Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats
Koya, D, Jirousek, M R, Lin, Y W, Ishii, H, Kuboki, K, King, G L
Published in The Journal of clinical investigation (01.07.1997)
Published in The Journal of clinical investigation (01.07.1997)
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Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor
Ishii, Hidehiro, Jirousek, Michael R., Koya, Daisuke, Takagi, Chikako, Xia, Pu, Clermont, Allen, Bursell, Sven-Erik, Kern, Timothy S., Ballas, Lawrence M., Heath, William F., Stramm, Lawrence E., Feener, Edward P., King, George L.
Published in Science (American Association for the Advancement of Science) (03.05.1996)
Published in Science (American Association for the Advancement of Science) (03.05.1996)
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Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
Xia, P, Aiello, L P, Ishii, H, Jiang, Z Y, Park, D J, Robinson, G S, Takagi, H, Newsome, W P, Jirousek, M R, King, G L
Published in The Journal of clinical investigation (01.11.1996)
Published in The Journal of clinical investigation (01.11.1996)
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Journal Article
Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway
Kunisaki, M, Bursell, S E, Clermont, A C, Ishii, H, Ballas, L M, Jirousek, M R, Umeda, F, Nawata, H, King, G L
Published in The American journal of physiology (01.08.1995)
Published in The American journal of physiology (01.08.1995)
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Synthesis of bisindolylmaleimides using a palladium catalyzed cross-coupling reaction
Neel, David A., Jirousek, Michael R., McDonald, John H.
Published in Bioorganic & medicinal chemistry letters (06.01.1998)
Published in Bioorganic & medicinal chemistry letters (06.01.1998)
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Journal Article
Targeted Overexpression of Protein Kinase C β 2 Isoform in Myocardium Causes Cardiomyopathy
Wakasaki, Hisao, Koya, Daisuke, Schoen, Frederick J., Jirousek, Michael R., Ways, D. Kirk, Hoit, Brian D., Walsh, Richard A., King, George L.
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.1997)
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(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and Related Analogues: Isozyme Selective Inhibitors of Protein Kinase Cβ
Jirousek, Michael R, Gillig, James R, Gonzalez, Cecile M, Heath, William F, McDonald, John H, Neel, David A, Rito, Christopher J, Singh, Upinder, Stramm, Lawrence E, Melikian-Badalian, Anita, Baevsky, Matthew, Ballas, Lawrence M, Hall, Steven E, Winneroski, Leonard L, Faul, Margaret M
Published in Journal of medicinal chemistry (05.07.1996)
Published in Journal of medicinal chemistry (05.07.1996)
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Antisense Protein Tyrosine Phosphatase 1B Reverses Activation of p38 Mitogen-Activated Protein Kinase in Liver of ob/ob Mice
Gum, Rebecca J, Gaede, Lori L, Heindel, Matthew A, Waring, Jeffrey F, Trevillyan, James M, Zinker, Bradley A, Stark, Margery E, Wilcox, Denise, Jirousek, Michael R, Rondinone, Cristina M, Ulrich, Roger G
Published in Molecular endocrinology (Baltimore, Md.) (01.06.2003)
Published in Molecular endocrinology (Baltimore, Md.) (01.06.2003)
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Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells
Clampit, Jill E, Meuth, Joseph L, Smith, Harriet T, Reilly, Regina M, Jirousek, Michael R, Trevillyan, James M, Rondinone, Cristina M
Published in Biochemical and biophysical research communications (10.01.2003)
Published in Biochemical and biophysical research communications (10.01.2003)
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The Protein Kinase C beta -Specific Inhibitor LY379196 Blocks TPA-Induced Monocytic Differentiation of HL60 Cells
Slosberg, ED, Yao, Y, Xing, F, Ikui, A, Jirousek, M R, Weinstein, IB
Published in Molecular carcinogenesis (01.03.2000)
Published in Molecular carcinogenesis (01.03.2000)
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Journal Article
In vitro enzymatic assays of protein tyrosine phosphatase 1B
Lubben, T, Clampit, J, Stashko, M, Trevillyan, J, Jirousek, M R
Published in Current protocols in pharmacology (01.08.2001)
Published in Current protocols in pharmacology (01.08.2001)
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Protein tyrosine phosphatase 1B inhibitors for diabetes
Jirousek, Michael R, Johnson, Theodore O, Ermolieff, Jacques
Published in Nature reviews. Drug discovery (01.09.2002)
Published in Nature reviews. Drug discovery (01.09.2002)
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A synthesis or indolizidines related to castanospermine and swainsonine
Jirousek, Michael R., Cheung, Adrian W-H., Babine, Robert E., Sass, Philip M., Schow, Steven R., Wick, Michael M.
Published in Tetrahedron letters (04.06.1993)
Published in Tetrahedron letters (04.06.1993)
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Structure activity studies on pseudo-symmetrical HIV-1 protease inhibitors
Babine, Robert E., Zhang, Nan, Schow, Steven R., Jirousek, Michael R., Johnson, Bernard D., Kerwar, Suresh S., Desai, Parimal R., Byrn, Randal A., Hastings, Richard C., Wick, Michael M.
Published in Bioorganic & medicinal chemistry letters (01.08.1993)
Published in Bioorganic & medicinal chemistry letters (01.08.1993)
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