In Vitro Antiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor
KOBAYASHI, Masanori, YOSHINAGA, Tomokazu, KAWAUCHI-MIKI, Shinobu, TAISHI, Teruhiko, KAWASUJI, Takashi, JOHNS, Brian A, UNDERWOOD, Mark R, GARVEY, Edward P, SATO, Akihiko, FUJIWARA, Tamio, SEKI, Takahiro, WAKASA-MORIMOTO, Chiaki, BROWN, Kevin W, FERRIS, Robert, FOSTER, Scott A, HAZEN, Richard J, MIKI, Shigeru, SUYAMA-KAGITANI, Akemi
Published in Antimicrobial Agents and Chemotherapy (01.02.2011)
Published in Antimicrobial Agents and Chemotherapy (01.02.2011)
Get full text
Journal Article
Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk
Feaver, Ryan E, Bowers, M. Scott, Cole, Banumathi K, Hoang, Steve, Lawson, Mark J, Taylor, Justin, LaMoreaux, Brian D, Zhao, Lin, Henke, Brad R, Johns, Brian A, Nyborg, Andrew C, Wamhoff, Brian R, Figler, Robert A
Published in PloS one (08.09.2023)
Published in PloS one (08.09.2023)
Get full text
Journal Article
Augmentation of response and remission to serial intravenous subanesthetic ketamine in treatment resistant depression
Shiroma, Paulo R, Johns, Brian, Kuskowski, Michael, Wels, Joseph, Thuras, Paul, Albott, C. Sophia, Lim, Kelvin O
Published in Journal of affective disorders (01.02.2014)
Published in Journal of affective disorders (01.02.2014)
Get full text
Journal Article
Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection
Yoshinaga, Tomokazu, Kobayashi, Masanori, Seki, Takahiro, Miki, Shigeru, Wakasa-Morimoto, Chiaki, Suyama-Kagitani, Akemi, Kawauchi-Miki, Shinobu, Taishi, Teruhiko, Kawasuji, Takashi, Johns, Brian A, Underwood, Mark R, Garvey, Edward P, Sato, Akihiko, Fujiwara, Tamio
Published in Antimicrobial agents and chemotherapy (01.01.2015)
Published in Antimicrobial agents and chemotherapy (01.01.2015)
Get full text
Journal Article
Carbamoyl Pyridone HIV‑1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744)
Johns, Brian A, Kawasuji, Takashi, Weatherhead, Jason G, Taishi, Teruhiko, Temelkoff, David P, Yoshida, Hiroshi, Akiyama, Toshiyuki, Taoda, Yoshiyuki, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Tanimoto, Norihiko, Jeffrey, Jerry, Foster, Scott A, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Johnson, Matthew N, Garvey, Edward P, Fujiwara, Tamio
Published in Journal of medicinal chemistry (25.07.2013)
Published in Journal of medicinal chemistry (25.07.2013)
Get full text
Journal Article
Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes
HIGHTOWER, Kendra E, WANG, Ruolan, SEKI, Takahiro, KOBAYASHI, Masanori, UNDERWOOD, Mark R, DEANDA, Felix, JOHNS, Brian A, WEAVER, Kurt, YINGNIAN SHEN, TOMBERLIN, Ginger H, LUKE CARTER, H, BRODERICK, Timothy, SIGETHY, Scott
Published in Antimicrobial Agents and Chemotherapy (01.10.2011)
Published in Antimicrobial Agents and Chemotherapy (01.10.2011)
Get full text
Journal Article
Molecular design and evaluation of aza-polycyclic carbamoyl pyridones as HIV-1 integrase strand transfer inhibitors
Akiyama, Toshiyuki, Johns, Brian A., Taoda, Yoshiyuki, Yoshida, Hiroshi, Taishi, Teruhiko, Kawasuji, Takashi, Murai, Hitoshi, Yoshinaga, Tomokazu, Sato, Akihiko, Seki, Takahiro, Koyama, Mikiko, Miki, Shigeru, Kawauchi-Miki, Shinobu, Kagitani-Suyama, Akemi, Fujiwara, Tamio
Published in Bioorganic & medicinal chemistry letters (01.10.2024)
Published in Bioorganic & medicinal chemistry letters (01.10.2024)
Get full text
Journal Article
The activity of the integrase inhibitor dolutegravir against HIV-1 variants isolated from raltegravir-treated adults
Underwood, Mark R, Johns, Brian A, Sato, Akihiko, Martin, Jeffrey N, Deeks, Steven G, Fujiwara, Tamio
Published in Journal of acquired immune deficiency syndromes (1999) (01.11.2012)
