Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells
Lloyd, Rebecca L., Wijnhoven, Paul W. G., Ramos-Montoya, Antonio, Wilson, Zena, Illuzzi, Giuditta, Falenta, Katarzyna, Jones, Gemma N., James, Neil, Chabbert, Christophe D., Stott, Jonathan, Dean, Emma, Lau, Alan, Young, Lucy A.
Published in Oncogene (18.06.2020)
Published in Oncogene (18.06.2020)
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Journal Article
Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically
Riches, Lucy C, Trinidad, Antonio G, Hughes, Gareth, Jones, Gemma N, Hughes, Adina M, Thomason, Andrew G, Gavine, Paul, Cui, Andy, Ling, Stephanie, Stott, Jonathan, Clark, Roger, Peel, Samantha, Gill, Pendeep, Goodwin, Louise M, Smith, Aaron, Pike, Kurt G, Barlaam, Bernard, Pass, Martin, O'Connor, Mark J, Smith, Graeme, Cadogan, Elaine B
Published in Molecular cancer therapeutics (01.01.2020)
Published in Molecular cancer therapeutics (01.01.2020)
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Adavosertib plus gemcitabine for platinum-resistant or platinum-refractory recurrent ovarian cancer: a double-blind, randomised, placebo-controlled, phase 2 trial
Lheureux, Stephanie, Cristea, Mihaela C, Bruce, Jeffrey P, Garg, Swati, Cabanero, Michael, Mantia-Smaldone, Gina, Olawaiye, Alexander B, Ellard, Susan L, Weberpals, Johanne I, Wahner Hendrickson, Andrea E, Fleming, Gini F, Welch, Stephen, Dhani, Neesha C, Stockley, Tracy, Rath, Prisni, Karakasis, Katherine, Jones, Gemma N, Jenkins, Suzanne, Rodriguez-Canales, Jaime, Tracy, Michael, Tan, Qian, Bowering, Valerie, Udagani, Smitha, Wang, Lisa, Kunos, Charles A, Chen, Eric, Pugh, Trevor J, Oza, Amit M
Published in The Lancet (British edition) (23.01.2021)
Published in The Lancet (British edition) (23.01.2021)
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Journal Article
ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib
Wilson, Zena, Odedra, Rajesh, Wallez, Yann, Wijnhoven, Paul W G, Hughes, Adina M, Gerrard, Joe, Jones, Gemma N, Bargh-Dawson, Hannah, Brown, Elaine, Young, Lucy A, O'Connor, Mark J, Lau, Alan
Published in Cancer research (Chicago, Ill.) (15.03.2022)
Published in Cancer research (Chicago, Ill.) (15.03.2022)
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Journal Article
SLFN11 informs on standard of care and novel treatments in a wide range of cancer models
Winkler, Claudia, Armenia, Joshua, Jones, Gemma N., Tobalina, Luis, Sale, Matthew J., Petreus, Tudor, Baird, Tarrion, Serra, Violeta, Wang, Anderson T., Lau, Alan, Garnett, Mathew J., Jaaks, Patricia, Coker, Elizabeth A., Pierce, Andrew J., O’Connor, Mark J., Leo, Elisabetta
Published in British journal of cancer (02.03.2021)
Published in British journal of cancer (02.03.2021)
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Journal Article
Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study
Yap, Timothy A, Krebs, Matthew G, Postel-Vinay, Sophie, El-Khouiery, Anthony, Soria, Jean-Charles, Lopez, Juanita, Berges, Alienor, Cheung, S Y Amy, Irurzun-Arana, Itziar, Goldwin, Andrew, Felicetti, Brunella, Jones, Gemma N, Lau, Alan, Frewer, Paul, Pierce, Andrew J, Clack, Glen, Stephens, Christine, Smith, Simon A, Dean, Emma, Hollingsworth, Simon J
Published in Clinical cancer research (01.10.2021)
Published in Clinical cancer research (01.10.2021)
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Journal Article
Time-dependent forgetting and retrieval practice effects in detailed visual long-term memory
Mercer, Tom, Jones, Gemma A
Published in Quarterly journal of experimental psychology (2006) (01.06.2019)
Published in Quarterly journal of experimental psychology (2006) (01.06.2019)
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Journal Article
Evaluation of UV‑C Decontamination of Clinical Tissue Sections for Spatially Resolved Analysis by Mass Spectrometry Imaging (MSI)
Dannhorn, Andreas, Ling, Stephanie, Powell, Steven, McCall, Eileen, Maglennon, Gareth, Jones, Gemma N, Pierce, Andrew J, Strittmatter, Nicole, Hamm, Gregory, Barry, Simon T, Bunch, Josephine, Goodwin, Richard J. A, Takats, Zoltan
Published in Analytical chemistry (Washington) (09.02.2021)
Published in Analytical chemistry (Washington) (09.02.2021)
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Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response
Willis, Sophie E., Winkler, Claudia, Roudier, Martine P., Baird, Tarrion, Marco-Casanova, Paola, Jones, Emma V., Rowe, Philip, Rodriguez-Canales, Jaime, Angell, Helen K., Ng, Felicia S. L., Waring, Paul M., Hodgson, Darren, Ledermann, Jonathan A., Weberpals, Johanne I., Dean, Emma, Harrington, Elizabeth A., Barrett, J. Carl, Pierce, Andrew J., Leo, Elisabetta, Jones, Gemma N.
