Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype
Chałupnik, Paulina, Vialko, Alina, Pickering, Darryl S, Hinkkanen, Markus, Donbosco, Stephanie, Møller, Thor C, Jensen, Anders A, Nielsen, Birgitte, Bay, Yasmin, Kristensen, Anders S, Johansen, Tommy N, Łątka, Kamil, Bajda, Marek, Szymańska, Ewa
Published in International journal of molecular sciences (08.08.2022)
Published in International journal of molecular sciences (08.08.2022)
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Synthesis and Antitumor Effect in Vitro and in Vivo of Substituted 1,3-Dihydroindole-2-ones
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Published in Journal of medicinal chemistry (14.10.2010)
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4-Hydroxy-1,2,5-oxadiazol-3-yl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Molecular Pharmacological Characterization at Ionotropic Glutamate Receptors of Compounds Related to Glutamate and Its Homologues
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Published in Journal of medicinal chemistry (27.05.2010)
Published in Journal of medicinal chemistry (27.05.2010)
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Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds
Pallesen, Jakob S, Narayanan, Dilip, Tran, Kim T, Solbak, Sara M. Ø, Marseglia, Giuseppe, Sørensen, Louis M. E, Høj, Lars J, Munafò, Federico, Carmona, Rosa M. C, Garcia, Anthony D, Desu, Haritha L, Brambilla, Roberta, Johansen, Tommy N, Popowicz, Grzegorz M, Sattler, Michael, Gajhede, Michael, Bach, Anders
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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A Tetrazolyl-Substituted Subtype-Selective AMPA Receptor Agonist
Vogensen, Stine B, Frydenvang, Karla, Greenwood, Jeremy R, Postorino, Giovanna, Nielsen, Birgitte, Pickering, Darryl S, Ebert, Bjarke, Bølcho, Ulrik, Egebjerg, Jan, Gajhede, Michael, Kastrup, Jette S, Johansen, Tommy N, Clausen, Rasmus P, Krogsgaard-Larsen, Povl
Published in Journal of medicinal chemistry (17.05.2007)
Published in Journal of medicinal chemistry (17.05.2007)
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Tritium and deuterium labelling of a kainate receptor antagonist and evaluation as a radioligand
Chałupnik, Paulina, Marek, Aleš, Hovah, Marie Emilie Leiticia, Pickering, Darryl S., Temperini, Piero, Donbosco, Stephanie, Szymańska, Ewa, Johansen, Tommy N.
Published in Journal of labelled compounds & radiopharmaceuticals (01.04.2024)
Published in Journal of labelled compounds & radiopharmaceuticals (01.04.2024)
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Structure-Activity Relationship and Solubility Studies of N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists
Chalupnik, Paulina, Vialko, Alina, Pickering, Darryl S., Nielsen, Birgitte, Bay, Yasmin, Kristensen, Anders Skov, Hinkkanen, Markus, Szczepanska, Katarzyna, Karcz, Tadeusz, Latacz, Gniewomir, Johansen, Tommy N., Szymanska, Ewa
Published in ChemMedChem (15.09.2023)
Published in ChemMedChem (15.09.2023)
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Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors
Szymańska, Ewa, Nielsen, Birgitte, Johansen, Tommy N., Cuñado Moral, Ana Maria, Pickering, Darryl S., Szczepańska, Katarzyna, Mickowska, Anna, Kieć-Kononowicz, Katarzyna
Published in European journal of medicinal chemistry (29.09.2017)
Published in European journal of medicinal chemistry (29.09.2017)
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N1‑Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X‑ray Crystallography, Structure–Affinity Relationships, and in Vitro Pharmacology
Pallesen, Jakob, Møllerud, Stine, Frydenvang, Karla, Pickering, Darryl S, Bornholdt, Jan, Nielsen, Birgitte, Pasini, Diletta, Han, Liwei, Marconi, Laura, Kastrup, Jette Sandholm, Johansen, Tommy N
Published in ACS chemical neuroscience (20.03.2019)
Published in ACS chemical neuroscience (20.03.2019)
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Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors
Szymanska, Ewa, Frydenvang, Karla, Pickering, Darryl S, Krintel, Christian, Nielsen, Birgitte, Kooshki, Ayesheh, Zachariassen, Linda G, Olsen, Lars, Kastrup, Jette S, Johansen, Tommy N
Published in Journal of medicinal chemistry (14.01.2016)
Published in Journal of medicinal chemistry (14.01.2016)
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N‑(7-(1H‑Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)‑yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X‑ray Crystallography, Structure–Affinity Relationships, and in Vitro and in Vivo Pharmacology
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Published in ACS chemical neuroscience (20.11.2019)
Published in ACS chemical neuroscience (20.11.2019)
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Design, synthesis and structure–activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands
Szymańska, Ewa, Chałupnik, Paulina, Szczepańska, Katarzyna, Cuñado Moral, Ana Maria, Pickering, Darryl S., Nielsen, Birgitte, Johansen, Tommy N., Kieć-Kononowicz, Katarzyna
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
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Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites
Sköld, Niklas, Nielsen, Birgitte, Olsen, Jacob, Han, Liwei, Olsen, Lars, Madsen, Ulf, Kristensen, Jesper L., Pickering, Darryl S., Johansen, Tommy N.
Published in Bioorganic & medicinal chemistry (01.10.2014)
Published in Bioorganic & medicinal chemistry (01.10.2014)
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Aryl‐ and heteroaryl‐substituted phenylalanines as AMPA receptor ligands
Szymańska, Ewa, Chałupnik, Paulina, Johansen, Tommy N., Nielsen, Birgitte, Cuñado Moral, Ana Maria, Pickering, Darryl S., Więckowska, Anna, Kieć‐Kononowicz, Katarzyna
Published in Chemical biology & drug design (01.12.2017)
Published in Chemical biology & drug design (01.12.2017)
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A New Phenylalanine Derivative Acts as an Antagonist at the AMPA Receptor GluA2 and Introduces Partial Domain Closure: Synthesis, Resolution, Pharmacology, and Crystal Structure
Szymańska, Ewa, Frydenvang, Karla, Contreras-Sanz, Alberto, Pickering, Darryl S, Frola, Elena, Serafimoska, Zorica, Nielsen, Birgitte, Kastrup, Jette S, Johansen, Tommy N
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands
Szymańska, Ewa, Pickering, Darryl S., Nielsen, Birgitte, Johansen, Tommy N.
Published in Bioorganic & medicinal chemistry (01.09.2009)
Published in Bioorganic & medicinal chemistry (01.09.2009)
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(S)-Homo-AMPA, a Specific Agonist at the mGlu6 Subtype of Metabotropic Glutamic Acid Receptors
Ahmadian, Haleh, Nielsen, Birgitte, Bräuner-Osborne, Hans, Johansen, Tommy N, Stensbøl, Tine B, Sløk, Frank A, Sekiyama, Naohiro, Nakanishi, Shigetada, Krogsgaard-Larsen, Povl, Madsen, Ulf
Published in Journal of medicinal chemistry (24.10.1997)
Published in Journal of medicinal chemistry (24.10.1997)
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Structural and Pharmacological Characterization of Phenylalanine-Based AMPA Receptor Antagonists at Kainate Receptors
Venskutonytė, Raminta, Frydenvang, Karla, Valadés, Elena Antón, Szymańska, Ewa, Johansen, Tommy N., Kastrup, Jette S., Pickering, Darryl S.
Published in ChemMedChem (01.10.2012)
Published in ChemMedChem (01.10.2012)
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