Novel Relaxin Receptor RXFP1 Agonist AZD3427 in the Treatment of Heart Failure: A Phase 1a/b, First-in-Human, Randomized, Single-Blind, Placebo-Controlled Study
Connolly, Kathleen, George, Richard, Omar, Sami, Matsson, Elin, Åstrand, Magnus, Althage, Magnus, Pettersen, Daniel, Mohamed, Esha, Fang, Kelly, Lima, Joao A C, Kujacic, Mirjana, Ödesjö, Helena, Turton, Michelle, Johannesson, Petra, Gabrielsen, Anders, Ufnal, Marcin
Published in Journal of the American Heart Association (06.08.2024)
Published in Journal of the American Heart Association (06.08.2024)
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Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction
Inghardt, Tord, Antonsson, Thomas, Ericsson, Cecilia, Hovdal, Daniel, Johannesson, Petra, Johansson, Carina, Jurva, Ulrik, Kajanus, Johan, Kull, Bengt, Michaëlsson, Erik, Pettersen, Anna, Sjögren, Tove, Sörensen, Henrik, Westerlund, Kristina, Lindstedt, Eva-Lotte
Published in Journal of medicinal chemistry (08.09.2022)
Published in Journal of medicinal chemistry (08.09.2022)
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Correction to “Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction”
Inghardt, Tord, Antonsson, Thomas, Ericsson, Cecilia, Hovdal, Daniel, Johannesson, Petra, Johansson, Carina, Jurva, Ulrik, Kajanus, Johan, Kull, Bengt, Michaëlsson, Erik, Pettersen, Anna, Sjögren, Tove, Sörensen, Henrik, Westerlund, Kristina, Lindstedt, Eva-Lotte
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
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Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)
Doyle, Kevin, Lönn, Hans, Käck, Helena, Van de Poël, Amanda, Swallow, Steve, Gardiner, Philip, Connolly, Stephen, Root, James, Wikell, Cecilia, Dahl, Göran, Stenvall, Kristina, Johannesson, Petra
Published in Journal of medicinal chemistry (27.10.2016)
Published in Journal of medicinal chemistry (27.10.2016)
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Identification of novel GPR81 agonist lead series for target biology evaluation
Davidsson, Öjvind, Nilsson, Kristina, Brånalt, Jonas, Andersson, Terese, Berggren, Kristina, Chen, Yantao, Fjellström, Ola, Gradén, Henrik, Gustafsson, Linda, Hermansson, Nils-Olov, Jansen, Frank, Johannesson, Petra, Ohlsson, Bengt, Tyrchan, Christian, Wellner, Annika, Wellner, Eric, Ölwegård-Halvarsson, Maria
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
Published in Bioorganic & medicinal chemistry letters (15.02.2020)
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Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)‑2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma
Munck af Rosenschöld, Magnus, Johannesson, Petra, Nikitidis, Antonios, Tyrchan, Christian, Chang, Hui-Fang, Rönn, Robert, Chapman, Dave, Ullah, Victoria, Nikitidis, Grigorios, Glader, Pernilla, Käck, Helena, Bonn, Britta, Wågberg, Fredrik, Björkstrand, Eva, Andersson, Ulf, Swedin, Linda, Rohman, Mattias, Andreasson, Theresa, Bergström, Eva Lamm, Jiang, Fanyi, Zhou, Xiao-Hong, Lundqvist, Anders J, Malmberg, Anna, Ek, Margareta, Gordon, Euan, Pettersen, Anna, Ripa, Lena, Davis, Andrew M
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Involvement of the metabolic sensor GPR81 in cardiovascular control
Wallenius, Kristina, Thalén, Pia, Björkman, Jan-Arne, Johannesson, Petra, Wiseman, John, Böttcher, Gerhard, Fjellström, Ola, Oakes, Nicholas D
Published in JCI insight (05.10.2017)
Published in JCI insight (05.10.2017)
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Synthesis and Functionalization of Cyclic Sulfonimidamides: A Novel Chiral Heterocyclic Carboxylic Acid Bioisostere
Pemberton, Nils, Graden, Henrik, Evertsson, Emma, Bratt, Emma, Lepistö, Matti, Johannesson, Petra, Svensson, Per H
Published in ACS medicinal chemistry letters (12.07.2012)
Published in ACS medicinal chemistry letters (12.07.2012)
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Design and Optimization of Pyrazinecarboxamide-Based Inhibitors of Diacylglycerol Acyltransferase 1 (DGAT1) Leading to a Clinical Candidate Dimethylpyrazinecarboxamide Phenylcyclohexylacetic Acid (AZD7687)
Barlind, Jonas G., Bauer, Udo A., Birch, Alan M., Birtles, Susan, Buckett, Linda K., Butlin, Roger J., Davies, Robert D. M., Eriksson, Jan W., Hammond, Clare D., Hovland, Ragnar, Johannesson, Petra, Johansson, Magnus J., Kemmitt, Paul D., Lindmark, Bo T., Morentin Gutierrez, Pablo, Noeske, Tobias A., Nordin, Andreas, O’Donnell, Charles J., Petersson, Annika U., Redzic, Alma, Turnbull, Andrew V., Vinblad, Johanna