Published in British journal of cancer (07.12.2021)
Published in British journal of cancer (07.12.2021)
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Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance
Serra, Violeta, Wang, Anderson T, Castroviejo-Bermejo, Marta, Polanska, Urszula M, Palafox, Marta, Herencia-Ropero, Andrea, Jones, Gemma N, Lai, Zhongwu, Armenia, Joshua, Michopoulos, Filippos, Llop-Guevara, Alba, Brough, Rachel, Gulati, Aditi, Pettitt, Stephen J, Bulusu, Krishna C, Nikkilä, Jenni, Wilson, Zena, Hughes, Adina, Wijnhoven, Paul W G, Ahmed, Ambar, Bruna, Alejandra, Gris-Oliver, Albert, Guzman, Marta, Rodríguez, Olga, Grueso, Judit, Arribas, Joaquin, Cortés, Javier, Saura, Cristina, Lau, Alan, Critchlow, Susan, Dougherty, Brian, Caldas, Carlos, Mills, Gordon B, Barrett, J Carl, Forment, Josep V, Cadogan, Elaine, Lord, Christopher J, Cruz, Cristina, Balmaña, Judith, O'Connor, Mark J
Published in Clinical cancer research (14.10.2022)
Published in Clinical cancer research (14.10.2022)
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Epitope Lability of Phosphorylated Biomarkers of the DNA Damage Response Pathway Results in Increased Vulnerability to Effects of Delayed or Incomplete Formalin Fixation
Wiseman, Elizabeth J., Moss, Jennifer I., Atkinson, James, Baakza, Hana, Hayes, Emily, Willis, Sophie E., Waring, Paul M., Rodriguez Canales, Jaime, Jones, Gemma N.
Published in The journal of histochemistry and cytochemistry (01.05.2023)
Published in The journal of histochemistry and cytochemistry (01.05.2023)
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Journal Article
Decellularization and Characterization of Porcine Superflexor Tendon: A Potential Anterior Cruciate Ligament Replacement
Jones, Gemma, Herbert, Anthony, Berry, Helen, Edwards, Jennifer Helen, Fisher, John, Ingham, Eileen
Published in Tissue engineering. Part A (01.02.2017)
Published in Tissue engineering. Part A (01.02.2017)
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Journal Article
Valproic Acid Confers Functional Pluripotency to Human Amniotic Fluid Stem Cells in a Transgene-free Approach
Moschidou, Dafni, Mukherjee, Sayandip, Blundell, Michael P., Drews, Katharina, Jones, Gemma N., Abdulrazzak, Hassan, Nowakowska, Beata, Phoolchund, Anju, Lay, Kenneth, Ramasamy, T Selvee, Cananzi, Mara, Nettersheim, Daniel, Sullivan, Mark, Frost, Jennifer, Moore, Gudrun, Vermeesch, Joris R., Fisk, Nicholas M., Thrasher, Adrian J., Atala, Anthony, Adjaye, James, Schorle, Hubert, De Coppi, Paolo, Guillot, Pascale V.
