A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH
Francque, Sven M, Bedossa, Pierre, Ratziu, Vlad, Anstee, Quentin M, Bugianesi, Elisabetta, Sanyal, Arun J, Loomba, Rohit, Harrison, Stephen A, Balabanska, Rozalina, Mateva, Lyudmila, Lanthier, Nicolas, Alkhouri, Naim, Moreno, Christophe, Schattenberg, Jörn M, Stefanova-Petrova, Diana, Vonghia, Luisa, Rouzier, Régine, Guillaume, Maeva, Hodge, Alexander, Romero-Gómez, Manuel, Huot-Marchand, Philippe, Baudin, Martine, Richard, Marie-Paule, Abitbol, Jean-Louis, Broqua, Pierre, Junien, Jean-Louis, Abdelmalek, Manal F
Published in The New England journal of medicine (21.10.2021)
Published in The New England journal of medicine (21.10.2021)
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Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease
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Published in Journal of hepatology (01.05.2021)
Published in Journal of hepatology (01.05.2021)
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Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension
Avouac, Jerome, Konstantinova, Irena, Guignabert, Christophe, Pezet, Sonia, Sadoine, Jeremy, Guilbert, Thomas, Cauvet, Anne, Tu, Ly, Luccarini, Jean-Michel, Junien, Jean-Louis, Broqua, Pierre, Allanore, Yannick
Published in Annals of the rheumatic diseases (01.11.2017)
Published in Annals of the rheumatic diseases (01.11.2017)
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Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis
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Published in Annals of the rheumatic diseases (01.12.2016)
Published in Annals of the rheumatic diseases (01.12.2016)
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The new‐generation pan‐peroxisome proliferator‐activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis
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Published in Hepatology communications (01.08.2017)
Published in Hepatology communications (01.08.2017)
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Odiparcil, a potential glycosaminoglycans clearance therapy in mucopolysaccharidosis VI-Evidence from in vitro and in vivo models
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Published in PloS one (15.05.2020)
Published in PloS one (15.05.2020)
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The pan-PPAR agonist lanifibranor improves cardiometabolic health in patients with metabolic dysfunction-associated steatohepatitis
Cooreman, Michael P., Butler, Javed, Giugliano, Robert P., Zannad, Faiez, Dzen, Lucile, Huot-Marchand, Philippe, Baudin, Martine, Beard, Daniel R., Junien, Jean-Louis, Broqua, Pierre, Abdelmalek, Manal F., Francque, Sven M.
Published in Nature communications (10.05.2024)
Published in Nature communications (10.05.2024)
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Chronic Inhibition of Circulating Dipeptidyl Peptidase IV by FE 999011 Delays the Occurrence of Diabetes in Male Zucker Diabetic Fatty Rats
SUDRE, Béatrice, BROQUA, Pierre, WHITE, Richard B, ASHWORTH, Doreen, EVANS, D. Michael, HAIGH, Robert, JUNIEN, Jean-Louis, AUBERT, Michel L
Published in Diabetes (New York, N.Y.) (01.05.2002)
Published in Diabetes (New York, N.Y.) (01.05.2002)
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Pharmacological Profile of a New, Potent, and Long-Acting Gonadotropin-Releasing Hormone Antagonist: Degarelix
Broqua, Pierre, Riviere, Pierre J-M, Conn, P Michael, Rivier, Jean E, Aubert, Michel L, Junien, Jean-Louis
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
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Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate
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Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
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The pan-PPAR agonist lanifibranor reduces development of lung fibrosis and attenuates cardiorespiratory manifestations in a transgenic mouse model of systemic sclerosis
Derrett-Smith, Emma, Clark, Kristina E N, Shiwen, Xu, Abraham, David J, Hoyles, Rachel K, Lacombe, Olivier, Broqua, Pierre, Junien, Jean Louis, Konstantinova, Irena, Ong, Voon H, Denton, Christopher P
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Published in Arthritis research & therapy (06.09.2021)
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Novel d-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral κ-opioid receptors
Vanderah, Todd W., Largent-Milnes, Tally, Lai, Josephine, Porreca, Frank, Houghten, Richard A., Menzaghi, Frédérique, Wisniewski, Kazimierz, Stalewski, Jacek, Sueiras-Diaz, Javier, Galyean, Robert, Schteingart, Claudio, Junien, Jean-Louis, Trojnar, Jerzy, Rivière, Pierre J.-M.
Published in European journal of pharmacology (31.03.2008)
Published in European journal of pharmacology (31.03.2008)
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Identification of biological markers of liver X receptor (LXR) activation at the cell surface of human monocytes
Rébé, Cédric, Filomenko, Rodolphe, Raveneau, Magalie, Chevriaux, Angélique, Ishibashi, Minako, Lagrost, Laurent, Junien, Jean Louis, Gambert, Philippe, Masson, David
Published in PloS one (21.11.2012)
Published in PloS one (21.11.2012)
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FE200041 (D-Phe-D-Phe-D-Nle-D-Arg-NH2): A peripheral efficacious kappa opioid agonist with unprecedented selectivity
Vanderah, Todd W, Schteingart, Claudio D, Trojnar, Jerzy, Junien, Jean-Louis, Lai, Josephine, Riviere, Pierre J-M
Published in The Journal of pharmacology and experimental therapeutics (01.07.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2004)
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Analgesic and antiinflammatory effects of two novel κ-opioid peptides
BINDER, Waltraud, MACHELSKA, Halina, MOUSA, Shaaban, SCHMITT, Thomas, RIVIERE, Pierre J. M, JUNIEN, Jean-Louis, STEIN, Christoph, SCHÄFER, Michael
Published in Anesthesiology (Philadelphia) (01.06.2001)
Published in Anesthesiology (Philadelphia) (01.06.2001)
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In vivo modulation of sigma receptor sites by calcitonin gene-related peptide in the mouse and rat hippocampal formation: radioligand binding and electrophysiological studies
Bouchard, P, Monnet, F, Bergeron, R, Roman, F, Junien, J L, de Montigny, C, Debonnel, G, Quirion, R
Published in The European journal of neuroscience (01.09.1995)
Published in The European journal of neuroscience (01.09.1995)
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