Search Results - "JOHANSEN, Tommy N" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype

Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype

by Chałupnik, Paulina, Vialko, Alina, Pickering, Darryl S, Hinkkanen, Markus, Donbosco, Stephanie, Møller, Thor C, Jensen, Anders A, Nielsen, Birgitte, Bay, Yasmin, Kristensen, Anders S, Johansen, Tommy N, Łątka, Kamil, Bajda, Marek, Szymańska, Ewa
Published in International journal of molecular sciences (08.08.2022)

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Synthesis and Antitumor Effect in Vitro and in Vivo of Substituted 1,3-Dihydroindole-2-ones

Synthesis and Antitumor Effect in Vitro and in Vivo of Substituted 1,3-Dihydroindole-2-ones

by Christensen, Mette K, Erichsen, Kamille D, Trojel-Hansen, Christina, Tjørnelund, Jette, Nielsen, Søren J, Frydenvang, Karla, Johansen, Tommy N, Nielsen, Birgitte, Sehested, Maxwell, Jensen, Peter B, Ikaunieks, Martins, Zaichenko, Andrei, Loza, Einars, Kalvinsh, Ivars, Björkling, Fredrik
Published in Journal of medicinal chemistry (14.10.2010)

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4-Hydroxy-1,2,5-oxadiazol-3-yl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Molecular Pharmacological Characterization at Ionotropic Glutamate Receptors of Compounds Related to Glutamate and Its Homologues

4-Hydroxy-1,2,5-oxadiazol-3-yl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Molecular Pharmacological Characterization at Ionotropic Glutamate Receptors of Compounds Related to Glutamate and Its Homologues

by Lolli, Marco L, Giordano, Cecilia, Pickering, Darryl S, Rolando, Barbara, Hansen, Kasper B, Foti, Antonio, Contreras-Sanz, Alberto, Amir, Ahmad, Fruttero, Roberta, Gasco, Alberto, Nielsen, Birgitte, Johansen, Tommy N
Published in Journal of medicinal chemistry (27.05.2010)

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Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

by Pallesen, Jakob S, Narayanan, Dilip, Tran, Kim T, Solbak, Sara M. Ø, Marseglia, Giuseppe, Sørensen, Louis M. E, Høj, Lars J, Munafò, Federico, Carmona, Rosa M. C, Garcia, Anthony D, Desu, Haritha L, Brambilla, Roberta, Johansen, Tommy N, Popowicz, Grzegorz M, Sattler, Michael, Gajhede, Michael, Bach, Anders
Published in Journal of medicinal chemistry (22.04.2021)

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A Tetrazolyl-Substituted Subtype-Selective AMPA Receptor Agonist

A Tetrazolyl-Substituted Subtype-Selective AMPA Receptor Agonist

by Vogensen, Stine B, Frydenvang, Karla, Greenwood, Jeremy R, Postorino, Giovanna, Nielsen, Birgitte, Pickering, Darryl S, Ebert, Bjarke, Bølcho, Ulrik, Egebjerg, Jan, Gajhede, Michael, Kastrup, Jette S, Johansen, Tommy N, Clausen, Rasmus P, Krogsgaard-Larsen, Povl
Published in Journal of medicinal chemistry (17.05.2007)

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Tritium and deuterium labelling of a kainate receptor antagonist and evaluation as a radioligand

Tritium and deuterium labelling of a kainate receptor antagonist and evaluation as a radioligand

by Chałupnik, Paulina, Marek, Aleš, Hovah, Marie Emilie Leiticia, Pickering, Darryl S., Temperini, Piero, Donbosco, Stephanie, Szymańska, Ewa, Johansen, Tommy N.
Published in Journal of labelled compounds & radiopharmaceuticals (01.04.2024)

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Structure-Activity Relationship and Solubility Studies of N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists

Structure-Activity Relationship and Solubility Studies of N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists

by Chalupnik, Paulina, Vialko, Alina, Pickering, Darryl S., Nielsen, Birgitte, Bay, Yasmin, Kristensen, Anders Skov, Hinkkanen, Markus, Szczepanska, Katarzyna, Karcz, Tadeusz, Latacz, Gniewomir, Johansen, Tommy N., Szymanska, Ewa
Published in ChemMedChem (15.09.2023)

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Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors

Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors

by Szymańska, Ewa, Nielsen, Birgitte, Johansen, Tommy N., Cuñado Moral, Ana Maria, Pickering, Darryl S., Szczepańska, Katarzyna, Mickowska, Anna, Kieć-Kononowicz, Katarzyna
Published in European journal of medicinal chemistry (29.09.2017)

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N1‑Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X‑ray Crystallography, Structure–Affinity Relationships, and in Vitro Pharmacology

N1‑Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X‑ray Crystallography, Structure–Affinity Relationships, and in Vitro Pharmacology

by Pallesen, Jakob, Møllerud, Stine, Frydenvang, Karla, Pickering, Darryl S, Bornholdt, Jan, Nielsen, Birgitte, Pasini, Diletta, Han, Liwei, Marconi, Laura, Kastrup, Jette Sandholm, Johansen, Tommy N
Published in ACS chemical neuroscience (20.03.2019)

