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Chen, Zhoumou, Doyle, Timothy M., Luongo, Livio, Largent-Milnes, Tally M., Giancotti, Luigino Antonio, Kolar, Grant, Squillace, Silvia, Boccella, Serena, Walker, John K., Pendleton, Alexander, Spiegel, Sarah, Neumann, William L., Vanderah, Todd W., Salvemini, Daniela
Published in Proceedings of the National Academy of Sciences - PNAS (21.05.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (21.05.2019)
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Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB
Murray, Meghan H, Valfort, Aurore Cecile, Koelblen, Thomas, Ronin, Céline, Ciesielski, Fabrice, Chatterjee, Arindam, Veerakanellore, Giri Babu, Elgendy, Bahaa, Walker, John K, Hegazy, Lamees, Burris, Thomas P
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Published in Nature communications (21.11.2022)
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Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa
Mehla, Jitender, Malloci, Giuliano, Mansbach, Rachael, López, Cesar A, Tsivkovski, Ruslan, Haynes, Keith, Leus, Inga V, Grindstaff, Sally B, Cascella, Robert H, D'Cunha, Napoleon, Herndon, Liam, Hengartner, Nicolas W, Margiotta, Enrico, Atzori, Alessio, Vargiu, Attilio V, Manrique, Pedro D, Walker, John K, Lomovskaya, Olga, Ruggerone, Paolo, Gnanakaran, S, Rybenkov, Valentin V, Zgurskaya, Helen I
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Published in mBio (19.01.2021)
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A Repurposed Drug Screen Identifies Compounds That Inhibit the Binding of the COVID-19 Spike Protein to ACE2
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Published in Frontiers in pharmacology (14.06.2021)
Published in Frontiers in pharmacology (14.06.2021)
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Predicting permeation of compounds across the outer membrane of P. aeruginosa using molecular descriptors
Manrique, Pedro D, Leus, Inga V, López, César A, Mehla, Jitender, Malloci, Giuliano, Gervasoni, Silvia, Vargiu, Attilio V, Kinthada, Rama K, Herndon, Liam, Hengartner, Nicolas W, Walker, John K, Rybenkov, Valentin V, Ruggerone, Paolo, Zgurskaya, Helen I, Gnanakaran, S
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Published in Communications chemistry (12.04.2024)
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Structural Bioinformatics-Based Prediction of Exceptional Selectivity of p38 MAP Kinase Inhibitor PH-797804
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Published in Biochemistry (Easton) (14.07.2009)
Published in Biochemistry (Easton) (14.07.2009)
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Multidrug Efflux Pumps and the Two-Faced Janus of Substrates and Inhibitors
Zgurskaya, Helen I, Walker, John K, Parks, Jerry M, Rybenkov, Valentin V
Published in Accounts of chemical research (16.02.2021)
Published in Accounts of chemical research (16.02.2021)
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A Synthetic ERR Agonist Alleviates Metabolic Syndrome
Billon, Cyrielle, Schoepke, Emmalie, Avdagic, Amer, Chatterjee, Arindam, Butler, Andrew A, Elgendy, Bahaa, Walker, John K, Burris, Thomas P
Published in The Journal of pharmacology and experimental therapeutics (01.02.2024)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2024)
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Discovery and Characterization of Atropisomer PH-797804, a p38 MAP Kinase Inhibitor, as a Clinical Drug Candidate
Xing, Li, Devadas, Balekudru, Devraj, Rajesh V., Selness, Shaun R., Shieh, Huey, Walker, John K., Mao, Michael, Messing, Dean, Samas, Brian, Yang, Jerry Z., Anderson, Gary D., Webb, Elizabeth G., Monahan, Joseph B.
Published in ChemMedChem (06.02.2012)
Published in ChemMedChem (06.02.2012)
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Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold
Green, Adam T., Moniruzzaman, Mohammad, Cooper, Connor J., Walker, John K., Smith, Jeremy C., Parks, Jerry M., Zgurskaya, Helen I.
Published in Biochimica et biophysica acta. General subjects (01.06.2020)
Published in Biochimica et biophysica acta. General subjects (01.06.2020)
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Identification and structure–activity relationships for a series of N, N-disubstituted 2-aminobenzothiazoles as potent inhibitors of S. aureus
Cao, Feng, Kinthada, Ramakumar, Boehm, Terri, D' Cunha, Napoleon, Leus, Inga V., Orth, Cari, Zgurskaya, Helen I., Walker, John K.
