Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease
Su, Haixia, Yao, Sheng, Zhao, Wenfeng, Zhang, Yumin, Liu, Jia, Shao, Qiang, Wang, Qingxing, Li, Minjun, Xie, Hang, Shang, Weijuan, Ke, Changqiang, Feng, Lu, Jiang, Xiangrui, Shen, Jingshan, Xiao, Gengfu, Jiang, Hualiang, Zhang, Leike, Ye, Yang, Xu, Yechun
Published in Nature communications (15.06.2021)
Published in Nature communications (15.06.2021)
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Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Yin, Wanchao, Mao, Chunyou, Luan, Xiaodong, Shen, Dan-Dan, Shen, Qingya, Su, Haixia, Wang, Xiaoxi, Zhou, Fulai, Zhao, Wenfeng, Gao, Minqi, Chang, Shenghai, Xie, Yuan-Chao, Tian, Guanghui, Jiang, He-Wei, Tao, Sheng-Ce, Shen, Jingshan, Jiang, Yi, Jiang, Hualiang, Xu, Yechun, Zhang, Shuyang, Zhang, Yan, Xu, H Eric
Published in Science (26.06.2020)
Published in Science (26.06.2020)
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Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2
Xie, Yuanchao, Yin, Wanchao, Zhang, Yumin, Shang, Weijuan, Wang, Zhen, Luan, Xiaodong, Tian, Guanghui, Aisa, Haji A., Xu, Yechun, Xiao, Gengfu, Li, Jia, Jiang, Hualiang, Zhang, Shuyang, Zhang, Leike, Xu, H. Eric, Shen, Jingshan
Published in Cell research (01.11.2021)
Published in Cell research (01.11.2021)
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Biological Activities of Artemisinin Derivatives Beyond Malaria
Liu, Xiaoyan, Cao, Jianguo, Huang, Guozheng, Zhao, Qingjie, Shen, Jingshan
Published in Current topics in medicinal chemistry (01.01.2019)
Published in Current topics in medicinal chemistry (01.01.2019)
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SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target
Xia, Bingqing, Shen, Xurui, He, Yang, Pan, Xiaoyan, Liu, Feng-Liang, Wang, Yi, Yang, Feipu, Fang, Sui, Wu, Yan, Duan, Zilei, Zuo, Xiaoli, Xie, Zhuqing, Jiang, Xiangrui, Xu, Ling, Chi, Hao, Li, Shuangqu, Meng, Qian, Zhou, Hu, Zhou, Yubo, Cheng, Xi, Xin, Xiaoming, Jin, Lin, Zhang, Hai-Lin, Yu, Dan-Dan, Li, Ming-Hua, Feng, Xiao-Li, Chen, Jiekai, Jiang, Hualiang, Xiao, Gengfu, Zheng, Yong-Tang, Zhang, Lei-Ke, Shen, Jingshan, Li, Jia, Gao, Zhaobing
Published in Cell research (01.08.2021)
Published in Cell research (01.08.2021)
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Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir
Jiang, Xiangrui, Su, Haixia, Shang, Weijuan, Zhou, Feng, Zhang, Yan, Zhao, Wenfeng, Zhang, Qiumeng, Xie, Hang, Jiang, Lei, Nie, Tianqing, Yang, Feipu, Xiong, Muya, Huang, Xiaoxing, Li, Minjun, Chen, Ping, Peng, Shaoping, Xiao, Gengfu, Jiang, Hualiang, Tang, Renhong, Zhang, Leike, Shen, Jingshan, Xu, Yechun
Published in Nature communications (13.10.2023)
Published in Nature communications (13.10.2023)
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The complete synthesis of favipiravir from 2-aminopyrazine
Guo, Qi, Xu, Mingshuo, Guo, Shuang, Zhu, Fuqiang, Xie, Yuanchao, Shen, Jingshan
Published in Chemical papers (01.05.2019)
Published in Chemical papers (01.05.2019)
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Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus
Wu, Chunhui, Wang, Yu, He, Yang, Wu, Song, Xie, Zhifei, Zhang, Jian, Shen, Jingshan, Wang, Zhen, He, Ling
Published in Neurobiology of learning and memory (01.01.2020)
Published in Neurobiology of learning and memory (01.01.2020)
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Astemizole Arrests the Proliferation of Cancer Cells by Disrupting the EZH2-EED Interaction of Polycomb Repressive Complex 2
Kong, Xiangqian, Chen, Limin, Jiao, Lianying, Jiang, Xiangrui, Lian, Fulin, Lu, Junyan, Zhu, Kongkai, Du, Daohai, Liu, Jingqiu, Ding, Hong, Zhang, Naixia, Shen, Jingshan, Zheng, Mingyue, Chen, Kaixian, Liu, Xin, Jiang, Hualiang, Luo, Cheng
Published in Journal of medicinal chemistry (26.11.2014)
Published in Journal of medicinal chemistry (26.11.2014)
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Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model