Published in Journal of medicinal chemistry (13.12.2012)
Published in Journal of medicinal chemistry (13.12.2012)
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Making medicinal chemistry more effective—application of Lean Sigma to improve processes, speed and quality
Andersson, Shalini, Armstrong, Alan, Björe, Annika, Bowker, Sue, Chapman, Steve, Davies, Rob, Donald, Craig, Egner, Bryan, Elebring, Thomas, Holmqvist, Sara, Inghardt, Tord, Johannesson, Petra, Johansson, Magnus, Johnstone, Craig, Kemmitt, Paul, Kihlberg, Jan, Korsgren, Pernilla, Lemurell, Malin, Moore, Jane, Pettersson, Jonas A., Pointon, Helen, Pontén, Fritiof, Schofield, Paul, Selmi, Nidhal, Whittamore, Paul
Published in Drug discovery today (01.06.2009)
Published in Drug discovery today (01.06.2009)
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Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats
Bengtsson, Christoffer, Blaho, Stefan, Saitton, David Blomberg, Brickmann, Kay, Broddefalk, Johan, Davidsson, Öjvind, Drmota, Tomas, Folmer, Rutger, Hallberg, Kenth, Hallén, Stefan, Hovland, Ragnar, Isin, Emre, Johannesson, Petra, Kull, Bengt, Larsson, Lars-Olof, Löfgren, Lars, Nilsson, Kristina E., Noeske, Tobias, Oakes, Nick, Plowright, Alleyn T., Schnecke, Volker, Ståhlberg, Pernilla, Sörme, Pernilla, Wan, Hong, Wellner, Eric, Öster, Linda
Published in Bioorganic & medicinal chemistry (15.05.2011)
Published in Bioorganic & medicinal chemistry (15.05.2011)
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Vinyl Sulfide Cyclized Analogues of Angiotensin II with High Affinity and Full Agonist Activity at the AT1 Receptor
Johannesson, Petra, Lindeberg, Gunnar, Johansson, Anja, Nikiforovich, Gregory V, Gogoll, Adolf, Synnergren, Barbro, Le Grèves, Madeleine, Nyberg, Fred, Karlén, Anders, Hallberg, Anders
Published in Journal of medicinal chemistry (25.04.2002)
Published in Journal of medicinal chemistry (25.04.2002)
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Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor
Johannesson, P, Lindeberg, G, Johansson, A, Nikiforovich, GV, Gogoll, A, Synnergren, B, Le Greves, M, Nyberg, F, Karlen, A, Hallberg, A
Published in Journal of medicinal chemistry (25.04.2002)
Published in Journal of medicinal chemistry (25.04.2002)
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1-[2-]-2--1235--4H-[32-d]-4-1-[2-AMINOMETHYLBENZYL]-2-THIOXO-1235-TETRAHYDRO-4H-PYRROLO[32-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE
JOHANNESSON PETRA, MICHAELSSON ERIK, LINDSTEDT ALSTERMARK EVA LOTTE, TOMKINSON NICHOLAS, GAN LI MING, JURVA ULRIK, STONEHOUSE JEFFREY PAUL, INGHARDT TORD BERTIL
Year of Publication 02.08.2017
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Year of Publication 02.08.2017
Patent
시클로프로판 카르복실산 유도체 및 이의 의약 용도
LINDH CARL JONAS, JOHANNESSON PETRA, RONN ROBERT, MUNCK AF ROSENSCHOELD MAGNUS, NIKITIDIS ANTONIOS, NIKITIDIS GRIGORIOS, SCHAAL WESLEY RALPH, TYRCHAN CHRISTIAN, ANDERSSON HANNA BIRGITTA ELLINOR, NILSSON PETER, RINGBERG ERIK
Year of Publication 08.01.2018
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Year of Publication 08.01.2018
Patent
AT2-Selective Angiotensin II Analogues Containing Tyrosine-Functionalized 5,5-Bicyclic Thiazabicycloalkane Dipeptide Mimetics
Johannesson, Petra, Erdélyi, Máté, Lindeberg, Gunnar, Frändberg, Per-Anders, Nyberg, Fred, Karlén, Anders, Hallberg, Anders
Published in Journal of medicinal chemistry (18.11.2004)
Published in Journal of medicinal chemistry (18.11.2004)
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AT 2 -Selective Angiotensin II Analogues Containing Tyrosine-Functionalized 5,5-Bicyclic Thiazabicycloalkane Dipeptide Mimetics
Johannesson, Petra, Erdélyi, Máté, Lindeberg, Gunnar, Frändberg, Per-Anders, Nyberg, Fred, Karlén, Anders, Hallberg, Anders
Published in Journal of medicinal chemistry (01.11.2004)
Published in Journal of medicinal chemistry (01.11.2004)
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1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
Michaelsson, Erik, Stonehouse, Jeffrey Paul, Jurva, Ulrik, Lindstedt-Alstermark, Eva-Lotte, Tomkinson, Nicholas, Inghardt, Tord Bertil, Johannesson, Petra, Gan, Li-Ming
Year of Publication 07.05.2024
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Year of Publication 07.05.2024
Patent