Classification and Characterization of Therapeutic Antibody Aggregates
Joubert, Marisa K., Luo, Quanzhou, Nashed-Samuel, Yasser, Wypych, Jette, Narhi, Linda O.
Published in The Journal of biological chemistry (15.07.2011)
Published in The Journal of biological chemistry (15.07.2011)
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Journal Article
Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics
Joubert, Marisa K, Deshpande, Meghana, Yang, Jane, Reynolds, Helen, Bryson, Christine, Fogg, Mark, Baker, Matthew P, Herskovitz, Jonathan, Goletz, Theresa J, Zhou, Lei, Moxness, Michael, Flynn, Gregory C, Narhi, Linda O, Jawa, Vibha
Published in PloS one (05.08.2016)
Published in PloS one (05.08.2016)
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Journal Article
Characterization of Subvisible Particles in Biotherapeutic Prefilled Syringes: The Role of Polysorbate and Protein on the Formation of Silicone Oil and Protein Subvisible Particles After Drop Shock
Jiao, Nancy, Barnett, Gregory V., Christian, Twinkle R., Narhi, Linda O., Joh, Nathan H., Joubert, Marisa K., Cao, Shawn
Published in Journal of pharmaceutical sciences (01.01.2020)
Published in Journal of pharmaceutical sciences (01.01.2020)
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Journal Article
Development of a Human Antibody Tolerant Mouse Model to Assess the Immunogenicity Risk Due to Aggregated Biotherapeutics
Bi, Vivian, Jawa, Vibha, Joubert, Marisa K., Kaliyaperumal, Arunan, Eakin, Catherine, Richmond, Karen, Pan, Oscar, Sun, Jilin, Hokom, Martha, Goletz, Theresa J., Wypych, Jette, Zhou, Lei, Kerwin, Bruce A., Narhi, Linda O., Arora, Taruna
Published in Journal of pharmaceutical sciences (01.10.2013)
Published in Journal of pharmaceutical sciences (01.10.2013)
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Journal Article
Immunogenicity of Therapeutic Protein Aggregates
Moussa, Ehab M., Panchal, Jainik P., Moorthy, Balakrishnan S., Blum, Janice S., Joubert, Marisa K., Narhi, Linda O., Topp, Elizabeth M.
Published in Journal of pharmaceutical sciences (01.02.2016)
Published in Journal of pharmaceutical sciences (01.02.2016)
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Journal Article
Observation of Heavy-Chain C-Terminal Amidation in Human Endogenous IgG
Shah, Bhavana, Li, Ming, Wypych, Jette, Joubert, Marisa K., Zhang, Zhongqi
Published in Journal of pharmaceutical sciences (01.09.2022)
Published in Journal of pharmaceutical sciences (01.09.2022)
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Journal Article
Determination of interactions between antibody biotherapeutics and copper by size exclusion chromatography (SEC) coupled with inductively coupled plasma mass spectrometry (ICP/MS)
Luo, Yanxin, Ronk, Michael, Joubert, Marisa K., Semin, David, Nashed-Samuel, Yasser
Published in Analytica chimica acta (04.11.2019)
Published in Analytica chimica acta (04.11.2019)
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Journal Article
Evaluating Immunogenicity Risk Due to Host Cell Protein Impurities in Antibody-Based Biotherapeutics
Jawa, Vibha, Joubert, Marisa K., Zhang, Qingchun, Deshpande, Meghana, Hapuarachchi, Suminda, Hall, Michael P., Flynn, Gregory C.
Published in The AAPS journal (01.11.2016)
Published in The AAPS journal (01.11.2016)
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Journal Article
Highly Aggregated Antibody Therapeutics Can Enhance the in Vitro Innate and Late-stage T-cell Immune Responses
Joubert, Marisa K., Hokom, Martha, Eakin, Catherine, Zhou, Lei, Deshpande, Meghana, Baker, Matthew P., Goletz, Theresa J., Kerwin, Bruce A., Chirmule, Naren, Narhi, Linda O., Jawa, Vibha
Published in The Journal of biological chemistry (20.07.2012)
Published in The Journal of biological chemistry (20.07.2012)
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Journal Article
A Mass Spectrometric Characterization of Light-Induced Modifications in Therapeutic Proteins
Zhang, Zhongqi, Chow, Sih-Yao, De Guzman, Ronandro, Joh, Nathan H., Joubert, Marisa K., Richardson, Jason, Shah, Bhavana, Wikström, Mats, Zhou, Zhaohui Sunny, Wypych, Jette
Published in Journal of pharmaceutical sciences (01.06.2022)
Published in Journal of pharmaceutical sciences (01.06.2022)
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Journal Article
Silicone Oil Particles in Prefilled Syringes With Human Monoclonal Antibody, Representative of Real-World Drug Products, Did Not Increase Immunogenicity in In Vivo and In Vitro Model Systems
Joh, Nathan H., Thomas, Lisa, Christian, Twinkle R., Verlinsky, Alla, Jiao, Nancy, Allotta, Nilo, Jawa, Vibha, Cao, Shawn, Narhi, Linda O., Joubert, Marisa K.
