Structure−Activity Relationships of the Quinolone Antibacterials against Mycobacteria: Effect of Structural Changes at N-1 and C-7
Renau, Thomas E, Sanchez, Joseph P, Gage, Jeffrey W, Dever, Julie A, Shapiro, Martin A, Gracheck, Stephen J, Domagala, John M
Published in Journal of medicinal chemistry (02.02.1996)
Published in Journal of medicinal chemistry (02.02.1996)
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Journal Article
3-Aminoquinazolinediones as a New Class of Antibacterial Agents Demonstrating Excellent Antibacterial Activity Against Wild-Type and Multidrug Resistant Organisms
Ellsworth, Edmund L, Tran, Tuan P, Hollis Showalter, H. D, Sanchez, Joseph P, Watson, Brian M, Stier, Michael A, Domagala, John M, Gracheck, Stephen J, Joannides, E. Themis, Shapiro, Martin A, Dunham, Steve A, Hanna, Debra L, Huband, Michael D, Gage, Jeffrey W, Bronstein, Joel C, Liu, Jia Yeu, Nguyen, Dai Q, Singh, Rajeshwar
Published in Journal of medicinal chemistry (02.11.2006)
Published in Journal of medicinal chemistry (02.11.2006)
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Journal Article
The Synthesis, Structure-Activity, and Structure-Side Effect Relationships of a Series of 8-Alkoxy- and 5-Amino-8-alkoxyquinolone Antibacterial Agents
Sanchez, Joseph P, Gogliotti, Rocco D, Domagala, John M, Gracheck, Stephen J, Huband, Michael D, Sesnie, Josephine A, Cohen, Michael A, Shapiro, Martin A
Published in Journal of medicinal chemistry (01.10.1995)
Published in Journal of medicinal chemistry (01.10.1995)
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Journal Article
Structure–activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors
Tran, Tuan P., Ellsworth, Edmund L., Sanchez, Joseph P., Watson, Brian M., Stier, Michael A., Showalter, H.D. Hollis, Domagala, John M., Shapiro, Martin A., Joannides, E. Themis, Gracheck, Stephen J., Nguyen, Dai Q., Bird, Paul, Yip, Judy, Sharadendu, Anurag, Ha, Chan, Ramezani, Saeed, Wu, Xiujuan, Singh, Rajeshwar
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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Journal Article
Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones
Hutchings, Kim M., Tran, Tuan P., Ellsworth, Edmund L., Watson, Brian M., Sanchez, Joseph P., Hollis Showalter, H.D., Stier, Michael A., Shapiro, Martin, Themis Joannides, E., Huband, Michael, Nguyen, Dai Q., Maiti, Samarendra, Li, Tingsheng, Tailor, Jyoti, Thomas, George, Ha, Chan, Singh, Rajeshwar
Published in Bioorganic & medicinal chemistry letters (15.09.2008)
Published in Bioorganic & medicinal chemistry letters (15.09.2008)
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Journal Article
Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship
Domagala, John M, Bridges, Alex J, Culbertson, Townley P, Gambino, Laura, Hagen, Susan E, Karrick, Gregory, Porter, Kenneth, Sanchez, Joseph P, Sesnie, Josephine A
Published in Journal of medicinal chemistry (01.03.1991)
Published in Journal of medicinal chemistry (01.03.1991)
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Journal Article
New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-disubstituted-1-pyrrolidinyl)quinoline-3-carboxylic acids
Hagen, Susan E, Domagala, John M, Heifetz, Carl L, Sanchez, Joseph P, Solomon, Marjorie
Published in Journal of medicinal chemistry (01.02.1990)
Published in Journal of medicinal chemistry (01.02.1990)
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Journal Article
New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay
Domagala, John M, Hanna, Lori Doyle, Heifetz, Carl L, Hutt, Marland P, Mich, Thomas F, Sanchez, Joseph P, Solomon, Marjorie
Published in Journal of medicinal chemistry (01.03.1986)
Published in Journal of medicinal chemistry (01.03.1986)
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Journal Article
Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids
Sanchez, Joseph P, Domagala, John M, Hagen, Susan E, Heifetz, Carl L, Hutt, Marland P, Nichols, Jeffry B, Trehan, Ashok K
Published in Journal of medicinal chemistry (01.05.1988)
Published in Journal of medicinal chemistry (01.05.1988)
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Journal Article
No Settlement, No Conquest: A History of the Coronado Entrada
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Book Review
Journal Article
Synthesis and pharmacological evaluation of 2,3-dihydro-1H-thieno[2,3-e][1,4]diazepines
Tinney, Francis J, Sanchez, Joseph P, Nogas, Joan A
Published in Journal of medicinal chemistry (01.06.1974)
Published in Journal of medicinal chemistry (01.06.1974)
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Journal Article
Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity
Sanchez, Joseph P, Domagala, John M, Heifetz, Carl L, Priebe, Stephen R, Sesnie, Josephine A, Trehan, Ashok K
Published in Journal of medicinal chemistry (01.05.1992)
Published in Journal of medicinal chemistry (01.05.1992)
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Journal Article
7-Substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials
Domagala, John M, Hagen, Susan E, Heifetz, Carl L, Hutt, Marland P, Mich, Thomas F, Sanchez, Joseph P, Trehan, Ashok K
Published in Journal of medicinal chemistry (01.03.1988)
Published in Journal of medicinal chemistry (01.03.1988)
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Journal Article