E-cadherin is required for metastasis in multiple models of breast cancer
Padmanaban, Veena, Krol, Ilona, Suhail, Yasir, Szczerba, Barbara M, Aceto, Nicola, Bader, Joel S, Ewald, Andrew J
Published in Nature (London) (01.09.2019)
Published in Nature (London) (01.09.2019)
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Design of a synthetic yeast genome
Richardson, Sarah M., Mitchell, Leslie A., Stracquadanio, Giovanni, Yang, Kun, Dymond, Jessica S., DiCarlo, James E., Lee, Dongwon, Huang, Cheng Lai Victor, Chandrasegaran, Srinivasan, Cai, Yizhi, Boeke, Jef D., Bader, Joel S.
Published in Science (American Association for the Advancement of Science) (10.03.2017)
Published in Science (American Association for the Advancement of Science) (10.03.2017)
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Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism
Gupta, Simone, Ellis, Shannon E, Ashar, Foram N, Moes, Anna, Bader, Joel S, Zhan, Jianan, West, Andrew B, Arking, Dan E
Published in Nature communications (10.12.2014)
Published in Nature communications (10.12.2014)
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Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters
Cheung, Kevin J., Padmanaban, Veena, Silvestri, Vanesa, Schipper, Koen, Cohen, Joshua D., Fairchild, Amanda N., Gorin, Michael A., Verdone, James E., Pienta, Kenneth J., Bader, Joel S., Ewald, Andrew J.
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2016)
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Synthetic Genomes
Zhang, Weimin, Mitchell, Leslie A, Bader, Joel S, Boeke, Jef D
Published in Annual review of biochemistry (20.06.2020)
Published in Annual review of biochemistry (20.06.2020)
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Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI and beyond
Mitchell, Leslie A., Wang, Ann, Stracquadanio, Giovanni, Kuang, Zheng, Wang, Xuya, Yang, Kun, Richardson, Sarah, Martin, J. Andrew, Zhao, Yu, Walker, Roy, Luo, Yisha, Dai, Hongjiu, Dong, Kang, Tang, Zuojian, Yang, Yanling, Cai, Yizhi, Heguy, Adriana, Ueberheide, Beatrix, Fenyö, David, Dai, Junbiao, Bader, Joel S., Boeke, Jef D.
Published in Science (American Association for the Advancement of Science) (10.03.2017)
Published in Science (American Association for the Advancement of Science) (10.03.2017)
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Priors, population sizes, and power in genome-wide hypothesis tests
Cai, Jitong, Zhan, Jianan, Arking, Dan E, Bader, Joel S
Published in BMC bioinformatics (26.04.2023)
Published in BMC bioinformatics (26.04.2023)
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Triple negative breast tumors contain heterogeneous cancer cells expressing distinct KRAS-dependent collective and disseminative invasion programs
Henriet, Elodie, Knutsdottir, Hildur, Grasset, Eloise M, Dunworth, Matthew, Haynes, Meagan, Bader, Joel S, Ewald, Andrew J
Published in Oncogene (03.03.2023)
Published in Oncogene (03.03.2023)
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Prioritizing drug targets by perturbing biological network response functions
Perrone, Matthew C, Lerner, Michael G, Dunworth, Matthew, Ewald, Andrew J, Bader, Joel S
Published in PLoS computational biology (27.06.2024)
Published in PLoS computational biology (27.06.2024)
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Synthetic chromosome arms function in yeast and generate phenotypic diversity by design
DYMOND, Jessica S, RICHARDSON, Sarah M, BOEKE, Annabel C, GOTTSCHLING, Daniel E, CHANDRASEGARAN, Srinivasan, BADER, Joel S, BOEKE, Jef D, COOMBES, Candice E, BABATZ, Timothy, MULLER, Heloise, ANNALURU, Narayana, BLAKE, William J, SCHWERZMANN, Joy W, JUNBIAO DAI, LINDSTROM, Derek L
Published in Nature (London) (22.09.2011)
Published in Nature (London) (22.09.2011)
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Journal Article
Twist1-induced dissemination preserves epithelial identity and requires E-cadherin
Shamir, Eliah R, Pappalardo, Elisa, Jorgens, Danielle M, Coutinho, Kester, Tsai, Wen-Ting, Aziz, Khaled, Auer, Manfred, Tran, Phuoc T, Bader, Joel S, Ewald, Andrew J
