GPR119 agonists for the treatment of type 2 diabetes
Jones, Robert M, Leonard, James N, Buzard, Daniel J, Lehmann, Juerg
Published in Expert opinion on therapeutic patents (01.10.2009)
Published in Expert opinion on therapeutic patents (01.10.2009)
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BioPrint meets the AI age: development of artificial intelligence-based ADMET models for the drug-discovery platform SAFIRE
Biehn, Sarah E, Goncalves, Luis Miguel, Lehmann, Juerg, Marty, Jessica D, Mueller, Christoph, Ramirez, Samuel A, Tillier, Fabien, Sage, Carleton R
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Published in Future medicinal chemistry (01.04.2024)
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Design and synthesis of new tricyclic indoles as potent modulators of the S1P(1) receptor
Buzard, Daniel J., Schrader, Thomas O., Zhu, Xiuwen, Lehmann, Juerg, Johnson, Ben, Kasem, Michelle, Kim, Sun Hee, Kawasaki, Andrew, Lopez, Luis, Moody, Jeanne, Han, Sangdon, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Thatte, Jayant, Gatlin, Joel, Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Mutation-Guided Unbiased Modeling of the Fat Sensor GPR119 for High-Yield Agonist Screening
Norn, Christoffer, Hauge, Maria, Engelstoft, Maja S., Kim, Sun Hee, Lehmann, Juerg, Jones, Robert M., Schwartz, Thue W., Frimurer, Thomas M.
Published in Structure (London) (01.12.2015)
Published in Structure (London) (01.12.2015)
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Journal Article
Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor
Buzard, Daniel J., Schrader, Thomas O., Zhu, Xiuwen, Lehmann, Juerg, Johnson, Ben, Kasem, Michelle, Kim, Sun Hee, Kawasaki, Andrew, Lopez, Luis, Moody, Jeanne, Han, Sangdon, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Thatte, Jayant, Gatlin, Joel, Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate‑1 Receptor
Buzard, Daniel J, Kim, Sun Hee, Lopez, Luis, Kawasaki, Andrew, Zhu, Xiuwen, Moody, Jeanne, Thoresen, Lars, Calderon, Imelda, Ullman, Brett, Han, Sangdon, Lehmann, Juerg, Gharbaoui, Tawfik, Sengupta, Dipanjan, Calvano, Lorene, Montalban, Antonio Garrido, Ma, You-An, Sage, Carleton, Gao, Yinghong, Semple, Graeme, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Chen, Weichao, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Christopher, Ronald J, Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Mills, David, Whelan, Kevin, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Gaidarov, Ibragim, Anthony, Todd, Unett, David J, Blackburn, Anthony, Rueter, Jaimie, Stirn, Scott, Behan, Dominic P, Jones, Robert M
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
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Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile
Semple, Graeme, Lehmann, Juerg, Wong, Amy, Ren, Albert, Bruce, Marc, Shin, Young-Jun, Sage, Carleton R., Morgan, Michael, Chen, Wei-Chao, Sebring, Kristen, Chu, Zhi-Liang, Leonard, James N., Al-Shamma, Hussein, Grottick, Andrew J., Du, Fuyong, Liang, Yin, Demarest, Keith, Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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SUBSTITUTED 1,2,3,4-TETRAHYDROCYCLOPENTA[b]INDOL-3-YL)ACETIC ACID DERIVATIVE USEFUL IN TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
DANIEL J BUZARD, ZHU XIUWEN, JONES ROBERT M, HAN SANGDON, JEANNE V MOODY, SCOTT STIRN, KIM SUN HE, JUERG LEHMANN, ULLMAN BRET
Year of Publication 29.07.2021
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Year of Publication 29.07.2021
Patent
Design and synthesis of new tricyclic indoles as potent modulators of the S1P sub(1) receptor
Buzard, Daniel J, Schrader, Thomas O, Zhu, Xiuwen, Lehmann, Juerg, Johnson, Ben, Kasem, Michelle, Kim, Sun Hee, Kawasaki, Andrew, Lopez, Luis, Moody, Jeanne, Han, Sangdon, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Thatte, Jayant, Gatlin, Joel, Jones, Robert M
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series
Han, Sangdon, Narayanan, Sanju, Kim, Sun Hee, Calderon, Imelda, Zhu, Xiuwen, Kawasaki, Andrew, Yue, Dawei, Lehmann, Juerg, Wong, Amy, Buzard, Daniel J., Semple, Graeme, Carroll, Chris, Chu, Zhi-Liang, Al-Sharmma, Hussein, Shu, Hsin-Hui, Tung, Shiu-Feng, Unett, David J., Behan, Dominic P., Yoon, Woo Hyun, Morgan, Michael, Usmani, Khawja A., Chen, Chuan, Sadeque, Abu, Leonard, James N., Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.08.2015)