Published in Journal of pharmaceutical sciences (01.01.2020)
Published in Journal of pharmaceutical sciences (01.01.2020)
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Journal Article
State-of-the-art and emerging trends in analytical approaches to pharmaceutical-product commercialization
Blue, Laura E, Guan, Xiaoyan, Joubert, Marisa K, Kuhns, Scott T, Moore, Stephanie, Semin, David J, Wikström, Mats, Wypych, Jette, Goudar, Chetan T
Published in Current opinion in biotechnology (01.12.2022)
Published in Current opinion in biotechnology (01.12.2022)
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Journal Article
Use of In Vitro Human Skin Models to Assess Potential Immune Activation In Response to Biotherapeutic Attributes and Process-related Impurities
Tokuda, Joshua M., Xie, Jiansong, Jawa, Vibha, Hawkins, Jenn M., Ferbas, John, Joh, Nathan H., Joubert, Marisa K.
Published in Journal of pharmaceutical sciences (01.04.2022)
Published in Journal of pharmaceutical sciences (01.04.2022)
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Journal Article
A High Threshold of Biotherapeutic Aggregate Numbers is Needed to Induce an Immunogenic Response In Vitro, In Vivo, and in the Clinic
Cohen, Joseph R., Brych, Stephen R., Prabhu, Siddharth, Bi, Vivian, Elbaradei, Ahmed, Tokuda, Joshua M., Xiang, Cathie, Hokom, Martha, Cui, Xiaohong, Ly, Claudia, Amos, Nathan, Sun, Jilin, Calamba, Dominador, Herskovitz, Jonathan, Capili, Allyson, Nourbakhsh, Kimya, Merlo, Anthony, Carreon, Julia, Wypych, Jette, Narhi, Linda O., Jawa, Vibha, Joubert, Marisa K.
Published in Pharmaceutical research (01.04.2024)
Published in Pharmaceutical research (01.04.2024)
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Journal Article
Impact of Precipitation of Antibody Therapeutics After Subcutaneous Injection on Pharmacokinetics and Immunogenicity
Kinderman, Francis, Yerby, Brittany, Jawa, Vibha, Joubert, Marisa K., Joh, Nathan H., Malella, Jennifer, Herskovitz, Johnathan, Xie, Jiansong, Ferbas, John, McBride, Helen J.
Published in Journal of pharmaceutical sciences (01.06.2019)
Published in Journal of pharmaceutical sciences (01.06.2019)
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Journal Article
Glycan engineering reveals interrelated effects of terminal galactose and core fucose on antibody‐dependent cell‐mediated cytotoxicity
Zhang, Qingchun, Joubert, Marisa K., Polozova, Alla, De Guzman, Ronandro, Lakamsani, Kamala, Kinderman, Francis, Xiang, Dong, Shami, Andrew, Miscalichi, Nahira, Flynn, Gregory C., Kuhns, Scott
Published in Biotechnology progress (01.11.2020)
Published in Biotechnology progress (01.11.2020)
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Journal Article
A cross-industry forum on benchmarking critical quality attribute identification and linkage to process characterization studies
Demmon, Sarah, Bhargava, Swapnil, Ciolek, Doreen, Halley, Jennifer, Jaya, Nomalie, Joubert, Marisa K., Koepf, Edward, Smith, Phillip, Trexler-Schmidt, Melody, Tsai, Philip
Published in Biologicals (01.09.2020)
Published in Biologicals (01.09.2020)
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Journal Article
Physical Characterization and In Vitro Biological Impact of Highly Aggregated Antibodies Separated into Size-Enriched Populations by Fluorescence-Activated Cell Sorting
Telikepalli, Srivalli, Shinogle, Heather E., Thapa, Prem S., Kim, Jae Hyun, Deshpande, Meghana, Jawa, Vibha, Russell Middaugh, C., Narhi, Linda O., Joubert, Marisa K., Volkin, David B.
Published in Journal of pharmaceutical sciences (01.05.2015)
Published in Journal of pharmaceutical sciences (01.05.2015)
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