Search Results - "JOHN DARBYSHIRE" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models

Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models

by Valente, Delphine, Mauriac, Christine, Schmidt, Thorsten, Focken, Ingo, Beninga, Jochen, Mackness, Brian, Qiu, Huawei, Vicat, Pascale, Kandira, Abdullah, Radošević, Katarina, Rao, Srini, Darbyshire, John, Kabiri, Mostafa
Published in mAbs (01.01.2020)

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Discovery of 3-Methyl-N-(1-oxy-3‘,4‘,5‘,6‘-tetrahydro-2‘H-[2,4‘-bipyridine]-1‘-ylmethyl)benzamide (ABT-670), an Orally Bioavailable Dopamine D4 Agonist for the Treatment of Erectile Dysfunction

Discovery of 3-Methyl-N-(1-oxy-3‘,4‘,5‘,6‘-tetrahydro-2‘H-[2,4‘-bipyridine]-1‘-ylmethyl)benzamide (ABT-670), an Orally Bioavailable Dopamine D4 Agonist for the Treatment of Erectile Dysfunction

by Patel, Meena V, Kolasa, Teodozyj, Mortell, Kathleen, Matulenko, Mark A, Hakeem, Ahmed A, Rohde, Jeffrey J, Nelson, Sherry L, Cowart, Marlon D, Nakane, Masaki, Miller, Loan N, Uchic, Marie E, Terranova, Marc A, El-Kouhen, Odile F, Donnelly-Roberts, Diana L, Namovic, Marian T, Hollingsworth, Peter R, Chang, Renjie, Martino, Brenda R, Wetter, Jill M, Marsh, Kennan C, Martin, Ruth, Darbyshire, John F, Gintant, Gary, Hsieh, Gin C, Moreland, Robert B, Sullivan, James P, Brioni, Jorge D, Stewart, Andrew O
Published in Journal of medicinal chemistry (14.12.2006)

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Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazines

Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazines

by Wagner, Rolf, Larson, Daniel P, Beno, David W. A, Bosse, Todd D, Darbyshire, John F, Gao, Yi, Gates, Bradley D, He, Wenping, Henry, Rodger F, Hernandez, Lisa E, Hutchinson, Douglas K, Jiang, Wen W, Kati, Warren M, Klein, Larry L, Koev, Gennadiy, Kohlbrenner, William, Krueger, A. Chris, Liu, Jinrong, Liu, Yaya, Long, Michelle A, Maring, Clarence J, Masse, Sherie V, Middleton, Tim, Montgomery, Debra A, Pratt, John K, Stuart, Patricia, Molla, Akhteruzzaman, Kempf, Dale J
Published in Journal of medicinal chemistry (26.03.2009)

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The use of soil biofilms for observing protozoan movement and feeding

The use of soil biofilms for observing protozoan movement and feeding

by Darbyshire, John F.
Published in FEMS microbiology letters (15.03.2005)

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Reaction Kinetics for Nitrosation of Cysteine and Glutathione in Aerobic Nitric Oxide Solutions at Neutral pH. Insights into the Fate and Physiological Effects of Intermediates Generated in the NO/O2 Reaction

Reaction Kinetics for Nitrosation of Cysteine and Glutathione in Aerobic Nitric Oxide Solutions at Neutral pH. Insights into the Fate and Physiological Effects of Intermediates Generated in the NO/O2 Reaction

by Wink, David A, Nims, Raymond W, Darbyshire, John F, Christodoulou, Danae, Hanbauer, Ingeborg, Cox, George W, Laval, Francoise, Laval, Jacques, Cook, John A
Published in Chemical research in toxicology (01.07.1994)

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Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as KATP channel openers

Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as KATP channel openers

by DRIZIN, Irene, ALTENBACH, Robert J, CARROLL, William A, BUCKNER, Steven A, WHITEAKER, Kristi L, SCOTT, Victoria E, DARBYSHIRE, John F, JAYANTI, Venkata, HENRY, Rodger F, COGHLAN, Michael J, GOPALAKRISHNAN, Murali
Published in Bioorganic & medicinal chemistry (15.04.2004)

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Functional diversity amongst soil protozoa

Functional diversity amongst soil protozoa

by Couteaux, M.M, Darbyshire, J.F
Published in Applied soil ecology : a section of Agriculture, ecosystems & environment (01.11.1998)

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Intramolecular Isotope Effects for Benzylic Hydroxylation of Isomeric Xylenes and 4,4‘-Dimethylbiphenyl by Cytochrome P450: Relationship between Distance of Methyl Groups and Masking of the Intrinsic Isotope Effect

Intramolecular Isotope Effects for Benzylic Hydroxylation of Isomeric Xylenes and 4,4‘-Dimethylbiphenyl by Cytochrome P450: Relationship between Distance of Methyl Groups and Masking of the Intrinsic Isotope Effect

by Iyer, Krishna R, Jones, Jeffrey P, Darbyshire, John F, Trager, William F
Published in Biochemistry (Easton) (10.06.1997)

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Experimental and Theoretical Study of the Effect of Active-Site Constrained Substrate Motion on the Magnitude of the Observed Intramolecular Isotope Effect for the P450 101 Catalyzed Benzylic Hydroxylation of Isomeric Xylenes and 4,4‘-Dimethylbiphenyl

