Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic
Chin, Emily N, Yu, Chenguang, Vartabedian, Vincent F, Jia, Ying, Kumar, Manoj, Gamo, Ana M, Vernier, William, Ali, Sabrina H, Kissai, Mildred, Lazar, Daniel C, Nguyen, Nhan, Pereira, Laura E, Benish, Brent, Woods, Ashley K, Joseph, Sean B, Chu, Alan, Johnson, Kristen A, Sander, Philipp N, Martínez-Peña, Francisco, Hampton, Eric N, Young, Travis S, Wolan, Dennis W, Chatterjee, Arnab K, Schultz, Peter G, Petrassi, H Michael, Teijaro, John R, Lairson, Luke L
Published in Science (American Association for the Advancement of Science) (21.08.2020)
Published in Science (American Association for the Advancement of Science) (21.08.2020)
Get full text
Journal Article
Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)
Tully, David C, Rucker, Paul V, Chianelli, Donatella, Williams, Jennifer, Vidal, Agnès, Alper, Phil B, Mutnick, Daniel, Bursulaya, Badry, Schmeits, James, Wu, Xiangdong, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Seidel, H. Martin, Molteni, Valentina, Liu, Bo, Phimister, Andrew, Joseph, Sean B, Laffitte, Bryan
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
Get full text
Journal Article
The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis
Janes, Jeff, Young, Megan E., Chen, Emily, Rogers, Nicole H., Burgstaller-Muehlbacher, Sebastian, Hughes, Laura D., Love, Melissa S., Hull, Mitchell V., Kuhen, Kelli L., Woods, Ashley K., Joseph, Sean B., Petrassi, H. Michael, McNamara, Case W., Tremblay, Matthew S., Su, Andrew I., Schultz, Peter G., Chatterjee, Arnab K.
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (16.10.2018)
Get full text
Journal Article
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions
Bakowski, Malina A., Beutler, Nathan, Wolff, Karen C., Kirkpatrick, Melanie G., Chen, Emily, Nguyen, Tu-Trinh H., Riva, Laura, Shaabani, Namir, Parren, Mara, Ricketts, James, Gupta, Anil K., Pan, Kastin, Kuo, Peiting, Fuller, MacKenzie, Garcia, Elijah, Teijaro, John R., Yang, Linlin, Sahoo, Debashis, Chi, Victor, Huang, Edward, Vargas, Natalia, Roberts, Amanda J., Das, Soumita, Ghosh, Pradipta, Woods, Ashley K., Joseph, Sean B., Hull, Mitchell V., Schultz, Peter G., Burton, Dennis R., Chatterjee, Arnab K., McNamara, Case W., Rogers, Thomas F.
Published in Nature communications (03.06.2021)
Published in Nature communications (03.06.2021)
Get full text
Journal Article
Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5‑Chloro‑N2‑(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)‑N4‑(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
Marsilje, Thomas H, Pei, Wei, Chen, Bei, Lu, Wenshuo, Uno, Tetsuo, Jin, Yunho, Jiang, Tao, Kim, Sungjoon, Li, Nanxin, Warmuth, Markus, Sarkisova, Yelena, Sun, Frank, Steffy, Auzon, Pferdekamper, AnneMarie C, Li, Allen G, Joseph, Sean B, Kim, Young, Liu, Bo, Tuntland, Tove, Cui, Xiaoming, Gray, Nathanael S, Steensma, Ruo, Wan, Yongqin, Jiang, Jiqing, Chopiuk, Greg, Li, Jie, Gordon, W. Perry, Richmond, Wendy, Johnson, Kevin, Chang, Jonathan, Groessl, Todd, He, You-Qun, Phimister, Andrew, Aycinena, Alex, Lee, Christian C, Bursulaya, Badry, Karanewsky, Donald S, Seidel, H. Martin, Harris, Jennifer L, Michellys, Pierre-Yves
Published in Journal of medicinal chemistry (25.07.2013)
Published in Journal of medicinal chemistry (25.07.2013)
Get full text
Journal Article
Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model
Mandikian, Danielle, Takahashi, Nene, Lo, Amy A, Li, Ji, Eastham-Anderson, Jeffrey, Slaga, Dionysos, Ho, Jason, Hristopoulos, Maria, Clark, Robyn, Totpal, Klara, Lin, Kedan, Joseph, Sean B, Dennis, Mark S, Prabhu, Saileta, Junttila, Teemu T, Boswell, C Andrew
