Synthesis and Structure−Activity Relationship of Fluoro Analogues of 8-{2-[4-(4-Methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as Selective α1d-Adrenergic Receptor Antagonists
Konkel, Michael J, Wetzel, John M, Cahir, Marie, Craig, Douglas A, Noble, Stewart A, Gluchowski, Charles
Published in Journal of medicinal chemistry (21.04.2005)
Published in Journal of medicinal chemistry (21.04.2005)
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Synthesis and SAR Investigations for Novel Melanin-Concentrating Hormone 1 Receptor (MCH1) Antagonists Part 1. The Discovery of Arylacetamides as Viable Replacements for the Dihydropyrimidinone Moiety of an HTS Hit
Jiang, Yu, Chen, Chien-An, Lu, Kai, Daniewska, Irena, De Leon, John, Kong, Ron, Forray, Carlos, Li, Boshan, Hegde, Laxminarayan G, Wolinsky, Toni D, Craig, Douglas A, Wetzel, John M, Andersen, Kim, Marzabadi, Mohammad R
Published in Journal of medicinal chemistry (09.08.2007)
Published in Journal of medicinal chemistry (09.08.2007)
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Synthesis and SAR Investigations for Novel Melanin-Concentrating Hormone 1 Receptor (MCH1) Antagonists Part 2: A Hybrid Strategy Combining Key Fragments of HTS Hits
Chen, Chien-An, Jiang, Yu, Lu, Kai, Daniewska, Irena, Mazza, Christine G, Negron, Leonardo, Forray, Carlos, Parola, Tony, Li, Boshan, Hegde, Laxminarayan G, Wolinsky, Toni D, Craig, Douglas A, Kong, Ron, Wetzel, John M, Andersen, Kim, Marzabadi, Mohammad R
Published in Journal of medicinal chemistry (09.08.2007)
Published in Journal of medicinal chemistry (09.08.2007)
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Design and Synthesis of Novel α1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia
Nagarathnam, Dhanapalan, Wetzel, John M, Miao, Shou Wu, Marzabadi, Mohammad R, Chiu, George, Wong, Wai C, Hong, Xingfang, Fang, James, Forray, Carlos, Branchek, Theresa A, Heydorn, William E, Chang, Raymond S. L, Broten, Theodore, Schorn, Terry W, Gluchowski, Charles
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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Localization of the alpha 1A-adrenoceptor in the human prostate
Lepor, H, Tang, R, Kobayashi, S, Shapiro, E, Forray, C, Wetzel, J M, Gluchowski, C
Published in The Journal of urology (01.12.1995)
Published in The Journal of urology (01.12.1995)
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De Novo Design of a Novel Oxazolidinone Analogue as a Potent and Selective α1A Adrenergic Receptor Antagonist with High Oral Bioavailability
Lagu, Bharat, Tian, Dake, Jeon, Yoon, Li, Chao, Wetzel, John M, Nagarathnam, Dhanapalan, Shen, Quanrong, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Ransom, Richard W, Chan, Tsing-Bao, O'Malley, Stacey S, Schorn, Terry W, Rodrigues, A. David, Kassahun, Kelem, Pettibone, Douglas J, Freidinger, Roger, Gluchowski, Charles
Published in Journal of medicinal chemistry (27.07.2000)
Published in Journal of medicinal chemistry (27.07.2000)
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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 4. Structure−Activity Relationship in the Dihydropyrimidine Series
Wong, Wai C, Sun, Wanying, Lagu, Bharat, Tian, Dake, Marzabadi, Mohammad R, Zhang, Fengqi, Nagarathnam, Dhanapalan, Miao, Shou W, Wetzel, John M, Peng, Jian, Forray, Carlos, Chang, Raymond S. L, Chen, Tsing B, Ransom, Richard, O'Malley, Stacey, Broten, Theodore P, Kling, Paul, Vyas, Kamlesh P, Zhang, Kanyin, Gluchowski, Charles
