Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain
Han, Sangdon, Thoresen, Lars, Jung, Jae-Kyu, Zhu, Xiuwen, Thatte, Jayant, Solomon, Michelle, Gaidarov, Ibragim, Unett, David J, Yoon, Woo Hyun, Barden, Jeremy, Sadeque, Abu, Usmani, Amin, Chen, Chuan, Semple, Graeme, Grottick, Andrew J, Al-Shamma, Hussein, Christopher, Ronald, Jones, Robert M
Published in ACS medicinal chemistry letters (14.12.2017)
Published in ACS medicinal chemistry letters (14.12.2017)
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The Absolute Configuration and Asymmetric Total Synthesis of the CP Molecules (CP-263,114 and CP-225,917, Phomoidrides B and A)
Nicolaou, K. C., Jung, Jae-Kyu, Yoon, Won Hyung, He, Yun, Zhong, Yong-Li, Baran, Phil S.
Published in Angewandte Chemie International Edition (15.05.2000)
Published in Angewandte Chemie International Edition (15.05.2000)
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New inhibitors of the thioredoxin–thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead
Wipf, Peter, Hopkins, Tamara D., Jung, Jae-Kyu, Rodriguez, Sonia, Birmingham, Anne, Southwick, Eileen C., Lazo, John S., Powis, Garth
Published in Bioorganic & medicinal chemistry letters (08.10.2001)
Published in Bioorganic & medicinal chemistry letters (08.10.2001)
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(1a R ,5a R )1a,3,5,5a-Tetrahydro-1 H -2,3-diaza-cyclopropa[ a ]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans
Boatman, P. Douglas, Lauring, Brett, Schrader, Thomas O., Kasem, Michelle, Johnson, Benjamin R., Skinner, Philip, Jung, Jae-Kyu, Xu, Jerry, Cherrier, Martin C., Webb, Peter J., Semple, Graeme, Sage, Carleton R., Knudsen, Jens, Chen, Ruoping, Luo, Wen-Lin, Caro, Luzelena, Cote, Josee, Lai, Eseng, Wagner, John, Taggart, Andrew K., Carballo-Jane, Ester, Hammond, Milton, Colletti, Steven L., Tata, James R., Connolly, Daniel T., Waters, M. Gerard, Richman, Jeremy G.
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
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3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice
Semple, Graeme, Skinner, Philip J, Gharbaoui, Tawfik, Shin, Young-Jun, Jung, Jae-Kyu, Cherrier, Martin C, Webb, Peter J, Tamura, Susan Y, Boatman, P. Douglas, Sage, Carleton R, Schrader, Thomas O, Chen, Ruoping, Colletti, Steven L, Tata, James R, Waters, M. Gerard, Cheng, Kang, Taggart, Andrew K, Cai, Tian-Quan, Carballo-Jane, Ester, Behan, Dominic P, Connolly, Daniel T, Richman, Jeremy G
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a] pentalen-4-carboxamides as potent and selective CB2 receptor agonists
Han, Sangdon, Thoresen, Lars, Zhu, Xiuwen, Narayanan, Sanju, Jung, Jae-Kyu, Strah-Pleynet, Sonja, Decaire, Marc, Choi, Karoline, Xiong, Yifeng, Yue, Dawei, Semple, Graeme, Thatte, Jayant, Solomon, Michelle, Fu, Lixia, Whelan, Kevin, Al-Shamma, Hussien, Gatlin, Joel, Chen, Ruoping, Dang, Huong, Pride, Cameron, Gaidarov, Ibragim, Unett, David J., Behan, Dominic P., Abu Sadeque, Usmani, Khawja A., Chen, Chuan, Edwards, Jeffrey, Morgan, Michael, Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (15.01.2015)
Published in Bioorganic & medicinal chemistry letters (15.01.2015)
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Analogues of Acifran: Agonists of the High and Low Affinity Niacin Receptors, GPR109a and GPR109b
Jung, Jae-Kyu, Johnson, Benjamin R, Duong, Tracy, Decaire, Marc, Uy, Jane, Gharbaoui, Tawfik, Boatman, P. Douglas, Sage, Carleton R, Chen, Ruoping, Richman, Jeremy G, Connolly, Daniel T, Semple, Graeme
Published in Journal of medicinal chemistry (05.04.2007)
Published in Journal of medicinal chemistry (05.04.2007)
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Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)
Boatman, P. Douglas, Schrader, Thomas O., Kasem, Michelle, Johnson, Benjamin R., Skinner, Philip J., Jung, Jae-Kyu, Xu, Jerry, Cherrier, Martin C., Webb, Peter J., Semple, Graeme, Sage, Carleton R., Knudsen, Jens, Chen, Ruoping, Taggart, Andrew K., Carballo-Jane, Ester, Richman, Jeremy G.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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