Published in Molecular therapy (07.08.2024)
Published in Molecular therapy (07.08.2024)
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Journal Article
The effects of irradiation on the biological and biomechanical properties of an acellular porcine superflexor tendon graft for cruciate ligament repair
Edwards, Jennifer H, Herbert, Anthony, Jones, Gemma L, Manfield, Iain W, Fisher, John, Ingham, Eileen
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01.11.2017)
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01.11.2017)
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Journal Article
Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation
Dillon, Magnus T, Guevara, Jeane, Mohammed, Kabir, Patin, Emmanuel C, Smith, Simon A, Dean, Emma, Jones, Gemma N, Willis, Sophie E, Petrone, Marcella, Silva, Carlos, Thway, Khin, Bunce, Catey, Roxanis, Ioannis, Nenclares, Pablo, Wilkins, Anna, McLaughlin, Martin, Jayme-Laiche, Adoracion, Benafif, Sarah, Nintos, Georgios, Kwatra, Vineet, Grove, Lorna, Mansfield, David, Proszek, Paula, Martin, Philip, Moore, Luiza, Swales, Karen E, Banerji, Udai, Saunders, Mark P, Spicer, James, Forster, Martin D, Harrington, Kevin J
Published in The Journal of clinical investigation (16.01.2024)
Published in The Journal of clinical investigation (16.01.2024)
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Journal Article
Ontological differences in first compared to third trimester human fetal placental chorionic stem cells
Jones, Gemma N, Moschidou, Dafni, Puga-Iglesias, Tamara-Isabel, Kuleszewicz, Katarzyna, Vanleene, Maximilien, Shefelbine, Sandra J, Bou-Gharios, George, Fisk, Nicholas M, David, Anna L, De Coppi, Paolo, Guillot, Pascale V
Published in PloS one (04.09.2012)
Published in PloS one (04.09.2012)
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Journal Article
A biomechanical characterisation of acellular porcine super flexor tendons for use in anterior cruciate ligament replacement: Investigation into the effects of fat reduction and bioburden reduction bioprocesses
Herbert, Anthony, Jones, Gemma L, Ingham, Eileen, Fisher, John
Published in Journal of biomechanics (02.01.2015)
Published in Journal of biomechanics (02.01.2015)
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Journal Article
Valproic Acid Confers Functional Pluripotency to Human Amniotic Fluid Stem Cells in a Transgene-free Approach
Moschidou, Dafni, Mukherjee, Sayandip, Blundell, Michael P, Drews, Katharina, Jones, Gemma N, Abdulrazzak, Hassan, Nowakowska, Beata, Phoolchund, Anju, Lay, Kenneth, Ramasamy, T Selvee, Cananzi, Mara, Nettersheim, Daniel, Sullivan, Mark, Frost, Jennifer, Moore, Gudrun, Vermeesch, Joris R, Fisk, Nicholas M, Thrasher, Adrian J, Atala, Anthony, Adjaye, James, Schorle, Hubert, De Coppi, Paolo, Guillot, Pascale V
Published in Molecular therapy (01.10.2012)
Published in Molecular therapy (01.10.2012)
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Journal Article
The effects of irradiation dose and storage time following treatment on the viscoelastic properties of decellularised porcine super flexor tendon
Herbert, Anthony, Edwards, Jennifer H, Jones, Gemma L, Ingham, Eileen, Fisher, John
Published in Journal of biomechanics (24.05.2017)
Published in Journal of biomechanics (24.05.2017)
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Journal Article
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry
Jones, Gemma N., Rooney, Claire, Griffin, Nicola, Roudier, Martine, Young, Lucy A., Garcia-Trinidad, Antonio, Hughes, Gareth D., Whiteaker, Jeffrey R., Wilson, Zena, Odedra, Rajesh, Zhao, Lei, Ivey, Richard G., Howat, William J., Harrington, Elizabeth A., Barrett, J. Carl, Ramos-Montoya, Antonio, Lau, Alan, Paulovich, Amanda G., Cadogan, Elaine B., Pierce, Andrew J.
Published in British journal of cancer (13.11.2018)
Published in British journal of cancer (13.11.2018)
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