Inactivation of Caspase‐1 in Rodent Brain: A Novel Anticonvulsive Strategy
Ravizza, Teresa, Lucas, Sian‐Marie, Balosso, Silvia, Bernardino, Liliana, Ku, George, Noé, Francesco, Malva, Joao, Randle, John C. R., Allan, Stuart, Vezzani, Annamaria
Published in Epilepsia (Copenhagen) (01.07.2006)
Published in Epilepsia (Copenhagen) (01.07.2006)
Get full text
Journal Article
IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients
Stack, Jeffrey H, Beaumont, Kevin, Larsen, Paul D, Straley, Kimberly S, Henkel, Greg W, Randle, John C. R, Hoffman, Hal M
Published in The Journal of immunology (1950) (15.08.2005)
Published in The Journal of immunology (1950) (15.08.2005)
Get full text
Journal Article
A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants
Adiwijaya, Bambang S, Herrmann, Eva, Hare, Brian, Kieffer, Tara, Lin, Chao, Kwong, Ann D, Garg, Varun, Randle, John C R, Sarrazin, Christoph, Zeuzem, Stefan, Caron, Paul R
Published in PLoS computational biology (01.04.2010)
Published in PLoS computational biology (01.04.2010)
Get full text
Journal Article
Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y14R Antagonist
Wen, Zhiwei, Salmaso, Veronica, Jung, Young-Hwan, Phung, Ngan B, Gopinatth, Varun, Shah, Qasim, Patterson, Alexandra T, Randle, John C. R, Chen, Zhoumou, Salvemini, Daniela, Lieberman, David I, Whitehead, Gregory S, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
Get full text
Journal Article
Structure–Activity Relationship of Heterocyclic P2Y14 Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres
Jung, Young-Hwan, Salmaso, Veronica, Wen, Zhiwei, Bennett, John M, Phung, Ngan B, Lieberman, David I, Gopinatth, Varun, Randle, John C. R, Chen, Zhoumou, Salvemini, Daniela, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
Get full text
Journal Article
Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y 14 Receptor Antagonists
Wen, Zhiwei, Pramanik, Asmita, Lewicki, Sarah A, Jung, Young-Hwan, Gao, Zhan-Guo, Randle, John C R, Cronin, Chunxia, Chen, Zhoumou, Giancotti, Luigino A, Whitehead, Gregory S, Liang, Bruce T, Breton, Sylvie, Salvemini, Daniela, Cook, Donald N, Jacobson, Kenneth A
Published in Journal of medicinal chemistry (13.07.2023)
Published in Journal of medicinal chemistry (13.07.2023)
Get full text
Journal Article
Alicyclic Ring Size Variation of 4‑Phenyl-2-naphthoic Acid Derivatives as P2Y14 Receptor Antagonists
Wen, Zhiwei, Pramanik, Asmita, Lewicki, Sarah A., Jung, Young-Hwan, Gao, Zhan-Guo, Randle, John C. R., Cronin, Chunxia, Chen, Zhoumou, Giancotti, Luigino A., Whitehead, Gregory S., Liang, Bruce T., Breton, Sylvie, Salvemini, Daniela, Cook, Donald N., Jacobson, Kenneth A.
Published in Journal of medicinal chemistry (13.07.2023)
Published in Journal of medicinal chemistry (13.07.2023)
Get full text
Journal Article
Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y 14 R Antagonist
Wen, Zhiwei, Salmaso, Veronica, Jung, Young-Hwan, Phung, Ngan B, Gopinatth, Varun, Shah, Qasim, Patterson, Alexandra T, Randle, John C R, Chen, Zhoumou, Salvemini, Daniela, Lieberman, David I, Whitehead, Gregory S, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
Get full text
Journal Article
Structure-Activity Relationship of Heterocyclic P2Y 14 Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres
Jung, Young-Hwan, Salmaso, Veronica, Wen, Zhiwei, Bennett, John M, Phung, Ngan B, Lieberman, David I, Gopinatth, Varun, Randle, John C R, Chen, Zhoumou, Salvemini, Daniela, Karcz, Tadeusz P, Cook, Donald N, Jacobson, Kenneth A
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
Get full text
Journal Article
Open-label phase 1b pilot study to assess the antiviral efficacy of simvastatin combined with sertraline in chronic hepatitis C patients
Patel, Keyur, Lim, Seng G, Cheng, Chow W, Lawitz, Eric, Tillmann, Hans L, Chopra, Narinder, Altmeyer, Ralf, Randle, John C R, McHutchison, John G
Published in Antiviral therapy (01.01.2011)
Published in Antiviral therapy (01.01.2011)
Get full text
Journal Article
Chimeras Derived from a P2Y14 Receptor Antagonist and UDP-Sugar Agonists for Potential Treatment of Inflammation
Wen, Zhiwei, Pramanik, Asmita, Lewicki, Sarah A., Jung, Young-Hwan, Gao, Zhan-Guo, Randle, John C. R., Breton, Sylvie, Chen, Zhoumou, Whitehead, Gregory S., Salvemini, Daniela, Cook, Donald N., Jacobson, Kenneth A.
