Search Results - "JOHN, M. FEVIG" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5‑HT2C Receptor Agonists

Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5‑HT2C Receptor Agonists

by Carpenter, Joseph, Wang, Ying, Wu, Gang, Feng, Jianxin, Ye, Xiang-Yang, Morales, Christian L, Broekema, Matthias, Rossi, Karen A, Miller, Keith J, Murphy, Brian J, Wu, Ginger, Malmstrom, Sarah E, Azzara, Anthony V, Sher, Philip M, Fevig, John M, Alt, Andrew, Bertekap, Robert L, Cullen, Mary Jane, Harper, Timothy M, Foster, Kimberly, Luk, Emily, Xiang, Qian, Grubb, Mary F, Robl, Jeffrey A, Wacker, Dean A
Published in Journal of medicinal chemistry (27.07.2017)

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Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT 2C Receptor Agonists

Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT 2C Receptor Agonists

by Carpenter, Joseph, Wang, Ying, Wu, Gang, Feng, Jianxin, Ye, Xiang-Yang, Morales, Christian L, Broekema, Matthias, Rossi, Karen A, Miller, Keith J, Murphy, Brian J, Wu, Ginger, Malmstrom, Sarah E, Azzara, Anthony V, Sher, Philip M, Fevig, John M, Alt, Andrew, Bertekap, Jr, Robert L, Cullen, Mary Jane, Harper, Timothy M, Foster, Kimberly, Luk, Emily, Xiang, Qian, Grubb, Mary F, Robl, Jeffrey A, Wacker, Dean A
Published in Journal of medicinal chemistry (27.07.2017)

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Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists

Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists

by Fevig, John M., Feng, Jianxin, Rossi, Karen A., Miller, Keith J., Wu, Ginger, Hung, Chen-Pin, Ung, Thao, Malmstrom, Sarah E., Zhang, Ge, Keim, William J., Cullen, Mary Jane, Rohrbach, Kenneth W., Qu, Qinling, Gan, Jinping, Pelleymounter, Mary Ann, Robl, Jeffrey A.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)

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Synthesis applications of cationic aza-Cope rearrangements. 24. The aza-Cope-Mannich approach to Strychnos alkaloids. Short stereocontrolled total syntheses of (.+-.)-dehydrotubifoline and (.+-.)-akuammicine

Synthesis applications of cationic aza-Cope rearrangements. 24. The aza-Cope-Mannich approach to Strychnos alkaloids. Short stereocontrolled total syntheses of (.+-.)-dehydrotubifoline and (.+-.)-akuammicine

by Angle, Steven R, Fevig, John M, Knight, Steven D, Marquis, Robert W, Overman, Larry E
Published in Journal of the American Chemical Society (01.05.1993)

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Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa

Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa

by FEVIG, John M, CACCIOLA, Joseph, BURIAK, Joseph, ROSSI, Karen A, KNABB, Robert M, LUETTGEN, Joseph M, WONG, Pancras C, BAI, Stephen A, WEXLER, Ruth R, LAM, Patrick Y. S
Published in Bioorganic & medicinal chemistry letters (15.07.2006)

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Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

by Pinto, Donald J. P, Orwat, Michael J, Wang, Shuaige, Fevig, John M, Quan, Mimi L, Amparo, Eugene, Cacciola, Joseph, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela M, Luettgen, Joseph M, Liang, Li, Aungst, Bruce J, Wright, Matthew R, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R, Lam, Patrick Y. S
Published in Journal of medicinal chemistry (15.02.2001)

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Structure-Based Design of Novel Guanidine/Benzamidine Mimics: Potent and Orally Bioavailable Factor Xa Inhibitors as Novel Anticoagulants

Structure-Based Design of Novel Guanidine/Benzamidine Mimics: Potent and Orally Bioavailable Factor Xa Inhibitors as Novel Anticoagulants

by Lam, Patrick Y. S, Clark, Charles G, Li, Renhua, Pinto, Donald J. P, Orwat, Michael J, Galemmo, Robert A, Fevig, John M, Teleha, Christopher A, Alexander, Richard S, Smallwood, Angela M, Rossi, Karen A, Wright, Matthew R, Bai, Stephen A, He, Kan, Luettgen, Joseph M, Wong, Pancras C, Knabb, Robert M, Wexler, Ruth R
Published in Journal of medicinal chemistry (09.10.2003)

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New approach to Strychnos alkaloids. Stereocontrolled total synthesis of (.+-.)-dehydrotubifoline

New approach to Strychnos alkaloids. Stereocontrolled total synthesis of (.+-.)-dehydrotubifoline

by Fevig, John M, Marquis, Robert W, Overman, Larry E
Published in Journal of the American Chemical Society (01.06.1991)

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Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa

Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa

by LI, Yun-Long, FEVIG, John M, WEXLER, Ruth R, LAM, Patrick Y. S, CACCIOLA, Joseph, BURIAK, Joseph, ROSSI, Karen A, JONA, Janan, KNABB, Robert M, LUETTGEN, Joseph M, WONG, Pancras C, BAI, Stephen A
Published in Bioorganic & medicinal chemistry letters (01.10.2006)

