Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study
Llanos-Cuentas, Alejandro, Prof, Lacerda, Marcus V, Prof, Rueangweerayut, Ronnatrai, MD, Krudsood, Srivicha, Prof, Gupta, Sandeep K, MD, Kochar, Sanjay K, MD, Arthur, Preetam, MD, Chuenchom, Nuttagarn, MD, Möhrle, Jörg J, PhD, Duparc, Stephan, MD, Ugwuegbulam, Cletus, PhD, Kleim, Jörg-Peter, PhD, Carter, Nick, MSc, Green, Justin A, MD, Kellam, Lynda, MSc
Published in The Lancet (British edition) (22.03.2014)
Published in The Lancet (British edition) (22.03.2014)
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Hemolytic Potential of Tafenoquine in Female Volunteers Heterozygous for Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency ( G6PD Mahidol Variant) versus G6PD-Normal Volunteers
Rueangweerayut, Ronnatrai, Bancone, Germana, Harrell, Emma J, Beelen, Andrew P, Kongpatanakul, Supornchai, Möhrle, Jörg J, Rousell, Vicki, Mohamed, Khadeeja, Qureshi, Ammar, Narayan, Sushma, Yubon, Nushara, Miller, Ann, Nosten, François H, Luzzatto, Lucio, Duparc, Stephan, Kleim, Jörg-Peter, Green, Justin A
Published in The American journal of tropical medicine and hygiene (01.09.2017)
Published in The American journal of tropical medicine and hygiene (01.09.2017)
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Tafenoquine co-administered with dihydroartemisinin–piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study
Sutanto, Inge, Soebandrio, Amin, Ekawati, Lenny L, Chand, Krisin, Noviyanti, Rintis, Satyagraha, Ari Winasti, Subekti, Decy, Santy, Yulia Widya, Crenna-Darusallam, Chelzie, Instiaty, Instiaty, Budiman, Waras, Prasetya, Catur Bidik, Lardo, Soroy, Elyazar, Iqbal, Duparc, Stephan, Cedar, Eve, Rolfe, Katie, Fernando, Disala, Berni, Alessandro, Jones, Siôn, Kleim, Jörg-Peter, Fletcher, Kim, Sharma, Hema, Martin, Ana, Taylor, Maxine, Goyal, Navin, Green, Justin A, Tan, Lionel K, Baird, J Kevin
Published in The Lancet infectious diseases (01.10.2023)
Published in The Lancet infectious diseases (01.10.2023)
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Pharmacokinetic interactions and safety evaluations of coadministered tafenoquine and chloroquine in healthy subjects
Miller, Ann K., Harrell, Emma, Ye, Li, Baptiste‐Brown, Sharon, Kleim, Jőrg‐Peter, Ohrt, Colin, Duparc, Stephan, Möhrle, Jörg J., Webster, Alison, Stinnett, Sandra, Hughes, Arlene, Griffith, Sandy, Beelen, Andrew P.
Published in British journal of clinical pharmacology (01.12.2013)
Published in British journal of clinical pharmacology (01.12.2013)
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Changes in Human Immunodeficiency Virus Type 1 Gag at Positions L449 and P453 Are Linked to I50V Protease Mutants In Vivo and Cause Reduction of Sensitivity to Amprenavir and Improved Viral Fitness In Vitro
Maguire, Michael F, Guinea, Rosario, Griffin, Philip, Macmanus, Sarah, Elston, Robert C, Wolfram, Josie, Richards, Naomi, Hanlon, Mary H, Porter, David J T, Wrin, Terri, Parkin, Neil, Tisdale, Margaret, Furfine, Eric, Petropoulos, Chris, Snowden, B Wendy, Kleim, Jörg-Peter
Published in Journal of Virology (01.08.2002)
Published in Journal of Virology (01.08.2002)
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Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases
Ren, Jingshan, Nichols, Charles E, Chamberlain, Philip P, Weaver, Kurt L, Short, Steven A, Chan, Joseph H, Kleim, Jörg-Peter, Stammers, David K
Published in Journal of medicinal chemistry (17.05.2007)
Published in Journal of medicinal chemistry (17.05.2007)
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The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance
Hsiou, Yu, Ding, Jianping, Das, Kalyan, Clark, Arthur D, Boyer, Paul L, Lewi, Paul, Janssen, Paul A.J, Kleim, Jörg-Peter, Rösner, Manfred, Hughes, Stephen H, Arnold, Edward
Published in Journal of molecular biology (01.06.2001)
Published in Journal of molecular biology (01.06.2001)
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Antiviral activity and safety of aplaviroc with lamivudine/zidovudine in HIV-infected, therapy-naive patients : the ASCENT (CCR102881) study
CURRIER, Judith, LAZZARIN, Adriano, SLOAN, Louis, CLUMECK, Nathan, SLIM, Jihad, MCCARTY, Deb, STEEL, Helen, KLEIM, Jorg-Peter, BONNY, Tab, MILLARD, Judith
Published in Antiviral therapy (01.01.2008)
Published in Antiviral therapy (01.01.2008)
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Concomitant Combination Therapy for HIV Infection Preferable over Sequential Therapy with 3TC and Non-Nucleoside Reverse Transcriptase Inhibitors
Balzarini, Jan, Pelemans, Heidi, Karlsson, Anna, De Clerco, Erik, Kleim, Jorg-Peter
Published in Proceedings of the National Academy of Sciences - PNAS (12.11.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (12.11.1996)
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Antiviral Activity of the Human Immunodeficiency Virus Type 1—Specific Nonnucleoside Reverse Transcriptase Inhibitor HBY 097 Alone and in Combination with Zidovudine in a Phase II Study
Kleim, Jörg-Peter, Winters, Mark, Dunkler, Anke, Suarez, José-Ramon, Rieß, Günther, Winkler, Irvin, Balzarini, Jan, Oette, Dagmar, Merigan, Thomas C.
