Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-Arylproline analogs
Bilodeau, François, Bailey, Murray D., Bhardwaj, Punit K., Bordeleau, Josée, Forgione, Pat, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Halmos, Ted, Jolicoeur, Eric S., Leblanc, Mélissa, Lemke, Christopher T., Naud, Julie, O’Meara, Jeff, White, Peter W., Llinàs-Brunet, Montse
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
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Journal Article
Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cagα of Helicobacter pylori
Morin, Claire, Verma, Vijay Tailor, Arya, Tarun, Casu, Bastien, Jolicoeur, Eric, Ruel, Réjean, Marinier, Anne, Sygusch, Jurgen, Baron, Christian
Published in Biochemistry and cell biology (01.06.2024)
Published in Biochemistry and cell biology (01.06.2024)
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Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV)
Beaulieu, Pierre L, Bös, Michael, Cordingley, Michael G, Chabot, Catherine, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Jolicoeur, Eric, LaPlante, Steven, McKercher, Ginette, Poirier, Martin, Poupart, Marc-André, Tsantrizos, Youla S, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Journal Article
From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: Indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons
Beaulieu, Pierre L., Gillard, James, Jolicoeur, Eric, Duan, Jianmin, Garneau, Michel, Kukolj, George, Poupart, Marc-André
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Journal Article
Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV)
Beaulieu, Pierre L, Bös, Michael, Cordingley, Michael G, Chabot, Catherine, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Jolicoeur, Eric, LaPlante, Steven, McKercher, Ginette, Poirier, Martin, Poupart, Marc-André, Tsantrizos, Youla S, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (28.08.2014)
Published in Journal of medicinal chemistry (28.08.2014)
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Journal Article
Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): Central amino acid linker and right-hand-side SAR studies
Beaulieu, Pierre L., Chabot, Catherine, Duan, Jianmin, Garneau, Michel, Gillard, James, Jolicoeur, Eric, Poirier, Martin, Poupart, Marc-André, Stammers, Timothy A., Kukolj, George, Tsantrizos, Youla S.
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Journal Article
N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies
Beaulieu, Pierre L., Jolicoeur, Eric, Gillard, James, Brochu, Christian, Coulombe, René, Dansereau, Nathalie, Duan, Jianmin, Garneau, Michel, Jakalian, Araz, Kühn, Peter, Lagacé, Lisette, LaPlante, Steven, McKercher, Ginette, Perrault, Stéphane, Poirier, Martin, Poupart, Marc-André, Stammers, Timothy, Thauvette, Louise, Thavonekham, Bounkham, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Allosteric N-acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase — Acylsulfonamides and acylsulfamides as carboxylic acid replacements
Beaulieu, Pierre L., Coulombe, Rene, Gillard, James, Brochu, Christian, Duan, Jianmin, Garneau, Michel, Jolicoeur, Eric, Kuhn, Peter, Poupart, Marc-Andre, Rancourt, Jean, Stammers, Timothy A., Thavonekham, Bounkham, Kukolj, George
Published in Canadian journal of chemistry (01.01.2013)
Published in Canadian journal of chemistry (01.01.2013)
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Journal Article
Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases
Gagnon, Alexandre, Amad, Ma’an H., Bonneau, Pierre R., Coulombe, René, DeRoy, Patrick L., Doyon, Louise, Duan, Jianmin, Garneau, Michel, Guse, Ingrid, Jakalian, Araz, Jolicoeur, Eric, Landry, Serge, Malenfant, Eric, Simoneau, Bruno, Yoakim, Christiane
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Journal Article
Generative Active Learning for the Search of Small-molecule Protein Binders
