PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow
Hopkins, Todd A, Ainsworth, William B, Ellis, Paul A, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Abraham, Vivek C, Algire, Mikkel A, Shi, Yan, Olson, Amanda M, Johnson, Eric F, Wilsbacher, Julie L, Maag, David
Published in Molecular cancer research (01.02.2019)
Published in Molecular cancer research (01.02.2019)
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Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors
Hopkins, Todd A, Shi, Yan, Rodriguez, Luis E, Solomon, Larry R, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Wilsbacher, Julie L, Gao, Wenqing, Olson, Amanda M, Stolarik, DeAnne F, Osterling, Donald J, Johnson, Eric F, Maag, David
Published in Molecular cancer research (01.11.2015)
Published in Molecular cancer research (01.11.2015)
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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
Tse, Christin, Shoemaker, Alexander R, Adickes, Jessica, Anderson, Mark G, Chen, Jun, Jin, Sha, Johnson, Eric F, Marsh, Kennan C, Mitten, Michael J, Nimmer, Paul, Roberts, Lisa, Tahir, Stephen K, Xiao, Yu, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen, Rosenberg, Saul H, Elmore, Steven W
Published in Cancer research (Chicago, Ill.) (01.05.2008)
Published in Cancer research (Chicago, Ill.) (01.05.2008)
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Adaptations for the Oxidation of Polycyclic Aromatic Hydrocarbons Exhibited by the Structure of Human P450 1A2
Sansen, Stefaan, Yano, Jason K., Reynald, Rosamund L., Schoch, Guillaume A., Griffin, Keith J., Stout, C. David, Johnson, Eric F.
Published in The Journal of biological chemistry (11.05.2007)
Published in The Journal of biological chemistry (11.05.2007)
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The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-Å Resolution
Yano, Jason K., Wester, Michael R., Schoch, Guillaume A., Griffin, Keith J., Stout, C. David, Johnson, Eric F.
Published in The Journal of biological chemistry (10.09.2004)
Published in The Journal of biological chemistry (10.09.2004)
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Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer
Penning, Thomas D, Zhu, Gui-Dong, Gandhi, Viraj B, Gong, Jianchun, Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F, Donawho, Cherrie K, Frost, David J, Bontcheva-Diaz, Velitchka, Bouska, Jennifer J, Osterling, Donald J, Olson, Amanda M, Marsh, Kennan C, Luo, Yan, Giranda, Vincent L
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
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Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection
Holdener, Martin, Hintermann, Edith, Bayer, Monika, Rhode, Antje, Rodrigo, Evelyn, Hintereder, Gudrun, Johnson, Eric F, Gonzalez, Frank J, Pfeilschifter, Josef, Manns, Michael P, Herrath, Matthias von G, Christen, Urs
Published in The Journal of experimental medicine (09.06.2008)
Published in The Journal of experimental medicine (09.06.2008)
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The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0-Ã Resolution
Wester, Michael R, Yano, Jason K, Schoch, Guillaume A, Yang, Christine, Griffin, Keith J, Stout, C David, Johnson, Eric F
Published in The Journal of biological chemistry (20.08.2004)
Published in The Journal of biological chemistry (20.08.2004)
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Ubiquitin-specific Cysteine Protease 2a (USP2a) Regulates the Stability of Aurora-A
Shi, Yan, Solomon, Larry R., Pereda-Lopez, Ana, Giranda, Vincent L., Luo, Yan, Johnson, Eric F., Shoemaker, Alexander R., Leverson, Joel, Liu, Xuesong
Published in The Journal of biological chemistry (11.11.2011)
Published in The Journal of biological chemistry (11.11.2011)
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An Open Conformation of Mammalian Cytochrome P450 2B4 at 1.6-Å Resolution
Scott, Emily E., He, You Ai, Wester, Michael R., White, Mark A., Chin, Christopher C., Halpert, James R., Johnson, Eric F., Stout, C. David
Published in Proceedings of the National Academy of Sciences - PNAS (11.11.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (11.11.2003)
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Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain
Mast, Natalia, White, Mark Andrew, Bjorkhem, Ingemar, Johnson, Eric F, Stout, C. David, Pikuleva, Irina A
Published in Proceedings of the National Academy of Sciences - PNAS (15.07.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (15.07.2008)
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Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases
Johnson, Eric F., Stout, C. David
Published in Biochemical and biophysical research communications (09.12.2005)
Published in Biochemical and biophysical research communications (09.12.2005)
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Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization
Yano, Jason K, Denton, Travis T, Cerny, Matthew A, Zhang, Xiaodong, Johnson, Eric F, Cashman, John R
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
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Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)
Miyashiro, Julie, Woods, Keith W., Park, Chang H., Liu, Xuesong, Shi, Yan, Johnson, Eric F., Bouska, Jennifer J., Olson, Amanda M., Luo, Yan, Fry, Elizabeth H., Giranda, Vincent L., Penning, Thomas D.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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