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Published in Journal of medicinal chemistry (14.11.2013)
Published in Journal of medicinal chemistry (14.11.2013)
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Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
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Published in Nature microbiology (01.10.2020)
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Functional Profiling of Recombinant NS3 Proteases from All Four Serotypes of Dengue Virus Using Tetrapeptide and Octapeptide Substrate Libraries
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Published in The Journal of biological chemistry (05.08.2005)
Published in The Journal of biological chemistry (05.08.2005)
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Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis
Lakshminarayana, Suresh B, Boshoff, Helena I M, Cherian, Joseph, Ravindran, Sindhu, Goh, Anne, Jiricek, Jan, Nanjundappa, Mahesh, Nayyar, Amit, Gurumurthy, Meera, Singh, Ramandeep, Dick, Thomas, Blasco, Francesca, Barry, 3rd, Clifton E, Ho, Paul C, Manjunatha, Ujjini H
Published in PloS one (20.08.2014)
Published in PloS one (20.08.2014)
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Enantioselective Synthesis of (−)-Gilbertine via a Cationic Cascade Cyclization
Jiricek, Jan, Blechert, Siegfried
Published in Journal of the American Chemical Society (24.03.2004)
Published in Journal of the American Chemical Society (24.03.2004)
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Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African trypanosomiasis
Rao, Srinivasa P S, Lakshminarayana, Suresh B, Jiricek, Jan, Kaiser, Marcel, Ritchie, Ryan, Myburgh, Elmarie, Supek, Frantisek, Tuntland, Tove, Nagle, Advait, Molteni, Valentina, Mäser, Pascal, Mottram, Jeremy C, Barrett, Michael P, Diagana, Thierry T
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Published in Tropical medicine and infectious disease (01.03.2020)
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Discovery of Tetrahydropyrazolopyrimidine Carboxamide Derivatives As Potent and Orally Active Antitubercular Agents
Yokokawa, Fumiaki, Wang, Gang, Chan, Wai Ling, Ang, Shi Hua, Wong, Josephine, Ma, Ida, Rao, Srinivasa P S, Manjunatha, Ujjini, Lakshminarayana, Suresh B, Herve, Maxime, Kounde, Cyrille, Tan, Bee Huat, Thayalan, Pamela, Ng, Seow Hwee, Nanjundappa, Mahesh, Ravindran, Sindhu, Gee, Peck, Tan, Maria, Wei, Liu, Goh, Anne, Chen, Pei-Yu, Lee, Kok Sin, Zhong, Chen, Wagner, Trixie, Dix, Ina, Chatterjee, Arnab K, Pethe, Kevin, Kuhen, Kelli, Glynne, Richard, Smith, Paul, Bifani, Pablo, Jiricek, Jan
Published in ACS medicinal chemistry letters (09.05.2013)
Published in ACS medicinal chemistry letters (09.05.2013)
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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
Pethe, Kevin, Bifani, Pablo, Jang, Jichan, Kang, Sunhee, Park, Seijin, Ahn, Sujin, Jiricek, Jan, Jung, Juyoung, Jeon, Hee Kyoung, Cechetto, Jonathan, Christophe, Thierry, Lee, Honggun, Kempf, Marie, Jackson, Mary, Lenaerts, Anne J, Pham, Ha, Jones, Victoria, Seo, Min Jung, Kim, Young Mi, Seo, Mooyoung, Seo, Jeong Jea, Park, Dongsik, Ko, Yoonae, Choi, Inhee, Kim, Ryangyeo, Kim, Se Yeon, Lim, SeungBin, Yim, Seung-Ae, Nam, Jiyoun, Kang, Hwankyu, Kwon, Haejin, Oh, Chun-Taek, Cho, Yoojin, Jang, Yunhee, Kim, Junghwan, Chua, Adeline, Tan, Bee Huat, Nanjundappa, Mahesh B, Rao, Srinivasa P S, Barnes, Whitney S, Wintjens, René, Walker, John R, Alonso, Sylvie, Lee, Saeyeon, Kim, Jungjun, Oh, Soohyun, Oh, Taegwon, Nehrbass, Ulf, Han, Sung-Jun, No, Zaesung, Lee, Jinhwa, Brodin, Priscille, Cho, Sang-Nae, Nam, Kiyean, Kim, Jaeseung
Published in Nature Medicine (01.09.2013)
Published in Nature Medicine (01.09.2013)
