Peptide Inhibitors of West Nile NS3 Protease: SAR Study of Tetrapeptide Aldehyde Inhibitors
Knox, John E, Ma, Ngai Ling, Yin, Zheng, Patel, Sejal J, Wang, Wei-Ling, Chan, Wai-Ling, Ranga Rao, K. R, Wang, Gang, Ngew, Xinyi, Patel, Viral, Beer, David, Lim, Siew Pheng, Vasudevan, Subhash G, Keller, Thomas H
Published in Journal of medicinal chemistry (02.11.2006)
Published in Journal of medicinal chemistry (02.11.2006)
Get full text
Journal Article
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS
Schulze, Christopher J., Seamon, Kyle J., Zhao, Yulei, Yang, Yu C., Cregg, Jim, Kim, Dongsung, Tomlinson, Aidan, Choy, Tiffany J., Wang, Zhican, Sang, Ben, Pourfarjam, Yasin, Lucas, Jessica, Cuevas-Navarro, Antonio, Ayala-Santos, Carlos, Vides, Alberto, Li, Chuanchuan, Marquez, Abby, Zhong, Mengqi, Vemulapalli, Vidyasiri, Weller, Caroline, Gould, Andrea, Whalen, Daniel M., Salvador, Anthony, Milin, Anthony, Saldajeno-Concar, Mae, Dinglasan, Nuntana, Chen, Anqi, Evans, Jim, Knox, John E., Koltun, Elena S., Singh, Mallika, Nichols, Robert, Wildes, David, Gill, Adrian L., Smith, Jacqueline A. M., Lito, Piro
Published in Science (American Association for the Advancement of Science) (18.08.2023)
Published in Science (American Association for the Advancement of Science) (18.08.2023)
Get full text
Journal Article
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
Holderfield, Matthew, Lee, Bianca J., Jiang, Jingjing, Tomlinson, Aidan, Seamon, Kyle J., Mira, Alessia, Patrucco, Enrico, Goodhart, Grace, Dilly, Julien, Gindin, Yevgeniy, Dinglasan, Nuntana, Wang, Yingyun, Lai, Lick Pui, Cai, Shurui, Jiang, Lingyan, Nasholm, Nicole, Shifrin, Nataliya, Blaj, Cristina, Shah, Harshit, Evans, James W., Montazer, Nilufar, Lai, Oliver, Shi, Jade, Ahler, Ethan, Quintana, Elsa, Chang, Stephanie, Salvador, Anthony, Marquez, Abby, Cregg, Jim, Liu, Yang, Milin, Anthony, Chen, Anqi, Ziv, Tamar Bar, Parsons, Dylan, Knox, John E., Klomp, Jennifer E., Roth, Jennifer, Rees, Matthew, Ronan, Melissa, Cuevas-Navarro, Antonio, Hu, Feng, Lito, Piro, Santamaria, David, Aguirre, Andrew J., Waters, Andrew M., Der, Channing J., Ambrogio, Chiara, Wang, Zhengping, Gill, Adrian L., Koltun, Elena S., Smith, Jacqueline A. M., Wildes, David, Singh, Mallika
Published in Nature (London) (23.05.2024)
Published in Nature (London) (23.05.2024)
Get full text
Journal Article
Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors
Burnett, G. Leslie, Yang, Yu C., Aggen, James B., Pitzen, Jennifer, Gliedt, Micah K., Semko, Chris M., Marquez, Abby, Evans, James W., Wang, Gang, Won, Walter S., Tomlinson, Aidan C. A., Kiss, Gert, Tzitzilonis, Christos, Thottumkara, Arun P., Cregg, James, Mellem, Kevin T., Choi, Jong S., Lee, Julie C., Zhao, Yongyuan, Lee, Bianca J., Meyerowitz, Justin G., Knox, John E., Jiang, Jingjing, Wang, Zhican, Wildes, David, Wang, Zhengping, Singh, Mallika, Smith, Jacqueline A. M., Gill, Adrian L.