Published in Bioorganic & medicinal chemistry letters (01.06.2023)
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Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs
Xu, Xin, Herdendorf, Timothy J, Duan, Huiquan, Rohlik, Denise L, Roy, Sourav, Zhou, Hinman, Alkhateeb, Haya, Khandelwal, Sanjay, Zhou, Qilong, Li, Ping, Arepally, Gowthami M, Walker, John K, Garcia, Brandon L, Geisbrecht, Brian V
Published in The Journal of immunology (1950) (15.02.2024)
Published in The Journal of immunology (1950) (15.02.2024)
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Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase
Selness, Shaun R., Devraj, Rajesh V., Monahan, Joseph B., Boehm, Terri L., Walker, John K., Devadas, Balekudru, Durley, Richard C., Kurumbail, Ravi, Shieh, Huey, Xing, Li, Hepperle, Michael, Rucker, Paul V., Jerome, Kevin D., Benson, Alan G., Marrufo, Laura D., Madsen, Heather M., Hitchcock, Jeff, Owen, Tom J., Christie, Lance, Promo, Michele A., Hickory, Brian S., Alvira, Edgardo, Naing, Win, Blevis-Bal, Radhika
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
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Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function
Xu, Weiyi, Billon, Cyrielle, Li, Hui, Wilderman, Andrea, Qi, Lei, Graves, Andrea, Rideb, Jernie Rae Dela Cruz, Zhao, Yuanbiao, Hayes, Matthew, Yu, Keyang, Losby, McKenna, Hampton, Carissa S, Adeyemi, Christiana M, Hong, Seok Jae, Nasiotis, Eleni, Fu, Chen, Oh, Tae Gyu, Fan, Weiwei, Downes, Michael, Welch, Ryan D, Evans, Ronald M, Milosavljevic, Aleksandar, Walker, John K, Jensen, Brian C, Pei, Liming, Burris, Thomas, Zhang, Lilei
Published in Circulation (New York, N.Y.) (16.01.2024)
Published in Circulation (New York, N.Y.) (16.01.2024)
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GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain
Braden, Kathryn, Giancotti, Luigino Antonio, Chen, Zhoumou, DeLeon, Chelsea, Latzo, Nick, Boehn, Terri, D'Cunha, Napoleon, Thompson, Bonne M, Doyle, Timothy M, McDonald, Jeffrey G, Walker, John K, Kolar, Grant R, Arnatt, Christopher Kent, Salvemini, Daniela
Published in The Journal of pharmacology and experimental therapeutics (01.11.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2020)
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Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity
Billon, Cyrielle, Sitaula, Sadichha, Banerjee, Subhashis, Welch, Ryan, Elgendy, Bahaa, Hegazy, Lamees, Oh, Tae Gyu, Kazantzis, Melissa, Chatterjee, Arindam, Chrivia, John, Hayes, Matthew E., Xu, Weiyi, Hamilton, Angelica, Huss, Janice M., Zhang, Lilei, Walker, John K., Downes, Michael, Evans, Ronald M., Burris, Thomas P.
Published in ACS chemical biology (21.04.2023)
Published in ACS chemical biology (21.04.2023)
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Machine Learning Algorithm Identifies an Antibiotic Vocabulary for Permeating Gram-Negative Bacteria
Mansbach, Rachael A, Leus, Inga V, Mehla, Jitender, Lopez, Cesar A, Walker, John K, Rybenkov, Valentin V, Hengartner, Nicolas W, Zgurskaya, Helen I, Gnanakaran, S
Published in Journal of chemical information and modeling (22.06.2020)
Published in Journal of chemical information and modeling (22.06.2020)
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Identification and Structure–Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli
Haynes, Keith M, Abdali, Narges, Jhawar, Varsha, Zgurskaya, Helen I, Parks, Jerry M, Green, Adam T, Baudry, Jerome, Rybenkov, Valentin V, Smith, Jeremy C, Walker, John K
Published in Journal of medicinal chemistry (27.07.2017)
Published in Journal of medicinal chemistry (27.07.2017)
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Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney
Wang, Xiaoxin X, Myakala, Komuraiah, Libby, Andrew E, Krawczyk, Ewa, Panov, Julia, Jones, Bryce A, Bhasin, Kanchan, Shults, Nataliia, Qi, Yue, Krausz, Kristopher W, Zerfas, Patricia M, Takahashi, Shogo, Daneshpajouhnejad, Parnaz, Titievsky, Avi, Taranenko, Elizaveta, Billon, Cyrielle, Chatterjee, Arindam, Elgendy, Bahaa, Walker, John K, Albanese, Chris, Kopp, Jeffrey B, Rosenberg, Avi Z, Gonzalez, Frank J, Guha, Udayan, Brodsky, Leonid, Burris, Thomas P, Levi, Moshe
Published in The American journal of pathology (01.12.2023)
Published in The American journal of pathology (01.12.2023)
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A Selective ERRα/γ Inverse Agonist, SLU-PP-1072, Inhibits the Warburg Effect and Induces Apoptosis in Prostate Cancer Cells
Schoepke, Emmalie, Billon, Cyrielle, Haynes, Keith M, Avdagic, Amer, Sitaula, Sadichha, Sanders, Ryan, Adeyemi, Christiana M, Walker, John K, Burris, Thomas P
Published in ACS chemical biology (18.09.2020)
Published in ACS chemical biology (18.09.2020)
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