Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2
Verma, Sharad K, Tian, Xinrong, LaFrance, Louis V, Duquenne, Céline, Suarez, Dominic P, Newlander, Kenneth A, Romeril, Stuart P, Burgess, Joelle L, Grant, Seth W, Brackley, James A, Graves, Alan P, Scherzer, Daryl A, Shu, Art, Thompson, Christine, Ott, Heidi M, Aller, Glenn S. Van, Machutta, Carl A, Diaz, Elsie, Jiang, Yong, Johnson, Neil W, Knight, Steven D, Kruger, Ryan G, McCabe, Michael T, Dhanak, Dashyant, Tummino, Peter J, Creasy, Caretha L, Miller, William H
Published in ACS medicinal chemistry letters (13.12.2012)
Published in ACS medicinal chemistry letters (13.12.2012)
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Journal Article
Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin
Knight, Steven D, Adams, Nicholas D, Burgess, Joelle L, Chaudhari, Amita M, Darcy, Michael G, Donatelli, Carla A, Luengo, Juan I, Newlander, Ken A, Parrish, Cynthia A, Ridgers, Lance H, Sarpong, Martha A, Schmidt, Stanley J, Van Aller, Glenn S, Carson, Jeffrey D, Diamond, Melody A, Elkins, Patricia A, Gardiner, Christine M, Garver, Eric, Gilbert, Seth A, Gontarek, Richard R, Jackson, Jeffrey R, Kershner, Kevin L, Luo, Lusong, Raha, Kaushik, Sherk, Christian S, Sung, Chiu-Mei, Sutton, David, Tummino, Peter J, Wegrzyn, Ronald J, Auger, Kurt R, Dhanak, Dashyant
Published in ACS medicinal chemistry letters (08.04.2010)
Published in ACS medicinal chemistry letters (08.04.2010)
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Journal Article
Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase
Adams, Nicholas D, Adams, Jerry L, Burgess, Joelle L, Chaudhari, Amita M, Copeland, Robert A, Donatelli, Carla A, Drewry, David H, Fisher, Kelly E, Hamajima, Toshihiro, Hardwicke, Mary Ann, Huffman, William F, Koretke-Brown, Kristin K, Lai, Zhihong V, McDonald, Octerloney B, Nakamura, Hiroko, Newlander, Ken A, Oleykowski, Catherine A, Parrish, Cynthia A, Patrick, Denis R, Plant, Ramona, Sarpong, Martha A, Sasaki, Kosuke, Schmidt, Stanley J, Silva, Domingos J, Sutton, David, Tang, Jun, Thompson, Christine S, Tummino, Peter J, Wang, Jamin C, Xiang, Hong, Yang, Jingsong, Dhanak, Dashyant
Published in Journal of medicinal chemistry (27.05.2010)
Published in Journal of medicinal chemistry (27.05.2010)
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Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)
Callahan, James F, Burgess, Joelle L, Fornwald, James A, Gaster, Laramie M, Harling, John D, Harrington, Frank P, Heer, Jag, Kwon, Chet, Lehr, Ruth, Mathur, A, Olson, Barbara A, Weinstock, Joseph, Laping, Nicholas J
Published in Journal of medicinal chemistry (28.02.2002)
Published in Journal of medicinal chemistry (28.02.2002)
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Journal Article
Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)
Yang, Hongfang, Medeiros, Patricia F, Raha, Kaushik, Elkins, Patricia, Lind, Kenneth E, Lehr, Ruth, Adams, Nicholas D, Burgess, Joelle L, Schmidt, Stanley J, Knight, Steven D, Auger, Kurt R, Schaber, Michael D, Franklin, G. Joseph, Ding, Yun, DeLorey, Jennifer L, Centrella, Paolo A, Mataruse, Sibongile, Skinner, Steven R, Clark, Matthew A, Cuozzo, John W, Evindar, Ghotas
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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Journal Article
