Obinutuzumab Pretreatment as a Novel Approach to Mitigate Formation of Anti-Drug Antibodies Against Cergutuzumab Amunaleukin in Patients with Solid Tumors
Peters, Solange, Angevin, Eric, Alonso-Gordoa, Teresa, Rohrberg, Kristoffer, Melero, Ignacio, Mellado, Begoña, Perez-Gracia, Jose-Luis, Tabernero, Josep, Adessi, Celine, Boetsch, Christophe, Watson, Carl, Dal Porto, Joseph, Dejardin, David, Del Nagro, Christopher, Nicolini, Valeria, Evers, Stefan, Klein, Christian, Leutgeb, Barbara, Pisa, Pavel, Rossmann, Eva, Saro, José, Umana, Pablo, Charo, Jehad, Teichgräber, Volker, Steeghs, Neeltje
Published in Clinical cancer research (15.04.2024)
Published in Clinical cancer research (15.04.2024)
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Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines
Klein, Christian, Waldhauer, Inja, Nicolini, Valeria G., Freimoser-Grundschober, Anne, Nayak, Tapan, Vugts, Danielle J., Dunn, Claire, Bolijn, Marije, Benz, Jörg, Stihle, Martine, Lang, Sabine, Roemmele, Michaele, Hofer, Thomas, van Puijenbroek, Erwin, Wittig, David, Moser, Samuel, Ast, Oliver, Brünker, Peter, Gorr, Ingo H., Neumann, Sebastian, de Vera Mudry, Maria Cristina, Hinton, Heather, Crameri, Flavio, Saro, Jose, Evers, Stefan, Gerdes, Christian, Bacac, Marina, van Dongen, Guus, Moessner, Ekkehard, Umaña, Pablo
Published in Oncoimmunology (04.03.2017)
Published in Oncoimmunology (04.03.2017)
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Journal Article
A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
Bacac, Marina, Fauti, Tanja, Sam, Johannes, Colombetti, Sara, Weinzierl, Tina, Ouaret, Djamila, Bodmer, Walter, Lehmann, Steffi, Hofer, Thomas, Hosse, Ralf J, Moessner, Ekkehard, Ast, Oliver, Bruenker, Peter, Grau-Richards, Sandra, Schaller, Teilo, Seidl, Annette, Gerdes, Christian, Perro, Mario, Nicolini, Valeria, Steinhoff, Nathalie, Dudal, Sherri, Neumann, Sebastian, von Hirschheydt, Thomas, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umaña, Pablo
Published in Clinical cancer research (01.07.2016)
Published in Clinical cancer research (01.07.2016)
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Preliminary clinical outcomes of ADP-A2M4CD8, a next-generation autologous T-cell receptor T-cell therapy, in patients with advanced urothelial cancer
Aggen, David H, Hong, David S., Clarke, Jeffrey Melson, Asch, Adam Steven, Calvo, Emiliano, Zugazagoitia, Jon, Butler, Marcus O., Moreno, Victor, Cervantes, Andres, Van Tine, Brian Andrew, Lawrence, Donald P., Johnson, Melissa Lynne, Brophy, Francine Elizabeth, Broad, Robyn, Isabelle, Martin, Gunn, Alasdair, Navenot, Jean-Marc, Saro, Jose, Norry, Elliot, Charlson, John A.
Published in Journal of clinical oncology (20.02.2023)
Published in Journal of clinical oncology (20.02.2023)
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Safety and efficacy from the phase 1 SURPASS trial of ADP-A2M4CD8, a next-generation T-cell receptor T-cell therapy, in patients with advanced esophageal, esophagogastric junction, or gastric cancer
Blum Murphy, Mariela A., Ajani, Jaffer A., Van Tine, Brian Andrew, Clarke, Jeffrey Melson, Butler, Marcus O., Lawrence, Donald P., Johnson, Melissa Lynne, Cervantes, Andres, Moreno, Victor, Hong, David S., Brophy, Francine Elizabeth, Navenot, Jean-Marc, Lin, Quan, Saro, Jose, Norry, Elliot
Published in Journal of clinical oncology (01.02.2023)
Published in Journal of clinical oncology (01.02.2023)
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2022-LBA-414-ESGO Preliminary clinical outcome of ADP-A2M4CD8, a next-generation autologous T-cell receptor T-cell therapy, in patients with advanced epithelial ovarian cancer
Moore, Kathleen, Asch, Adam, Moreno, Victor, Calvo, Emiliano, Butler, Marcus, Zugazagoitia, Jon, Hong, David, Galal, Ahmed, Ostios, Lorena, de Miguel, Maria, Lin, Quan, Annareddy, Thejo, Brophy, Francine, Rosenberg, Marisa, Seiders, Theresa, Naidoo, Revashnee, Bath, Natalie, Saro, Jose, Norry, Elliot, Clarke, Jeffrey
Published in International journal of gynecological cancer (27.10.2022)
Published in International journal of gynecological cancer (27.10.2022)
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Journal Article
TYPE II ANTI-CD20 ANTIBODY FOR REDUCING FORMATION OF ANTI-DRUG ANTIBODIES
EVA ROSSMANN, CHRISTIAN KLEIN, JOSE SARO, STEFAN EVERS, MARINA BACAC, PAVEL PISA, PABLO UMANA
Year of Publication 11.07.2023