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 2. Approaches To Eliminate Opioid Agonist Metabolites via Modification of Linker and 4-Methoxycarbonyl-4-phenylpiperidine Moiety
Murali Dhar, T. G, Nagarathnam, Dhanapalan, Marzabadi, Mohammad R, Lagu, Bharat, Wong, Wai C, Chiu, George, Tyagarajan, Sriram, Miao, Shou Wu, Zhang, Fengqi, Sun, Wanying, Tian, Dake, Shen, Quanrong, Zhang, Jack, Wetzel, John M, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Schorn, Terry W, Chen, Tsing Bao, O'Malley, Stacy, Ransom, Richard, Schneck, Kathryn, Bendesky, Robert, Harrell, Charles M, Vyas, Kamlesh P, Zhang, Kanyin, Gilbert, John, Pettibone, Douglas J, Patane, Michael A, Bock, Mark G, Freidinger, Roger M, Gluchowski, Charles
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 1. Structure−Activity Relationship in Dihydropyrimidinones
Nagarathnam, Dhanapalan, Miao, Shou Wu, Lagu, Bharat, Chiu, George, Fang, James, Murali Dhar, T. G, Zhang, Jack, Tyagarajan, Sriram, Marzabadi, Mohammad R, Zhang, Fengqi, Wong, Wai C, Sun, Wanying, Tian, Dake, Wetzel, John M, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Ransom, Richard W, Schorn, Terry W, Chen, Tsing B, O'Malley, Stacey, Kling, Paul, Schneck, Kathryn, Bendesky, Robert, Harrell, Charles M, Vyas, Kamlesh P, Gluchowski, Charles
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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Discovery of .alpha.1a-Adrenergic Receptor Antagonists Based on the L-Type Ca2+ Channel Antagonist Niguldipine
Wetzel, John M, Miao, Shou Wu, Forray, Carlos, Borden, Laurence A, Branchek, Theresa A, Gluchowski, Charles
Published in Journal of medicinal chemistry (01.05.1995)
Published in Journal of medicinal chemistry (01.05.1995)
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Identification of a Dihydropyridine as a Potent α1a Adrenoceptor-Selective Antagonist That Inhibits Phenylephrine-Induced Contraction of the Human Prostate
Wong, Wai C, Chiu, George, Wetzel, John M, Marzabadi, Mohammad R, Nagarathnam, Dhanapalan, Wang, Diana, Fang, James, Miao, Shou Wu, Hong, Xingfang, Forray, Carlos, Vaysse, Pierre J.-J, Branchek, Theresa A, Gluchowski, Charles, Tang, Rui, Lepor, Herbert
Published in Journal of medicinal chemistry (02.07.1998)
Published in Journal of medicinal chemistry (02.07.1998)
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Characterization of specific binding of [formula omitted]L-762,459, a selective α1A-adrenoceptor radioligand to rat and human tissues
O'Malley, Stacey S, Chen, Tsing B, Francis, Barbara E, Gibson, Raymond E, Burns, H.Donald, DiSalvo, Jerry, Bayne, Marvin L, Wetzel, John M, Nagarathnam, Dhanapalan, Marzabadi, Mohammad, Gluchowski, Charles, Chang, Raymond S.L
Published in European journal of pharmacology (01.05.1998)
Published in European journal of pharmacology (01.05.1998)
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Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF
Bonini, James A., Jones, Kenneth A., Adham, Nika, Forray, Carlos, Artymyshyn, Roman, Durkin, Margaret M., Smith, Kelli E., Tamm, Joseph A., Boteju, Lakmal W., Lakhlani, Parul P., Raddatz, Rita, Yao, Wen-Jeng, Ogozalek, Kristine L., Boyle, Noel, Kouranova, Evguenia V., Quan, Yong, Vaysse, Pierre J., Wetzel, John M., Branchek, Theresa A., Gerald, Christophe, Borowsky, Beth
Published in The Journal of biological chemistry (15.12.2000)
Published in The Journal of biological chemistry (15.12.2000)
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