SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer
Chen, Hao, Libring, Sarah, Ruddraraju, Kasi Viswanatharaju, Miao, Jinmin, Solorio, Luis, Zhang, Zhong-Yin, Wendt, Michael K.
Published in Oncogene (03.12.2020)
Published in Oncogene (03.12.2020)
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Journal Article
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Kano, Yoshihito, Gebregiworgis, Teklab, Marshall, Christopher B., Radulovich, Nikolina, Poon, Betty P. K., St-Germain, Jonathan, Cook, Jonathan D., Valencia-Sama, Ivette, Grant, Benjamin M. M., Herrera, Silvia Gabriela, Miao, Jinmin, Raught, Brian, Irwin, Meredith S., Lee, Jeffrey E., Yeh, Jen Jen, Zhang, Zhong-Yin, Tsao, Ming-Sound, Ikura, Mitsuhiko, Ohh, Michael
Published in Nature communications (15.01.2019)
Published in Nature communications (15.01.2019)
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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors
Gebregiworgis, Teklab, Kano, Yoshihito, St-Germain, Jonathan, Radulovich, Nikolina, Udaskin, Molly L., Mentes, Ahmet, Huang, Richard, Poon, Betty P. K., He, Wenguang, Valencia-Sama, Ivette, Robinson, Claire M., Huestis, Melissa, Miao, Jinmin, Yeh, Jen Jen, Zhang, Zhong-Yin, Irwin, Meredith S., Lee, Jeffrey E., Tsao, Ming-Sound, Raught, Brian, Marshall, Christopher B., Ohh, Michael, Ikura, Mitsuhiko
Published in Nature communications (01.11.2021)
Published in Nature communications (01.11.2021)
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Journal Article
Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity
Miao, Jinmin, Bai, Yunpeng, Miao, Yiming, Qu, Zihan, Dong, Jiajun, Zhang, Ruo-Yu, Aggarwal, Devesh, Jassim, Brenson A, Nguyen, Quyen, Zhang, Zhong-Yin
Published in Molecules (Basel, Switzerland) (01.10.2023)
Published in Molecules (Basel, Switzerland) (01.10.2023)
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Journal Article
Mutations in the Gene Encoding Cystatin B in Progressive Myoclonus Epilepsy (EPM1)
Pennacchio, Len A., Lehesjoki, Anna-Elina, Stone, Nancy E., Willour, Virginia L., Virtaneva, Kimmo, Miao, Jinmin, D'Amato, Elena, Ramirez, Lucia, Faham, Malek, Koskiniemi, Marjaleena, Warrington, Janet A., Norio, Reijo, de la Chapelle, Albert, Cox, David R., Myers, Richard M.
Published in Science (American Association for the Advancement of Science) (22.03.1996)
Published in Science (American Association for the Advancement of Science) (22.03.1996)
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Journal Article
Unstable minisatellite expansion causing recessively inherited myoclonus epilepsy, EPM1
Chapelle, Albert de la, Dieguez-Lucena, José L, Myers, Richard M, Pennacchio, Len A, Koskiniemi, Marjaleena, Tassinari, Carlo A, D'Amato, Elena, Michelucci, Roberto, Omer, Salah, Avanzini, Giuliano, Franceschetti, Silvana, Krahe, Ralf, Lehesjoki, Anna-Elina, Norio, Reijo, Miao, Jinmin, Virtaneva, Kimmo
Published in Nature genetics (01.04.1997)
Published in Nature genetics (01.04.1997)
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Journal Article
Copper-promoted site-selective carbonylation of sp3 and sp2 C-H bonds with nitromethane
Wu, Xuesong, Miao, Jinmin, Li, Yanrong, Li, Guigen, Ge, Haibo
Published in Chemical science (Cambridge) (01.08.2016)
Published in Chemical science (Cambridge) (01.08.2016)
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Journal Article
Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
Wang, Xu, Yang, Chao, Wang, Xuejie, Miao, Jinmin, Chen, Weitao, Zhou, Yiren, Xu, Ying, An, Yongyan, Cheng, Aifang, Ye, Wenkang, Chen, Mengxian, Song, Dong, Yuan, Xue, Wang, Jiguang, Qian, Peiyuan, Wu, Angela Ruohao, Zhang, Zhong-Yin, Liu, Kai
Published in Neuron (Cambridge, Mass.) (18.01.2023)
Published in Neuron (Cambridge, Mass.) (18.01.2023)
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Journal Article
Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides
Miao, Jinmin, Richards, Nigel G. J., Ge, Haibo
Published in Chemical communications (Cambridge, England) (04.09.2014)
Published in Chemical communications (Cambridge, England) (04.09.2014)
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Journal Article
Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T‐Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy
Dong, Jiajun, Miao, Jinmin, Miao, Yiming, Qu, Zihan, Zhang, Sheng, Zhu, Peipei, Wiede, Florian, Jassim, Brenson A., Bai, Yunpeng, Nguyen, Quyen, Lin, Jianping, Chen, Lan, Tiganis, Tony, Tao, W. Andy, Zhang, Zhong‐Yin
Published in Angewandte Chemie International Edition (22.05.2023)
Published in Angewandte Chemie International Edition (22.05.2023)
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Journal Article
Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers
Miao, Yiming, Bai, Yunpeng, Miao, Jinmin, Murray, Allison A, Lin, Jianping, Dong, Jiajun, Qu, Zihan, Zhang, Ruo-Yu, Nguyen, Quyen D, Wang, Shaomeng, Yu, Jingmei, Nguele Meke, Frederick, Zhang, Zhong-Yin
Published in The Journal of clinical investigation (01.08.2024)
Published in The Journal of clinical investigation (01.08.2024)
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Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases
Dong, Jiajun, Jassim, Brenson A., Milholland, Kedric L., Qu, Zihan, Bai, Yunpeng, Miao, Yiming, Miao, Jinmin, Ma, Yuan, Lin, Jianping, Hall, Mark C., Zhang, Zhong-Yin
Published in Journal of medicinal chemistry (13.06.2024)
Published in Journal of medicinal chemistry (13.06.2024)
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Journal Article
Discovery and evaluation of novel SHIP-1 inhibitors
Miao, Jinmin, Lin, Jianping, Dong, Jiajun, Amarasinghe, Ovini, Mason, Emily R., Chu, Shaoyou, Qu, Zihan, Cullers, Clayton C., Putt, Karson S., Zhang, Zhong-Yin
Published in Bioorganic & medicinal chemistry (15.11.2024)
Published in Bioorganic & medicinal chemistry (15.11.2024)
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