Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders
Bruns, Robert F., Mitchell, Stephen N., Wafford, Keith A., Harper, Alex J., Shanks, Elaine A., Carter, Guy, O'Neill, Michael J., Murray, Tracey K., Eastwood, Brian J., Schaus, John M., Beck, James P., Hao, Junliang, Witkin, Jeffrey M., Li, Xia, Chernet, Eyassu, Katner, Jason S., Wang, Hong, Ryder, John W., Masquelin, Meghane E., Thompson, Linda K., Love, Patrick L., Maren, Deanna L., Falcone, Julie F., Menezes, Michelle M., Zhang, Linli, Yang, Charles R., Svensson, Kjell A.
Published in Neuropharmacology (01.01.2018)
Published in Neuropharmacology (01.01.2018)
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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S‑2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
Monn, James A, Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Hao, Junliang, Reinhard, Matt R, Henry, Steven S, Goldsmith, Paul J, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Xiang, Chuanxi, Catlow, John T, Swanson, Steven, Sanger, Helen, Broad, Lisa M, Johnson, Michael P, Knopp, Kelly L, Simmons, Rosa M. A, Johnson, Bryan G, Shaw, David B, McKinzie, David L
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Synthesis and Pharmacological Characterization of C4‑(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)‑2-Amino-4-(1H‑1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist
Monn, James A, Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R, Henry, Steven S, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Getman, Brian G, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Journal Article
Unified Total Synthesis of Pteriatoxins and Their Diastereomers
Matsuura, Fumiyoshi, Peters, René, Anada, Masahiro, Harried, Scott S, Hao, Junliang, Kishi, Yoshito
Published in Journal of the American Chemical Society (14.06.2006)
Published in Journal of the American Chemical Society (14.06.2006)
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Journal Article
Chemistry and Biology of Diazonamide A: Second Total Synthesis and Biological Investigations
Nicolaou, K. C, Hao, Junliang, Reddy, Mali V, Rao, Paraselli Bheema, Rassias, Gerasimos, Snyder, Scott A, Huang, Xianhai, Chen, David Y.-K, Brenzovich, William E, Giuseppone, Nicolas, Giannakakou, Paraskevi, O'Brate, Aurora
Published in Journal of the American Chemical Society (13.10.2004)
Published in Journal of the American Chemical Society (13.10.2004)
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Journal Article
Total Synthesis and Stereochemistry of Pinnatoxins B and C
Matsuura, Fumiyoshi, Hao, Junliang, Reents, Reinhard, Kishi, Yoshito
Published in Organic letters (20.07.2006)
Published in Organic letters (20.07.2006)
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Journal Article
The Second Total Synthesis of Diazonamide A
Nicolaou, K. C., Bheema Rao, Paraselli, Hao, Junliang, Reddy, Mali Venkat, Rassias, Gerasimos, Huang, Xianhai, Chen, David Y.-K., Snyder, Scott A.
Published in Angewandte Chemie (International ed.) (17.04.2003)
Published in Angewandte Chemie (International ed.) (17.04.2003)
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Journal Article
Stereochemistry of Pteriatoxins A, B, and C
Hao, Junliang, Matsuura, Fumiyoshi, Kishi, Yoshito, Kita, Masaki, Uemura, Daisuke, Asai, Naoki, Iwashita, Takashi
Published in Journal of the American Chemical Society (21.06.2006)
Published in Journal of the American Chemical Society (21.06.2006)
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The allosteric dopamine D1 receptor potentiator, DETQ, ameliorates subchronic phencyclidine-induced object recognition memory deficits and enhances cortical acetylcholine efflux in male humanized D1 receptor knock-in mice
Meltzer, Herbert Y., Rajagopal, Lakshmi, Matrisciano, Francesco, Hao, Junliang, Svensson, Kjell A., Huang, Mei
Published in Behavioural brain research (01.04.2019)
Published in Behavioural brain research (01.04.2019)
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Ensemble Docking Approach to Mitigate Pregnane X Receptor-Mediated CYP3A4 Induction Risk
Chen, Qi, Zhou, Xin, Rehmel, Jessica, Steele, James P., Svensson, Kjell A., Beck, James P., Hembre, Erik J., Hao, Junliang
Published in Journal of chemical information and modeling (09.01.2023)
Published in Journal of chemical information and modeling (09.01.2023)
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Effects of DPTQ, a novel positive allosteric modulator of the dopamine D1 receptor, on spontaneous eye blink rate and spatial working memory in the nonhuman primate
Castner, Stacy A., Zhang, Linli, Yang, Charles R., Hao, Junliang, Cramer, Jeffrey W., Wang, Xushan, Bruns, Robert F., Marston, Hugh, Svensson, Kjell A., Williams, Graham V.
Published in Psychopharmacology (01.05.2023)
Published in Psychopharmacology (01.05.2023)
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Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor
Durham, Timothy B., Hao, Junliang, Spinazze, Patrick, Stack, Douglas R., Toth, James L., Massey, Steven, Mbofana, Curren T., Johnston, Richard D., Lineswala, Jayana P., Wrobleski, Aaron, Mínguez, Jose Miguel, Perez, Carlos, Smith, Daryl L., Lamar, Jason, Leon, Rebecca, Corkins, Christopher, Durbin, Jim, Tung, Frances, Guo, Sherry, Linder, Ryan J., Yumibe, Nathan, Wang, Wei, MacKrell, James, Antonellis, Meghan, Mascaro, Bethany
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Intracellular Binding Site for a Positive Allosteric Modulator of the Dopamine D1 Receptor
Wang, Xushan, Heinz, Beverly A, Qian, Yue-Wei, Carter, Joan H, Gadski, Robert A, Beavers, Lisa S, Little, Sheila P, Yang, Charles R, Beck, James P, Hao, Junliang, Schaus, John M, Svensson, Kjell A, Bruns, Robert F
Published in Molecular pharmacology (01.10.2018)
Published in Molecular pharmacology (01.10.2018)
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Synthesis and Pharmacological Characterization of 2‑(2,6-Dichlorophenyl)-1-((1S,3R)‑5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)‑yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor
Hao, Junliang, Beck, James P, Schaus, John M, Krushinski, Joseph H, Chen, Qi, Beadle, Christopher D, Vidal, Paloma, Reinhard, Matthew R, Dressman, Bruce A, Massey, Steven M, Boulet, Serge L, Cohen, Michael P, Watson, Brian M, Tupper, David, Gardinier, Kevin M, Myers, Jason, Johansson, Anette M, Richardson, Jeffery, Richards, Daniel S, Hembre, Erik J, Remick, David M, Coates, David A, Bhardwaj, Rajni M, Diseroad, Benjamin A, Bender, David, Stephenson, Greg, Wolfangel, Craig D, Diaz, Nuria, Getman, Brian G, Wang, Xu-shan, Heinz, Beverly A, Cramer, Jeff W, Zhou, Xin, Maren, Deanna L, Falcone, Julie F, Wright, Rebecca A, Mitchell, Stephen N, Carter, Guy, Yang, Charles R, Bruns, Robert F, Svensson, Kjell A
Published in Journal of medicinal chemistry (10.10.2019)
Published in Journal of medicinal chemistry (10.10.2019)
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Structural Basis for (S)‑3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor
Chen, Qi, Ho, Joseph D, Ashok, Sheela, Vargas, Michelle C, Wang, Jing, Atwell, Shane, Bures, Mark, Schkeryantz, Jeffery M, Monn, James A, Hao, Junliang
Published in Journal of medicinal chemistry (21.11.2018)
Published in Journal of medicinal chemistry (21.11.2018)
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