Published in Molecular cancer therapeutics (01.04.2018)
Published in Molecular cancer therapeutics (01.04.2018)
Get full text
Journal Article
LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response
Bensinger, Steven J., Bradley, Michelle N., Joseph, Sean B., Zelcer, Noam, Janssen, Edith M., Hausner, Mary Ann, Shih, Roger, Parks, John S., Edwards, Peter A., Jamieson, Beth D., Tontonoz, Peter
Published in Cell (11.07.2008)
Published in Cell (11.07.2008)
Get full text
Journal Article
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis
Chianelli, Donatella, Rucker, Paul V, Roland, Jason, Tully, David C, Nelson, John, Liu, Xiaodong, Bursulaya, Badry, Hernandez, Eloy D, Wu, Jane, Prashad, Mahavir, Schlama, Thierry, Liu, Yugang, Chu, Alan, Schmeits, James, Huang, David J, Hill, Robert, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Liu, Bo, Richmond, Wendy, Sancho-Martinez, Ignacio, Phimister, Andrew, Seidel, H. Martin, Badman, Michael K, Joseph, Sean B, Laffitte, Bryan, Molteni, Valentina
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
Get full text
Journal Article
Pharmacological expansion of type 2 alveolar epithelial cells promotes regenerative lower airway repair
Shao, Sida, Zhang, Nan, Specht, Gregory P, You, Shaochen, Song, Lirui, Fu, Qiangwei, Huang, David, You, Hengyao, Shu, Jian, Domissy, Alain, Li, Shuangwei, Nguyen-Tran, Van, Joseph, Sean B, Chatterjee, Arnab K, Chen, Jeffrey Jian, Schultz, Peter G, Bollong, Michael J
Published in Proceedings of the National Academy of Sciences - PNAS (16.04.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (16.04.2024)
Get full text
Journal Article
Engineering of a Potent, Long-Acting NPY2R Agonist for Combination with a GLP-1R Agonist as a Multi-Hormonal Treatment for Obesity
Lear, Sam, Pflimlin, Elsa, Zhou, Zhihong, Huang, David, Weng, Sharon, Nguyen-Tran, Van, Joseph, Sean B, Roller, Shane, Peterson, Scott, Li, Jing, Tremblay, Matthew, Schultz, Peter G, Shen, Weijun
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
Get full text
Journal Article
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
Tontonoz, Peter, Joseph, Sean B, Castrillo, Antonio, Laffitte, Bryan A, Mangelsdorf, David J
Published in Nature medicine (01.02.2003)
Published in Nature medicine (01.02.2003)
Get full text
Journal Article
Neratinib protects pancreatic beta cells in diabetes
Ardestani, Amin, Li, Sijia, Annamalai, Karthika, Lupse, Blaz, Geravandi, Shirin, Dobrowolski, Aleksandra, Yu, Shan, Zhu, Siying, Baguley, Tyler D., Surakattula, Murali, Oetjen, Janina, Hauberg-Lotte, Lena, Herranz, Raquel, Awal, Sushil, Altenhofen, Delsi, Nguyen-Tran, Van, Joseph, Sean, Schultz, Peter G., Chatterjee, Arnab K., Rogers, Nikki, Tremblay, Matthew S., Shen, Weijun, Maedler, Kathrin
Published in Nature communications (01.11.2019)
Published in Nature communications (01.11.2019)
Get full text
Journal Article
Pharmacological YAP activation promotes regenerative repair of cutaneous wounds
Grzelak, Edyta M, Elshan, N G R Dayan, Shao, Sida, Bulos, Maya L, Joseph, Sean B, Chatterjee, Arnab K, Chen, Jian Jeffrey, Nguyên-Trân, Vân, Schultz, Peter G, Bollong, Michael J
Published in Proceedings of the National Academy of Sciences - PNAS (11.07.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (11.07.2023)
Get full text
Journal Article
Engineering a Potent, Long-Acting, and Periphery-Restricted Oxytocin Receptor Agonist with Anorexigenic and Body Weight Reducing Effects
Pflimlin, Elsa, Zhou, Zhihong, Amso, Zaid, Fu, Qiangwei, Lee, Candy, Muppiddi, Avinash, Joseph, Sean B, Nguyen-Tran, Vân, Shen, Weijun