Published in ACS pharmacology & translational science (11.10.2024)
Published in ACS pharmacology & translational science (11.10.2024)
Get full text
Journal Article
Chimeras Derived from a P2Y 14 Receptor Antagonist and UDP-Sugar Agonists for Potential Treatment of Inflammation
Wen, Zhiwei, Pramanik, Asmita, Lewicki, Sarah A, Jung, Young-Hwan, Gao, Zhan-Guo, Randle, John C R, Breton, Sylvie, Chen, Zhoumou, Whitehead, Gregory S, Salvemini, Daniela, Cook, Donald N, Jacobson, Kenneth A
Published in ACS pharmacology & translational science (11.10.2024)
Published in ACS pharmacology & translational science (11.10.2024)
Get full text
Journal Article
Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y(14) Receptor Antagonists
Wen, Zhiwei, Pramanik, Asmita, Lewicki, Sarah A., Jung, Young-Hwan, Gao, Zhan-Guo, Randle, John C. R., Cronin, Chunxia, Chen, Zhoumou, Giancotti, Luigino A., Whitehead, Gregory S., Liang, Bruce T., Breton, Sylvie, Salvemini, Daniela, Cook, Donald N., Jacobson, Kenneth A.
Published in Journal of medicinal chemistry (29.06.2023)
Published in Journal of medicinal chemistry (29.06.2023)
Get full text
Journal Article
Structure-Activity Relationship of Heterocyclic P2Y(14) Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres
Jung, Young-Hwan, Salmaso, Veronica, Wen, Zhiwei, Bennett, John M., Phung, Ngan B., Lieberman, David, Gopinatth, Varun, Randle, John C. R., Chen, Zhoumou, Salvemini, Daniela, Karcz, Tadeusz P., Cook, Donald N., Jacobson, Kenneth A.
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
Get full text
Journal Article
( S )-1-(( S )-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2 R ,3 S )-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18
Wannamaker, Woods, Davies, Robert, Namchuk, Mark, Pollard, John, Ford, Pamella, Ku, George, Decker, Caroline, Charifson, Paul, Weber, Peter, Germann, Ursula A., Kuida, Keisuke, Randle, John C. R.
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
Get full text
Journal Article
Indeno[1,2-b]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity
Jimonet, Patrick, Ribeill, Yves, Bohme, Georg Andrees, Boireau, Alain, Chevé, Michel, Damour, Dominique, Doble, Adam, Genevois-Borella, Arielle, Herman, Frédéric, Imperato, Assunta, Le Guern, Sylvain, Manfré, Franco, Pratt, Jeremy, Randle, John C. R, Stutzmann, Jean-Marie, Mignani, Serge
Published in Journal of medicinal chemistry (15.06.2000)
Published in Journal of medicinal chemistry (15.06.2000)
Get full text
Journal Article
Rapid decrease of wild-type hepatitis C virus on telaprevir treatment
ADIWIJAYA, Bambang S, HARE, Brian, CARON, Paul R, RANDLE, John Cr, NEUMANN, Avidan U, REESINK, Hendrik W, ZEUZEM, Stefan, HERRMANN, Eva
Published in Antiviral therapy (01.01.2009)
Published in Antiviral therapy (01.01.2009)
Get full text
Journal Article
(S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18
Woods Wannamaker, Robert Davies, Mark Namchuk, John Pollard, Pamella Ford, George Ku, Caroline Decker, Paul Charifson, Peter Weber, Ursula A. Germann, Keisuke Kuida, John C. R. Randle
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
Get full text
Journal Article