Crowd computing: using competitive dynamics to develop and refine highly predictive models
Bentzien, Jörg, Muegge, Ingo, Hamner, Ben, Thompson, David C.
Published in Drug discovery today (01.05.2013)
Published in Drug discovery today (01.05.2013)
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Journal Article
Identification of Highly Efficacious Glucocorticoid Receptor Agonists with a Potential for Reduced Clinical Bone Side Effects
Harcken, Christian, Riether, Doris, Kuzmich, Daniel, Liu, Pingrong, Betageri, Raj, Ralph, Mark, Emmanuel, Michel, Reeves, Jonathan T, Berry, Angela, Souza, Donald, Nelson, Richard M, Kukulka, Alison, Fadra, Tazmeen N, Zuvela-Jelaska, Ljiljana, Dinallo, Roger, Bentzien, Jörg, Nabozny, Gerald H, Thomson, David S
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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DemQSAR: predicting human volume of distribution and clearance of drugs
Demir-Kavuk, Ozgur, Bentzien, Jörg, Muegge, Ingo, Knapp, Ernst-Walter
Published in Journal of computer-aided molecular design (01.12.2011)
Published in Journal of computer-aided molecular design (01.12.2011)
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An in Silico Method for Predicting Ames Activities of Primary Aromatic Amines by Calculating the Stabilities of Nitrenium Ions
Bentzien, Jörg, Hickey, Eugene R, Kemper, Raymond A, Brewer, Mark L, Dyekjær, Jane D, East, Stephen P, Whittaker, Mark
Published in Journal of chemical information and modeling (22.02.2010)
Published in Journal of chemical information and modeling (22.02.2010)
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Identification of a Potent Sodium Hydrogen Exchanger Isoform 1 (NHE1) Inhibitor with a Suitable Profile for Chronic Dosing and Demonstrated Cardioprotective Effects in a Preclinical Model of Myocardial Infarction in the Rat
Huber, John D, Bentzien, Jörg, Boyer, Stephen J, Burke, Jennifer, De Lombaert, Stéphane, Eickmeier, Christian, Guo, Xin, Haist, James V, Hickey, Eugene R, Kaplita, Paul, Karmazyn, Morris, Kemper, Raymond, Kennedy, Charles A, Kirrane, Thomas, Madwed, Jeffrey B, Mainolfi, Elizabeth, Nagaraja, Nelamangara, Soleymanzadeh, Fariba, Swinamer, Alan, Eldrup, Anne B
Published in Journal of medicinal chemistry (23.08.2012)
Published in Journal of medicinal chemistry (23.08.2012)
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Substituted phenyl as a steroid A-ring mimetic: Providing agonist activity to a class of arylsulfonamide nonsteroidal glucocorticoid ligands
DiSalvo, Darren, Kuzmich, Daniel, Bentzien, Jörg, Regan, John, Kukulka, Alison, Fadra-Khan, Tazmeen, Nelson, Richard, Harcken, Christian, Thomson, David, Nabozny, Gerald
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Journal Article
Function-regulating pharmacophores in a sulfonamide class of glucocorticoid receptor agonists
Kuzmich, Daniel, Bentzien, Jörg, Betageri, Raj, DiSalvo, Darren, Fadra-Khan, Tazmeen, Harcken, Christian, Kukulka, Alison, Nabozny, Gerald, Nelson, Richard, Pack, Edward, Souza, Donald, Thomson, David
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Journal Article
Nonsteroidal Dissociated Glucocorticoid Agonists Containing Azaindoles as Steroid A-Ring Mimetics
Riether, Doris, Harcken, Christian, Razavi, Hossein, Kuzmich, Daniel, Gilmore, Thomas, Bentzien, Jörg, Pack, Edward J, Souza, Donald, Nelson, Richard M, Kukulka, Alison, Fadra, Tazmeen N, Zuvela-Jelaska, Ljiljana, Pelletier, Josephine, Dinallo, Roger, Panzenbeck, Mark, Torcellini, Carol, Nabozny, Gerald H, Thomson, David S
Published in Journal of medicinal chemistry (23.09.2010)
Published in Journal of medicinal chemistry (23.09.2010)
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Journal Article
Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore
Razavi, Hossein, Riether, Doris, Harcken, Christian, Bentzien, Joerg, Dinallo, Roger M., Souza, Donald, Nelson, Richard M., Kukulka, Alison, Fadra-Khan, Tazmeen N., Pack, Edward J., Zuvela-Jelaska, Ljiljana, Pelletier, Josephine, Panzenbeck, Mark, Torcellini, Carol A., Proudfoot, John R., Nabozny, Gerald H., Thomson, David S.