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Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors

Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors

by Quan, Mimi L., Han, Qi, Fevig, John M., Lam, Patrick Y.S., Bai, Steve, Knabb, Robert M., Luettgen, Joseph M., Wong, Pancras C., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)

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Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core

Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core

by Fevig, John M., Pinto, Donald J., Han, Qi, Quan, Mimi L., Pruitt, James R., Jacobson, Irina C., Galemmo, Jr, Robert A., Wang, Shuaige, Orwat, Michael J., Bostrom, Lori L., Knabb, Robert M., Wong, Pancras C., Lam, Patrick Y.S., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry letters (12.03.2001)

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Rational design of boropeptide thrombin inhibitors: β,β-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile

by Fevig, John M, Buriak, Joseph, Cacciola, Joseph, Alexander, Richard S, Kettner, Charles A, Knabb, Robert M, Pruitt, James R, Weber, Patricia C, Wexler, Ruth R
Published in Bioorganic & medicinal chemistry letters (03.02.1998)

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Biochemical and Crystallographic Characterization of Homologous Non-peptidic Thrombin Inhibitors Having Alternate Binding Modes

Biochemical and Crystallographic Characterization of Homologous Non-peptidic Thrombin Inhibitors Having Alternate Binding Modes

by Strickland, Corey L., Fevig, John. M., Galemmo Jr, Robert A., Wells, Brian L., Kettner, Charles A., Weber, Patricia C.
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.1998)

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Preparation of 1-(4-methoxyphenyl)-1 H-pyrazolo[4,3- d]pyrimidin-7(6 H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa

Preparation of 1-(4-methoxyphenyl)-1 H-pyrazolo[4,3- d]pyrimidin-7(6 H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa

by Fevig, John M., Cacciola, Joseph, Buriak, Joseph, Rossi, Karen A., Knabb, Robert M., Luettgen, Joseph M., Wong, Pancras C., Bai, Stephen A., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (2006)

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Preparation of 1-(3-aminobenzo[ d]isoxazol-5-yl)-1 H-pyrazolo[4,3- d]pyrimidin-7(6 H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa

Preparation of 1-(3-aminobenzo[ d]isoxazol-5-yl)-1 H-pyrazolo[4,3- d]pyrimidin-7(6 H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa

by Li, Yun-Long, Fevig, John M., Cacciola, Joseph, Buriak, Joseph, Rossi, Karen A., Jona, Janan, Knabb, Robert M., Luettgen, Joseph M., Wong, Pancras C., Bai, Stephen A., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (2006)

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The aza-Cope-Mannich approach to Strychnos alkaloids. Short stereocontrolled total syntheses of (±)-dehydrotubifoline and (±)-akuammicine

The aza-Cope-Mannich approach to Strychnos alkaloids. Short stereocontrolled total syntheses of (±)-dehydrotubifoline and (±)-akuammicine

by ANGLE, S. R, FEVIG, J. M, KNIGHT, S. D, MARQUIS, R. W, OVERMAN, L. E
Published in Journal of the American Chemical Society (01.05.1993)

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Journal Article

7,8-DIHYDRO-1,6-NAPHTHYRIDIN-5(6H)-ONE UND VERWANDTE BICYCLISCHE VERBINDUNGEN ALS HEMMER DER DIPEPTIDYL-PEPTIDASE IV SOWIE VERFAHREN

7,8-DIHYDRO-1,6-NAPHTHYRIDIN-5(6H)-ONE UND VERWANDTE BICYCLISCHE VERBINDUNGEN ALS HEMMER DER DIPEPTIDYL-PEPTIDASE IV SOWIE VERFAHREN

by FEVIG, JOHN M, FENG, JIANXIN
Year of Publication 15.03.2012

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Patent

7,8-DIHYDRO-1,6-NAPHTHYRIDIN-5(6H)-ONES AND RELATED BICYCLIC COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS

7,8-DIHYDRO-1,6-NAPHTHYRIDIN-5(6H)-ONES AND RELATED BICYCLIC COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS

by FEVIG, JOHN M, FENG, JIANXIN
Year of Publication 14.03.2012

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Patent

Synthesis and activity studies of conformationally restricted α-ketoamide factor Xa inhibitors

Synthesis and activity studies of conformationally restricted α-ketoamide factor Xa inhibitors

by CACCIOLA, J, FEVIG, J. M, STOUTEN, P. F. W, ALEXANDER, R. S, KNABB, R. M, WEXLER, R. R
Published in Bioorganic & medicinal chemistry letters (05.06.2000)

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Design and synthesis of ring-constrained boropeptide thrombin inhibitors

Design and synthesis of ring-constrained boropeptide thrombin inhibitors

by Fevig, John M., Abelman, Matthew M., Brittelli, David R., Kettner, Charles A., Knabb, Robert M., Weber, Patricia C.
Published in Bioorganic & medicinal chemistry letters (1996)

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