Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents
Charrier, Jean-Damien, Durrant, Steven J, Golec, Julian M. C, Kay, David P, Knegtel, Ronald M. A, MacCormick, Somhairle, Mortimore, Michael, O'Donnell, Michael E, Pinder, Joanne L, Reaper, Philip M, Rutherford, Alistair P, Wang, Paul S. H, Young, Stephen C, Pollard, John R
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
Reaper, Philip M, Griffiths, Matthew R, Long, Joanna M, Charrier, Jean-Damien, Maccormick, Somhairle, Charlton, Peter A, Golec, Julian M C, Pollard, John R
Published in Nature chemical biology (13.04.2011)
Published in Nature chemical biology (13.04.2011)
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Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA
Swan, Michael K., Legris, Valerie, Tanner, Adam, Reaper, Philip M., Vial, Sarah, Bordas, Rebecca, Pollard, John R., Charlton, Peter A., Golec, Julian M. C., Bertrand, Jay A.
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2014)
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2014)
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VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis
Weber, Peter, Wang, Ping, Maddens, Stephane, Wang, Paul Sh, Wu, Rongqian, Miksa, Michael, Dong, Weifeng, Mortimore, Michael, Golec, Julian M C, Charlton, Peter
Published in Critical care (London, England) (01.01.2009)
Published in Critical care (London, England) (01.01.2009)
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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
Miller, Karen M, Harrington, Elizabeth A, Bebbington, David, Moore, Jeff, Rasmussen, Richele K, Ajose-Adeogun, Abi O, Nakayama, Tomoko, Graham, Joanne A, Demur, Cecile, Hercend, Thierry, Diu-Hercend, Anita, Su, Michael, Golec, Julian M C
Published in Nature medicine (01.03.2004)
Published in Nature medicine (01.03.2004)
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Tricyclic heteroaromatic systems containing a bridgehead nitrogen atom. Part 3. [1,2,4]Triazolo[3′,4′ : 3,2]pyrazolo[3,4-d]pyrimidines, tetrazolo[1′,5′ : 1,5]pyrazolo[3,4-d]pyrimidines and pyrimido-[5′,4′ : 4,5]pyrazolo[3,2-c][1,2,4]triazines
Golec, Julian M. C., Scrowston, Richard M., Dunleavy, Michael
Published in J. Chem. Soc., Perkin Trans. 1 (1992)
Published in J. Chem. Soc., Perkin Trans. 1 (1992)
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The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity
Wei, Yunyi, Fox, Ted, Chambers, Steve P, Sintchak, JoAnne, Coll, Joyce T, Golec, Julian MC, Swenson, Lora, Wilson, Keith P, Charifson, Paul S
Published in Chemistry & biology (01.06.2000)
Published in Chemistry & biology (01.06.2000)
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Addendum: VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
Harrington, Elizabeth A, Bebbington, David, Moore, Jeff, Rasmussen, Richele K, Ajose-Adeogun, Abi O, Nakayama, Tomoko, Graham, Joanne A, Demur, Cecile, Hercend, Thierry, Diu-Hercend, Anita, Su, Michael, Golec, Julian M C, Miller, Karen M
Published in Nature medicine (01.04.2007)
Published in Nature medicine (01.04.2007)
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Journal Article
Caspase inhibitors and uses thereof
Golec, Julian M. C, Charifson, Paul S, Charrier, Jean-Damien, Binch, Hayley Marie
Year of Publication 16.10.2012
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Year of Publication 16.10.2012
Patent
Caspase inhibitors and uses thereof
BINCH HAYLEY MARIE, CHARRIER JEAN-DAMIEN, CHARIFSON PAUL S, GOLEC JULIAN M. C
Year of Publication 16.10.2012
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Year of Publication 16.10.2012
Patent