Published in The Journal of infectious diseases (01.03.1999)
Published in The Journal of infectious diseases (01.03.1999)
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Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors
Balzarini, J, De Clercq, E, Carbonez, A, Burt, V, Kleim, J P
Published in AIDS research and human retroviruses (10.04.2000)
Published in AIDS research and human retroviruses (10.04.2000)
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Selective Pressure of a Quinoxaline Nonnucleoside Inhibitor of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase (RT) on HIV-1 Replication Results in the Emergence of Nucleoside RT-Inhibitor-Specific (RT Leu-74 → Val or Ile and Val-75 → Leu or Ile) HIV-1 mutants
Kleim, Jörg-Peter, Rösner, Manfred, Winkler, Irvin, Paessens, Arno, Kirsch, Reinhard, Hsiou, Yu, Arnold, Edward, Riess, Günther
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.1996)
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Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria
Lacerda, Marcus V.G, Llanos-Cuentas, Alejandro, Krudsood, Srivicha, Lon, Chanthap, Saunders, David L, Mohammed, Rezika, Yilma, Daniel, Batista Pereira, Dhelio, Espino, Fe E.J, Mia, Reginaldo Z, Chuquiyauri, Raul, Val, Fernando, Casapía, Martín, Monteiro, Wuelton M, Brito, Marcelo A.M, Costa, Mônica R.F, Buathong, Nillawan, Noedl, Harald, Diro, Ermias, Getie, Sisay, Wubie, Kalehiwot M, Abdissa, Alemseged, Zeynudin, Ahmed, Abebe, Cherinet, Tada, Mauro S, Brand, Françoise, Beck, Hans-Peter, Angus, Brian, Duparc, Stephan, Kleim, Jörg-Peter, Kellam, Lynda M, Rousell, Victoria M, Jones, Siôn W, Hardaker, Elizabeth, Mohamed, Khadeeja, Clover, Donna D, Fletcher, Kim, Breton, John J, Ugwuegbulam, Cletus O, Green, Justin A, Koh, Gavin C.K.W
Published in The New England journal of medicine (17.01.2019)
Published in The New England journal of medicine (17.01.2019)
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Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype
VAN LAETHEM, Kristel, WITVROUW, Myriam, VANDAMME, Anne-Mieke, PANNECOUQUE, Christophe, VAN REMOORTEL, Barbara, SCHMIT, Jean-Claude, ESNOUF, Robert, KLEIM, Jörg-Peter, BALZARINI, Jan, DESMYTER, Jan, DE CLERCQ, Erik
Published in AIDS (London) (30.03.2001)
Published in AIDS (London) (30.03.2001)
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Reverse Transcriptase Fidelity and HIV-1 Variation
Preston, Bradley D., Keulen, Wilco, Nijhuis, Monique, Schuurman, Rob, Berkhout, Ben, Boucher, Charles, Balzarini, Jan, Pelemans, Heidi, De Clercq, Erik, Karlsson, Anna, Kleim, Jörg-Peter, Prasad, Vinayaka R., Drosopoulos, William C., Wainberg, Mark A.
Published in Science (American Association for the Advancement of Science) (10.01.1997)
Published in Science (American Association for the Advancement of Science) (10.01.1997)
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Retention of marked sensitivity to ( S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-Dihydroquinoxaline-2(1H)-Thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2′,3′-dideoxy-3′-thiacytidine (Lamivudine)
Balzarini, Jan, Pelemans, Heidi, Riess, Gunther, Roesner, Manfred, Winkler, Irvin, De Ckrcq, Erik, Kleim, Jörg-Peter
Published in Biochemical pharmacology (01.03.1998)
Published in Biochemical pharmacology (01.03.1998)
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