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
Get full text
Journal Article
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Jiang, Jingjing, Jiang, Lingyan, Maldonato, Benjamin J, Wang, Yingyun, Holderfield, Matthew, Aronchik, Ida, Winters, Ian P, Salman, Zeena, Blaj, Cristina, Menard, Marie, Brodbeck, Jens, Chen, Zhe, Wei, Xing, Rosen, Michael J, Gindin, Yevgeniy, Lee, Bianca J, Evans, James W, Chang, Stephanie, Wang, Zhican, Seamon, Kyle J, Parsons, Dylan, Cregg, James, Marquez, Abby, Tomlinson, Aidan C A, Yano, Jason K, Knox, John E, Quintana, Elsa, Aguirre, Andrew J, Arbour, Kathryn C, Reed, Abby, Gustafson, W Clay, Gill, Adrian L, Koltun, Elena S, Wildes, David, Smith, Jacqueline A M, Wang, Zhengping, Singh, Mallika
Published in Cancer discovery (09.04.2024)
Published in Cancer discovery (09.04.2024)
Get full text
Journal Article
Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography
Kroeck, Kyle G., Sacco, Michael D., Smith, Emmanuel W., Zhang, Xiujun, Shoun, Daniel, Akhtar, Afroza, Darch, Sophie E., Cohen, Frederick, Andrews, Logan D., Knox, John E., Chen, Yu
Published in Scientific reports (29.10.2019)
Published in Scientific reports (29.10.2019)
Get full text
Journal Article
Synthesis and antitubercular activity of 7-(R)-and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824
XIAOJIN LI, MANJUNATHA, Ujjini H, GOODWIN, Michael B, KNOX, John E, LIPINSKI, Christopher A, KELLER, Thomas H, BARRY, Clifton E, DOWD, Cynthia S
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
Get full text
Journal Article
Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis
Kurabachew, Mekonnen, Lu, Stephen H. J., Krastel, Philipp, Schmitt, Esther K., Suresh, Bangalore L., Goh, Anne, Knox, John E., Ma, Ngai Ling, Jiricek, Jan, Beer, David, Cynamon, Michael, Petersen, Frank, Dartois, Veronique, Keller, Thomas, Dick, Thomas, Sambandamurthy, Vasan K.
Published in Journal of antimicrobial chemotherapy (01.10.2008)
Published in Journal of antimicrobial chemotherapy (01.10.2008)
Get full text
Journal Article
Chemical failure modes of AlQ3-based OLEDs: AlQ3 hydrolysis
Knox, John E, Halls, Mathew D, Hratchian, Hrant P, Schlegel, H Bernhard
Published in Physical chemistry chemical physics : PCCP (01.01.2006)
Published in Physical chemistry chemical physics : PCCP (01.01.2006)
Get more information
Journal Article
Experimental and Theoretical Study of the Coordination of 1,2,4-Triazolato, Tetrazolato, and Pentazolato Ligands to the [K(18-crown-6)]+ Fragment
Kobrsi, Issam, Zheng, Wenjun, Knox, John E, Heeg, Mary Jane, Schlegel, H. Bernhard, Winter, Charles H
Published in Inorganic chemistry (16.10.2006)
Published in Inorganic chemistry (16.10.2006)
Get full text
Journal Article
HETEROCYCLIC CARBOXYLATE COMPOUNDS AS GLYCOLATE OXIDASE INHIBITORS
GUO HONGYAN, PYUN HYUNG-JUNG, MANOJ C DESAI, AURPON W MITRA, AMY S LEE, JOHN E KNOX, JULIAN A CODELLI, DEVLEENA M SHIVAKUMAR, XU LIANHONG
Year of Publication 16.04.2024
Get full text
Year of Publication 16.04.2024
Patent
Yellow fever virus NS3 protease: peptide-inhibition studies
Lohr, Kristina, Knox, John E, Phong, Wai Yee, Ma, Ngai Ling, Yin, Zheng, Sampath, Aruna, Patel, Sejal J, Wang, Wei-Ling, Chan, Wai-Ling, Rao, K. R. Ranga, Wang, Gang, Vasudevan, Subhash G, Keller, Thomas H, Lim, Siew Pheng
Published in Journal of general virology (01.08.2007)
Published in Journal of general virology (01.08.2007)
Get full text
Journal Article
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors
Yin, Zheng, Patel, Sejal J., Wang, Wei-Ling, Chan, Wai-Ling, Ranga Rao, K.R., Wang, Gang, Ngew, Xinyi, Patel, Viral, Beer, David, Knox, John E., Ma, Ngai Ling, Ehrhardt, Claus, Lim, Siew Pheng, Vasudevan, Subhash G., Keller, Thomas H.