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
Get full text
Journal Article
Neuroprotective Activities of Long-Acting Granulocyte–Macrophage Colony-Stimulating Factor (mPDM608) in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Intoxicated Mice
Olson, Katherine E., Namminga, Krista L., Schwab, Aaron D., Thurston, Mackenzie J., Lu, Yaman, Woods, Ashley, Lei, Lei, Shen, Weijun, Wang, Feng, Joseph, Sean B., Gendelman, Howard E., Mosley, R. Lee
Published in Neurotherapeutics (01.10.2020)
Published in Neurotherapeutics (01.10.2020)
Get full text
Journal Article
Discovery of CMX990: A Potent SARS-CoV‑2 3CL Protease Inhibitor Bearing a Novel Warhead
Dayan Elshan, N. G. R., Wolff, Karen C., Riva, Laura, Woods, Ashley K., Grabovyi, Gennadii, Wilson, Katy, Pedroarena, James, Ghorai, Sourav, Nazarian, Armen, Weiss, Frank, Liu, Yuyin, Mazumdar, Wrickban, Song, Lirui, Okwor, Neechi, Malvin, Jacqueline, Bakowski, Malina A., Beutler, Nathan, Kirkpatrick, Melanie G., Gebara-Lamb, Amal, Huang, Edward, Nguyen-Tran, Vân T. B., Chi, Victor, Li, Shuangwei, Rogers, Thomas F., McNamara, Case W., Gupta, Anil Kumar, Rahimi, Alireza, Chen, Jian Jeffrey, Joseph, Sean B., Schultz, Peter G., Chatterjee, Arnab K.
Published in Journal of medicinal chemistry (22.02.2024)
Published in Journal of medicinal chemistry (22.02.2024)
Get full text
Journal Article
Tropifexor‐Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents
Hernandez, Eloy D., Zheng, Lianxing, Kim, Young, Fang, Bin, Liu, Bo, Valdez, Reginald A., Dietrich, William F., Rucker, Paul V., Chianelli, Donatella, Schmeits, James, Bao, Dingjiu, Zoll, Jocelyn, Dubois, Claire, Federe, Glenn C., Chen, Lihao, Joseph, Sean B., Klickstein, Lloyd B., Walker, John, Molteni, Valentina, McNamara, Peter, Meeusen, Shelly, Tully, David C., Badman, Michael K., Xu, Jie, Laffitte, Bryan
Published in Hepatology communications (01.08.2019)
Published in Hepatology communications (01.08.2019)
Get full text
Journal Article
Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics
Bumbaca Yadav, Daniela, Sharma, Vikas K., Boswell, Charles Andrew, Hotzel, Isidro, Tesar, Devin, Shang, Yonglei, Ying, Yong, Fischer, Saloumeh K., Grogan, Jane L., Chiang, Eugene Y., Urban, Konnie, Ulufatu, Sheila, Khawli, Leslie A., Prabhu, Saileta, Joseph, Sean, Kelley, Robert F.
Published in The Journal of biological chemistry (11.12.2015)
Published in The Journal of biological chemistry (11.12.2015)
Get full text
Journal Article
Correction to “Discovery of CMX990: A Potent SARS-CoV‑2 3CL Protease Inhibitor Bearing a Novel Warhead”
Elshan, N. G. R. Dayan, Wolff, Karen C., Riva, Laura, Woods, Ashley K., Grabovyi, Gennadii, Wilson, Katy, Pedroarena, James, Ghorai, Sourav, Nazarian, Armen, Weiss, Frank, Liu, Yuyin, Mazumdar, Wrickban, Song, Lirui, Okwor, Neechi, Malvin, Jacqueline, Liu, Dongdong, Bakowski, Malina A., Beutler, Nathan, Kirkpatrick, Melanie G., Gebara-Lamb, Amal, Huang, Edward, Nguyen-Tran, Vân T. B., Chi, Victor, Li, Shuangwei, Rogers, Thomas F., McNamara, Case W., Gupta, Anil Kumar, Rahimi, Alireza, Chen, Jian Jeffrey, Joseph, Sean B., Schultz, Peter G., Chatterjee, Arnab K.
Published in Journal of medicinal chemistry (27.06.2024)
Published in Journal of medicinal chemistry (27.06.2024)
Get full text
Journal Article
Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism
Castrillo, Antonio, Joseph, Sean B, Vaidya, Sagar A, Haberland, Margaret, Fogelman, Alan M, Cheng, Genhong, Tontonoz, Peter
Published in Molecular cell (01.10.2003)
Published in Molecular cell (01.10.2003)
Get full text
Journal Article