Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)
Roth, Gerald J, Heckel, Armin, Colbatzky, Florian, Handschuh, Sandra, Kley, Jörg, Lehmann-Lintz, Thorsten, Lotz, Ralf, Tontsch-Grunt, Ulrike, Walter, Rainer, Hilberg, Frank
Published in Journal of medicinal chemistry (23.07.2009)
Published in Journal of medicinal chemistry (23.07.2009)
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Journal Article
The azulene scaffold from a medicinal chemist's perspective: Physicochemical and in vitro parameters relevant for drug discovery
Leino, Teppo O., Sieger, Peter, Yli-Kauhaluoma, Jari, Wallén, Erik A.A., Kley, Jörg T.
Published in European journal of medicinal chemistry (05.07.2022)
Published in European journal of medicinal chemistry (05.07.2022)
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Journal Article
Discovery and development of BI 1265162, an ENaC inhibitor for the treatment of cystic fibrosis
Betzemeier, Bodo, Braun, Clemens, Sieger, Peter, Heckel, Armin, Linz, Günter, Linehan, Brian, Veser, Thomas, Wiedenmayer, Dieter, Kley, Jörg T.
Published in European journal of medicinal chemistry (05.02.2024)
Published in European journal of medicinal chemistry (05.02.2024)
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Journal Article
Chemical Derivatization Enables MALDI-TOF-Based High-Throughput Screening for Microbial Trimethylamine (TMA)-Lyase Inhibitors
Winter, Martin, Bretschneider, Tom, Thamm, Sven, Kleiner, Carola, Grabowski, Daniel, Chandler, Sarah, Ries, Robert, Kley, Jörg T., Fowler, Danielle, Bartlett, Christina, Binetti, Ralph, Broadwater, John, Luippold, Andreas H., Bischoff, Daniel, Büttner, Frank H.
Published in SLAS discovery (01.08.2019)
Published in SLAS discovery (01.08.2019)
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Journal Article
Design, synthesis and evaluation of MCH receptor 1 antagonists—Part III: Discovery of pre-clinical development candidate BI 186908
Oost, Thorsten, Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Müller, Stephan, Roth, Gerald J., Rudolf, Klaus, Arndt, Kirsten, Budzinski, Ralph, Lenter, Martin, Lotz, Ralf R.H., Maier, Gerd-Michael, Markert, Michael, Thomas, Leo, Stenkamp, Dirk
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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Journal Article
Design, synthesis and evaluation of MCH receptor 1 antagonists—Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition
Roth, Gerald J., Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Müller, Stephan G., Oost, Thorsten, Rudolf, Klaus, Arndt, Kirsten, Budzinski, Ralph, Lenter, Martin, Lotz, Ralf R.H., Schindler, Marcus, Thomas, Leo, Stenkamp, Dirk
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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Journal Article
Design, synthesis and evaluation of MCH receptor 1 antagonists—Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414
Müller, Stephan G., Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Lustenberger, Philipp, Oost, Thorsten, Roth, Gerald J., Rudolf, Klaus, Arndt, Kirsten, Lenter, Martin, Lotz, Ralf R.H., Maier, Gerd-Michael, Markert, Michael, Schindler, Marcus, Stenkamp, Dirk
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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Journal Article
Cytotoxic Efficacy and Influence on Cellular Phospholipid Metabolism of 2-Hydroxy- and 2-O-Acetyl-Octadecylphosphocholines
HILDENBRAND, Bernd, KLEY, Jörg T, HABERSTROH, Frank, FREUDENBERG, Marina A, AZEMAR, Marc, UNGER, Clemens, MASSING, Ulrich
Published in Anticancer research (01.11.2006)
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Published in Anticancer research (01.11.2006)
Journal Article
Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability
Heine, Niklas, Weber, Alexander, Pautsch, Alexander, Gottschling, Dirk, Uphues, Ingo, Bauer, Margit, Ebenhoch, Rebecca, Magarkar, Aniket, Nosse, Bernd, Kley, Jörg Thomas
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
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Journal Article
Crystal structures of human and mouse ketohexokinase provide a structural basis for species‐ and isoform‐selective inhibitor design
Ebenhoch, Rebecca, Bauer, Margit, Romig, Helmut, Gottschling, Dirk, Kley, Jörg Thomas, Heine, Niklas, Weber, Alexander, Uphues, Ingo, Nar, Herbert, Pautsch, Alexander
Published in Acta crystallographica. Section D, Biological crystallography. (01.10.2023)
Published in Acta crystallographica. Section D, Biological crystallography. (01.10.2023)
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Journal Article
Targeting of endothelial KDR receptors with 3G2 immunoliposomes in vitro
Benzinger, Petra, Martiny-Baron, Georg, Reusch, Petra, Siemeister, Gerd, Kley, Jörg T, Marmé, Dieter, Unger, Clemens, Massing, Ulrich
Published in Biochimica et biophysica acta (01.06.2000)
Published in Biochimica et biophysica acta (01.06.2000)
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Journal Article
Novel compounds for treating inflammatory diseases
KLEY, JORG, JUNG, BIRGIT, WALTER, RAINER, GOEGGEL, ROLF, MACK, JUERGEN, ANDERSKEWITZ, RALF, DOLLINGER, HORST, NICKOLAUS, PETER
Year of Publication 28.06.2012
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Year of Publication 28.06.2012
Patent
Medicaments for the treatment or prevention of fibrotic diseases
PARK, JOHN, KLEY, JORG, CHAUDHARY, NVEED, LEHMANN-LINTZ, THORSTEN, HECKEL, ARMIN, ROTH, GERALD
Year of Publication 09.02.2012
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Year of Publication 09.02.2012
Patent
MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
KLEY JORG, PARK JOHN EDWARD, LEHMANN-LINTZ THORSTEN, CHAUDHARY NVEED, ROTH GERALD JURGEN, HECKEL ARMIN
Year of Publication 31.10.2009
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Year of Publication 31.10.2009
Patent