Published in Bioorganic & medicinal chemistry letters (15.04.2014)
Published in Bioorganic & medicinal chemistry letters (15.04.2014)
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Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores
Betageri, Raj, Gilmore, Thomas, Kuzmich, Daniel, Kirrane, Thomas M., Bentzien, Jörg, Wiedenmayer, Dieter, Bekkali, Younes, Regan, John, Berry, Angela, Latli, Bachir, Kukulka, Alison J., Fadra, Tazmeen N., Nelson, Richard M., Goldrick, Susan, Zuvela-Jelaska, Ljiljana, Souza, Don, Pelletier, Josephine, Dinallo, Roger, Panzenbeck, Mark, Torcellini, Carol, Lee, Heewon, Pack, Edward, Harcken, Christian, Nabozny, Gerald, Thomson, David S.
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
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2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket
Lo, Ho Yin, Bentzien, Jörg, Fleck, Roman W, Pullen, Steven S, Khine, Hnin Hnin, Woska, Jr, Joseph R, Kugler, Stanley Z, Kashem, Mohammed A, Takahashi, Hidenori
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design
Cook, Brian N., Bentzien, Jörg, White, Andre, Nemoto, Peter A., Wang, Ji, Man, Chuk C., Soleymanzadeh, Fariba, Khine, Hnin Hnin, Kashem, Mohammed A., Kugler, Stanley Z., Wolak, John P., Roth, Gregory P., De Lombaert, Stéphane, Pullen, Steven S., Takahashi, Hidenori
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS
LARSON, ERIC THOMAS, SHEN, YUE, BOSANAC, TODD, BENTZIEN, JOERG, TSCHANTZ, MATT AARON, BURKE, MICHAEL JASON, FRYER, RYAN MICHAEL, MAO, WANG, SOLEYMANZADEH, FARIBA, MCKIBBEN, BRYAN PATRICK
Year of Publication 30.04.2024
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Year of Publication 30.04.2024
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HETEROAMATIC COMPOUNDS AS BTK INHIBITORS
TODD BOSANAC, RYAN MICHAEL FRYER, JOERG BENTZIEN, ERIC THOMAS LARSON, BRYAN PATRICK MCKIBBEN, YUE SHEN, FARIBA SOLEYMANZADEH, MATT AARON TSCHANTZ, MICHAEL JASON BURKE, WANG MAO
Year of Publication 19.06.2023
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Year of Publication 19.06.2023
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BIPYRAZOLYL DERIVATIVES USEFUL FOR THE TREATMENT OF AUTOIMMUNE DISEASES
Burke, Michael Jason, Bosanac, Todd, Bentzien, Joerg, Tschantz, Matt Aaron, Mao, Wang, McKibben, Bryan Patrick, Shen, Yue, Soleymanzadeh, Fariba, Larson, Eric Thomas, Fryer, Ryan Michael
Year of Publication 04.03.2022
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Year of Publication 04.03.2022
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Year of Publication 24.01.2022
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Year of Publication 24.01.2022
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BURKE Michael Jason, SOLEYMANZADEH Fariba, BENTZIEN Joerg, SHEN Yue, TSCHANTZ Matt Aaron, LARSON Eric Thomas, BOSANAC Todd, MAO Wang, FRYER Ryan Michael, MCKIBBEN Bryan Patrick
Year of Publication 31.12.2021
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Year of Publication 31.12.2021
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Bipyrazolylderivater egnede til behandling af autoimmunsygdomme
TSCHANTZ, Matt Aaron, BOSANAC, Todd, SHEN, Yue, Bentzien, Joerg, BURKE, Michael Jason, SOLEYMANZADEH, Fariba, MAO, Wang, FRYER, Ryan Michael, MCKIBBEN, Bryan Patrick, LARSON, Eric Thomas
Year of Publication 06.12.2021
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Year of Publication 06.12.2021
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BIPYRAZOLYL DERIVATIVES USEFUL FOR THE TREATMENT OF AUTOIMMUNE DISEASES
LARSON, ERIC THOMAS, SHEN, YUE, BOSANAC, TODD, BENTZIEN, JOERG, TSCHANTZ, MATT AARON, BURKE, MICHAEL JASON, FRYER, RYAN MICHAEL, MAO, WANG, SOLEYMANZADEH, FARIBA, MCKIBBEN, BRYAN PATRICK
Year of Publication 30.11.2021
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Year of Publication 30.11.2021
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