Korablyov, Maksym, Liu, Cheng-Hao, Jain, Moksh, van der Sloot, Almer M, Jolicoeur, Eric, Ruediger, Edward, Nica, Andrei Cristian, Bengio, Emmanuel, Lapchevskyi, Kostiantyn, St-Cyr, Daniel, Schuetz, Doris Alexandra, Butoi, Victor Ion, Rector-Brooks, Jarrid, Blackburn, Simon, Feng, Leo, Nekoei, Hadi, Gottipati, SaiKrishna, Vijayan, Priyesh, Gupta, Prateek, Rampášek, Ladislav, Avancha, Sasikanth, Bacon, Pierre-Luc, Hamilton, William L, Paige, Brooks, Misra, Sanchit, Jastrzebski, Stanislaw Kamil, Kaul, Bharat, Precup, Doina, Hernández-Lobato, José Miguel, Segler, Marwin, Bronstein, Michael, Marinier, Anne, Tyers, Mike, Bengio, Yoshua
Year of Publication 02.05.2024
Year of Publication 02.05.2024
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Journal Article
Enantioselective Synthesis of Spiropentanes from Hydroxymethylallenes
Charette, André B, Jolicoeur, Eric, Bydlinski, Gregory A. S
Published in Organic letters (18.10.2001)
Published in Organic letters (18.10.2001)
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Journal Article
Generative Active Learning for the Search of Small-molecule Protein Binders
Korablyov, Maksym, Cheng-Hao, Liu, Jain, Moksh, Almer M van der Sloot, Jolicoeur, Eric, Ruediger, Edward, Nica, Andrei Cristian, Bengio, Emmanuel, Lapchevskyi, Kostiantyn, St-Cyr, Daniel, Schuetz, Doris Alexandra, Butoi, Victor Ion, Rector-Brooks, Jarrid, Blackburn, Simon, Feng, Leo, Nekoei, Hadi, Gottipati, SaiKrishna, Vijayan, Priyesh, Gupta, Prateek, Rampášek, Ladislav, Avancha, Sasikanth, Bacon, Pierre-Luc, Hamilton, William L, Brooks, Paige, Misra, Sanchit, Stanislaw Kamil Jastrzebski, Kaul, Bharat, Precup, Doina, José Miguel Hernández-Lobato, Segler, Marwin, Bronstein, Michael, Marinier, Anne, Tyers, Mike, Bengio, Yoshua
Published in arXiv.org (02.05.2024)
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Published in arXiv.org (02.05.2024)
Paper
HEPATITIS C VIRUS NS5B POLYMERASE INHIBITOR BINDING POCKET
POUPART, MARC ANDRE, JOLICOEUR, ERIC, BEAULIEU, PIERRE LOUIS, KUKOLJ, GEORGE, LAPLANTE, STEVEN, COULOMBE, RENE
Year of Publication 07.07.2015
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Year of Publication 07.07.2015
Patent
HEPATITIS C VIRUS NS5B-POLYMERASEINHIBITOR-BINDENDE LOMME
POUPART, MARC-ANDRE, JOLICOEUR, ERIC, KUKOLJ, GEORGE, LAPLANTE, STEVEN, COULOMBE, RENE, BEAULIEU, PIERRE, LOUIS
Year of Publication 24.02.2014
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Year of Publication 24.02.2014
Patent
HEPATITIS C VIRUS NS5B POLYMERASE INHIBITOR BINDING POCKET
POUPART, MARC-ANDRE, JOLICOEUR, ERIC, KUKOLJ, GEORGE, LAPLANTE, STEVEN, COULOMBE, RENE, BEAULIEU, PIERRE, LOUIS
Year of Publication 08.01.2014
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Year of Publication 08.01.2014
Patent
Inhibitors of cytomegalovirus
Villemure Elisia, Hucke Oliver, Rancourt Jean, Surprenant Simon, Jolicoeur Eric, Thibeault Carl, Kuhn Cyrille, Leblanc Melissa, Beaulieu Pierre L, Grand-Maitre Chantal, Moreau Benoit, Décor Anne, Lacoste Jean-Eric
Year of Publication 29.11.2016
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Year of Publication 29.11.2016
Patent
INHIBITORS OF CYTOMEGALOVIRUS
LEBLANC, MELISSA, SURPRENANT, SIMON, THIBEAULT, CARL, MOREAU, BENOIT, KUHN, CYRILLE, HUCKE, OLIVER, JOLICOEUR, ERIC, DÉCOR, ANNE, GRAND-MAITRE, CHANTAL, BEAULIEU, PIERRE L, LACOSTE, JEAN-ERIC, VILLEMURE, ELISIA, RANCOURT, JEAN
Year of Publication 14.09.2016
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Year of Publication 14.09.2016
Patent
INHIBITORS OF CYTOMEGALOVIRUS
HUCKE OLIVER, THIBEAULT CARL, KUHN CYRILLE, RANCOURT JEAN, BEAULIEU PIERRE L, VILLEMURE ELISIA, MOREAU BENOIT, DÉCOR ANNE, SURPRENANT SIMON, LACOSTE JEAN-ERIC, LEBLANC MELISSA, GRAND-MAITRE CHANTAL, JOLICOEUR ERIC
Year of Publication 01.10.2015
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Year of Publication 01.10.2015
Patent