Extensive Rigid Analogue Design Maps the Binding Conformation of Potent N‑Benzylphenethylamine 5‑HT2A Serotonin Receptor Agonist Ligands
Juncosa, Jose I, Hansen, Martin, Bonner, Lisa A, Cueva, Juan Pablo, Maglathlin, Rebecca, McCorvy, John D, Marona-Lewicka, Danuta, Lill, Markus A, Nichols, David E
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Published in ACS chemical neuroscience (16.01.2013)
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Design and Mechanism of (S)‑3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ‑Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction
Juncosa, Jose I, Takaya, Kenji, Le, Hoang V, Moschitto, Matthew J, Weerawarna, Pathum M, Mascarenhas, Romila, Liu, Dali, Dewey, Stephen L, Silverman, Richard B
Published in Journal of the American Chemical Society (14.02.2018)
Published in Journal of the American Chemical Society (14.02.2018)
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Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a] phenanthridines
PABLO CUEVA, Juan, CHEMEL, Benjamin R, JUNCOSA, Jose I, LILL, Markus A, WATTS, Val J, NICHOLS, David E
Published in European journal of medicinal chemistry (01.02.2012)
Published in European journal of medicinal chemistry (01.02.2012)
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PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation
Wu, Rui, Sanishvili, Ruslan, Belitsky, Boris R., Juncosa, Jose I., Le, Hoang V., Lehrer, Helaina J. S., Farley, Michael, Silverman, Richard B., Petsko, Gregory A., Ringe, Dagmar, Liu, Dali
Published in Proceedings of the National Academy of Sciences - PNAS (11.04.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (11.04.2017)
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Mechanism of Inactivation of γ‑Aminobutyric Acid Aminotransferase by (1S,3S)‑3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115)
Lee, Hyunbeom, Doud, Emma H, Wu, Rui, Sanishvili, Ruslan, Juncosa, Jose I, Liu, Dali, Kelleher, Neil L, Silverman, Richard B
Published in Journal of the American Chemical Society (25.02.2015)
Published in Journal of the American Chemical Society (25.02.2015)
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Two continuous coupled assays for ornithine-δ-aminotransferase
Juncosa, Jose I., Lee, Hyunbeom, Silverman, Richard B.
Published in Analytical biochemistry (15.09.2013)
Published in Analytical biochemistry (15.09.2013)
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Probing the Steric Space at the Floor of the D1 Dopamine Receptor Orthosteric Binding Domain: 7α-, 7β-, 8α-, and 8β-Methyl Substituted Dihydrexidine Analogues
Cueva, Juan Pablo, Gallardo-Godoy, Alejandra, Juncosa, Jose I, Vidi, Pierre A, Lill, Markus A, Watts, Val J, Nichols, David E
Published in Journal of medicinal chemistry (11.08.2011)
Published in Journal of medicinal chemistry (11.08.2011)
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Mapping the Catechol Binding Site in Dopamine D1 Receptors: Synthesis and Evaluation of Two Parallel Series of Bicyclic Dopamine Analogues
Bonner, Lisa A., Laban, Uros, Chemel, Benjamin R., Juncosa, Jose I., Lill, Markus A., Watts, Val J., Nichols, David E.
Published in ChemMedChem (06.06.2011)
Published in ChemMedChem (06.06.2011)
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Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent GABA Aminotransferase Inactivator for the Treatment of Addiction
Juncosa, Jose I., Takaya, Kenji, Le, Hoang V., Moschitto, Matthew J., Weerawarna, Pathum M., Mascarenhas, Romila, Liu, Dali, Dewey, Stephen L., Silverman, Richard B.
Published in Journal of the American Chemical Society (30.01.2018)
Published in Journal of the American Chemical Society (30.01.2018)
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Journal Article
Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1 S ,3 S )-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115)
Lee, Hyunbeom, Doud, Emma H., Wu, Rui, Sanishvili, Ruslan, Juncosa, Jose I., Liu, Dali, Kelleher, Neil L., Silverman, Richard B.
Published in Journal of the American Chemical Society (10.02.2015)
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Published in Journal of the American Chemical Society (10.02.2015)
Journal Article
Probing the Steric Space at the Floor of the D-1 Dopamine Receptor Orthosteric Binding Domain: 7 alpha-, 7 beta-, 8 alpha-, and 8 beta-Methyl Substituted Dihydrexidine Analogues
Cueva, Juan Pablo, Gallardo-Godoy, Alejandra, Juncosa, Jose I., Vidi, Pierre A., Lill, Markus A., Watts, Val J., Nichols, David E.
Published in Journal of medicinal chemistry (11.08.2011)
Published in Journal of medicinal chemistry (11.08.2011)
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Journal Article
Analogues of doxanthrine reveal differences between the dopamine D 1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[ a]phenanthridines
Cueva, Juan Pablo, Chemel, Benjamin R., Juncosa, Jose I., Lill, Markus A., Watts, Val J., Nichols, David E.
Published in European journal of medicinal chemistry (01.02.2012)
Published in European journal of medicinal chemistry (01.02.2012)
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Journal Article
Mapping the Catechol Binding Site in Dopamine D 1 Receptors: Synthesis and Evaluation of Two Parallel Series of Bicyclic Dopamine Analogues
Bonner, Lisa A., Laban, Uros, Chemel, Benjamin R., Juncosa, Jose I., Lill, Markus A., Watts, Val J., Nichols, David E.
Published in ChemMedChem (06.06.2011)
Published in ChemMedChem (06.06.2011)
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Journal Article
Probing the Steric Space at the Floor of the D 1 Dopamine Receptor Orthosteric Binding Domain: 7α-, 7β-, 8α-, and 8β-Methyl Substituted Dihydrexidine Analogues
Cueva, Juan Pablo, Gallardo-Godoy, Alejandra, Juncosa, Jose I., Vidi, Pierre A., Lill, Markus A., Watts, Val J., Nichols, David E.
Published in Journal of medicinal chemistry (11.08.2011)
Published in Journal of medicinal chemistry (11.08.2011)
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