Synthesis and Pharmacological Evaluation of 3-[(4-Oxo-4H-pyrido[3,2-e][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile Derivatives as Orally Active AMPA Receptor Antagonists
Inami, Hiroshi, Shishikura, Jun-ichi, Yasunaga, Tomoyuki, Hirano, Masaaki, Kimura, Takenori, Yamashita, Hiroshi, Ohno, Kazushige, Sakamoto, Shuichi
Published in Chemical & pharmaceutical bulletin (01.07.2019)
Published in Chemical & pharmaceutical bulletin (01.07.2019)
Get full text
Journal Article
Synthesis, structure–activity relationships, and anticonvulsant activities of 2-amino-4H-pyrido[3,2-e][1,3]thiazin-4-one derivatives as orally active AMPA receptor antagonists
Inami, Hiroshi, Shishikura, Jun-ichi, Yasunaga, Tomoyuki, Ohno, Kazushige, Yamashita, Hiroshi, Kato, Kota, Sakamoto, Shuichi
Published in Bioorganic & medicinal chemistry (15.04.2015)
Published in Bioorganic & medicinal chemistry (15.04.2015)
Get full text
Journal Article
Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liability
Ogiyama, Takashi, Yonezawa, Koichi, Inoue, Makoto, Katayama, Naoko, Watanabe, Toshihiro, Yoshimura, Seiji, Gotoh, Takayasu, Kiso, Tetsuo, Koakutsu, Akiko, Kakimoto, Shuichiro, Shishikura, Jun-ichi
Published in Bioorganic & medicinal chemistry (01.08.2015)
Published in Bioorganic & medicinal chemistry (01.08.2015)
Get full text
Journal Article
Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain
Ogiyama, Takashi, Yonezawa, Koichi, Inoue, Makoto, Watanabe, Toshihiro, Sugano, Yukihito, Gotoh, Takayasu, Kiso, Tetsuo, Koakutsu, Akiko, Kakimoto, Shuichiro, Shishikura, Jun-ichi
Published in Bioorganic & medicinal chemistry (01.08.2015)
Published in Bioorganic & medicinal chemistry (01.08.2015)
Get full text
Journal Article
Suppression of fully kindled seizure and retardation of kindling acquisition by YM928 in the rat kindling model of epilepsy
Yamashita, Hiroshi, Ohno, Kazushige, Inami, Hiroshi, Shishikura, Jun-ichi, Sakamoto, Shuichi, Okada, Masamichi, Yamaguchi, Tokio
Published in European journal of pharmacology (28.06.2004)
Published in European journal of pharmacology (28.06.2004)
Get full text
Journal Article
Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels
Ogiyama, Takashi, Inoue, Makoto, Honda, Shugo, Yamada, Hiroyoshi, Watanabe, Toshihiro, Gotoh, Takayasu, Kiso, Tetsuo, Koakutsu, Akiko, Kakimoto, Shuichiro, Shishikura, Jun-ichi
Published in Bioorganic & medicinal chemistry (15.12.2014)
Published in Bioorganic & medicinal chemistry (15.12.2014)
Get full text
Journal Article
Corrigendum to “Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels” [Bioorg. Med. Chem. 22 (2014) 6899–6907]
Ogiyama, Takashi, Inoue, Makoto, Honda, Shugo, Yamada, Hiroyoshi, Watanabe, Toshihiro, Gotoh, Takayasu, Kiso, Tetsuo, Koakutsu, Akiko, Kakimoto, Shuichiro, Shishikura, Jun-ichi
Published in Bioorganic & medicinal chemistry (01.09.2015)
Published in Bioorganic & medicinal chemistry (01.09.2015)
Get full text
Journal Article
Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats
Yamashita, Hiroshi, Ohno, Kazushige, Amada, Yoko, Inami, Hiroshi, Shishikura, Jun-Ichi, Sakamoto, Shuichi, Okada, Masamichi, Yamaguchi, Tokio
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.08.2004)
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.08.2004)
Get full text
Journal Article
In-vitro characterization of YM872, a selective, potent and highly water-soluble alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist
Kohara, A, Okada, M, Tsutsumi, R, Ohno, K, Takahashi, M, Shimizu-Sasamata, M, Shishikura, J, Inami, H, Sakamoto, S, Yamaguchi, T
Published in Journal of pharmacy and pharmacology (01.07.1998)
Published in Journal of pharmacy and pharmacology (01.07.1998)
Get more information
Journal Article
Effects of 2-[N-(4-chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an orally active alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, in models of generalized epileptic seizure in mice and rats
Yamashita, Hiroshi, Ohno, Kazushige, Amada, Yoko, Hattori, Hanae, Ozawa-Funatsu, Yukiko, Toya, Takashi, Inami, Hiroshi, Shishikura, Jun-Ichi, Sakamoto, Shuichi, Okada, Masamichi, Yamaguchi, Tokio