Novel ATP-Competitive Kinesin Spindle Protein Inhibitors
Parrish, Cynthia A, Adams, Nicholas D, Auger, Kurt R, Burgess, Joelle L, Carson, Jeffrey D, Chaudhari, Amita M, Copeland, Robert A, Diamond, Melody A, Donatelli, Carla A, Duffy, Kevin J, Faucette, Leo F, Finer, Jeffrey T, Huffman, William F, Hugger, Erin D, Jackson, Jeffrey R, Knight, Steven D, Luo, Lusong, Moore, Michael L, Newlander, Ken A, Ridgers, Lance H, Sakowicz, Roman, Shaw, Antony N, Sung, Chiu-Mei M, Sutton, David, Wood, Kenneth W, Zhang, Shu-Yun, Zimmerman, Michael N, Dhanak, Dashyant
Published in Journal of medicinal chemistry (04.10.2007)
Published in Journal of medicinal chemistry (04.10.2007)
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Journal Article
Direct design of a potent non-peptide fibrinogen receptor antagonist based on the structure and conformation of a highly constrained cyclic RGD peptide
Ku, Thomas W, Ali, Fadia E, Barton, Linda S, Bean, John W, Bondinell, William E, Burgess, Joelle L, Callahan, James F, Calvo, Raul R, Chen, Lichong
Published in Journal of the American Chemical Society (01.09.1993)
Published in Journal of the American Chemical Society (01.09.1993)
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Journal Article
Design and synthesis of a C7 mimetic for the predicted .gamma.-turn conformation found in several constrained RGD antagonists
Callahan, James F, Bean, John W, Burgess, Joelle L, Eggleston, Drake S, Hwang, Shing Mei, Kopple, Kenneth D, Koster, Paul F, Nichols, Andrew, Peishoff, Catherine E
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Journal Article
Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR)
Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn, Carson, Jeff D., Elkins, Patricia A., Diamond, Melody, Gardiner, Christine M., Garver, Eric, Luo, Lusong, Raha, Kaushik, Sung, Chiu-Mei, Tummino, Peter J., Auger, Kurt R., Dhanak, Dashyant
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295
Qian, Xiangping, McDonald, Andrew, Zhou, Han-Jie, Adams, Nicholas D, Parrish, Cynthia A, Duffy, Kevin J, Fitch, Duke M, Tedesco, Rosanna, Ashcraft, Luke W, Yao, Bing, Jiang, Hong, Huang, Jennifer K, Marin, Melchor V, Aroyan, Carrie E, Wang, Jianchao, Ahmed, Seyed, Burgess, Joelle L, Chaudhari, Amita M, Donatelli, Carla A, Darcy, Michael G, Ridgers, Lance H, Newlander, Ken A, Schmidt, Stanley J, Chai, Deping, Colón, Mariela, Zimmerman, Michael N, Lad, Latesh, Sakowicz, Roman, Schauer, Stephen, Belmont, Lisa, Baliga, Ramesh, Pierce, Daniel W, Finer, Jeffrey T, Wang, Zhengping, Morgan, Bradley P, Morgans, David J, Auger, Kurt R, Sung, Chiu-Mei, Carson, Jeff D, Luo, Lusong, Hugger, Erin D, Copeland, Robert A, Sutton, David, Elliott, John D, Jackson, Jeffrey R, Wood, Kenneth W, Dhanak, Dashyant, Bergnes, Gustave, Knight, Steven D
Published in ACS medicinal chemistry letters (08.04.2010)
Published in ACS medicinal chemistry letters (08.04.2010)
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Journal Article
Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin
Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Luengo, Juan I., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn S., Carson, Jeffrey D., Diamond, Melody A., Elkins, Patricia A., Gardiner, Christine M., Garver, Eric, Gilbert, Seth A., Gontarek, Richard R., Jackson, Jeffrey R., Kershner, Kevin L., Luo, Lusong, Raha, Kaushik, Sherk, Christian S., Sung, Chiu-Mei, Sutton, David, Tummino, Peter J., Wegrzyn, Ronald J., Auger, Kurt R., Dhanak, Dashyant