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Year of Publication 11.07.2023
Patent
Abstract 1494: Combination of CEA TCB, a novel T-cell bispecific antibody for the treatment of solid tumors, with PD-L1 checkpoint blockade
Bacac, Marina, Fauti, Tanja, Colombetti, Sara, Fahrni, Linda, Nicolini, Valeria, Gerdes, Christian, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 2217: Combining CEA-IL2v and FAP-IL2v immunocytokines with PD-L1 checkpoint blockade
Nicolini, Valeria, Waldhauer, Inja, Freimoser-Grundschober, Anne, Evers, Stefan, Saro, Jose, Bacac, Marina, Gerdes, Christian, Umana, Pablo, Klein, Christian
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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TYPE II ANTI-CD20 ANTIBODIES FOR REDUCING FORMATION OF ANTI-DRUG ANTIBODIES
EVA ROSSMANN, CHRISTIAN KLEIN, JOSE SARO, STEFAN EVERS, MARINA BACAC, PAVEL PISA, PABLO UMANA
Year of Publication 14.10.2021
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Year of Publication 14.10.2021
Patent
Abstract 2481: CEA TCB, a novel T-cell bispecific antibody with potent in vitro and in vivo antitumor activity against solid tumors
Bacac, Marina, Fauti, Tanja, Colombetti, Sara, Sam, Johannes, Nicolini, Valeria, Steinhoff, Nathalie, Ast, Oliver, Bruenker, Peter, Hosse, Ralf, Hofer, Thomas, Moessner, Ekkehard, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
ITOC2 – 037. CEA TCB, A novel T-cell bispecific antibody with potent in vitro and in vivo antitumour activity against solid tumours
Bacac, Marina, Fauti, Tanja, Colombetti, Sara, Sam, Johannes, Nicolini, Valeria, Steinhoff, Nathalie, Ast, Oliver, Bruenker, Peter, Hosse, Ralf, Hofer, Thomas, Moessner, Ekkehard, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umaña, Pablo
Published in European journal of cancer (1990) (01.03.2015)
Published in European journal of cancer (1990) (01.03.2015)
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89Zr-labeled CEA-targeted IL-2 variant immunocytokine in patients with solid tumors: CEA-mediated tumor accumulation and role of IL-2 receptor-binding
van Brummelen, Emilie M.J., Huisman, Marc C., de Wit-van der Veen, Linda J., Nayak, Tapan K., Stokkel, Marcel P.M., Mulder, Emma R., Hoekstra, Otto S., Vugts, Danielle J., Van Dongen, Guus A.M.S., Verheul, Henk M., Evers, Stefan, Tessier, Jean J. L., Saro, Jose, Schellens, Jan H.M., Menke-van der Houven van Oordt, C. Willemien
Published in Oncotarget (15.05.2018)
Published in Oncotarget (15.05.2018)
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Journal Article
89 Zr-labeled CEA-targeted IL-2 variant immunocytokine in patients with solid tumors: CEA-mediated tumor accumulation and role of IL-2 receptor-binding
van Brummelen, Emilie M J, Huisman, Marc C, de Wit-van der Veen, Linda J, Nayak, Tapan K, Stokkel, Marcel P M, Mulder, Emma R, Hoekstra, Otto S, Vugts, Danielle J, Van Dongen, Guus A M S, Verheul, Henk M, Evers, Stefan, Tessier, Jean J L, Saro, Jose, Schellens, Jan H M, Menke-van der Houven van Oordt, C Willemien
Published in Oncotarget (15.05.2018)
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Published in Oncotarget (15.05.2018)
Journal Article
New phase 1 SURPASS trial cohort: Early-line ADP-A2M4CD8 T-cell receptor T-cell therapy plus pembrolizumab in urothelial carcinoma
Aggen, David H, Garcia, Alejandro, Saro Suarez, Jose M, Sauer, Amy, Cristiani, Sebastiano, Brophy, Francine Elizabeth, Streets, Sharon, Norry, Elliot, Nelson, Ariel Ann, Kilari, Deepak, Garmezy, Benjamin, Charlson, John A., Zugazagoitia, Jon, Calvo, Emiliano, Moreno, Irene, Moreno, Victor, Hoimes, Christopher J., Hong, David S., Cervantes, Andres
Published in Journal of clinical oncology (01.02.2024)
Published in Journal of clinical oncology (01.02.2024)
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Journal Article
School Libraries’ Network: A Report on a Direct Accompaniment Experience
Conde, Elsa, Santos, Lucília, Afonso, João, Saro, José
Published in IASL conference proceedings (28.02.2021)
Published in IASL conference proceedings (28.02.2021)
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TYPE II ANTI-CD20 ANTIBODY FOR REDUCING FORMATION OF ANTI-DRUG ANTIBODIES OR CYTOKINE RELEASE
PISA, PAVEL, ROSSMANN, EVA, EVERS, STEFAN, KLEIN, CHRISTIAN, BACAC, MARINA, SARO, JOSE, UMANA, PABLO
Year of Publication 28.05.2024
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Year of Publication 28.05.2024
Patent