Published in Bioorganic & medicinal chemistry letters (01.08.2015)
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Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists
Buzard, Daniel J., Kim, Sun Hee, Lehmann, Juerg, Han, Sangdon, Calderon, Imelda, Wong, Amy, Kawasaki, Andrew, Narayanan, Sanju, Bhat, Rohit, Gharbaoui, Tawfik, Lopez, Luis, Yue, Dawei, Whelan, Kevin, Al-Shamma, Hussien, Unett, David J., Shu, Hsin-Hui, Tung, Shiu-Feng, Chang, Steve, Chuang, Ching-Fen, Morgan, Michael, Sadeque, Abu, Chu, Zhi-Liang, Leonard, James N., Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
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SUBSTITUTION TYPE 1,2,3,4-TETRAHYDROCYCLOPENTA[B]INDOL-3-YL)ACETIC ACID DERIVATIVE USEFUL IN TREATMENTS OF AUTOIMMUNE DISORDER AND INFLAMMATORY DISORDER
DANIEL J BUZARD, ZHU XIUWEN, JONES ROBERT M, HAN SANGDON, JEANNE V MOODY, SCOTT STIRN, KIM SUN HE, JUERG LEHMANN, ULLMAN BRET
Year of Publication 05.12.2019
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Year of Publication 05.12.2019
Patent
Cobalt-Mediated [2+2+2] Cycloaddition versus CH and NH Activation of Pyridones and Pyrazinones with Alkynes: An Experimental Study
Aubert, Corinne, Betschmann, Patrick, Eichberg, Michael J., Gandon, Vincent, Heckrodt, Thilo J., Lehmann, Jürg, Malacria, Max, Masjost, Birgit, Paredes, Elisa, Vollhardt, K. Peter C., Whitener, Glenn D.
Published in Chemistry : a European journal (01.01.2007)
Published in Chemistry : a European journal (01.01.2007)
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Journal Article
SUBSTITUTED 1,2,3,4-TETRAHYDROCYCLOPENTA[b]INDOL-3-YL)ACETIC ACID DERIVATIVES USEFUL IN TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
DANIEL J BUZARD, ZHU XIUWEN, JONES ROBERT M, HAN SANGDON, JEANNE V MOODY, SCOTT STIRN, KIM SUN HE, JUERG LEHMANN, ULLMAN BRET
Year of Publication 14.06.2018
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Year of Publication 14.06.2018
Patent
GPR119 agonists 2009-2011
Buzard, Daniel J, Lehmann, Juerg, Han, Sangdon, Jones, Robert M
Published in Pharmaceutical patent analyst (01.07.2012)
Published in Pharmaceutical patent analyst (01.07.2012)
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Journal Article
SUBSTITUTED 1,2,3,4-TETRAHYDROCYCLOPENTA[B]INDOL-3-YL)ACETIC ACID DERIVATIVES USEFUL IN TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
DANIEL J BUZARD, ZHU XIUWEN, JONES ROBERT M, HAN SANGDON, JEANNE V MOODY, SCOTT STIRN, KIM SUN HE, JUERG LEHMANN, ULLMAN BRET
Year of Publication 03.03.2016
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Year of Publication 03.03.2016
Patent
Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease
Buzard, Daniel J., Han, Sangdon, Lopez, Luis, Kawasaki, Andrew, Moody, Jeanne, Thoresen, Lars, Ullman, Brett, Lehmann, Juerg, Calderon, Imelda, Zhu, Xiuwen, Gharbaoui, Tawfik, Sengupta, Dipanjan, Krishnan, Ashwin, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Thatte, Jayant, Solomon, Michelle, Fu, Lixia, Whelan, Kevin, Liu, Ling, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Xing, Charles, Espinola, Sheryll, Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
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Solubilized phenyl-pyrazole ureas as potent, selective 5-HT2A inverse-agonists and their application as antiplatelet agents
DOSA, Peter I, STRAH-PLEYNET, Sonja, WEBB, Robert R, ADAMS, John W, RAMIREZ, Juan, RICHMAN, Jeremy G, THOMSEN, William, SEMPLE, Graeme, TEEGARDEN, Bradley R, JAYAKUMAR, Honnappa, CASPER, Martin, DECAIRE, Marc, YIFENG XIONG, LEHMANN, Juerg, CHOI, Karoline, ELWELL, Katie, WONG, Amy
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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Solubilized phenyl-pyrazole ureas as potent, selective 5-HT sub(2A) inverse-agonists and their application as antiplatelet agents
Dosa, Peter I, Strah-Pleynet, Sonja, Jayakumar, Honnappa, Casper, Martin, Decaire, Marc, Xiong, Yifeng, Lehmann, Juerg, Choi, Karoline, Elwell, Katie, Wong, Amy, Webb, Robert R, Adams, John W, Ramirez, Juan, Richman, Jeremy G, Thomsen, William, Semple, Graeme, Teegarden, Bradley R
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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