Zhang, Ruxue, Zhang, Yumin, Zheng, Wei, Shang, Weijuan, Wu, Yan, Li, Ning, Xiong, Jun, Jiang, Hualiang, Shen, Jingshan, Xiao, Gengfu, Xie, Yuanchao, Zhang, Leike
Published in Signal transduction and targeted therapy (16.04.2022)
Published in Signal transduction and targeted therapy (16.04.2022)
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9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation
Lv, Jie, Zhuang, Wei, Zhang, Yan, Xie, Ling, Xiang, Zhenglong, Zhao, Qingjie, Jiang, Xiangrui, Shen, Jingshan, Du, Changsheng
Published in Inflammation (01.10.2021)
Published in Inflammation (01.10.2021)
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Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir, Its Parent Nucleoside and β-d-N4-hydroxycytidine
Xie, Yuanchao, Guo, Xiaozhen, Hu, Tianwen, Wei, Daibao, Ma, Xiuli, Wu, Jiaqiang, Huang, Bing, Shen, Jingshan
Published in Virologica Sinica (01.10.2021)
Published in Virologica Sinica (01.10.2021)
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Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors
Xu, Zhijian, Liu, Zheng, Chen, Tong, Chen, TianTian, Wang, Zhen, Tian, Guanghui, Shi, Jing, Wang, Xuelan, Lu, Yunxiang, Yan, Xiuhua, Wang, Guan, Jiang, Hualiang, Chen, Kaixian, Wang, Shudong, Xu, Yechun, Shen, Jingshan, Zhu, Weiliang
Published in Journal of medicinal chemistry (11.08.2011)
Published in Journal of medicinal chemistry (11.08.2011)
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Combination of miR159 Mimics and Irinotecan Utilizing Lipid Nanoparticles for Enhanced Treatment of Colorectal Cancer
Yang, Rulei, Liu, Yiran, Yang, Ning, Zhang, Tian, Hou, Jiazhen, He, Zongyan, Wang, Yutong, Sun, Xujie, Shen, Jingshan, Jiang, Hualiang, Xie, Yuanchao, Lang, Tianqun
Published in Pharmaceutics (01.04.2024)
Published in Pharmaceutics (01.04.2024)
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A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir
Zhang, Yumin, Sun, Yuan, Xie, Yuanchao, Shang, Weijuan, Wang, Zhen, Jiang, Hualiang, Shen, Jingshan, Xiao, Gengfu, Zhang, Leike
Published in Signal transduction and targeted therapy (22.09.2023)
Published in Signal transduction and targeted therapy (22.09.2023)
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Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review
Xie, Yuanchao, Ogah, Comfort Alicha, Jiang, Xiangrui, Li, Jianfeng, Shen, Jingshan
Published in Current drug targets (01.01.2016)
Published in Current drug targets (01.01.2016)
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Impurity study of tecovirimat
Bonku, Emmanuel Mintah, Qin, Hongjian, Odilov, Abdullajon, Abduahadi, Safomuddin, Desta Guma, Samuel, Yang, Feipu, Xing, Xinglong, Wang, Xukun, Shen, Jingshan
Published in Heliyon (15.05.2024)
Published in Heliyon (15.05.2024)
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The novel small-molecule TPN10456 inhibits Th17 cell differentiation and protects against experimental autoimmune encephalomyelitis
Yang, Cuixia, Lv, Jie, Jiang, Xiangrui, Xiang, Zhenglong, Gong, Ran, Xing, Jiahua, Liu, Guangyu, Xie, Ling, Saimaier, Kandireya, Zhang, Yan, Wang, Junjian, Shen, Hu, Pan, Juping, Shen, Jingshan, Du, Changsheng
Published in Cellular & molecular immunology (01.12.2020)
Published in Cellular & molecular immunology (01.12.2020)
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Direct esterification of amides by the dimethylsulfate-mediated activation of amide C–N bonds
Qin, Hongjian, Han, Zijian, Bonku, Emmanuel Mintah, Sun, Haiguo, Odilov, Abdullajon, Zhu, Fuqiang, Abduahadi, Safomuddin, Zhu, Weiliang, Shen, Jingshan, Aisa, Haji A.
Published in Communications chemistry (27.04.2024)
Published in Communications chemistry (27.04.2024)
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Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity
Chen, Zhi, Tian, Guanghui, Wang, Zhen, Jiang, Hualiang, Shen, Jingshan, Zhu, Weiliang
Published in Journal of chemical information and modeling (26.04.2010)
Published in Journal of chemical information and modeling (26.04.2010)
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