The Current State of NAD+‐Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets
Schiedel, Matthias, Robaa, Dina, Rumpf, Tobias, Sippl, Wolfgang, Jung, Manfred
Published in Medicinal research reviews (01.01.2018)
Published in Medicinal research reviews (01.01.2018)
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Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)
Schiedel, Matthias, Herp, Daniel, Hammelmann, Sören, Swyter, Sören, Lehotzky, Attila, Robaa, Dina, Oláh, Judit, Ovádi, Judit, Sippl, Wolfgang, Jung, Manfred
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Journal Article
KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases
Simon, Roman P, Robaa, Dina, Alhalabi, Zayan, Sippl, Wolfgang, Jung, Manfred
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site
Rumpf, Tobias, Schiedel, Matthias, Karaman, Berin, Roessler, Claudia, North, Brian J, Lehotzky, Attila, Oláh, Judit, Ladwein, Kathrin I, Schmidtkunz, Karin, Gajer, Markus, Pannek, Martin, Steegborn, Clemens, Sinclair, David A, Gerhardt, Stefan, Ovádi, Judit, Schutkowski, Mike, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred
Published in Nature communications (12.02.2015)
Published in Nature communications (12.02.2015)
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Journal Article
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants
Marek, Martin, Shaik, Tajith B, Heimburg, Tino, Chakrabarti, Alokta, Lancelot, Julien, Ramos-Morales, Elizabeth, Da Veiga, Cyrielle, Kalinin, Dmitrii, Melesina, Jelena, Robaa, Dina, Schmidtkunz, Karin, Suzuki, Takayoshi, Holl, Ralph, Ennifar, Eric, Pierce, Raymond J, Jung, Manfred, Sippl, Wolfgang, Romier, Christophe
Published in Journal of medicinal chemistry (21.11.2018)
Published in Journal of medicinal chemistry (21.11.2018)
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Journal Article
Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors
Vögerl, Katharina, Ong, Nghia, Senger, Johanna, Herp, Daniel, Schmidtkunz, Karin, Marek, Martin, Müller, Martin, Bartel, Karin, Shaik, Tajith B, Porter, Nicholas J, Robaa, Dina, Christianson, David W, Romier, Christophe, Sippl, Wolfgang, Jung, Manfred, Bracher, Franz
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
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Journal Article
Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors
Senger, Johanna, Melesina, Jelena, Marek, Martin, Romier, Christophe, Oehme, Ina, Witt, Olaf, Sippl, Wolfgang, Jung, Manfred
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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Journal Article
Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis
Heimburg, Tino, Chakrabarti, Alokta, Lancelot, Julien, Marek, Martin, Melesina, Jelena, Hauser, Alexander-Thomas, Shaik, Tajith B, Duclaud, Sylvie, Robaa, Dina, Erdmann, Frank, Schmidt, Matthias, Romier, Christophe, Pierce, Raymond J, Jung, Manfred, Sippl, Wolfgang
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Journal Article
Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy
Wagner, Julia M, Hackanson, Björn, Lübbert, Michael, Jung, Manfred
Published in Clinical epigenetics (01.12.2010)
Published in Clinical epigenetics (01.12.2010)
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Journal Article
Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure–Activity Relationship Study
Schiedel, Matthias, Rumpf, Tobias, Karaman, Berin, Lehotzky, Attila, Oláh, Judit, Gerhardt, Stefan, Ovádi, Judit, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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Journal Article
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity
Darwish, Salma, Ghazy, Ehab, Heimburg, Tino, Herp, Daniel, Zeyen, Patrik, Salem-Altintas, Rabia, Ridinger, Johannes, Robaa, Dina, Schmidtkunz, Karin, Erdmann, Frank, Schmidt, Matthias, Romier, Christophe, Jung, Manfred, Oehme, Ina, Sippl, Wolfgang
Published in International journal of molecular sciences (07.07.2022)
Published in International journal of molecular sciences (07.07.2022)
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Journal Article
Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines
Zessin, Matthes, Meleshin, Marat, Hilscher, Sebastian, Schiene-Fischer, Cordelia, Barinka, Cyril, Jung, Manfred, Schutkowski, Mike
Published in International journal of molecular sciences (01.04.2023)
Published in International journal of molecular sciences (01.04.2023)
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Journal Article
Structure-Based Development of an Affinity Probe for Sirtuin 2
Schiedel, Matthias, Rumpf, Tobias, Karaman, Berin, Lehotzky, Attila, Gerhardt, Stefan, Ovádi, Judit, Sippl, Wolfgang, Einsle, Oliver, Jung, Manfred
Published in Angewandte Chemie (International ed.) (05.02.2016)
Published in Angewandte Chemie (International ed.) (05.02.2016)
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Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases
Chakrabarti, Alokta, Melesina, Jelena, Kolbinger, Fiona R, Oehme, Ina, Senger, Johanna, Witt, Olaf, Sippl, Wolfgang, Jung, Manfred
Published in Future medicinal chemistry (01.09.2016)
Published in Future medicinal chemistry (01.09.2016)
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Journal Article
Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor
Willmann, Dominica, Lim, Soyoung, Wetzel, Stefan, Metzger, Eric, Jandausch, Anett, Wilk, Wolfram, Jung, Manfred, Forne, Ignasi, Imhof, Axel, Janzer, Andreas, Kirfel, Jutta, Waldmann, Herbert, Schüle, Roland, Buettner, Reinhard
Published in International journal of cancer (01.12.2012)
Published in International journal of cancer (01.12.2012)
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Structure-metabolism relationships of valine and tert-leucine-derived synthetic cannabinoid receptor agonists: a systematic comparison of the in vitro phase I metabolism using pooled human liver microsomes and high-resolution mass spectrometry
Franz, Florian, Jechle, Hanna, Wilde, Maurice, Angerer, Verena, Huppertz, Laura M., Longworth, Mitchell, Kassiou, Michael, Jung, Manfred, Auwärter, Volker
Published in Forensic toxicology (01.07.2019)
Published in Forensic toxicology (01.07.2019)
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Journal Article
Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni
Marek, Martin, Kannan, Srinivasaraghavan, Hauser, Alexander-Thomas, Moraes Mourão, Marina, Caby, Stéphanie, Cura, Vincent, Stolfa, Diana A, Schmidtkunz, Karin, Lancelot, Julien, Andrade, Luiza, Renaud, Jean-Paul, Oliveira, Guilherme, Sippl, Wolfgang, Jung, Manfred, Cavarelli, Jean, Pierce, Raymond J, Romier, Christophe
Published in PLoS pathogens (01.09.2013)
Published in PLoS pathogens (01.09.2013)
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