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Nagle, Advait, Biggart, Agnes, Be, Celine, Srinivas, Honnappa, Hein, Andreas, Caridha, Diana, Sciotti, Richard J, Pybus, Brandon, Kreishman-Deitrick, Mara, Bursulaya, Badry, Lai, Yin H, Gao, Mu-Yun, Liang, Fang, Mathison, Casey J. N, Liu, Xiaodong, Yeh, Vince, Smith, Jeffrey, Lerario, Isabelle, Xie, Yongping, Chianelli, Donatella, Gibney, Michael, Berman, Ashley, Chen, Yen-Liang, Jiricek, Jan, Davis, Lauren C, Liu, Xianzhong, Ballard, Jaime, Khare, Shilpi, Eggimann, Fabian Kurt, Luneau, Alexandre, Groessl, Todd, Shapiro, Michael, Richmond, Wendy, Johnson, Kevin, Rudewicz, Patrick J, Rao, Srinivasa P. S, Thompson, Christopher, Tuntland, Tove, Spraggon, Glen, Glynne, Richard J, Supek, Frantisek, Wiesmann, Christian, Molteni, Valentina
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
Singh, Ramandeep, Manjunatha, Ujjini, Boshoff, Helena I.M, Ha, Young Hwan, Niyomrattanakit, Pornwaratt, Ledwidge, Richard, Dowd, Cynthia S, Lee, Ill Young, Kim, Pilho, Zhang, Liang, Kang, Sunhee, Keller, Thomas H, Jiricek, Jan, Barry, Clifton E. 3rd
Published in Science (American Association for the Advancement of Science) (28.11.2008)
Published in Science (American Association for the Advancement of Science) (28.11.2008)
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Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections
Rao, Srinivasa P S, Gould, Matthew K, Noeske, Jonas, Saldivia, Manuel, Jumani, Rajiv S, Ng, Pearly S, René, Olivier, Chen, Yen-Liang, Kaiser, Marcel, Ritchie, Ryan, Francisco, Amanda Fortes, Johnson, Nila, Patra, Debjani, Cheung, Harry, Deniston, Colin, Schenk, Andreas D, Cortopassi, Wilian A, Schmidt, Remo S, Wiedemar, Natalie, Thomas, Bryanna, Palkar, Rima, Ghafar, Nahdiyah A, Manoharan, Vanessa, Luu, Catherine, Gable, Jonathan E, Wan, Kah Fei, Myburgh, Elmarie, Mottram, Jeremy C, Barnes, Whitney, Walker, John, Wartchow, Charles, Aziz, Natasha, Osborne, Colin, Wagner, Juergen, Sarko, Christopher, Kelly, John M, Manjunatha, Ujjini H, Mäser, Pascal, Jiricek, Jan, Lakshminarayana, Suresh B, Barrett, Michael P, Diagana, Thierry T
Published in Science (American Association for the Advancement of Science) (30.06.2023)
Published in Science (American Association for the Advancement of Science) (30.06.2023)
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Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis
Rao, Srinivasa P S, Lakshminarayana, Suresh B, Kondreddi, Ravinder R, Herve, Maxime, Camacho, Luis R, Bifani, Pablo, Kalapala, Sarath K, Jiricek, Jan, Ma, Ng L, Tan, Bee H, Ng, Seow H, Nanjundappa, Mahesh, Ravindran, Sindhu, Seah, Peck G, Thayalan, Pamela, Lim, Siao H, Lee, Boon H, Goh, Anne, Barnes, Whitney S, Chen, Zhong, Gagaring, Kerstin, Chatterjee, Arnab K, Pethe, Kevin, Kuhen, Kelli, Walker, John, Feng, Gu, Babu, Sreehari, Zhang, Lijun, Blasco, Francesca, Beer, David, Weaver, Margaret, Dartois, Veronique, Glynne, Richard, Dick, Thomas, Smith, Paul W, Diagana, Thierry T, Manjunatha, Ujjini H
Published in Science translational medicine (04.12.2013)
Published in Science translational medicine (04.12.2013)
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Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)
Koester, Dennis C., Marx, Vanessa M., Williams, Sarah, Jiricek, Jan, Dauphinais, Maxime, René, Olivier, Miller, Sarah L., Zhang, Lei, Patra, Debjani, Chen, Yen-Liang, Cheung, Harry, Gable, Jonathan, Lakshminarayana, Suresh B., Osborne, Colin, Galarneau, Jean-Rene, Kulkarni, Upendra, Richmond, Wendy, Bretz, Angela, Xiao, Linda, Supek, Frantisek, Wiesmann, Christian, Honnappa, Srinivas, Be, Celine, Mäser, Pascal, Kaiser, Marcel, Ritchie, Ryan, Barrett, Michael P., Diagana, Thierry T., Sarko, Christopher, Rao, Srinivasa P. S.
