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DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance and Progress to Date
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Published in Medicinal research reviews (01.05.2015)
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Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia
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Inhibition of Glucose-6-Phosphate Dehydrogenase Activity Attenuates Right Ventricle Pressure and Hypertrophy Elicited by VEGFR Inhibitor + Hypoxia
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Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2
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Published in Biochemical journal (01.07.2016)
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ERK5 is a critical mediator of inflammation-driven cancer
Finegan, Katherine G, Perez-Madrigal, Diana, Hitchin, James R, Davies, Clare C, Jordan, Allan M, Tournier, Cathy
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Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia
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Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei
Ortíz, Cecilia, Moraca, Francesca, Laverriere, Marc, Jordan, Allan, Hamilton, Niall, Comini, Marcelo A
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L-Proline Prevents Endoplasmic Reticulum Stress in Microglial Cells Exposed to L-azetidine-2-carboxylic Acid
Piper, Jordan Allan, Al Hammouri, Nour, Jansen, Margo Iris, Rodgers, Kenneth J, Musumeci, Giuseppe, Dhungana, Amolika, Ghorbanpour, Sahar Masoumeh, Bradfield, Laura A, Castorina, Alessandro
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First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib
James, Dominic I, Smith, Kate M, Jordan, Allan M, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, Jones, Stuart, Kelly, Paul, McGonagle, Alison E, Small, Helen, Stowell, Alexandra I. J, Tucker, Julie, Waddell, Ian D, Waszkowycz, Bohdan, Ogilvie, Donald J
Published in ACS chemical biology (18.11.2016)
Published in ACS chemical biology (18.11.2016)
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In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor
Gilmartin, Aidan G, Groy, Arthur, Gore, Elizabeth R, Atkins, Charity, Long, Edward R, Montoute, Monica N, Wu, Zining, Halsey, Wendy, McNulty, Dean E, Ennulat, Daniela, Rueda, Lourdes, Pappalardi, Melissa, Kruger, Ryan G, McCabe, Michael T, Raoof, Ali, Butlin, Roger, Stowell, Alexandra, Cockerill, Mark, Waddell, Ian, Ogilvie, Donald, Luengo, Juan, Jordan, Allan, Benowitz, Andrew B
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Published in Haematologica (Roma) (01.07.2021)
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The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
Harris, William J., Huang, Xu, Lynch, James T., Hitchin, James R., Li, Yaoyong, Ciceri, Filippo, Blaser, Julian G., Greystoke, Brigit F., Jordan, Allan M., Ogilvie, Donald J., Somervaille, Tim C.P.
Published in Cancer cell (12.06.2012)
Published in Cancer cell (12.06.2012)
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Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation
Joshi, Sachindra Raj, Kitagawa, Atsushi, Jacob, Christina, Hashimoto, Ryota, Dhagia, Vidhi, Ramesh, Amrit, Zheng, Connie, Zhang, Hui, Jordan, Allan, Waddell, Ian, Leopold, Jane, Hu, Cheng-Jun, McMurtry, Ivan F, D'Alessandro, Angelo, Stenmark, Kurt R, Gupte, Sachin A
Published in American journal of physiology. Lung cellular and molecular physiology (01.04.2020)
Published in American journal of physiology. Lung cellular and molecular physiology (01.04.2020)
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Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer
Jain, Aditi, Agostini, Lebaron C, McCarthy, Grace A, Chand, Saswati N, Ramirez, AnnJosette, Nevler, Avinoam, Cozzitorto, Joseph, Schultz, Christopher W, Lowder, Cinthya Yabar, Smith, Kate M, Waddell, Ian D, Raitses-Gurevich, Maria, Stossel, Chani, Gorman, Yulia Glick, Atias, Dikla, Yeo, Charles J, Winter, Jordan M, Olive, Kenneth P, Golan, Talia, Pishvaian, Michael J, Ogilvie, Donald, James, Dominic I, Jordan, Allan M, Brody, Jonathan R
Published in Cancer research (Chicago, Ill.) (01.09.2019)
Published in Cancer research (Chicago, Ill.) (01.09.2019)
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Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides
Waszkowycz, Bohdan, Smith, Kate M, McGonagle, Alison E, Jordan, Allan M, Acton, Ben, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, James, Dominic I, Jones, Clifford D, Jones, Stuart, Mould, Daniel P, Small, Helen F, Stowell, Alexandra I. J, Tucker, Julie A, Waddell, Ian D, Ogilvie, Donald J
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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