Published in The Journal of cell biology (03.03.2014)
Published in The Journal of cell biology (03.03.2014)
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Journal Article
Engineering the ribosomal DNA in a megabase synthetic chromosome
Zhang, Weimin, Zhao, Guanghou, Luo, Zhouqing, Lin, Yicong, Wang, Lihui, Guo, Yakun, Wang, Ann, Jiang, Shuangying, Jiang, Qingwen, Gong, Jianhui, Wang, Yun, Hou, Sha, Huang, Jing, Li, Tianyi, Qin, Yiran, Dong, Junkai, Qin, Qin, Zhang, Jiaying, Zou, Xinzhi, He, Xi, Zhao, Li, Xiao, Yibo, Xu, Meng, Cheng, Erchao, Huang, Ning, Zhou, Tong, Shen, Yue, Walker, Roy, Luo, Yisha, Kuang, Zheng, Mitchell, Leslie A., Yang, Kun, Richardson, Sarah M., Wu, Yi, Li, Bing-Zhi, Yuan, Ying-Jin, Yang, Huanming, Lin, Jiwei, Chen, Guo-Qiang, Wu, Qingyu, Bader, Joel S., Cai, Yizhi, Boeke, Jef D., Dai, Junbiao
Published in Science (American Association for the Advancement of Science) (10.03.2017)
Published in Science (American Association for the Advancement of Science) (10.03.2017)
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Heterozygous diploid and interspecies SCRaMbLEing
Shen, Michael J, Wu, Yi, Yang, Kun, Li, Yunxiang, Xu, Hui, Zhang, Haoran, Li, Bing-Zhi, Li, Xia, Xiao, Wen-Hai, Zhou, Xiao, Mitchell, Leslie A, Bader, Joel S, Yuan, Yingjin, Boeke, Jef D
Published in Nature communications (22.05.2018)
Published in Nature communications (22.05.2018)
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Journal Article
SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes
Shen, Yue, Stracquadanio, Giovanni, Wang, Yun, Yang, Kun, Mitchell, Leslie A, Xue, Yaxin, Cai, Yizhi, Chen, Tai, Dymond, Jessica S, Kang, Kang, Gong, Jianhui, Zeng, Xiaofan, Zhang, Yongfen, Li, Yingrui, Feng, Qiang, Xu, Xun, Wang, Jun, Wang, Jian, Yang, Huanming, Boeke, Jef D, Bader, Joel S
Published in Genome research (01.01.2016)
Published in Genome research (01.01.2016)
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Journal Article
The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation
Kang, Tae Hyuk, Park, Yongjin, Bader, Joel S, Friedmann, Theodore
Published in PloS one (09.10.2013)
Published in PloS one (09.10.2013)
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Molecular and systems approaches towards drought-tolerant canola crops
Zhu, Mengmeng, Monroe, J. Grey, Suhail, Yasir, Villiers, Florent, Mullen, Jack, Pater, Dianne, Hauser, Felix, Jeon, Byeong Wook, Bader, Joel S., Kwak, June M., Schroeder, Julian I., McKay, John K., Assmann, Sarah M.
Published in The New phytologist (01.06.2016)
Published in The New phytologist (01.06.2016)
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Deficiency of the novel exopolyphosphatase Rv1026/PPX2 leads to metabolic downshift and altered cell wall permeability in Mycobacterium tuberculosis
Chuang, Yu-Min, Bandyopadhyay, Nirmalya, Rifat, Dalin, Rubin, Harvey, Bader, Joel S, Karakousis, Petros C
Published in mBio (17.03.2015)
Published in mBio (17.03.2015)
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Technological challenges and milestones for writing genomes
Ostrov, Nili, Beal, Jacob, Ellis, Tom, Gordon, D Benjamin, Karas, Bogumil J, Lee, Henry H, Lenaghan, Scott C, Schloss, Jeffery A, Stracquadanio, Giovanni, Trefzer, Axel, Bader, Joel S, Church, George M, Coelho, Cintia M, Efcavitch, J William, Güell, Marc, Mitchell, Leslie A, Nielsen, Alec A K, Peck, Bill, Smith, Alexander C, Stewart, Jr, C Neal, Tekotte, Hille
Published in Science (American Association for the Advancement of Science) (18.10.2019)
Published in Science (American Association for the Advancement of Science) (18.10.2019)
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Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity
Li, Ling, Knutsdottir, Hildur, Hui, Ken, Weiss, Matthew J, He, Jin, Philosophe, Benjamin, Cameron, Andrew M, Wolfgang, Christopher L, Pawlik, Timothy M, Ghiaur, Gabriel, Ewald, Andrew J, Mezey, Esteban, Bader, Joel S, Selaru, Florin M
Published in JCI insight (24.01.2019)
Published in JCI insight (24.01.2019)
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