Published in Journal of medicinal chemistry (08.09.2022)
Published in Journal of medicinal chemistry (08.09.2022)
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A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
Pethe, Kevin, Sequeira, Patricia C, Agarwalla, Sanjay, Rhee, Kyu, Kuhen, Kelli, Phong, Wai Yee, Patel, Viral, Beer, David, Walker, John R, Duraiswamy, Jeyaraj, Jiricek, Jan, Keller, Thomas H, Chatterjee, Arnab, Tan, Mai Ping, Ujjini, Manjunatha, Rao, Srinivasa P.S, Camacho, Luis, Bifani, Pablo, Mak, Puiying A, Ma, Ida, Barnes, S. Whitney, Chen, Zhong, Plouffe, David, Thayalan, Pamela, Ng, Seow Hwee, Au, Melvin, Lee, Boon Heng, Tan, Bee Huat, Ravindran, Sindhu, Nanjundappa, Mahesh, Lin, Xiuhua, Goh, Anne, Lakshminarayana, Suresh B, Shoen, Carolyn, Cynamon, Michael, Kreiswirth, Barry, Dartois, Veronique, Peters, Eric C, Glynne, Richard, Brenner, Sydney, Dick, Thomas
Published in Nature communications (01.08.2010)
Published in Nature communications (01.08.2010)
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Structure−Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles
Kim, Pilho, Zhang, Liang, Manjunatha, Ujjini H, Singh, Ramandeep, Patel, Sejal, Jiricek, Jan, Keller, Thomas H, Boshoff, Helena I, Barry, Clifton E, Dowd, Cynthia S
Published in Journal of medicinal chemistry (12.03.2009)
Published in Journal of medicinal chemistry (12.03.2009)
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Structure−Activity Relationships of Antitubercular Nitroimidazoles. 2. Determinants of Aerobic Activity and Quantitative Structure−Activity Relationships
Kim, Pilho, Kang, Sunhee, Boshoff, Helena I, Jiricek, Jan, Collins, Margaret, Singh, Ramandeep, Manjunatha, Ujjini H, Niyomrattanakit, Pornwaratt, Zhang, Liang, Goodwin, Michael, Dick, Thomas, Keller, Thomas H, Dowd, Cynthia S, Barry, Clifton E
Published in Journal of medicinal chemistry (12.03.2009)
Published in Journal of medicinal chemistry (12.03.2009)
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Structure–Activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of (( S )-2-Nitro-6,7-dihydro-5 H -imidazo[2,1- b ][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-Amino PA-824)
Cherian, Joseph, Choi, Inhee, Nayyar, Amit, Manjunatha, Ujjini H., Mukherjee, Tathagata, Lee, Yong Sok, Boshoff, Helena I., Singh, Ramandeep, Ha, Young Hwan, Goodwin, Michael, Lakshminarayana, Suresh B., Niyomrattanakit, Pornwaratt, Jiricek, Jan, Ravindran, Sindhu, Dick, Thomas, Keller, Thomas H., Dartois, Veronique, Barry, Clifton E.
Published in Journal of medicinal chemistry (25.08.2011)
Published in Journal of medicinal chemistry (25.08.2011)
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