick, Justin R., Yates, Christopher M., White, Peter S., Johnson, Jeffrey S.
Published in Angewandte Chemie International Edition (15.04.2005)
Published in Angewandte Chemie International Edition (15.04.2005)
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Discovery of potent and selective reversible Bruton’s tyrosine kinase inhibitors
Qiu, Hui, Ali, Zahid, Bender, Andrew, Caldwell, Richard, Chen, Yi-Ying, Fang, Zhizhou, Gardberg, Anna, Glaser, Nina, Goettsche, Anja, Goutopoulos, Andreas, Grenningloh, Roland, Hanschke, Bettina, Head, Jared, Johnson, Theresa, Jones, Christopher, Jones, Reinaldo, Kulkarni, Shashank, Maurer, Christine, Morandi, Federica, Neagu, Constantin, Poetzsch, Sven, Potnick, Justin, Schmidt, Ralf, Roe, Katherine, Viacava Follis, Ariele, Wing, Carolyn, Zhu, Xiaohua, Sherer, Brian
Published in Bioorganic & medicinal chemistry (15.06.2021)
Published in Bioorganic & medicinal chemistry (15.06.2021)
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Journal Article
Discovery of potent and selective reversible Bruton?s tyrosine kinase inhibitors
Qiu, Hui, Ali, Zahid, Bender, Andrew, Caldwell, Richard, Chen, Yi-Ying, Fang, Zhizhou, Gardberg, Anna, Glaser, Nina, Goettsche, Anja, Goutopoulos, Andreas, Grenningloh, Roland, Hanschke, Bettina, Head, Jared, Johnson, Theresa, Jones, Christopher, Jones, Reinaldo, Kulkarni, Shashank, Maurer, Christine, Morandi, Federica, Neagu, Constantin, Poetzsch, Sven, Potnick, Justin, Schmidt, Ralf, Roe, Katherine, Follis, Ariele Viacava, Wing, Carolyn, Zhu, Xiaohua, Sherer, Brian
Published in Bioorganic & medicinal chemistry (15.06.2021)
Published in Bioorganic & medicinal chemistry (15.06.2021)
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Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers
DeSelm, Lizbeth, Huck, Bayard, Lan, Ruoxi, Neagu, Constantin, Potnick, Justin, Xiao, Yufang, Chen, Xiaoling, Jones, Reinaldo, Richardson, Thomas E, Heasley, Brian H, Haxell, Thomas, Moore, Joseph, Tian, Hui, Georgi, Katrin, Rohdich, Felix, Sutton, Amanda, Johnson, Theresa, Mochalkin, Igor, Jackson, Jennifer, Lin, Jing, Crowley, Lindsey, Machl, Andreas, Clark, Anderson, Wilker, Erik, Sherer, Brian, Goutopoulos, Andreas
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Synthesis and SAR development of quinoline analogs as novel P2X7 receptor antagonists
Xiao, Yufang, Karra, Srinivasa, Goutopoulos, Andreas, Morse, Noune Tahmassian, Zhang, Susan, Dhanabal, Mohanraj, Tian, Hui, Seenisamy, Jeyaprakashnarayanan, Jayadevan, Jayashankaran, Caldwell, Richard, Potnick, Justin, Bleich, Matthew, Chekler, Eugene, Sherer, Brian, Sriraman, Venkataraman
Published in Bioorganic & medicinal chemistry letters (01.07.2019)
Published in Bioorganic & medicinal chemistry letters (01.07.2019)
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Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression
Guler, Satenig, DiPoto, Maria C., Crespo, Alejandro, Caldwell, Richard, Doerfel, Benjamin, Grossmann, Nina, Ho, Kevin, Huck, Bayard, Jones, Christopher CV, Lan, Ruoxi, Musil, Djordje, Potnick, Justin, Schilke, Heike, Sherer, Brian, Simon, Stephanie, Sirrenberg, Christian, Zhang, Zhuo, Liu-Bujalski, Lesley
Published in ACS medicinal chemistry letters (11.05.2023)
Published in ACS medicinal chemistry letters (11.05.2023)
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Optimization of the efflux ratio and permeability of covalent irreversible BTK inhibitors
Qiu, Hui, Liu-Bujalski, Lesley, Caldwell, Richard D., Viacava Follis, Ariele, Gardberg, Anna, Goutopoulos, Andreas, Grenningloh, Roland, Head, Jared, Johnson, Theresa, Jones, Christopher C.V., Jones, Reinaldo, Mochalkin, Igor, Morandi, Federica, Neagu, Constantin, Potnick, Justin, Sherer, Brian
Published in Bioorganic & medicinal chemistry letters (01.11.2018)
Published in Bioorganic & medicinal chemistry letters (01.11.2018)
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Journal Article
Discovery of Affinity‐Based Probes for Btk Occupancy Assays
Qiu, Hui, Caldwell, Richard, Liu‐Bujalski, Lesley, Goutopoulos, Andreas, Jones, Reinaldo, Potnick, Justin, Sherer, Brian, Bender, Andrew, Grenningloh, Roland, Xu, Daigen, Gardberg, Anna, Mochalkin, Igor, Johnson, Theresa, Viacava Follis, Ariele, Head, Jared, Morandi, Federica
Published in ChemMedChem (22.01.2019)
Published in ChemMedChem (22.01.2019)
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NOVEL HETEROCYCLIC CARBOXAMIDES AS MODULATORS OF KINASE ACTIVITY
LAN RUOXI, CONSTANTIN NEAGU, THERESA L JOHNSON, LIZBETH CELESTE DE SELM, XIAO YUFANG, JUSTIN POTNICK, BAYARD R HUCK, SRINIVASA R KARRA, CHEN XIAOLING
Year of Publication 02.11.2017
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Year of Publication 02.11.2017
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