Published in The Journal of pharmacology and experimental therapeutics (01.01.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2004)
Get full text
Journal Article
Functional Characterization of YM928, a Novel Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist
Ohno, Kazushige, Tsutsumi, Rie, Matsumoto, Naoyuki, Yamashita, Hiroshi, Amada, Yoko, Shishikura, Jun-Ichi, Yatsugi, Hiroshi Inami Shin-Ichi, Okada, Masamichi, Sakamoto, Shuichi, Yamaguchi, Tokio
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
Get full text
Journal Article
YM872: A Selective, Potent and Highly Water‐Soluble α‐Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid Receptor Antagonist
Takahashi, Masayasu, Kohara, Atsuyuki, Shishikura, Jun‐ichi, Kawasaki‐Yatsugi, Sachiko, Ni, Jian Wei, Yatsugi, Shin‐ichi, Sakamoto, Shuichi, Okada, Masamichi, Shimizu‐Sasamata, Masao, Yamaguchi, Tokio
Published in CNS drug reviews (01.12.2002)
Published in CNS drug reviews (01.12.2002)
Get full text
Journal Article
Favorskii Rearrangement and Carbon–Carbon Bond-Cleavage of α-Chloro-α-sulfonyl Ketones: A Synthesis of Carboxylic Acids and Their Derivatives from Aldehydes and Ketones
Satoh, Tsuyoshi, Oguro, Kazuko, Shishikura, Jun-ichi, Kanetaka, Naomi, Okada, Reiko, Yamakawa, Koji
Published in Bulletin of the Chemical Society of Japan (01.08.1993)
Published in Bulletin of the Chemical Society of Japan (01.08.1993)
Get full text
Journal Article
Effects of 2-[N-(4-Chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an Orally Active α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonist, in Models of Generalized Epileptic Seizure in Mice and Rats
Hiroshi Yamashita, Kazushige Ohno, Yoko Amada, Hanae Hattori, Yukiko Ozawa-Funatsu, Takashi Toya, Hiroshi Inami, Jun-Ichi Shishikura, Shuichi Sakamoto, Masamichi Okada, Tokio Yamaguchi
Published in The Journal of pharmacology and experimental therapeutics (01.01.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2004)
Get full text
Journal Article
Effects of 2-[ N -(4-Chlorophenyl)- N -methylamino]-4 H -pyrido[3.2- e ]-1,3-thiazin-4-one (YM928), an Orally Active α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonist, in Models of Generalized Epileptic Seizure in Mice and Rats
Yamashita, Hiroshi, Ohno, Kazushige, Amada, Yoko, Hattori, Hanae, Ozawa-Funatsu, Yukiko, Toya, Takashi, Inami, Hiroshi, Shishikura, Jun-Ichi, Sakamoto, Shuichi, Okada, Masamichi, Yamaguchi, Tokio
Published in The Journal of pharmacology and experimental therapeutics (01.01.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2004)
Get full text
Journal Article
Functional Characterization of YM928, a Novel Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist
Kazushige Ohno, Rie Tsutsumi, Naoyuki Matsumoto, Hiroshi Yamashita, Yoko Amada, Jun-Ichi Shishikura, Hiroshi Inami Shin-Ichi Yatsugi, Masamichi Okada, Shuichi Sakamoto, Tokio Yamaguchi
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
Get full text
Journal Article
Functional characterization of YM928, a novel moncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist
Ohno, Kazushige, Tsutsumi, Rie, Matsumoto, Naoyuki, Yamashita, Hiroshi, Amada, Yoko, Shishikura, Jun-ichi, Yatsugi, Hiroshi Inami Shin-Ichi, Okada, Masamichi, Sakamoto, Shuichi, Yamaguchi, Tokio
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
Journal Article
A novel AMPA receptor antagonist, YM872, reduces infarct size after MCA occlusion in rats
Kawasaki-Yatsugi, Sachiko, Yatsugi, Shin-ichi, Takahashi, Masayasu, Toya, Takashi, Ichiki, Chikako, Shimizu-Sasamata, Masao, Yamaguchi, Tokio, Shishikura, Jun-ichi, Minematsu, Kazuo
Published in Japanese Journal of Pharmacology (1998)
Published in Japanese Journal of Pharmacology (1998)
Get full text
Journal Article
YM872, a novel selective alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, reduces brain damage after permanent focal cerebral ischemia in cats
Takahashi, M, Ni, J W, Kawasaki-Yatsugi, S, Toya, T, Yatsugi, S I, Shimizu-Sasamata, M, Koshiya, K, Shishikura, J I, Sakamoto, S, Yamaguchi, T
Published in The Journal of pharmacology and experimental therapeutics (01.02.1998)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.02.1998)
Journal Article