Experimental and Theoretical Study of the Effect of Active-Site Constrained Substrate Motion on the Magnitude of the Observed Intramolecular Isotope Effect for the P450 101 Catalyzed Benzylic Hydroxylation of Isomeric Xylenes and 4,4‘-Dimethylbiphenyl

by Audergon, Christian, Iyer, Krishna R, Jones, Jeffrey P, Darbyshire, John F, Trager, William F
Published in Journal of the American Chemical Society (13.01.1999)

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Soil protozoa

Soil protozoa

by Darbyshire, J.F. (ed.)
Year of Publication 1994

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Theory for the observed isotope effects on the formation of multiple products by different kinetic mechanisms of cytochrome P450 enzymes

Theory for the observed isotope effects on the formation of multiple products by different kinetic mechanisms of cytochrome P450 enzymes

by Gillette, James R, Darbyshire, John F, Sugiyama, Katsumi
Published in Biochemistry (Easton) (15.03.1994)

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A review of the effects of manipulation of the cysteine residues of rat aryl sulfotransferase IV

A review of the effects of manipulation of the cysteine residues of rat aryl sulfotransferase IV

by Marshall, A.David, Darbyshire, John F, McPhie, Peter, Jakoby, William B
Published in Chemico-biological interactions (20.02.1998)

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Deuterium Isotope Effects on A-Ring and D-Ring Metabolism of Testosterone by CYP2C11: Evidence for Dissociation of Activated Enzyme-Substrate Complexes

Deuterium Isotope Effects on A-Ring and D-Ring Metabolism of Testosterone by CYP2C11: Evidence for Dissociation of Activated Enzyme-Substrate Complexes

by Darbyshire, John F, Gillette, James R, Nagata, Kiyoshi, Sugiyama, Katsumi
Published in Biochemistry (Easton) (01.03.1994)

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Inactivation of horseradish peroxidase by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine

Inactivation of horseradish peroxidase by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine

by Sugiyama, Katsumi, Woods, Amina, Cotter, Robert J, Highet, Robert J, Darbyshire, John F, Osawa, Yoichi, Gillette, James R
Published in Chemical research in toxicology (01.11.1994)

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A review of the effects of manipulation of the cysteine residues of rat aryl sulfotransferase IV1Presented at the 3rd International Sulfation Workshop, Drymen, Scotland, September 23, 1996.1

A review of the effects of manipulation of the cysteine residues of rat aryl sulfotransferase IV1Presented at the 3rd International Sulfation Workshop, Drymen, Scotland, September 23, 1996.1

by Marshall, A.David, Darbyshire, John F, McPhie, Peter, Jakoby, William B
Published in Chemico-biological interactions (01.02.1998)

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pH-Dependent One- and Two-Electron Oxidation of 3,5-Dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine Catalyzed by Horseradish Peroxidase

pH-Dependent One- and Two-Electron Oxidation of 3,5-Dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine Catalyzed by Horseradish Peroxidase

by Sugiyama, Katsumi, Correia, Maria A, Thummel, Kenneth E, Nagata, Kiyoshi, Darbyshire, John F, Osawa, Yoichi, Gillette, James R
Published in Chemical research in toxicology (01.09.1994)

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Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the nitric oxide/oxygen reaction

Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the nitric oxide/oxygen reaction

by Wink, David A, Darbyshire, John F, Nims, Raymond W, Saavedra, Joseph E, Ford, Peter C
Published in Chemical research in toxicology (01.01.1993)

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Discovery of 3-methyl-N-(1-oxy-3 ',4 ',5 ',6 '-tetrahydro-2 ' H-[2,4 '-bipyridine]-1 '-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D-4 agonist for the treatment of erectile dysfunction

Discovery of 3-methyl-N-(1-oxy-3 ',4 ',5 ',6 '-tetrahydro-2 ' H-[2,4 '-bipyridine]-1 '-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D-4 agonist for the treatment of erectile dysfunction

by Patel, Meena V., Kolasa, Teodozyj, Mortell, Kathleen, Matulenko, Mark A., Hakeem, Ahmed A., Rohde, Jeffrey J., Nelson, Sherry L., Cowart, Marlon D., Nakane, Masaki, Miller, Loan N., Uchic, Marie E., Terranova, Marc A., El-Kouhen, Odile F., Donnelly-Roberts, Diana L., Namovic, Marian T., Hollingsworth, Peter R., Chang, Renjie, Martino, Brenda R., Wetter, Jill M., Marsh, Kennan C., Martin, Ruth, Darbyshire, John F., Gintant, Gary, Hsieh, Gin C., Moreland, Robert B., Sullivan, James P., Brioni, Jorge D., Stewart, Andrew O.
Published in Journal of medicinal chemistry (14.12.2006)

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Control of Activity through Oxidative Modification at the Conserved Residue Cys66 of Aryl Sulfotransferase IV

Control of Activity through Oxidative Modification at the Conserved Residue Cys66 of Aryl Sulfotransferase IV

by Marshall, A. David, Darbyshire, John F., Hunter, Ann P., McPhie, Peter, Jakoby, William B.
Published in The Journal of biological chemistry (14.04.1997)

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Methods in Soil Zoology

Methods in Soil Zoology

by Darbyshire, John
Published in Soil biology & biochemistry (01.07.1995)

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