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Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

by Szymanska, Ewa, Frydenvang, Karla, Pickering, Darryl S, Krintel, Christian, Nielsen, Birgitte, Kooshki, Ayesheh, Zachariassen, Linda G, Olsen, Lars, Kastrup, Jette S, Johansen, Tommy N
Published in Journal of medicinal chemistry (14.01.2016)

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N‑(7-(1H‑Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)‑yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X‑ray Crystallography, Structure–Affinity Relationships, and in Vitro and in Vivo Pharmacology

N‑(7-(1H‑Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)‑yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X‑ray Crystallography, Structure–Affinity Relationships, and in Vitro and in Vivo Pharmacology

by Møllerud, Stine, Hansen, Rie B, Pallesen, Jakob, Temperini, Piero, Pasini, Diletta, Bornholt, Jan, Nielsen, Birgitte, Mamedova, Esmira, Chalupnik, Paulina, Paternain, Ana V, Lerma, Juan, Diaz-delCastillo, Marta, Andreasen, Jesper T, Frydenvang, Karla, Kastrup, Jette S, Johansen, Tommy N, Pickering, Darryl S
Published in ACS chemical neuroscience (20.11.2019)

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Bioactivation of Diclofenac in Vitro and in Vivo: Correlation to Electrochemical Studies

Bioactivation of Diclofenac in Vitro and in Vivo: Correlation to Electrochemical Studies

by Madsen, Kim G, Skonberg, Christian, Jurva, Ulrik, Cornett, Claus, Hansen, Steen H, Johansen, Tommy N, Olsen, Jørgen
Published in Chemical research in toxicology (01.05.2008)

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Design, synthesis and structure–activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands

Design, synthesis and structure–activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands

by Szymańska, Ewa, Chałupnik, Paulina, Szczepańska, Katarzyna, Cuñado Moral, Ana Maria, Pickering, Darryl S., Nielsen, Birgitte, Johansen, Tommy N., Kieć-Kononowicz, Katarzyna
Published in Bioorganic & medicinal chemistry letters (15.11.2016)

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Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites

Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites

by Sköld, Niklas, Nielsen, Birgitte, Olsen, Jacob, Han, Liwei, Olsen, Lars, Madsen, Ulf, Kristensen, Jesper L., Pickering, Darryl S., Johansen, Tommy N.
Published in Bioorganic & medicinal chemistry (01.10.2014)

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Aryl‐ and heteroaryl‐substituted phenylalanines as AMPA receptor ligands

Aryl‐ and heteroaryl‐substituted phenylalanines as AMPA receptor ligands

by Szymańska, Ewa, Chałupnik, Paulina, Johansen, Tommy N., Nielsen, Birgitte, Cuñado Moral, Ana Maria, Pickering, Darryl S., Więckowska, Anna, Kieć‐Kononowicz, Katarzyna
Published in Chemical biology & drug design (01.12.2017)

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A New Phenylalanine Derivative Acts as an Antagonist at the AMPA Receptor GluA2 and Introduces Partial Domain Closure: Synthesis, Resolution, Pharmacology, and Crystal Structure

A New Phenylalanine Derivative Acts as an Antagonist at the AMPA Receptor GluA2 and Introduces Partial Domain Closure: Synthesis, Resolution, Pharmacology, and Crystal Structure

by Szymańska, Ewa, Frydenvang, Karla, Contreras-Sanz, Alberto, Pickering, Darryl S, Frola, Elena, Serafimoska, Zorica, Nielsen, Birgitte, Kastrup, Jette S, Johansen, Tommy N
Published in Journal of medicinal chemistry (27.10.2011)

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3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands

3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands

by Szymańska, Ewa, Pickering, Darryl S., Nielsen, Birgitte, Johansen, Tommy N.
Published in Bioorganic & medicinal chemistry (01.09.2009)

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(S)-Homo-AMPA, a Specific Agonist at the mGlu6 Subtype of Metabotropic Glutamic Acid Receptors

(S)-Homo-AMPA, a Specific Agonist at the mGlu6 Subtype of Metabotropic Glutamic Acid Receptors

by Ahmadian, Haleh, Nielsen, Birgitte, Bräuner-Osborne, Hans, Johansen, Tommy N, Stensbøl, Tine B, Sløk, Frank A, Sekiyama, Naohiro, Nakanishi, Shigetada, Krogsgaard-Larsen, Povl, Madsen, Ulf
Published in Journal of medicinal chemistry (24.10.1997)

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A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2

A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2

by Bräuner-Osborne, Hans, Hermit, Mette B, Nielsen, Birgitte, Krogsgaard-Larsen, Povl, Johansen, Tommy N
Published in European journal of pharmacology (06.10.2000)

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Structural and Pharmacological Characterization of Phenylalanine-Based AMPA Receptor Antagonists at Kainate Receptors

Structural and Pharmacological Characterization of Phenylalanine-Based AMPA Receptor Antagonists at Kainate Receptors

by Venskutonytė, Raminta, Frydenvang, Karla, Valadés, Elena Antón, Szymańska, Ewa, Johansen, Tommy N., Kastrup, Jette S., Pickering, Darryl S.
Published in ChemMedChem (01.10.2012)

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