Published in ACS medicinal chemistry letters (19.01.2010)
Published in ACS medicinal chemistry letters (19.01.2010)
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Journal Article
Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists
Samanen, James M, Ali, Fadia E, Barton, Linda S, Bondinell, William E, Burgess, Joelle L, Callahan, James F, Calvo, Raul R, Chen, Wenting, Chen, Lichong, Erhard, Karl, Feuerstein, Giora, Heys, Richard, Hwang, Shing-Mei, Jakas, Dalia R, Keenan, Richard M, Ku, Thomas W, Kwon, Chet, Lee, Chao-Pin, Miller, William H, Newlander, Kenneth A, Nichols, Andrew, Parker, Michael, Peishoff, Catherine E, Rhodes, Gerald, Ross, Steven, Shu, Arthur, Simpson, Richard, Takata, Dennis, Yellin, Tobias O, Uzsinskas, Irene, Venslavsky, Joseph W, Yuan, Chuan-Kui, Huffman, William F
Published in Journal of medicinal chemistry (06.12.1996)
Published in Journal of medicinal chemistry (06.12.1996)
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Journal Article
Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5)
Callahan, James F, Burgess, Joelle L, Fornwald, James A, Gaster, Laramie M, Harling, John D, Harrington, Frank P, Heer, Jag, Kwon, Chet, Lehr, Ruth, Mathur, A, Olson, Barbara A, Weinstock, Joseph, Laping, Nicholas J
Published in Journal of medicinal chemistry (28.02.2002)
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Published in Journal of medicinal chemistry (28.02.2002)
Journal Article
The use of γ-turn mimetics to define peptide secondary structure
Callahan, James F., Newlander, Kenneth A., Burgess, Joelle L., Eggleston, Drake S., Nichols, Andrew, Wong, Angela, Huffman, William F.
Published in Tetrahedron (23.04.1993)
Published in Tetrahedron (23.04.1993)
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Journal Article
CALCILYTIC COMPOUNDS
AMPARO M. LAGO, JAMES FRANCIS CALLAHAN, ERIC G. DEL MAR, JOELLE L. BURGESS, WILLIAM M. BRYAN, PRADIP KUMAR BHATNAGAR
Year of Publication 13.01.2017
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Year of Publication 13.01.2017
Patent
Conformational study of eight-membered diazocine turn mimics by two-dimensional NMR spectroscopy
Bean, John W., Briand, Jacques, Burgess, Joelle L., Callahan, James F.
Published in FEBS letters (07.11.1994)
Published in FEBS letters (07.11.1994)
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Journal Article
NAPHTHYRIDINE, DERIVATIVES AS P13 KINASE INHIBITORS
CHAUDHARI, AMITA, M, PARRISH, CYNTHIA, A, BURGESS, JOELLE, L, KNIGHT, STEVEN, DAVID, ADAMS, NICHOLAS, D
Year of Publication 17.08.2011
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Year of Publication 17.08.2011
Patent
NAPHTHYRIDINE, DERIVATIVES AS P13 KINASE INHIBITORS
ADAMS NICHOLAS D, PARRISH CYNTHIA A, CHAUDHARI AMITA M, KNIGHT DAVID, BURGESS JOELLE L
Year of Publication 15.07.2010
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Year of Publication 15.07.2010
Patent
NAPHTHYRIDINE, DERIVATIVES AS P13 KINASE INHIBITORS
CHAUDHARI, AMITA, M, PARRISH, CYNTHIA, A, BURGESS, JOELLE, L, KNIGHT, STEVEN, DAVID, ADAMS, NICHOLAS, D
Year of Publication 24.02.2010
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Year of Publication 24.02.2010
Patent