Published in Journal of acquired immune deficiency syndromes (1999) (01.11.2012)
Get more information
Journal Article
A Phase IIa Study Evaluating Safety, Pharmacokinetics, and Antiviral Activity of GSK2838232, a Novel, Second-generation Maturation Inhibitor, in Participants With Human Immunodeficiency Virus Type 1 Infection
DeJesus, Edwin, Harward, Sara, Jewell, Roxanne C, Johnson, Mark, Dumont, Etienne, Wilches, Viviana, Halliday, Fiona, Talarico, Christine L, Jeffrey, Jerry, Gan, Jianjun, Xu, Jianfeng, Felizarta, Franco, Scribner, Anita, Ramgopal, Moti, Benson, Paul, Johns, Brian A
Published in Clinical infectious diseases (22.08.2020)
Published in Clinical infectious diseases (22.08.2020)
Get full text
Journal Article
Parenteral platforms for tunable, long-acting administration of a highly hydrophobic antiretroviral drug
Akhavein, Nima, Baum, Marc M., Gunawardana, Manjula, Moss, John A., Calvez, Sandrine, Remedios-Chan, Mariana, Fanter, Rob, Lenhard, Steve, Rusk, Samantha, Azzarano, Leonard, McCoy, Deborah, Jucker, Beat, Johns, Brian, Burke, Matt, Velthuisen, Emile
Published in Scientific reports (21.05.2024)
Published in Scientific reports (21.05.2024)
Get full text
Journal Article
Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles
Kawasuji, Takashi, Johns, Brian A, Yoshida, Hiroshi, Weatherhead, Jason G, Akiyama, Toshiyuki, Taishi, Teruhiko, Taoda, Yoshiyuki, Mikamiyama-Iwata, Minako, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Tanimoto, Norihiko, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Garvey, Edward P, Fujiwara, Tamio
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
Get full text
Journal Article
Imidazo[1,2- a]pyridines with potent activity against herpesviruses
Gudmundsson, Kristjan S., Johns, Brian A.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Get full text
Journal Article
Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore
Kawasuji, Takashi, Johns, Brian A, Yoshida, Hiroshi, Taishi, Teruhiko, Taoda, Yoshiyuki, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Fujiwara, Tamio
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
Get full text
Journal Article
Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia
Armstrong, Allison J, Henke, Brad R, Collado, Maria Sol, Taylor, Justin M, Pourtaheri, Taylor D, Dillberger, John E, Roper, Thomas D, Wamhoff, Brian R, Olson, Matthew W, Figler, Robert A, Hoang, Stephen A, Reardon, John E, Johns, Brian A
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
Get full text
Journal Article
Inhibition of the Ribonuclease H Activity of HIV-1 Reverse Transcriptase by GSK5750 Correlates with Slow Enzyme-Inhibitor Dissociation
Beilhartz, Greg L., Ngure, Marianne, Johns, Brian A., DeAnda, Felix, Gerondelis, Peter, Götte, Matthias
Published in The Journal of biological chemistry (06.06.2014)
Published in The Journal of biological chemistry (06.06.2014)
Get full text
Journal Article
A novel small molecule approach for the treatment of propionic and methylmalonic acidemias
Armstrong, Allison J., Collado, Maria Sol, Henke, Brad R., Olson, Matthew W., Hoang, Stephen A., Hamilton, Christin A., Pourtaheri, Taylor D., Chapman, Kimberly A., Summar, Marshall M., Johns, Brian A., Wamhoff, Brian R., Reardon, John E., Figler, Robert A.
Published in Molecular genetics and metabolism (01.05.2021)
Published in Molecular genetics and metabolism (01.05.2021)
Get full text
Journal Article
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore
Johns, Brian A., Weatherhead, Jason G., Allen, Scott H., Thompson, James B., Garvey, Edward P., Foster, Scott A., Jeffrey, Jerry L., Miller, Wayne H.
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Get full text
Journal Article