Published in Bioorganic & medicinal chemistry letters (2006)
Published in Bioorganic & medicinal chemistry letters (2006)
Get full text
Journal Article
Synthesis, Structure, and Properties of Magnesocene Amine Adducts. Structural Distortions Arising from N−H···C5H5 - Hydrogen Bonding and Molecular Orbital Calculations Thereof
Xia, Aibing, Knox, John E, Heeg, Mary Jane, Schlegel, H. Bernhard, Winter, Charles H
Published in Organometallics (29.09.2003)
Published in Organometallics (29.09.2003)
Get full text
Journal Article
Weak Carbon−Hydrogen−Nitrogen Interactions Affect the Heterocyclic Ligand Bonding Modes in Barium Complexes Containing η2-Tetrazolato and η2-Pentazolato Ligands
Kobrsi, Issam, Knox, John E, Heeg, Mary Jane, Schlegel, H. Bernhard, Winter, Charles H
Published in Inorganic chemistry (11.07.2005)
Published in Inorganic chemistry (11.07.2005)
Get full text
Journal Article
MCL-1 INHIBITORS
WATKINS WILLIAM J, HWANG TAE H, DEVAN NADUTHAMBI, DAVID W LIN, SCOTT E LAZERWITH, JUAN A GUERRERO, CHU HANG, KOBAYASHI TETSUYA, ANNA E HURTLEY, LI XIAOFEN, DARRYL KATO, YANG HONG, CHANDRASEKAR VENKATARAMANI, JONATHAN W MEDLEY, JIANG LAN, MICHAEL L MITCHELL, ZACHARY NEWBY, NEIL H SQUIRES, JOHN E KNOX, VICKIE H TSUI
Year of Publication 01.07.2021
Get full text
Year of Publication 01.07.2021
Patent
Synthesis, Structure, Bridge−Terminal Exchange Kinetics, and Molecular Orbital Calculations of Pyrazolate-Bridged Digallium Complexes Containing Bridging Phenyl Groups
Sirimanne, Chatu T, Knox, John E, Heeg, Mary Jane, Schlegel, H. Bernhard, Winter, Charles H
Published in Journal of the American Chemical Society (17.09.2003)
Published in Journal of the American Chemical Society (17.09.2003)
Get full text
Journal Article
AMINOTRIAZINE DERIVATIVES USEFUL AS TANK-BINDING KINASE INHIBITOR COMPOUNDS
WATKINS WILLIAM J, ZHAO ZHONGDONG, DEVAN NADUTHAMBI, CHANDRASEKAR VENKATARAMANI, JOHN E KNOX JR, JOSHUA A KAPLAN, JUAN A GUERRERO, SCOTT A MITCHELL, BARTON W PHILLIPS, JENNIFER R LO, DU ZHIMIN, WANG PEIYUAN
Year of Publication 11.10.2018
Get full text
Year of Publication 11.10.2018
Patent
Abstract 1261: A next generation tri-complex KRASG12C(ON) inhibitor directly targets the active, GTP-bound state of mutant RAS and may overcome resistance to KRASG12C(OFF) inhibition
Nichols, Robert J., Cregg, Jim, Schulze, Christopher J., Wang, Zhican, Yang, Kevin, Jiang, Jingjing, Whalen, Daniel M., Hansen, Rich, Garrenton, Lindsay S., Bermingham, Alun, Knox, John E., Choy, Tiffany, Reyes, Denise, Rios, Mayra, Seamon, Kyle, Longhi, Michael, Chou, Kang-Jye, Li, Shaoling, Wildes, David P., Singh, Mallika, Koltun, Elena S., Gill, Adrian L., Smith, Jacqueline A. M.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Get full text
Journal Article